Question about LDN and Immodium interaction

[Guest guest]

Hello all:

I have Crohn's and recently decided to try LDN. My symptoms aren't

bad right now, but i'm trying to stop progression of the disease.

I got LDN (1.5MG) from a local compounding pharmacy and was clear

that I needed Avicel as a filler since I am lactose intolerant. I

confirmed this from the pharmacy when i picked it up.

I've tried starting LDN twice now (a single 1.5MG dose) and both

nights I tried it, it caused an extreme laxative effect. I had

extremely intense cramping for 5-6 hours of the night and was in and

out of the bathroom repeatedly. The first time I thought it might

have been a coincidence, but now I know it was the LDN. I never have

symptoms like this with Crohn's (in fact, I'm never up in the middle

of the night at all).

My initial thought is that this could be some kind of interaction

with Immodium (I take 2 in the morning each day). I know Immodium is

an opiate derivative. My thought is maybe the LDN is blocking the

action of the Immodium and causing almost an opposite, laxative

effect.

Anyone have any thoughts on this? I can't seem to find anything

online about Immodium interaction. Quite discouraged -- was hoping

LDN might be the trick but I clearly can't take it with this kind of

side effect.

Thanks.

[Guest guest]

The adults that use ldn here have had no gi effects. Both use the

cream.

>

> Hello all:

>

> I have Crohn's and recently decided to try LDN. My symptoms aren't

> bad right now, but i'm trying to stop progression of the disease.

>

> I got LDN (1.5MG) from a local compounding pharmacy and was clear

> that I needed Avicel as a filler since I am lactose intolerant. I

> confirmed this from the pharmacy when i picked it up.

>

> I've tried starting LDN twice now (a single 1.5MG dose) and both

> nights I tried it, it caused an extreme laxative effect. I had

> extremely intense cramping for 5-6 hours of the night and was in

and

> out of the bathroom repeatedly. The first time I thought it might

> have been a coincidence, but now I know it was the LDN. I never

have

> symptoms like this with Crohn's (in fact, I'm never up in the

middle

> of the night at all).

>

> My initial thought is that this could be some kind of interaction

> with Immodium (I take 2 in the morning each day). I know Immodium

is

> an opiate derivative. My thought is maybe the LDN is blocking the

> action of the Immodium and causing almost an opposite, laxative

> effect.

>

> Anyone have any thoughts on this? I can't seem to find anything

> online about Immodium interaction. Quite discouraged -- was hoping

> LDN might be the trick but I clearly can't take it with this kind

of

> side effect.

>

> Thanks.

>

>

>

[Guest guest]

Yes it is. In the process, they remove the euophroic compounds (so you don't get any high), but leave in the compounds that "slow down" the GI tract which is how it works. What is unclear is whether the compounds that are left would be nullified by the LDN.

Would the LDN be nullified by the Immodium or the other way around, and would taking both together make you ill? I have had an iffy tummy all week, and had taken some immodium and boy oh boy do I feel sick!!

Thanks

Celia

[Guest guest]

Here's a post that explains what Loperamide is:

http://www.ncbi.nlm.nih.gov/pubmed/2820051

It is an " opiate agonist. " Since Naltrexone is an opiate antagonist,

it is possible I guess that combining the two could cause the kind of

reaction I had.

>

> Thanks Crystal, so I guess the next question is what is in the

Loperamide as all of that other stuff seems ok?

> My first LDN was filled with Calcium Carbonate, got this changed to

lactose, is this better absorbed?

> Thanks again

> Celia

>

[Guest guest]

Yes,

I am quite sure you're right! Good luck now,

trying again. Please, send a post to ask for

advices if you need some, and don't forget to

tell us how you are.

The best from Ingrid

[low dose naltrexone] Re: Question about LDN and Immodium interactionHere's a post that explains what Loperamide is:http://www.ncbi.nlm.nih.gov/pubmed/2820051It is an "opiate agonist." Since Naltrexone is an opiate antagonist, it is possible I guess that combining the two could cause the kind of reaction I had.>> Thanks Crystal, so I guess the next question is what is in the

Loperamide as all of that other stuff seems ok? > My first LDN was filled with Calcium Carbonate, got this changed to lactose, is this better absorbed?> Thanks again> Celia>