Belinda re TIMING OF DOSE & METABOLISM & CAPSULE FILLER

[Guest guest]

Hi Belinda,

re TIMING OF DOSE & METABOLISM & CAPSULE FILLER

We all understand LDN is most effective when the dose is taken between 10pm and

2am, however; I don't believe

this is the only variable factor necessitating consideration when targeting

optimum efficacy.

Metabolism is another variable factor that must be considered, especially when

working with such small doses.

Each person's metabolism is different - we metabolise foods, medications, etc

differently.

Also, a person's normal metabolism can change over short or long periods of time

- weeks, days, even hours -

in response to other variable lifestyle factors such as changes in diet,

exercise, supplements, medications,

etc.

Antioxidants, for example; as supplements, detoxes, or even teas or dark

chocolate; can speed metabolism

(speed exit).

This means it's unlikely every person can take advantage of the full four-hour

(10pm to 2am) medication window

and achieve optimum efficacy.

Perhaps ...

a) Those with a slow metabolism may benefit most from the earliest dosage window

for LDN.

Those with a fast metabolism may benefit most from the latest dosage window

for LDN.

You know your own body better than anyone else - so please give consideration to

your own normal metabolism,

and consider anything that could be impacting metabolisation of LDN.

Speed of metabolism is also relevant to choice of capsule fillers: Some time

back now it was determined that

calcium carbonate was not the ideal filler in LDN capsules because it had a

tendency to compact and therefore,

could slow down release of the active ingredient (Naltrexone). For those who

already had a slow metabolism,

you can see how a delay in the release of the active ingredient could very well

be counterproductive.

To summarise, in my (unqualified) opinion, the bottom line here is this ...

1. As the Naltrexone dose is minute, the timing of each person's dose will be

dependent on multiple variable

factors that must be given due consideration if optimum efficacy is to be

achieved.

2. Antioxidants (and anything else that may interfere with metabolising LDN)

should not be taken in the

evening near to when you take your LDN as they may negatively impact

metabolisation of such a small dose of

Naltrexone.

Kind regards,

Cris

casehealth.com.au

5e. Re: Is the time to take LDN, the same every night?

Posted by: " Gunn Dybfest " gunn.ingrid@... gunn.ingrid

Date: Sat Jan 12, 2008 2:51 pm ((PST))

Hi Belinda,

welcome to this board, it's nice to have another european here!

To be a part of this group you will alway get nice and friendly

support. Please, enjoy whenever you want, and don't think about

your English, it hasn't been a problem at all not being too much of

an language expert in here ;-)..

I am doing the same thing as you, it variates when I take my ldn,

i jump between 11.pm and 00.30 am, and to be honest, I don't

think it's too smart :-)...so I have to decide taking it more regularly.

I think someone in here wrote that it's quite neccessary doing so.

But I forget sometimes.....but never till the next day....

I come from Norway, it's a little country, we're only 4.5 millions

here....and I think it's fantastic that in such a little country, 200

doctors prescribes ldn to their patients :-)

With all the best

from

Ingrid

5d. Re: Is the time to take LDN, the same every night?

Posted by: " LarryGC " larrygc@... larrygc12

Date: Sat Jan 12, 2008 2:35 pm ((PST))

For the first 4 or so years I took my LDN between 1230 and 0230 am every day...

it varied a lot, depending how

involved I got at work and when I realized I didn't take it.

http://www.larrygc.com/mystory I can't imagine

getting better results if I had taken it the same same minute every day.

5a. Is the time to take LDN, the same every night?

Posted by: " cocoontjebelinda " ms@... cocoontjebelinda

Date: Sat Jan 12, 2008 7:03 am ((PST))

Hi LDN-people,

Im a girl from The Netherlands (with progressive MS dx. 08 2007) and

on LDN for about 70 day's now (4,5 mg). I have found all the

information over LDN on the Internet, I buy and make my own liquid LDN

without prescription from my neuro.

I dont have experienced yet a decrease in symptomes (besides less

tingling in my legs). I have a strong believe in LDN and I've read

serveral great stories. Im still progressing but I hope the LDN will

stop or slower that.

Im reading here for several months but I still have a tiny question. I

know you must take LDN between 9pm/3am, so I taking LDN before I go to

bed. Sometimes its 23.00 but another night its 01.00. Is this a

problem? Is it better to take LDN on the same time each night?

Thanks in advance!

You all do great work by helping us with your information! My doctor

only knows about LDN because I told him so and that is not always

handy when you are insecure about things...

Sorry for my bad English but Im doing my best! :-)

Belinda

[Guest guest]

Thank you for your explanation about metabolism!

Im not an expert either but I think I have a slower working

metabolism. I have always cold feets and hands and dont eat much on a day.

I will try to take the LDN at 22.00 hour to check if that will work

better for me!

I make my own liquid LDN (with tapwater, they say it has a good

quality her in the Netherlands) from the Revia tablets so I dont have

the problem with the fillers.

The anti-oxidants I used to take, I always take them in the morning,

so that cant be the problem also.

I dont take any medicine besides the LDN.

Thank for the advice!

With the best wishes,

Belinda

>

> Hi Belinda,

>

> re TIMING OF DOSE & METABOLISM & CAPSULE FILLER

>

> We all understand LDN is most effective when the dose is taken

between 10pm and 2am, however; I don't believe

> this is the only variable factor necessitating consideration when

targeting optimum efficacy.

>

> Metabolism is another variable factor that must be considered,

especially when working with such small doses.

>

> Each person's metabolism is different - we metabolise foods,

medications, etc differently.

>

> Also, a person's normal metabolism can change over short or long

periods of time - weeks, days, even hours -

> in response to other variable lifestyle factors such as changes in

diet, exercise, supplements, medications,

> etc.

>

> Antioxidants, for example; as supplements, detoxes, or even teas or

dark chocolate; can speed metabolism

> (speed exit).

>

> This means it's unlikely every person can take advantage of the full

four-hour (10pm to 2am) medication window

> and achieve optimum efficacy.

>

> Perhaps ...

> a) Those with a slow metabolism may benefit most from the earliest

dosage window for LDN.

> Those with a fast metabolism may benefit most from the latest

dosage window for LDN.

>

> You know your own body better than anyone else - so please give

consideration to your own normal metabolism,

> and consider anything that could be impacting metabolisation of LDN.

>

> Speed of metabolism is also relevant to choice of capsule fillers:

Some time back now it was determined that

> calcium carbonate was not the ideal filler in LDN capsules because

it had a tendency to compact and therefore,

> could slow down release of the active ingredient (Naltrexone). For

those who already had a slow metabolism,

> you can see how a delay in the release of the active ingredient

could very well be counterproductive.

>

> To summarise, in my (unqualified) opinion, the bottom line here is

this ...

>

> 1. As the Naltrexone dose is minute, the timing of each person's

dose will be dependent on multiple variable

> factors that must be given due consideration if optimum efficacy is

to be achieved.

>

> 2. Antioxidants (and anything else that may interfere with

metabolising LDN) should not be taken in the

> evening near to when you take your LDN as they may negatively impact

metabolisation of such a small dose of

> Naltrexone.

>

> Kind regards,

> Cris

> casehealth.com.au