biotin

[Guest guest]

It's urine and BM's. She has been going so much. I will see how it is

tomorrow.

On Nov 6, 2008, at 5:05 PM, P. wrote:

> Getting rid of yeast will. That is what they are both working toward.

> Is it excessive diarrhea, or just normal BM or are you taking urine. I

> don't know that it would increase urine.

> P.

>

> Arias wrote:

> >

> > Would biotin or custom probiotics make you go to the bathroom a lot?

> >

> >

>

>

[Guest guest]

>

> Can I give biotin with a meal and digestive enzymes or is it best to

give on an empty stomach

> and/or away from digestive enzymes? Also do I need to give it

separate from GSE and if so

> how long do I need to wait?

You can give it any time you want, with or without food, with or

without GSE. It does require magnesium for proper absorption.

Dana

[Guest guest]

>

> Would biotin or custom probiotics make you go to the bathroom a lot?

Yeast die off can cause excessive urination, so it might be that.

Dana

[Guest guest]

Only 4mg 2x's a day? Do you give anything else for yeast? I am giving

15mg. 3x's a day. My girl is pretty yeasty.

On Nov 16, 2008, at 2:15 AM, Walter Antonello wrote:

> Hello Dana and all,

>

> My son has been having Biotin for quite sometime. I started at a

> very low dose and now he is having 4mg twice a day, but for the

> last couple of days he has been showing some flu type symptoms,

> sneezing a lot, very tired, watery/itchy eyes and nose and

> coughing, I gave him a charcoal cap, this morning and he went to

> sleep straight away and when he woke up he felt better.

>

> Could this be a die-off reaction? and what should I do?

>

> My other son does not get those symptoms from the same dose.

>

> I would appreciate your comments and suggestions.

>

> Olga

>

>

[Guest guest]

> Hello Dana and all,

> My son has been having Biotin for quite sometime. I started at a

very low dose and now he is having 4mg twice a day, but for the last

couple of days he has been showing some flu type symptoms, sneezing a

lot, very tired, watery/itchy eyes and nose and coughing, I gave him a

charcoal cap, this morning and he went to sleep straight away and when

he woke up he felt better.

> Could this be a die-off reaction? and what should I do?

Not sure, but it could have been some yeast leaving his body.

My son had those symptoms when I increased his vitamin C, because it

pulled cold/flu viruses out of his brain.

Dana

[Guest guest]

Hello,

What is a charcoal cap? is it used with flu symptoms?

thank you

> > Hello Dana and all,

> > My son has been having Biotin for quite sometime. I started at a

> very low dose and now he is having 4mg twice a day, but for the last

> couple of days he has been showing some flu type symptoms, sneezing

a

> lot, very tired, watery/itchy eyes and nose and coughing, I gave

him a

> charcoal cap, this morning and he went to sleep straight away and

when

> he woke up he felt better.

> > Could this be a die-off reaction? and what should I do?

>

>

> Not sure, but it could have been some yeast leaving his body.

>

> My son had those symptoms when I increased his vitamin C, because it

> pulled cold/flu viruses out of his brain.

>

> Dana

>

[Guest guest]

Higher doses of biotin do require more magnesium.

There is also some interesting research linking OCD type issues with

biotin deficiency in the basal ganglia, and some encouraging results

with some patients using higher dose biotin for a short period to

correct the deficiency. Some patients reported sleep issues developing

while on the higher dose biotin, which was then corrected by increasing

magnesium.

Biotin obviously plays a number of important roles.

Arias wrote:

>

> My dd is on the biotin and becoming super irritable. Could this be

> because I haven't added magnesium yet?

>

>

[Guest guest]

If you're low in magnesium, it can REALLY constipate you " !!!

[ ] Biotin

My dd is on the biotin and becoming super irritable. Could this be

because I haven't added magnesium yet?

[Guest guest]

thanks Barb! totally rolling here - we do like our magnesium, in many

myriad forms, at our house, lolol...wishing you the best, elizabeth

>

> If you're low in magnesium, it can REALLY constipate you " !!!

> [ ] Biotin

>

>

> My dd is on the biotin and becoming super irritable. Could this be

> because I haven't added magnesium yet?

>

>

>

>

>

>

[Guest guest]

>

> My dd is on the biotin and becoming super irritable. Could this be

> because I haven't added magnesium yet?

At my house, biotin without magnesium caused constipation, muscle

cramps, head banging [meaning headache], and nasty behavior.

Even with magnesium, if I gave too much biotin, it would cause headache.

So you might need to lower the dose, or add magnesium, or both.

Dana

[Guest guest]

you canget biotin at any health food store, it is one of the B

vitamins. HTH Blessings, Conrad

In , " david_j_mead " <david_j_mead@...>

wrote:

>

> Where do you buy biotin? I looked at Kirkmans but they do not carry

> it. Is it liquid? Taste? My daughter presently takes GSE for yeast

> flare ups but I'm thinking I should alternate. She has also had an

> increased problem with gag reflex recently over things like sinus

drip,

> the feel of shampoo in the shower,etc. Am wondering if its yeast.

> Thanks for any info.

>

>

>

[Guest guest]

>

> Where do you buy biotin?

At my local health food store.

>>Is it liquid?

Very small capsule. In fact, I used biotin capsules when I was

teaching my kids how to swallow capsules.

>>Taste?

Not sure. When I was opening capsules, my kids did not complain about

the taste of the biotin.

Dana

[Guest guest]

>

> does anyone give biotin on an empty stomache?

I have given it, and used it myself, both with food and on an empty

stomach. It appears to work well either way.

Dana

[Guest guest]

>

> Is there a certain ratio for biotin and mag?

Depends on how deficient you are. In the beginning, when my kids were

significantly deficient in biotin, it required more than 1000mg

magnesium to prevent constipation. As things progressed, I was able

to reduce the dose of the magnesium.

Dana

[Guest guest]

Lucky Vitamin usually has the best overall prices for me. And if you

spend more than $100 shipping is free. I can easily spend $100.

Here's a search for biotin at Shopzilla . . .

http://www.shopzilla.com/vitamins-nutrition/biotin/150/products

>

> where does everyone get there biotin? i am looking for the best price.

>

[Guest guest]

>

> where does everyone get there biotin? i am looking for the best price.

I get mine at my local health food store. I pay around $5-8 per

bottle, depending on the brand.

Dana

[Guest guest]

how many capsules is that? sound a lot cheaper than what i pay at

whole foods, although i get 120 capsules

On Feb 8, 2009, at 9:31 AM, danasview wrote:

>

> >

> > where does everyone get there biotin? i am looking for the best

> price.

>

> I get mine at my local health food store. I pay around $5-8 per

> bottle, depending on the brand.

>

> Dana

>

>

>

[Guest guest]

Do you have a Super Supplements nearby? I have found them to have almost

everything I need at the best price.

TJ

________________________________

From: Neecy <thinkingheads@...>

Sent: Sunday, February 8, 2009 7:40:33 AM

Subject: Re: [ ] Re: Biotin

how many capsules is that? sound a lot cheaper than what i pay at

whole foods, although i get 120 capsules

On Feb 8, 2009, at 9:31 AM, danasview wrote:

>

> >

> > where does everyone get there biotin? i am looking for the best

> price.

>

> I get mine at my local health food store. I pay around $5-8 per

> bottle, depending on the brand.

>

> Dana

>

>

>

[Guest guest]

Go to www.iHerb.com and search for " biotin " to check out the prices. I'm using

Now brand,

100 capsules for $3.76 (1000 mcg). Shipping is fast and reasonable -- even for

me, and I'm

overseas.

Click " Free shipping " at the top for rates.

-Ann

>

> where does everyone get there biotin? i am looking for the best price.

>

[Guest guest]

>

> how many capsules is that? sound a lot cheaper than what i pay at

> whole foods, although i get 120 capsules

What I have right now, is Henry's brand biotin, 5mg capsules. There

are 60 capsules and I have a vague memory that I paid $4.78 for the

bottle.

Dana

[Guest guest]

>

> Bee,

>

> I had remembered reading something on Dr. Mercola's site about raw eggs and

how it affects biotin levels. Your recommendations seem to have enough biotin

to compensate. Before I read your website, I had bought another supplement of

just Biotin, because my multiple, although high in other B's was low in Biotin.

Dr. Mercola has some great articles on eating raw eggs, and how beneficial they

are. The one in particular about

Biotin-http://articles.mercola.com/sites/articles/newsletter-archive/2005/2/9.as\

px. I tried doing a search in the group about Biotin, but there was too much

mention of it to pin down that particular information. I would appreciate your

thoughts. Thanks.

+++Hi . As you found out the subject about eggs and biotin has been

discussed numerous times on this group, and suffice it to say: 1) Dr. Mercola

has waffled back and forth about eggs so many times it is unbelieveable, so I

wouldn't rely on him regarding eggs anyway.

2) The Weston A. Price Foundation and Dr. Mercola have gone head to head on

issues with eggs, and I don't believe either one of them is correct, and my

friend, an Orthmolecular Physician agrees with me.

3) I don't believe in maligning good foods from Mother Nature that have been

consumed for thousands of years.

4) " If " biotin were an issue then wild animals that eat a lot of them wouldn't

be healthy.

You do not need any more biotin than is found in the vitamin B complex I

recommend - since all B vitamins work together, and if you take more of one it

depletes the body's stores of the other kinds of B vitamins.

Bee

[Guest guest]

>

> Hi Bee --

> I was looking more closely at the B vitamins in my B-50 supplement. They all

conform to your recommendations. But I also noticed that the biotin, though it

was 50 mcg, was only 17% of the RDA, which as you know is the minimum required,

according to federal standards. All the others, even though they are either 50

mg or 50 mcg, provide much more than 100% of the RDA. Isn't 50 mcg of biotin too

low, since it's not even 1/5 of the RDA? Should we consider supplementing with

some more biotin?

> (By the way, this has nothing to do with the egg white controversy, which you

have repeatedly addressed. I agree with you and the Price Foundation.)

+++Hi Roy T. I don't look at federal standards since they are so out of whack

anyway. People on this program aren't getting biotin deficiency symptoms, so

that's enough for me! I take the same amount and have done great for many years.

Here's a good reference, and it says the therapeutic dose of Biotin is a minimum

of 50 mcg, and two B complex per day that I recommend equals 100 mcg:

http://www.acu-cell.com/bx2.html

Yes, Dr. Mercola certainly got it wrong about eggs. Could we say he got " egg

on his face? " lol!

All the best, Bee

>

[Guest guest]

>

> Is it ok to take extra Biotin?

>

> I have some here that I used to take to help with hair growth.

+++Hi Lara. No, you do not need to take any extra biotin than what is in the

Vitamin B complex I recommend and foods. " More is not better. "

All the best, Bee

[Guest guest]

I've read that the dose varies. We use Bariatric Advantage 5 mg.

Anne

Anne Marquart, MS, RD, LD / Bariatric Dietitian / Roller Weight Loss and Advance Surgery / 1280 E. Stearns/ Fayetteville, Ar / 479.445.6460 / amarquart@... / www.rollerweightloss.com

biotin

Can anyone tell me off-hand what amount of Biotin supplementation is recommended to promote hair and nail growth in post surgery patients?Thanks!Jillian McMullen, RD, LD/Nville, FL

[Guest guest]

Anne and Jillian,

You may not be aware but if your patients are absorbing excess oxalate after

gastric bypass surgery, then oxalate getting into cells may inhibit biotin

dependent enzymes. I discovered this little known fact in the literature some

years ago. Sort of coincidentally, years before that I had studied carefully

the basic science articles talking about the symptoms of biotin deficiency and

which enzymes need biotin, and how high a safe dose can go.

For years, no one found an unsafe level of biotin, but finally, a study came out

and determined a lethal dose.

The highest " safe " level was determined in rats to be 38 mgs/kg/day, still a

whopping dose compared to anything I've heard used in any human condition.

See: http://www.jstage.jst.go.jp/article/bbb/71/12/2977/_pdf or abstract

below.

The dystonia article also below has the highest dose I've heard of being used in

humans at 5-10 mgs/kg/day and there was no reported toxicity.

Of course, this dose is quite a bit higher than anyone was thinking about giving

here!

In autism circles, where excess absorption of oxalate also seems to occur for

other GI reasons, I have heard of some children being given as high as 40 mgs a

day because they got more benefit than a lower dose, but I have not heard of

anyone prescribing over that. 10 to 20 mgs per day is a far more typical

effective dose in autism.

There are studies that show if oxalate is inhibiting biotin dependent enzymes,

that taking more biotin does help counter that inhibition.

Most of the enzymes that are inhibited by this effect of oxalate on biotin's

function are carboxylase enzymes, but the same motif that binds and uses biotin

is found in an enzyme called carbomyl phosphate synthetase. This enzyme is

important for making pyrimidines, detoxifying ammonia, and making arginine.

Who would think that biotin would function there!

Anyway, I have also put an abstract below for an article that looked at other

non-carboxylase functions of biotin. It certainly makes interesting reading and

gets us away from thinking that biotin is just for skin and nails.

I've seen direct evidence of specific enzyme inhibition in organic acid testing

which reports metabolites that increase or decrease when biotin-dependent

proteins are inhibited.

I hope this expands your awareness of this vitamin whose far-reaching effects

have been very under appreciated.

Annu Rev Nutr. 2005;25:175-96.[] Links

Uptake, localization, and noncarboxylase roles of biotin.

Zempleni J.

Department of Nutrition and Health Sciences and Departments of Biochemistry and

Animal Science, University of Nebraska at Lincoln, Nebraska 68583-0806, USA.

Jzempleni2@...

Evidence is emerging that biotin participates in processes other than classical

carboxylation reactions. Specifically, novel roles for biotin in cell signaling,

gene expression, and chromatin structure have been identified in recent years.

Human cells accumulate biotin by using both the sodium-dependent multivitamin

transporter and monocarboxylate transporter 1. These transporters and other

biotin-binding proteins partition biotin to compartments involved in biotin

signaling: cytoplasm, mitochondria, and nuclei. The activity of cell signals

such as biotinyl-AMP, Sp1 and Sp3, nuclear factor (NF)-kappaB, and receptor

tyrosine kinases depends on biotin supply. Consistent with a role for biotin and

its catabolites in modulating these cell signals, greater than 2000

biotin-dependent genes have been identified in various human tissues. Many

biotin-dependent gene products play roles in signal transduction and localize to

the cell nucleus, consistent with a role for biotin in cell signaling.

Posttranscriptional events related to ribosomal activity and protein folding may

further contribute to effects of biotin on gene expression. Finally, research

has shown that biotinidase and holocarboxylase synthetase mediate covalent

binding of biotin to histones (DNA-binding proteins), affecting chromatin

structure; at least seven biotinylation sites have been identified in human

histones. Biotinylation of histones appears to play a role in cell

proliferation, gene silencing, and the cellular response to DNA repair. Roles

for biotin in cell signaling and chromatin structure are consistent with the

notion that biotin has a unique significance in cell biology.

PMID: 16011464 [PubMed - indexed for MEDLINE]

1: Biosci Biotechnol Biochem. 2007 Dec;71(12):2977-84. Epub 2007 Dec 7.

Effects of excess biotin administration on the growth and urinary excretion of

water-soluble vitamins in young rats.

Sawamura H, Fukuwatari T, Shibata K.

Laboratories of Food Science and Nutrition, Department of Life Style Studies,

School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga,

Japan.

To determine the effects of excess biotin administration on growth and

water-soluble vitamin metabolism, weaning rats were fed on a 20% casein diet

containing 0.00002% biotin, or same diet with 0.04, 0.08, 0.10, 0.20, 0.50, 0.80

or 1.0% added biotin for 28 days. More than 0.08% biotin administration

decreased

the food intake and body weight gain compared with the levels in control rats.

An

accumulation of biotin in such tissues as the liver, brain and kidney increased

in a dose-dependent manner, and the both bound and free biotin contents in the

liver also increased in a dose-dependent manner. An excess administration of

biotin did not affect the urinary excretion of other water-soluble vitamins,

suggesting no effect on the metabolism of other water-soluble vitamins. The

results of the food intake and body weight gain indicated that the lowest

observed adverse effect level for young rats was 79.2 mg/kg body weight/day,

while the no observed adverse effect level was 38.4 mg/kg/day. These results

suggested immediately setting a tolerable upper intake level for biotin.

PMID: 18071266 [PubMed - indexed for MEDLINE]

Brain. 1998 Jul;121 ( Pt 7):1267-79.[] Links

Biotin-responsive basal ganglia disease: a novel entity.

Ozand PT, Gascon GG, Al Essa M, Joshi S, Al Jishi E, Bakheet S, Al Watban J,

Al-Kawi MZ, Dabbagh O.

Department of Paediatrics, King Faisal Specialist Hospital and Research Centre,

Riyadh, Saudi Arabia. ozand@...

We describe a novel, biotin-responsive basal ganglia disease in 10 patients. At

onset, it appears as a subacute encephalopathy, with confusion, dysarthria and

dysphagia with occasional supranuclear facial nerve palsy or external

ophthalmoplegia, and progresses to severe cogwheel rigidity, dystonia and

quadriparesis. These symptoms disappear within a few days if biotin (5-10

mg/kg/day) is administered, and there are no neurological sequelae. They

reappear within 1 month if biotin is discontinued. Patients diagnosed late, or

who have had repeated episodes, suffer from residual symptoms such as

paraparesis, mild mental retardation or dystonia. The numerous biochemical

studies of intermediary metabolism, like the autoimmune and toxicological

studies, enzyme assays including biotinidase, carboxylase and lysosomal

activities, and bacterial and viral studies were all normal. The aetiology may

be related to a defect in the transporter of biotin across the blood-brain

barrier. The only consistent radiological abnormality was central necrosis of

the head of the caudate bilaterally and complete, or partial, involvement of the

putamen on brain MRI. This was present during the initial acute encephalopathy

and remained unchanged during follow-up of 3-10 years. Although its aetiology is

unknown, it is important to recognize this disease, since its symptoms may be

reversed and the progression of its clinical course prevented simply by

providing biotin.

PMID: 9679779 [PubMed - indexed for MEDLINE

Biochim Biophys Acta. 1983 Sep 22;763(2):180-2.Links

The effect of oxalate on gluconeogenesis by isolated chicken hepatocytes.

Increased sensitivity to inhibition as a result of biotin deficiency.

Bannister DW, O'Neill IE.

Addition of varying concentrations of oxalate to isolated chicken hepatocytes

reduced gluconeogenesis from lactate in a manner indicating that pyruvate

carboxylase was not the rate-limiting step. With hepatocytes from

biotin-deficient chicks, sensitivity to inhibition was increased, and was

consistent with pyruvate carboxylase being rate-limiting. Administration of

biotin to deficient chicks overnight restores sensitivity to oxalate to normal.

PMID: 6615890 [PubMed - indexed for MEDLINE

On the reported presence of biotin in carbamyl phosphate synthetase.

Huston RB, Cohen PP.

Biochemistry. 1969 Jun;8(6):2658-61. No abstract available. PMID: 4895023

[PubMed - indexed for MEDLINE]Related citations

12.

Carbamyl phosphate synthetase. A biotin enzyme.

Wellner VP, Santos JI, Meister A.

Biochemistry. 1968 Aug;7(8):2848-51. No abstract available. PMID: 4875281

[PubMed - indexed for MEDLINE]Related citations

>

> I've read that the dose varies. We use Bariatric Advantage 5 mg.

>

> Anne

>

>

> Anne Marquart, MS, RD, LD / Bariatric Dietitian / Roller Weight Loss and

Advance Surgery / 1280 E. Stearns/ Fayetteville, Ar / 479.445.6460

begin_of_the_skype_highlighting              479.445.6460      end_of_the_skype_\

highlighting / amarquart@... / www.rollerweightloss.com

> biotin

>

> Can anyone tell me off-hand what amount of Biotin supplementation is

recommended to promote hair and nail growth in post surgery patients?

>

> Thanks!

>

> Jillian McMullen, RD, LD/N

> ville, FL

>