LDN causing headache? shingles? in new user

[Guest guest]

Hi all

I just took my 4th dose of 1.5 mg of LDN last night. Each morning, I

have awakened with a 'hang-over' type headache. Am I doing something

wrong or is this common?

Also, My MS has become IV steroid dependant. Each month when I take the

dose of IV steroids, I break out in shingles on the same day as

treatment. For that reason I had my last IV (and bout of shingles) on

3/17/06. To my surprize, I broke out in shingles again yesterday. Any

thoughts?

btw...I have had great improvement since day 1 on the LDN. If the 1.5

works that well, I can't wait to go on the 3.0!

[Guest guest]

,

If I were you I would seriously consider emailing Dr.

Zagon

about this, and get the facts from the 'horse's

mouth'.

Below is an excerpt from a blog contributed to by

Elaine

whose book about LDN and Dr. Zagon will be published

this fall.

You can allso find writings of hers on Suite101 site.

" This is an excellent description of LDN. The only

thing I would change is the night-time dosing. In a

recent conversation Sammy Jo and I had with Dr. Ian

Zagon from Pennsylvania State University, he mentioned

that there were several misconceptions about LDN that

have spread on the Internet, which primarily have to

do with dosing.

He said that LDN does NOT need to be taken at night as

endorphin production is not affected by circadian

rhythm. The most common side effects of LDN are sleep

disturbances, which can cause people to feel as though

they're awake all night or they can experience vivid,

often disturbing dreams. These effects are avoided by

taking LDN in the morning. LDN also tends to increase

energy, which is problematic at night but a benefit

when using daytime dosing.

Dr. Zagon also explained that the initial starting

dose should be based on weight and one's condition.

For most people at a weight of 150 lbs. a dose of 4.5

mg works fine. However, people with multiple sclerosis

who have muscle spasticity usually do better on a dose

of 3.0 mg. The recommended dose is 3-10 mg daily

although some people do better taking LDN every other

day. Because effects (increased production of

endogenous opiates) last from 24-72 hours the effects

aren't lost.  For thyroid disease, taking 3 mg every

other day would probably be better than 1.5 mg every

day. This is based on studies showing that a 3 mg

daily dose causes a 200-300 percent increase in

endogenous opioids. The effects at lower doses aren't

proportional.  I've included some of this information

in the new article on LDN I added tonight. "

I hope this is of help to you,

Jackie

--- NANCY <nancyrekowski@...> wrote:

> Hi all

>

> I just took my 4th dose of 1.5 mg of LDN last night.

> Each morning, I

> have awakened with a 'hang-over' type headache. Am I

> doing something

> wrong or is this common?

>

> Also, My MS has become IV steroid dependant. Each

> month when I take the

> dose of IV steroids, I break out in shingles on the

> same day as

> treatment. For that reason I had my last IV (and

> bout of shingles) on

> 3/17/06. To my surprize, I broke out in shingles

> again yesterday. Any

> thoughts?

>

> btw...I have had great improvement since day 1 on

> the LDN. If the 1.5

> works that well, I can't wait to go on the 3.0!

>

>

>

>

________________________________________________________________________________\

____

You rock. That's why Blockbuster's offering you one month of Blockbuster Total

Access, No Cost.

http://tc.deals./tc/blockbuster/text5.com

[Guest guest]

Where is Dr. Zagon's clinical trial results on humans(not lab

rats/animals) listed that he has proven night time dosing is no

different than daytime dosing? Dr. Bihari experiemented with the

times and dosages in human patients with all sorts of diseases for

well over 20 years so I consider that a clinical trial.

I know when I tried to change from night time dosing to daytime

dosing, within 5 days I was headed back to needing my mobility

scooter, when I switched back to night time dosing I started improving

again. I'm with chronic progressive MS. A few of us with progressive

forms of MS tried this night time to daytime switch and we started

losing what we had gained. Same with my grandma's Alzheimer's. I fear

Dr. Zagon is about to cause many chronic progressive MS'ers alot of

problems and we won't see near the success with this form of MS on LDN

as we have in the past. A clinical trial using LDN in humans with

chronic progressive MS'ers in daytime compared to night time should

have been conducted before such information released. Circadian

Rhythm has nothing to do with the way LDN works. Bihari discovered

that we produce the MOST endorphins between the hours of 2am and 4am

and to get the best overall boost in beta-endorphins, LDN needs to be

in one's system during this 2am to 4am time frame to get the BEST

endorphin production; that's why we need to take LDN between 9pm and

3am. Have you ever noticed even without LDN we tend to awaken

sometimes during the 2am to 4am time frame, that's because you are

producing more beta-endorphins during those hours and it can sometimes

cause you to awaken, that time frame is our peak endorphin prodction

time frame. Dr. M. Gironi, Italian neurologist who is currently

conducting the LDN for MS clinical trial has already proven via blood

testing that beta-endorphins are MUCH lower in people with more

progressive forms of MS compared to those with relapsing/remitting

forms. Someone with a milder form of MS may be able to do okay on

daytime LDN dosing but us more progressive MS patients need all the

endorphins we can get to keep a halt in the progression of our

diseases.

I'm through preaching now,

, LDN user nearly 5 years for chronic progressive MS.

[Guest guest]

>

> Hi all

>

> I just took my 4th dose of 1.5 mg of LDN last night. Each morning, I

> have awakened with a 'hang-over' type headache. Am I doing something

> wrong or is this common?

>

> Also, My MS has become IV steroid dependant. Each month when I take

the

> dose of IV steroids, I break out in shingles on the same day as

> treatment. For that reason I had my last IV (and bout of shingles)

on

> 3/17/06. To my surprize, I broke out in shingles again yesterday.

Any

> thoughts?

>

> btw...I have had great improvement since day 1 on the LDN. If the

1.5

> works that well, I can't wait to go on the 3.0!

>

>

>

===============

Stop the steroid treatments as they are terrible for your immune

system and get yourself tested for candida yeast overgrowth. Steroids

fuel candida yeast.

What is the filler in your LDN capsules? What pharmacy are you using?

[Guest guest]

Bren and all,

I'm new to this so I'm still in the investigatory

phase. But it would seem logical to consider that

someone having sleep disturbances

try a different schedule. Or, in the case of on

her 4th night

of LDN, a sleep aid of some sort (Ambien) might help.

I'm a cancer patient so I'm not at all up on MS

issues. But I do know

that often orthodoxy leaves out a few people.

Jackie

--- Bren <b63powell@...> wrote:

>

> Where is Dr. Zagon's clinical trial results on

> humans(not lab

> rats/animals) listed that he has proven night time

> dosing is no

> different than daytime dosing? Dr. Bihari

> experiemented with the

> times and dosages in human patients with all sorts

> of diseases for

> well over 20 years so I consider that a clinical

> trial.

>

> I know when I tried to change from night time dosing

> to daytime

> dosing, within 5 days I was headed back to needing

> my mobility

> scooter, when I switched back to night time dosing I

> started improving

> again. I'm with chronic progressive MS. A few of

> us with progressive

> forms of MS tried this night time to daytime switch

> and we started

> losing what we had gained. Same with my grandma's

> Alzheimer's. I fear

> Dr. Zagon is about to cause many chronic progressive

> MS'ers alot of

> problems and we won't see near the success with this

> form of MS on LDN

> as we have in the past. A clinical trial using LDN

> in humans with

> chronic progressive MS'ers in daytime compared to

> night time should

> have been conducted before such information

> released. Circadian

> Rhythm has nothing to do with the way LDN works.

> Bihari discovered

> that we produce the MOST endorphins between the

> hours of 2am and 4am

> and to get the best overall boost in

> beta-endorphins, LDN needs to be

> in one's system during this 2am to 4am time frame to

> get the BEST

> endorphin production; that's why we need to take LDN

> between 9pm and

> 3am. Have you ever noticed even without LDN we tend

> to awaken

> sometimes during the 2am to 4am time frame, that's

> because you are

> producing more beta-endorphins during those hours

> and it can sometimes

> cause you to awaken, that time frame is our peak

> endorphin prodction

> time frame. Dr. M. Gironi, Italian neurologist who

> is currently

> conducting the LDN for MS clinical trial has already

> proven via blood

> testing that beta-endorphins are MUCH lower in

> people with more

> progressive forms of MS compared to those with

> relapsing/remitting

> forms. Someone with a milder form of MS may be able

> to do okay on

> daytime LDN dosing but us more progressive MS

> patients need all the

> endorphins we can get to keep a halt in the

> progression of our

> diseases.

>

> I'm through preaching now,

>

> , LDN user nearly 5 years for chronic

> progressive MS.

>

>

________________________________________________________________________________\

____

You rock. That's why Blockbuster's offering you one month of Blockbuster Total

Access, No Cost.

http://tc.deals./tc/blockbuster/text5.com

[Guest guest]

-,

So I wonder if that is just for progressive msers? I have to take my

LDN at 9pm (instead of 10 for daylight savings time)just because I can

not stay awake that late, and if I wake up, I forget. Once daylight

savings time is over, I will take at 9pm and see if it makes a difference

Question: Since LDN needs to be refridgerated, can I still have it

next to my bed to take during the right hours? It wont be kept cold then.

Saundra

-- In low dose naltrexone , " Bren " <b63powell@...> wrote:

>

>

> Where is Dr. Zagon's clinical trial results on humans(not lab

> rats/animals) listed that he has proven night time dosing is no

> different than daytime dosing? Dr. Bihari experiemented with the

> times and dosages in human patients with all sorts of diseases for

> well over 20 years so I consider that a clinical trial.

>

> I know when I tried to change from night time dosing to daytime

> dosing, within 5 days I was headed back to needing my mobility

> scooter, when I switched back to night time dosing I started improving

> again. I'm with chronic progressive MS. A few of us with progressive

> forms of MS tried this night time to daytime switch and we started

> losing what we had gained. Same with my grandma's Alzheimer's. I fear

> Dr. Zagon is about to cause many chronic progressive MS'ers alot of

> problems and we won't see near the success with this form of MS on LDN

> as we have in the past. A clinical trial using LDN in humans with

> chronic progressive MS'ers in daytime compared to night time should

> have been conducted before such information released. Circadian

> Rhythm has nothing to do with the way LDN works. Bihari discovered

> that we produce the MOST endorphins between the hours of 2am and 4am

> and to get the best overall boost in beta-endorphins, LDN needs to be

> in one's system during this 2am to 4am time frame to get the BEST

> endorphin production; that's why we need to take LDN between 9pm and

> 3am. Have you ever noticed even without LDN we tend to awaken

> sometimes during the 2am to 4am time frame, that's because you are

> producing more beta-endorphins during those hours and it can sometimes

> cause you to awaken, that time frame is our peak endorphin prodction

> time frame. Dr. M. Gironi, Italian neurologist who is currently

> conducting the LDN for MS clinical trial has already proven via blood

> testing that beta-endorphins are MUCH lower in people with more

> progressive forms of MS compared to those with relapsing/remitting

> forms. Someone with a milder form of MS may be able to do okay on

> daytime LDN dosing but us more progressive MS patients need all the

> endorphins we can get to keep a halt in the progression of our

> diseases.

>

> I'm through preaching now,

>

> , LDN user nearly 5 years for chronic progressive MS.

>

[Guest guest]

>

> -,

> So I wonder if that is just for progressive msers? I have to take my

> LDN at 9pm (instead of 10 for daylight savings time)just because I

can

> not stay awake that late, and if I wake up, I forget. Once daylight

> savings time is over, I will take at 9pm and see if it makes a

difference

> Question: Since LDN needs to be refridgerated, can I still have it

> next to my bed to take during the right hours? It wont be kept cold

then.

> Saundra

============

If you are using the compounded capsule form of LDN it does not have

to be refrigerated unless acidophilus that is not a non-refrigerate

was used.

To give you an example. When we first started my grandma on LDN 3

years ago for advanced Alzheimer's, when we switched to DST I forgot

to tell my aunt to change my grandma's dose to 10pm instead of keeping

it at 9pm. Within 4 days we noticed my grandma's big gains on LDN

slipping and slipping fast. It took me a few more days to realize I

had forgotten to alert my aunt to change dosing time to 10pm during

DST. Two days after my aunt changed my grandma's dosing to 10pm she

started improving again. My grandma's Alzheimer's improved a good bit

and has not gotten any worse since starting LDN 3 years ago. My

grandma on LDN can stay alone while my aunt works and 8 hour day, my

grandma off LDN needs 24 hour suppervision and talks completely off

the wall.

Set an alarm clock to awake you at 10pm or 11pm to take your LDN.

If one has sleep disturbance on LDN use a sleep aid until your body

adjusts to the extra endorphins.

[Guest guest]

Liquid LDN must be kept refrigerated, not the capsules.

Art

--

>

> -,

> So I wonder if that is just for progressive msers? I have to take my

> LDN at 9pm (instead of 10 for daylight savings time)just because I can

> not stay awake that late, and if I wake up, I forget. Once daylight

> savings time is over, I will take at 9pm and see if it makes a

difference

> Question: Since LDN needs to be refridgerated, can I still have it

> next to my bed to take during the right hours? It wont be kept cold

then.

> Saundra

[Guest guest]

Thanks for all the responses! I got my LDN from Irmats, NY (they were

great and speedy) and I'm not sure about the filler. I no longer will

be doing the IV steroids as I now (also) have transverse myelitis and

posturpetic neuralgia from the chronic shingles that occurred after

each IV. Thats what led me on my quest for LDN. So, I'm still not

sure...why the headaches?

> >

> >Stop the steroid treatments as they are terrible for your immune

> system and get yourself tested for candida yeast overgrowth.

Steroids

> fuel candida yeast.

>

> What is the filler in your LDN capsules? What pharmacy are you

using?

>

>

>

Hi all

> >

> > I just took my 4th dose of 1.5 mg of LDN last night. Each

morning, I

> > have awakened with a 'hang-over' type headache. Am I doing

something

> > wrong or is this common?

> >

> > Also, My MS has become IV steroid dependant. Each month when I

take

> the

> > dose of IV steroids, I break out in shingles on the same day as

> > treatment. For that reason I had my last IV (and bout of

shingles)

> on

> > 3/17/06. To my surprize, I broke out in shingles again

yesterday.

> Any

> > thoughts?

> >

> > btw...I have had great improvement since day 1 on the LDN. If the

> 1.5

> > works that well, I can't wait to go on the 3.0!

> >

> >

> >

> ===============

>

>

[Guest guest]

LDN can cause headache in the early days of treatment but if the

headaches persist more than 5 or 6 days then look at the culprit being

the filler. Everyone ought to know what filler is being used in their

LDN capsules. Ask the pharmacist.