Guest guest Posted November 19, 2009 Report Share Posted November 19, 2009 How did you fins out that you both have the gene mutation? Di somebody recommend you be tested and if so, do you just ask your primary physician to test for it? Thanks for the info. From: trys7392 <trys7392@...> Subject: MTHFR Gene mutation? Date: Thursday, November 19, 2009, 5:41 PM Â My daughter's blood work just came back today showing she has MTHFR gene mutation. It is a double mutation. From myself and husband. He states that she cannot metabolize folic acid and will need to take it as Metafolin for the rest of her life. Has anyone had this same experience. The more info that I am reading on the internet, the more questions that I have. It is showing that this gene is linked to autism. If anyone knows about this, please let me know. Thanks! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 19, 2009 Report Share Posted November 19, 2009 we have had this testing done. There is nothing conclusive that this gene mutuation does, but our doctor (DAN) told us that this means we should definately have our kids (they both have this) on MB12 shots. On Thu, Nov 19, 2009 at 9:00 PM, <sandyjramirez@...>wrote: > > > How did you fins out that you both have the gene mutation? Di somebody > recommend you be tested and if so, do you just ask your primary physician to > test for it? > Thanks for the info. > > > > From: trys7392 <trys7392@... <trys7392%40>> > Subject: MTHFR Gene mutation? > <%40> > Date: Thursday, November 19, 2009, 5:41 PM > > > > > My daughter's blood work just came back today showing she has MTHFR gene > mutation. It is a double mutation. From myself and husband. He states that > she cannot metabolize folic acid and will need to take it as Metafolin for > the rest of her life. Has anyone had this same experience. The more info > that I am reading on the internet, the more questions that I have. It is > showing that this gene is linked to autism. If anyone knows about this, > please let me know. > Thanks! > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 20, 2009 Report Share Posted November 20, 2009 It's not that this genetic mutation " causes " autism, but it can be a factor in recovery. The majority of the population in the US and I believe northern Europe (could be wrong about that) have some form of the mutation. There are two alleles involved and one can either be heterozygous or homozygous for the mutation. While people with high homocysteine can have this mutation, not all people with this mutation have problems with homocysteine. I've had a hard time getting any helpful information about all this, but I do think that there is a problem with folic acid uptake in people with the mutation. How poor the uptake is may have to do with the combination of alleles. Taking easily absorbable forms of folic acid can help with the metabolism of the B-vitamins and likewise help with methionine formation. I suppose because it can impact methylation (part of the detox cycle) one could conclude it is linked to autism if the cause of autism in a child is due to an inability to detox. (just my opinion) According to Labcorp, https://www.labcorp.com/wps/portal/!ut/p/c1/04_SB8K8xLLM9MSSzPy8xBz9CP0os_hA CzO_QCM_IwMLXyM3AyNjMycDU2dXQwN3M6B8JG55AwMCusNB9uHXD5I3wAEcDfT9PPJzU_Uj9aPM 40NdTYINPS2NDfxd3Q0MjMw9fTwtLfwNDYwN9UP0C3IjDLJMIhUB94XRqA!!/dl2/d1/L0lDU0lK SmdvS1VRIS9JSFNBQ0lpTXlDb3FiRURBSUEhIS9ZQTQ1NDUwLTVGMHN0eWp3LzdfVUU0UzFJOTMw T0VHMDAyN0lMSTk4TzEwMzEvcXBfX182OC9zcGZfQWN0aW9uTmFtZS9zcGZfQWN0aW9uTGlzdGVu ZXI!/?testId=407853 & spf_strutsAction=%212fshowDetail.do one mutation, C677T results in the enzyme (MTHFR is an enzyme) being 20-percent less efficient at metabolizing homocysteine. Being homozygous for this allele (having 2 of the same copy) one is likely to have elevated levels. (Folic acid supplementation can help lower this.) A second mutation, A1298C is also relatively common. Being heterozygous for the 2 mutations (having one A1298C and one C677T) may have the same results as homozygous for C677T. However, having two copies of A1298C may not produce the same results. Whew! Did you get all that?! My caveat: I would not take all of what I've mentioned as gospel. Though I have researched it, there is conflicting data... in MD MTHFR Gene mutation? My daughter's blood work just came back today showing she has MTHFR gene mutation. It is a double mutation. From myself and husband. He states that she cannot metabolize folic acid and will need to take it as Metafolin for the rest of her life. Has anyone had this same experience. The more info that I am reading on the internet, the more questions that I have. It is showing that this gene is linked to autism. If anyone knows about this, please let me know. Thanks! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 20, 2009 Report Share Posted November 20, 2009 We've not gene tested. However, MB12 shots provoked wild, aggressive behavior as did folic acid and folinic acid. It was not until I tried 5 methyltetrahydrofolate that my daughter was able to tolerate folate. After having her on this for awhile I was able to add the MB12 with no negative results. > > It's not that this genetic mutation " causes " autism, but it can be a factor > in recovery. The majority of the population in the US and I believe > northern Europe (could be wrong about that) have some form of the mutation. > There are two alleles involved and one can either be heterozygous or > homozygous for the mutation. > > While people with high homocysteine can have this mutation, not all people > with this mutation have problems with homocysteine. I've had a hard time > getting any helpful information about all this, but I do think that there is > a problem with folic acid uptake in people with the mutation. How poor the > uptake is may have to do with the combination of alleles. Taking easily > absorbable forms of folic acid can help with the metabolism of the > B-vitamins and likewise help with methionine formation. I suppose because > it can impact methylation (part of the detox cycle) one could conclude it is > linked to autism if the cause of autism in a child is due to an inability to > detox. (just my opinion) > > According to Labcorp, > https://www.labcorp.com/wps/portal/!ut/p/c1/04_SB8K8xLLM9MSSzPy8xBz9CP0os_hA > CzO_QCM_IwMLXyM3AyNjMycDU2dXQwN3M6B8JG55AwMCusNB9uHXD5I3wAEcDfT9PPJzU_Uj9aPM > 40NdTYINPS2NDfxd3Q0MjMw9fTwtLfwNDYwN9UP0C3IjDLJMIhUB94XRqA!!/dl2/d1/L0lDU0lK > SmdvS1VRIS9JSFNBQ0lpTXlDb3FiRURBSUEhIS9ZQTQ1NDUwLTVGMHN0eWp3LzdfVUU0UzFJOTMw > T0VHMDAyN0lMSTk4TzEwMzEvcXBfX182OC9zcGZfQWN0aW9uTmFtZS9zcGZfQWN0aW9uTGlzdGVu > ZXI!/?testId=407853 & spf_strutsAction=%212fshowDetail.do one mutation, C677T > results in the enzyme (MTHFR is an enzyme) being 20-percent less efficient > at metabolizing homocysteine. Being homozygous for this allele (having 2 of > the same copy) one is likely to have elevated levels. (Folic acid > supplementation can help lower this.) A second mutation, A1298C is also > relatively common. Being heterozygous for the 2 mutations (having one > A1298C and one C677T) may have the same results as homozygous for C677T. > However, having two copies of A1298C may not produce the same results. > > Whew! Did you get all that?! > > My caveat: I would not take all of what I've mentioned as gospel. Though I > have researched it, there is conflicting data... > > in MD > > > > > MTHFR Gene mutation? > > > > My daughter's blood work just came back today showing she has MTHFR gene > mutation. It is a double mutation. From myself and husband. He states that > she cannot metabolize folic acid and will need to take it as Metafolin for > the rest of her life. Has anyone had this same experience. The more info > that I am reading on the internet, the more questions that I have. It is > showing that this gene is linked to autism. If anyone knows about this, > please let me know. > Thanks! > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 21, 2009 Report Share Posted November 21, 2009 What does MTHFR stand for? I don't mean to be vulgar, but if I saw this on a license plate I would think it stood for... > > It's not that this genetic mutation " causes " autism, but it can be a factor > in recovery. The majority of the population in the US and I believe > northern Europe (could be wrong about that) have some form of the mutation. > There are two alleles involved and one can either be heterozygous or > homozygous for the mutation. > > While people with high homocysteine can have this mutation, not all people > with this mutation have problems with homocysteine. I've had a hard time > getting any helpful information about all this, but I do think that there is > a problem with folic acid uptake in people with the mutation. How poor the > uptake is may have to do with the combination of alleles. Taking easily > absorbable forms of folic acid can help with the metabolism of the > B-vitamins and likewise help with methionine formation. I suppose because > it can impact methylation (part of the detox cycle) one could conclude it is > linked to autism if the cause of autism in a child is due to an inability to > detox. (just my opinion) > > According to Labcorp, > https://www.labcorp.com/wps/portal/!ut/p/c1/04_SB8K8xLLM9MSSzPy8xBz9CP0os_hA > CzO_QCM_IwMLXyM3AyNjMycDU2dXQwN3M6B8JG55AwMCusNB9uHXD5I3wAEcDfT9PPJzU_Uj9aPM > 40NdTYINPS2NDfxd3Q0MjMw9fTwtLfwNDYwN9UP0C3IjDLJMIhUB94XRqA!!/dl2/d1/L0lDU0lK > SmdvS1VRIS9JSFNBQ0lpTXlDb3FiRURBSUEhIS9ZQTQ1NDUwLTVGMHN0eWp3LzdfVUU0UzFJOTMw > T0VHMDAyN0lMSTk4TzEwMzEvcXBfX182OC9zcGZfQWN0aW9uTmFtZS9zcGZfQWN0aW9uTGlzdGVu > ZXI!/?testId=407853 & spf_strutsAction=%212fshowDetail.do one mutation, C677T > results in the enzyme (MTHFR is an enzyme) being 20-percent less efficient > at metabolizing homocysteine. Being homozygous for this allele (having 2 of > the same copy) one is likely to have elevated levels. (Folic acid > supplementation can help lower this.) A second mutation, A1298C is also > relatively common. Being heterozygous for the 2 mutations (having one > A1298C and one C677T) may have the same results as homozygous for C677T. > However, having two copies of A1298C may not produce the same results. > > Whew! Did you get all that?! > > My caveat: I would not take all of what I've mentioned as gospel. Though I > have researched it, there is conflicting data... > > in MD > > > > > MTHFR Gene mutation? > > > > My daughter's blood work just came back today showing she has MTHFR gene > mutation. It is a double mutation. From myself and husband. He states that > she cannot metabolize folic acid and will need to take it as Metafolin for > the rest of her life. Has anyone had this same experience. The more info > that I am reading on the internet, the more questions that I have. It is > showing that this gene is linked to autism. If anyone knows about this, > please let me know. > Thanks! > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 21, 2009 Report Share Posted November 21, 2009 On Nov 21, 2009, at 4:32 AM, S wrote: > What does MTHFR stand for? I don't mean to be vulgar, but if I saw > this on a license plate I would think it stood for... > > It's an enzyme... methylenetetrahydrofolate reductase Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 21, 2009 Report Share Posted November 21, 2009 Yes I am herterozygotic for both COMT*2 MTHFR mutations.There are two genes involved,I have mutations of both. I was wondering if anyone knew of any immune problems that might be related to methyation disorders? Does she have insanely high porphyrins too ? How about an elevated megaloblastic anemia panel? I have all this and more. This is all fairly new.Those of us who have found doctors to test for it are very lucky.                                  From: trys7392 <trys7392@...> Subject: MTHFR Gene mutation? Date: Thursday, November 19, 2009, 6:41 PM  My daughter's blood work just came back today showing she has MTHFR gene mutation. It is a double mutation. From myself and husband. He states that she cannot metabolize folic acid and will need to take it as Metafolin for the rest of her life. Has anyone had this same experience. The more info that I am reading on the internet, the more questions that I have. It is showing that this gene is linked to autism. If anyone knows about this, please let me know. Thanks! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 21, 2009 Report Share Posted November 21, 2009 My DAN! ordered it for me,without even telling me.LabCorp in Dallas will do it,and it will be covered by your insurance.Others insist it must be done in Paris,but LabCorp is who Thoughtful House uses. Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â From: trys7392 <trys7392 (DOT) com> Subject: MTHFR Gene mutation? Date: Thursday, November 19, 2009, 5:41 PM Â My daughter's blood work just came back today showing she has MTHFR gene mutation. It is a double mutation. From myself and husband. He states that she cannot metabolize folic acid and will need to take it as Metafolin for the rest of her life. Has anyone had this same experience. The more info that I am reading on the internet, the more questions that I have. It is showing that this gene is linked to autism. If anyone knows about this, please let me know. Thanks! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 22, 2009 Report Share Posted November 22, 2009 We just went to a metabolic genetics specialist and she refused to do it for us... Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 23, 2009 Report Share Posted November 23, 2009 http://www.center4autism.org/therapyMETH.asp From: S <iferstevens@...> Subject: Re: MTHFR Gene mutation? Date: Saturday, November 21, 2009, 5:32 AM Â What does MTHFR stand for? I don't mean to be vulgar, but if I saw this on a license plate I would think it stood for... > > It's not that this genetic mutation " causes " autism, but it can be a factor > in recovery. The majority of the population in the US and I believe > northern Europe (could be wrong about that) have some form of the mutation. > There are two alleles involved and one can either be heterozygous or > homozygous for the mutation. > > While people with high homocysteine can have this mutation, not all people > with this mutation have problems with homocysteine. I've had a hard time > getting any helpful information about all this, but I do think that there is > a problem with folic acid uptake in people with the mutation. How poor the > uptake is may have to do with the combination of alleles. Taking easily > absorbable forms of folic acid can help with the metabolism of the > B-vitamins and likewise help with methionine formation. I suppose because > it can impact methylation (part of the detox cycle) one could conclude it is > linked to autism if the cause of autism in a child is due to an inability to > detox. (just my opinion) > > According to Labcorp, > https://www. labcorp.com/ wps/portal/!ut/p/c1/04_ SB8K8xLLM9MSSzPy 8xBz9CP0os_ hA > CzO_QCM_IwMLXyM3AyN jMycDU2dXQwN3M6B 8JG55AwMCusNB9uH XD5I3wAEcDfT9PPJ zU_Uj9aPM > 40NdTYINPS2NDfxd3Q0 MjMw9fTwtLfwNDYw N9UP0C3IjDLJMIhU B94XRqA!! /dl2/d1/L0lDU0lK > SmdvS1VRIS9JSFNBQ0l pTXlDb3FiRURBSUE hIS9ZQTQ1NDUwLTV GMHN0eWp3LzdfVUU 0UzFJOTMw > T0VHMDAyN0lMSTk4TzE wMzEvcXBfX182OC9 zcGZfQWN0aW9uTmF tZS9zcGZfQWN0aW9 uTGlzdGVu > ZXI!/?testId= 407853 & spf_ strutsAction= %212fshowDetail. do one mutation, C677T > results in the enzyme (MTHFR is an enzyme) being 20-percent less efficient > at metabolizing homocysteine. Being homozygous for this allele (having 2 of > the same copy) one is likely to have elevated levels. (Folic acid > supplementation can help lower this.) A second mutation, A1298C is also > relatively common. Being heterozygous for the 2 mutations (having one > A1298C and one C677T) may have the same results as homozygous for C677T. > However, having two copies of A1298C may not produce the same results. > > Whew! Did you get all that?! > > My caveat: I would not take all of what I've mentioned as gospel. Though I > have researched it, there is conflicting data... > > in MD > > > > > MTHFR Gene mutation? > > > > My daughter's blood work just came back today showing she has MTHFR gene > mutation. It is a double mutation. From myself and husband. He states that > she cannot metabolize folic acid and will need to take it as Metafolin for > the rest of her life. Has anyone had this same experience. The more info > that I am reading on the internet, the more questions that I have. It is > showing that this gene is linked to autism. If anyone knows about this, > please let me know. > Thanks! > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 23, 2009 Report Share Posted November 23, 2009 Where were they ? A lot of mainstream doctors and hospitals think you are nuts if you talk about this stuff.Especially if you have an autism diagnosis. Â Autism is a " mental illness " after all. Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â From: droyle2007 <dionneberes@...> Subject: Re: MTHFR Gene mutation? Date: Sunday, November 22, 2009, 5:21 AM Â We just went to a metabolic genetics specialist and she refused to do it for us... Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 26, 2009 Report Share Posted November 26, 2009 Good Laugh !! DEB K > > > From: droyle2007 <dionneberes@...> > Subject: Re: MTHFR Gene mutation? > > Date: Sunday, November 22, 2009, 5:21 AM > > > Â > > > > We just went to a metabolic genetics specialist and she refused to do it for us... > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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