Re: liver, inositol and biotin

[Guest guest]

Hi Dana, and all

Peat, PhD, in one of his newsletters, mentioned that biotin can harm the

liver unless it is taken with inositol. By googling liver, inositol and biotin,

I found a 1948 article, that talks about this at

www.jbc.org/content/176/1/429.full.pdf If I read this article correctly, it is

when biotin and folic acid are combined with a lot of other B vitamins

(sometimes they used liver fraction as a source of the other B vitamins) that

the biotin could cause a fatty liver, unless inositol is added to the mix. (The

rats were on a fat free and high carbohydrate diet in order to promote the

synthesis of fat.)

As I posted recently, inositol increases the motility of the stomach and small

intestine. This may help if you have constipation, but not be so great if you

have diarrhea. So, be careful with the amount.

Polly

[Guest guest]

Do you know what the amount of inositol should be given? My son takes 10mg

daily of biotin. He is very sensitive to B vitamins ~ makes him super hyper.

thanks!

>

> Hi Dana, and all

>

> Peat, PhD, in one of his newsletters, mentioned that biotin can harm

the liver unless it is taken with inositol. By googling liver, inositol and

biotin, I found a 1948 article, that talks about this at

www.jbc.org/content/176/1/429.full.pdf If I read this article correctly, it is

when biotin and folic acid are combined with a lot of other B vitamins

(sometimes they used liver fraction as a source of the other B vitamins) that

the biotin could cause a fatty liver, unless inositol is added to the mix. (The

rats were on a fat free and high carbohydrate diet in order to promote the

synthesis of fat.)

>

> As I posted recently, inositol increases the motility of the stomach and small

intestine. This may help if you have constipation, but not be so great if you

have diarrhea. So, be careful with the amount.

>

> Polly

>

[Guest guest]

I found a recommendation at an Attention Deficit / Attention Deficit

Hyperactivity Disorder (ADD/ADHD) website. It was 500 mg to 1,500 mg of inositol

taken a half hour before bedtime, to help with sleep. They suggested that

inositol might be a better solution to sleep problems than melatonin. Here is

the link.

http://addadhdadvances.com/inositol.html

I've also read that an adult gets around 1,000 mg of inositol in their diet each

day. So, that much is possibly a reasonable amount to supplement without

worrying too much about side effects in a healthy individual. Some studies use

mega-dosing of 18,000 mg and above. I assume you wouldn't want to use anywhere

near that much without good reason.

As for your use of 10 mg of biotin. I don't know how effective that much would

be for dysbiosis. You will have to ask the others who have tried it. I found a

hair product that used 3 mg of biotin along with 600 mg of inositol. That gives

you an idea of what seems to work with hair loss. I'm sure they weren't thinking

about the liver when they came up with that particular ratio of biotin to

inositol in their product. They were probably only considering the amount that

might do some good in the body.

When experimenting with the amount and time of day to use inositol, take into

consideration that inositol will increase the motility of the stomach and small

intestines. Inositol may be good for those who are under-methylated, but

bothersome for those who are over-methylated. One website mentioned a transient

effect in some people, where the inositol initially caused diarrhea, but this

stopped after a while.

>

> Do you know what the amount of inositol should be given? My son takes 10mg

daily of biotin. He is very sensitive to B vitamins ~ makes him super hyper.

> thanks!

>

>