LDN QUESTION

[Guest guest]

I'm still undx'ed to date.I have been on LDN since August 15th

2003.I feel it's working.But couple of questions.While taking LDN

does anyone sx's seem to kick up a little then settle down.I'm going

through that now.I still get the tingling and numbness and

burning.But I guess thats normal not sure.Funny how I went through a

whole lot of tests in the last 4.5 years and they still tell me its

not MS.

[Guest guest]

I just sent this to someone, and rather than repeat myself again,I thought I would send it to the list. It explains what you describe:

, over on http://www.voy.com/156761/ posted this, from Dr.Lawrence.

It has a useful description not only of why the activity canstill happen in the early stages of LDN use, but of why, in thelong term, it still works: rebalancing of T-cell production.

The good news is, the explanation is also of why it treats MS, andif whatever it is that stimulated the activity in the first placewill also assist in destruction of the helper cells, or anyway onceyou have produced enough new suppressor cells, you should start to seeresults.

I think I may have some of what he calls accommodation and I calltachyphylaxis. Therefore I will soon take a 2-day holiday from LDN.

This should counteract the effects of my being on a larger dose andthen reducing it, and put me even more on track.

-Sullivan

"In addition, there may also be some initial transient, thoughtemporary, increase in MS symptoms.

Experience in using this method has demonstrated most commonly, suchas disturbed sleep, occasionally with vivid, bizarre and disturbingdreams, tiredness, fatigue, spasm and pain. These increased symptomsusually fade and disappear within five to seven days.

Rarely, other transient symptoms have included more severe pain and spasm, headache, diarrhea or vomiting. These additional symptoms would appear to be associated with the previous frequent use of strong analgesics, which effectively create an addiction and dependency, thus increasing the body's sensitivity to pain.

It has also recently become apparent that some patients have experienced additional symptoms, such as muscle stiffness or pain, after a few weeks of therapy. This is believed to be due to an occasional increased sensitivity to the lactose filler used in the capsules. If this should occur, a similar preparation, using calcium carbonate filler, may be provided as an alternative.

The early but temporary increase in symptoms may also perhaps be explained when we consider the manner in which this drug is expected to work.

Initially, MS occurs due to a reduction in the activity of the controlling influence of the suppressor T-cells within the immune system.

During an acute relapse, the overall number of T-cells is reduced, the normal balance of helper T-cells and suppressor T-cells is disrupted and the damaging helper (CD-4) T-cells tend to predominate. This is the situation most pronounced during an acute relapse but occurs similarly, but to a lesser extent, in chronic progressive MS.

Under the influence of LDN there will be an expected increase in the overall numbers of T-cells but, because the CD-4, helper T-cells tend to predominate at this time, an increase in their numbers will expectedly tend to increase MS symptoms.

It is only when the numbers of suppressor T-cells effectively "catch up" that the normal balance is restored and symptoms once again diminish and improve."