Re: Acid stable protease / Zymeprime

[Guest guest]

>>>It says that the protease is not acid stable. So does this mean it

would digest in the upper less acid part of the stomach and then be

> neutralised in the lower more acidic part of the stomach. Then for

> someone like me with a very sensitive gut it would be inactive

before reaching the small intestine?

My understanding is that although plant/microbially enzymes have a

much broader stability range of pH 2-12, not every enzyme is active

throughout the entire range. Some are more active in pH 2-6, while

others may have a range of pH 4-10, and others pH 6-12. Accordingly,

the 'acid stable' proteases are more active in the low acid pH

regions of the stomach acid, and other proteases are active in the

higher alkaline pH of the small intestines. In this respect, having

acid stable proteases and other proteases means there would be

proteases of some type active in all areas of the digestive tract.

Most broad-spectrume enzyme products contain a mix nowadays (or

should).

Enzymedica has an illustration of this concept here (first digram

with the three curves on it):

http://www.enzymedica.com/therablend.php

But when you say you have sensitive digestion, how would this affect

you? I mean, are you wanting more proteases active in acid

conditions? Or would being extra sensitive mean you want less

proteases active at any one time? Not sure I understand the question.

You can contact the company as well. I'm going to look into this

further too, just to make sure.

.

[Guest guest]

Hi , I have checked this out a bit more pparently acid stable

protease is actually a type of protease rather than a statement of

being stable in acid. My issue though is my stomach seems to get

bloated 1+1/2-2 hrs after using enzymes and I lose weight. The most I

have used them for is about 3 weeks, I tried Vgest and lacto last and

was thinking of trying zymeprime. I think my issues are because of a

leaky gut and possibly proteases and die off? Is the weight loss

normal, is it cause by the proteases damaging the gut?

Phil

>

> >>>It says that the protease is not acid stable. So does this mean

it

> would digest in the upper less acid part of the stomach and then be

> > neutralised in the lower more acidic part of the stomach. Then

for

> > someone like me with a very sensitive gut it would be inactive

> before reaching the small intestine?

>

>

> My understanding is that although plant/microbially enzymes have a

> much broader stability range of pH 2-12, not every enzyme is active

> throughout the entire range. Some are more active in pH 2-6, while

> others may have a range of pH 4-10, and others pH 6-12.

Accordingly,

> the 'acid stable' proteases are more active in the low acid pH

> regions of the stomach acid, and other proteases are active in the

> higher alkaline pH of the small intestines. In this respect, having

> acid stable proteases and other proteases means there would be

> proteases of some type active in all areas of the digestive tract.

> Most broad-spectrume enzyme products contain a mix nowadays (or

> should).

>

> Enzymedica has an illustration of this concept here (first digram

> with the three curves on it):

> http://www.enzymedica.com/therablend.php

>

> But when you say you have sensitive digestion, how would this

affect

> you? I mean, are you wanting more proteases active in acid

> conditions? Or would being extra sensitive mean you want less

> proteases active at any one time? Not sure I understand the

question.

> You can contact the company as well. I'm going to look into this

> further too, just to make sure.

>

> .

>

[Guest guest]

Phil,

The more common proteases used in the US nutraceutical industry comes

from two sources: the preferred one : Aspergillus oryzae (a fungus

that produces the acid proteases) and sometimes it comes with a mix

with Bacillus subtilis proteases (neutral proteases). Fungus love to

leave in acidic pHs so most of their enzymes do have OPTIMUN pH at

acid pH. However it does not means that fungal enzymes can not be

active at very low or very high pHs. Also most of the pH " damage " on

enzymes is reversible, meaning that the enzyme can do its job when pH

conditions turn to be again in its " operational " range.

When you talk about Aspergillus proteases, you can be sure that in

most digestive enzyme formulations, you will be able to find various

proteases, as for example Aspergillus oryzae strains produce the

followings proteases:

- One (1) Acid Endopeptidase

- Two (2) Neutral Endopeptidases

- One (1)Alkaline Endopeptidase

- Four (4) Exo-Carboxipeptidases

- Three (3) Exo-Aminopeptidases

- One (1) Prolyl dipeptidyl peptidase

This wide spectrum of proteolytic activity is that make fungal enzymes

very appropiate to be used as a dietary supplement. Also, it allows

you to consider that some protease activity will happens inside your

body at any time in different parts or organs when you are taking oral

enzymes from fungal origin.

Best regards,

VICTOR

> >

> > >>>It says that the protease is not acid stable. So does this mean

> it

> > would digest in the upper less acid part of the stomach and then

be

> > > neutralised in the lower more acidic part of the stomach. Then

> for

> > > someone like me with a very sensitive gut it would be inactive

> > before reaching the small intestine?

> >

> >

> > My understanding is that although plant/microbially enzymes have a

> > much broader stability range of pH 2-12, not every enzyme is

active

> > throughout the entire range. Some are more active in pH 2-6, while

> > others may have a range of pH 4-10, and others pH 6-12.

> Accordingly,

> > the 'acid stable' proteases are more active in the low acid pH

> > regions of the stomach acid, and other proteases are active in the

> > higher alkaline pH of the small intestines. In this respect,

having

> > acid stable proteases and other proteases means there would be

> > proteases of some type active in all areas of the digestive tract.

> > Most broad-spectrume enzyme products contain a mix nowadays (or

> > should).

> >

> > Enzymedica has an illustration of this concept here (first digram

> > with the three curves on it):

> > http://www.enzymedica.com/therablend.php

> >

> > But when you say you have sensitive digestion, how would this

> affect

> > you? I mean, are you wanting more proteases active in acid

> > conditions? Or would being extra sensitive mean you want less

> > proteases active at any one time? Not sure I understand the

> question.

> > You can contact the company as well. I'm going to look into this

> > further too, just to make sure.

> >

> > .

> >

>

[Guest guest]

Phil:

I forget to tell you that the consumption of oral proteases do not

represent any risk for humans. Take in care that each time you eat

pinneaple or papaya fruit, or even some raw meats like the arabian raw

" kibbe " or some sushis, you are eating active proteases. The point is

that the body " in some way " recognized the protein as a protease and

put a " safety device " on it -another protein called alpha-2-

macroglobulin or similar- in order to prevent any damage to your own

tissues. That happens all the time inside your body with your own

proteases. The most amazing fact is that the body knows when to

eliminate the " safety device " in order to allow the protease to do its

job. So under good health conditions you will never be attacked by

external or by your own proteases.

Weigth elimination is another good outcome from enzyme consumption. As

you pointed that you feel bloated after enzyme consumption, I would

say that you are in a cleaning step in which you are eliminating some

indigested material that was retained in the gut. That material goes

to the colon were the bacteria use it for food and by the way, for gas

production. If you continue with enzymes you will see that bloating

tends to dissapears.

Best luck,

VICTOR

> >

> > >>>It says that the protease is not acid stable. So does this mean

> it

> > would digest in the upper less acid part of the stomach and then

be

> > > neutralised in the lower more acidic part of the stomach. Then

> for

> > > someone like me with a very sensitive gut it would be inactive

> > before reaching the small intestine?

> >

> >

> > My understanding is that although plant/microbially enzymes have a

> > much broader stability range of pH 2-12, not every enzyme is

active

> > throughout the entire range. Some are more active in pH 2-6, while

> > others may have a range of pH 4-10, and others pH 6-12.

> Accordingly,

> > the 'acid stable' proteases are more active in the low acid pH

> > regions of the stomach acid, and other proteases are active in the

> > higher alkaline pH of the small intestines. In this respect,

having

> > acid stable proteases and other proteases means there would be

> > proteases of some type active in all areas of the digestive tract.

> > Most broad-spectrume enzyme products contain a mix nowadays (or

> > should).

> >

> > Enzymedica has an illustration of this concept here (first digram

> > with the three curves on it):

> > http://www.enzymedica.com/therablend.php

> >

> > But when you say you have sensitive digestion, how would this

> affect

> > you? I mean, are you wanting more proteases active in acid

> > conditions? Or would being extra sensitive mean you want less

> > proteases active at any one time? Not sure I understand the

> question.

> > You can contact the company as well. I'm going to look into this

> > further too, just to make sure.

> >

> > .

> >

>