Guest guest Posted October 7, 2002 Report Share Posted October 7, 2002 http://www.lef.org/protocols/index.shtml Mark this may help you Lori Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 9, 2002 Report Share Posted October 9, 2002 Dear Mark, I'm not a chemist so I'm not sure if what I'm sharing is relevant or not. I did take dimethylglycine (DMG) -- not tri -- and initially it seemed to be helping me establish a consistent seizure pattern. After taking it for about three months, I noticed that I felt worse. I was having more seizures and generally felt run-down. I hope this is helpful to your research, even if it is not directly related to your question. If I can share anything else that will be helpful, please let me know! Best wishes, Carrol Mark Schauss wrote:Has anyone experienced an increase in the incidence and/or severity of seizure activity with the use of TMG (Trimethylglycine)? I'm researching information for my paper and need to hear personal experiences. In health, Mark Schauss www.carbonbased.com (updated site - comments welcome) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 9, 2002 Report Share Posted October 9, 2002 Mark- My son experienced more seizures and gut problems with more mythelation. My idea would be to know whether your an over methaltor or under. If your under than this is for you, if not, your not doing yourself any favors? The idea being, if you reach for this stuff to give you methylation, might that not also give you more homocystein problems and b-12 problems (especially if you don't supplement with added b-12?) . Stomach acid and pH may be the key here? Kathy Re: [ ] TMG > > Dear Mark, > I'm not a chemist so I'm not sure if what I'm sharing is relevant or not. I did take dimethylglycine (DMG) -- not tri -- and initially it seemed to be helping me establish a consistent seizure pattern. After taking it for about three months, I noticed that I felt worse. I was having more seizures and generally felt run-down. > > I hope this is helpful to your research, even if it is not directly related to your question. If I can share anything else that will be helpful, please let me know! > > Best wishes, > Carrol > > > Mark Schauss wrote:Has anyone experienced an increase in the incidence and/or severity of > seizure activity with the use of TMG (Trimethylglycine)? > > I'm researching information for my paper and need to hear personal > experiences. > > In health, > Mark Schauss > www.carbonbased.com (updated site - comments welcome) > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 9, 2002 Report Share Posted October 9, 2002 Dear Mark, My initial response is good, but then there is an adverse reaction, hyperness, etc. Why not contact Walsh on this issue? He may be able to give you some good feedback on it. He advises anyone with excess methylation to avoid methionine supplements. Zoe INTRODUCING THE PFEIFFER TREATMENT CENTER .... determines whether the patient has an imbalance in metal metabolism, methylation ... of the Organization. The Health Research Institute was founded by Walsh ... www.hriptc.org/introducing_HRIxPTC.htm Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 8, 2003 Report Share Posted January 8, 2003 Where can SAM-e be purchased the cheapest? > I posted some stuff about TMG the other day - maybe it didn't show up on >the list? Here's some cut and pasted stuff from [ >http://www.naturallyhigh.co.uk ]http://www.naturallyhigh.co.uk > >Ali > >Trimethylglycine (TMG) >An alternative to SAMe is trimethylglycine (TMG) also a methyl donor. The >body can make SAMe directly from TMG, which is both stable and much less >expensive. While it has not been as extensively researched as SAMe, the >fact that it is a direct precursor of SAMe would predict that its effect >would be very similar. >TMG is also known as glycine betaine, not to be confused with " betaine >hydrochloride " which is used to help increase stomach acid. A precursor >to >SAMe, TMG turns into homocysteine, a substance toxic to the heart, into >SAMe and methionine. This process also yields DMG (dimethylglycine), a >well-known performance enhancer, which thus doubles TMG's benefits. >Extracted from sugar beets, TMG is also found in broccoli and spinach. It >has no reported side effects other than brief muscle tension headaches >and >only if it is taken in large quantities without food. Optimal doses >needed >to raise SAMe are 1,000 - 3000 mg per day. In combined formulas, a >100-250 >mg dose is sufficient. >An important point is that SAMe and TMG, unlike many other natural and >synthetic antidepressants, are safe to take during pregnancy and nursing. >There are also no reported negative interactions with other medications, >such as antidepressants. This makes them particularly useful in the >elderly >who are often on a variety of medications, and are also more sensitive to >side effects. SAMe can be used safely with other natural supplements, >too, >including St 's Wort. >A word of caution: Though not reported in the literature, I have seen >higher doses c irritability, anxiety, or insomnia in some individuals In >this case, lower the dose, but if the effect continues, the product >should >be stopped. By the same token, SAMe's antidepressant activity may lead to >the manic phase in individuals with bipolar (manic) depression, so such >individuals should not take SAMe unless under medical supervision. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 31, 2003 Report Share Posted July 31, 2003 It does if you also add the bottom line. TMG | Sorry the link does not work try this one. | Dave x | http://www.nutrimed.com/HOMO.HTM | | | | This list is intended for patients to share personal experiences with each other, not to give medical advice. If you are interested in any treatment discussed here, please consult your doctor. | | Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 30, 2004 Report Share Posted July 30, 2004 > We're getting ready to start the B12 shots and Chad's doctor wanted > to start out with supplementing the Folapro and TMG. What dose of TMG have you been giving Chad? My son takes 125 mg of DMG but I don't know what the dosing is for TMG. The bottles of TMG I've seen contain 750 mg capsules or tablets. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 2, 2004 Report Share Posted August 2, 2004 > What dose of TMG have you been giving Chad? My son takes 125 mg of > DMG but I don't know what the dosing is for TMG. The bottles of TMG > I've seen contain 750 mg capsules or tablets. We are doing 500 mgs of TMG twice daily. I've got to double check with Chad's doctor regarding the folapro dosage. She intially said 800mcg twice daily. That is actually what I read on Jill presentations from a DAN conference back in the fall of 2003. Here's the link for the fall 2003 DAN conference: http://www.autism.com/ari/dan/science/Jill.htm And according to the above link. . .TMG was in mcgs too. I've not seen TMG sold in mcgs only in mgs. Another question for his doctor! I'm glad you asked this. . . it made me re-evaluate until I can talk with his doctor again. I've seen the dosage on the folapro as being anywhere from 500 to 800 mcgs b.i.d. for this protocol. The tablet itself is 800 mcgs. His doctor is out of town this week so I won't know until next week. But for now, I'm just doing a total of 800 mcg's of folapro a day. I'm just splitting the pill in two. Now I'm thinking I may have to cut back on the TMG too. I found this on http://www.diagnose-me.com/treat/T36338.html " TMG supplementation may sometimes produce hyperactivity in autistic children. Folic acid appears to help neutralize this effect at one or two 800mcg tablets. [Autism Res Rev Int 10( 3): 7, 1996] " I found this to be true with my son, at the higher levels of folapro with the TMG, he calmed down a lot! He even went to bed early one night! So at least I've found where two 800 mcgs were used with TMG at the mgs dosage. This makes me feel somewhat better. I'm still going to be cautious until I can talk with his doctor. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 10, 2005 Report Share Posted November 10, 2005 Hi, Doug. Thanks for posting your experience with TMG. I'm glad it seems to be helping you, and I hope it keeps up. The fact that you tested low in glutathionation, the fact that TMG seems to be helping you, and the fact that you are able to take the alpha lipoic acid product that previously gave you trouble, now that you are taking the TMG, all suggest to me that you did have a problem in methylation. I do think it would be worthwhile to try folinic acid together with methyl-B12, since this may mean that you have a genetic problem in your folate metabolism, and that would bypass it. Rich > > Goodmorning > > I would like to post my recent experience using TMG. > > After reading Jo,s post and Richs post after attending the DANI > conference I noticed some similarities with my situation and decided > to try TMG. > > I cannot tolerate Immunepro and suffer from increased mental fog and > symptoms when using Lipoic acid similar to the symptoms with > immunepro. I have tested low in glutathionation in a functional liver > detox test. > > I started TMG 500mg 2 times a day late last week and have found a > marked improvement in brain fog (reduced by about 70%).This has also > led to an improvement in mood. > > I use folic acid & have used methyl B12 previously with no similar effect. > > I have not tried immunepro since but am using a product with lipoic > acid in it which did give me bad brain fog and also lipo glutathione > with no ill effect. > > Not sure based on this if folinic acid would be a worth a try as well. > > All i know i am thankful for the benefit a have had so far from TMG > and greatly appreciate the input from Rich & Jo that lead me down this > path. > > regds Doug > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 10, 2005 Report Share Posted November 10, 2005 Hi Doug, That's great news! Alpha lipoic acid has a similar effect on me too - though less pronounced than the Immunopro. As an experiment, I started taking the B12 with the TMG five days ago and found I can now tolerate it. I usually find it really increases my fatigue and cognitive problems and feel heavy - like lead. Now I am noticing a bright feeling and an overall reduction in brain fog. One side affect I have noticed though, is that I am little bit wired. I started Folinic Acid three days ago, and have had no ill effects with it, I haven't really noticed any additional difference - though, I am feeling pretty good so far. Jo :-) > > Goodmorning > > I would like to post my recent experience using TMG. > > After reading Jo,s post and Richs post after attending the DANI > conference I noticed some similarities with my situation and decided > to try TMG. > > I cannot tolerate Immunepro and suffer from increased mental fog and > symptoms when using Lipoic acid similar to the symptoms with > immunepro. I have tested low in glutathionation in a functional liver > detox test. > > I started TMG 500mg 2 times a day late last week and have found a > marked improvement in brain fog (reduced by about 70%).This has also > led to an improvement in mood. > > I use folic acid & have used methyl B12 previously with no similar effect. > > I have not tried immunepro since but am using a product with lipoic > acid in it which did give me bad brain fog and also lipo glutathione > with no ill effect. > > Not sure based on this if folinic acid would be a worth a try as well. > > All i know i am thankful for the benefit a have had so far from TMG > and greatly appreciate the input from Rich & Jo that lead me down this > path. > > regds Doug > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 10, 2005 Report Share Posted November 10, 2005 Hi , The instruction on the bottle of the NOW TMG that I take, is, to take preferably with meals. Hope this helps. Jo :-) > > > Does anyone know if TMG should be taken with food or on an empty stomach > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 10, 2005 Report Share Posted November 10, 2005 thanks Jo I have kirkmans and it just says take as directed?? I will take it with meals Re: TMG > Hi , > > The instruction on the bottle of the NOW TMG that I take, is, to take > preferably with > meals. > > Hope this helps. > > Jo :-) > > >> >> >> Does anyone know if TMG should be taken with food or on an empty stomach >> >> >> >> >> >> >> >> > >> > > > > > > > > This list is intended for patients to share personal experiences with each > other, not to give medical advice. If you are interested in any treatment > discussed here, please consult your doctor. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 10, 2005 Report Share Posted November 10, 2005 Gooday Jo thanks for the feedback on folinic acid and B12 . Based on yr & Rich,s information I am going to try these and report back on how they go. My benefits from TMG have been mainly brainfog & mood but i am hopeful that over time i might see some benefits with physical energy as well. Thanks again Doug > > > > Goodmorning > > > > I would like to post my recent experience using TMG. > > > > After reading Jo,s post and Richs post after attending the DANI > > conference I noticed some similarities with my situation and decided > > to try TMG. > > > > I cannot tolerate Immunepro and suffer from increased mental fog and > > symptoms when using Lipoic acid similar to the symptoms with > > immunepro. I have tested low in glutathionation in a functional liver > > detox test. > > > > I started TMG 500mg 2 times a day late last week and have found a > > marked improvement in brain fog (reduced by about 70%).This has also > > led to an improvement in mood. > > > > I use folic acid & have used methyl B12 previously with no similar effect. > > > > I have not tried immunepro since but am using a product with lipoic > > acid in it which did give me bad brain fog and also lipo glutathione > > with no ill effect. > > > > Not sure based on this if folinic acid would be a worth a try as well. > > > > All i know i am thankful for the benefit a have had so far from TMG > > and greatly appreciate the input from Rich & Jo that lead me down this > > path. > > > > regds Doug > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 23, 2005 Report Share Posted November 23, 2005 Trimethylglicine - it is used to get the estradiol out of your system if you are using Indoplex/DIM to keep your E2 in check. --------------------------------- FareChase - Search multiple travel sites in one click. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 13, 2006 Report Share Posted January 13, 2006 I think I posted this on how I keep my E2 down. I use Indolplex/DIM with TMG. I take the Indolplex/DIM after dinner and the TMG at bed time. TMG helps wash out the E's from the liver and turns into SAM-E. So I sleep better. Also take Zinc/Copper. http://www.ritecare.com/prodsheets/PHY-15336.html http://www.ritecare.com/prodsheets/PHY-15336.html http://www.myvitanet.com/zincop100cnt.html I also do Maca just ordered some $27.00 for a KG or 2.2 lbs I do 1/2 tsp full in the morning with applesauce and 1/2 tsp at noon with yogurt. Helps a lot with BP, libido and it levels off hormones. Phil don defevers <dd4459@...> wrote: I am taking 1/2 tab. daily but what is TMG, and where do i get it, and how much do I take, going back for blood work in 1 month, I will have been on weekly T shots for 5 weeks. My starting E2 level was 33. Did a 100mg. shot today and got a little rush and face turned a bit red, is that normal? --------------------------------- Photos – Showcase holiday pictures in hardcover Photo Books. You design it and we’ll bind it! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 14, 2006 Report Share Posted January 14, 2006 I'll only address the TMG. TMG is short for trimethylglycine. It is also known a betaine base. It is a metabolite of choline. It is serves as a methyl group donor which lowers homocysteine level which a good for the heart and blood vessels. It donates it methyl groups for the biosynthesis of methionine and other molecules. It raises the SAMe levels. In is used by the liver. The chloride salt is used to increase gastric acid and as a lipotropic agent. I take the choride form as a supplement to increase stomach acid levels in prevent " acid " reflux. For the effect quite marked. If I eat a fatty meal and don't take the supplement I belch and it goes on for hours. Now that I know it has other benefits I take it ever day. So you see there is an acidic form I am taking and there is the mildly basic form others are using here. Beyond A Century carries the mildly basic form as a bulk powder for 150 grams it costs $6.50 not counting shipping. I get the acidic form for the Health food store and it also a lower cost supplement. If you don't shop carefully you can end up paying a price several times higher. I understand people take up to around six grams of TMG. I take about three grams of betaine chloride with pepsin because that is the dose that is sufficient to improve digestion. I am not sure as to the dose likely need to speed estrogen metabolization...to lower estrogen levels. Perhaps 2 or 3 grams? And unrelated comment below. I'll add that Prilosec and all the related PPI meds used to treat GERD will lower testosterone and raise estrogen levels besides being directly toxic to the nervous system. It because of the PPI meds that I have used in the past, I read this group. > > I am taking 1/2 tab. daily but what is TMG, and where do i get it, and how much do I take, going back for blood work in 1 month, I will have been on weekly T shots for 5 weeks. My starting E2 level was 33. Did a 100mg. shot today and got a little rush and face turned a bit red, is that normal? > > > > > --------------------------------- > Photos – Showcase holiday pictures in hardcover > Photo Books. You design it and we'll bind it! > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2007 Report Share Posted March 2, 2007 Yes, if you give TMG, a methylator to a child who is overmethylated this is often the response you get, weepy, overemotional. You could try a different methylator, DMG, mb12, but my best guess is she is already methylated and any other methylators will make her worse. Fwiw, I recently read that they give large amounts of niacinamide to overmethylators to balance out the methylation. I had a hard time with that as ours was clearly undermethylated (TMG was wonderful for her) but so was niacinamide, however a recent trial again with niacinamide with no methylators found the same thing after about a week, weepy behavior. Hope I didn't confuse you with the second part of the last paragraph, confusing. I'd be interested to see what she did with about 400 mgs of niacinamide a day. TMG I picked up 2 sample tablets of TMG at the conference and without thinking about it I gave them to my daughter. She has had two easily disturbed, very weepy days with purple eyes and much more difficult behaviour than normal. Is this possibly linked to the TMG or is it a co-incidence? Does anyone know or have similar experiences?xx Sally Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2007 Report Share Posted March 2, 2007 It was a Kirkman free sample. I threw the packet away yesterday and the binmen came and took it away today before the link occurred to me. So if it had TMG and B12 it would have had lots of methylation potential (you can tell I don't know what I'm doing) >>If it was the capsules Sally it did have Folinic and MB12 in - I have some of the samples here so I just checked Mandi x Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2007 Report Share Posted March 2, 2007 hi when we used tng with my son shane he got very hyperactive lots of spinning and stimming behavior we stopped them for three days to see if he calmer down and he did so have not used them since, mind you probably didnt help that the tmg also had folinic acid and b12 in them kirkman make lots of combinations. melissaxx --- Eva family wrote: > I picked up 2 sample tablets of TMG at the > conference and without > thinking about it I gave them to my daughter. She > has had two easily > disturbed, very weepy days with purple eyes and much > more difficult > behaviour than normal. Is this possibly linked to > the TMG or is it a > co-incidence? Does anyone know or have similar > experiences? > xx Sally > ________________________________________________________________________________\ ____ 8:00? 8:25? 8:40? Find a flick in no time with the Search movie showtime shortcut. http://tools.search./shortcuts/#news Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2007 Report Share Posted March 2, 2007 I think this reaction is different, the hyperactivity, we got extreme hyperactivity with DMG, tried TMG and the improvements were miraculous. In the case of hyperactivity, I would try another methylator, either DMG or MB12 as you might get another, really good response. But the weepy, irritable behavior, to me, with a methylator signifies over methylation. P.S. -It took us a long time to try the TMG after our disastrous experience with DMG, but we were very glad we did. Re: TMG hi when we used tng with my son shane he got veryhyperactive lots of spinning and stimming behavior westopped them for three days to see if he calmer downand he did so have not used them since, mind youprobably didnt help that the tmg also had folinic acidand b12 in them kirkman make lots of combinations.melissaxx--- Eva family <bobsallyevantlworld> wrote:> I picked up 2 sample tablets of TMG at the> conference and without > thinking about it I gave them to my daughter. She> has had two easily > disturbed, very weepy days with purple eyes and much> more difficult > behaviour than normal. Is this possibly linked to> the TMG or is it a > co-incidence? Does anyone know or have similar> experiences?> xx Sally> __________________________________________________________8:00? 8:25? 8:40? Find a flick in no time with the Search movie showtime shortcut.http://tools.search./shortcuts/#news Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2007 Report Share Posted March 2, 2007 thanks very much . What does it mean to say "overmethylated"? You are right the second paragraph did confuse me but you are being very helpful. I thought when I posted -- all reactions, even bad ones, should tell us something if only we know what. Any further information on methylation would be gratefully received Sally Cochran wrote: Yes, if you give TMG, a methylator to a child who is overmethylated this is often the response you get, weepy, overemotional. You could try a different methylator, DMG, mb12, but my best guess is she is already methylated and any other methylators will make her worse. Fwiw, I recently read that they give large amounts of niacinamide to overmethylators to balance out the methylation. I had a hard time with that as ours was clearly undermethylated (TMG was wonderful for her) but so was niacinamide, however a recent trial again with niacinamide with no methylators found the same thing after about a week, weepy behavior. Hope I didn't confuse you with the second part of the last paragraph, confusing. I'd be interested to see what she did with about 400 mgs of niacinamide a day. TMG I picked up 2 sample tablets of TMG at the conference and without thinking about it I gave them to my daughter. She has had two easily disturbed, very weepy days with purple eyes and much more difficult behaviour than normal. Is this possibly linked to the TMG or is it a co-incidence? Does anyone know or have similar experiences? xx Sally No virus found in this incoming message. Checked by AVG Free Edition. Version: 7.5.446 / Virus Database: 268.18.5/707 - Release Date: 01/03/2007 14:43 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2007 Report Share Posted March 2, 2007 It was a Kirkman free sample. I threw the packet away yesterday and the binmen came and took it away today before the link occurred to me. So if it had TMG and B12 it would have had lots of methylation potential (you can tell I don't know what I'm doing) xx Sally melissa easthope wrote: hi when we used tng with my son shane he got very hyperactive lots of spinning and stimming behavior we stopped them for three days to see if he calmer down and he did so have not used them since, mind you probably didnt help that the tmg also had folinic acid and b12 in them kirkman make lots of combinations. melissaxx --- Eva family <bobsallyeva@ ntlworld. com> wrote: > I picked up 2 sample tablets of TMG at the > conference and without > thinking about it I gave them to my daughter. She > has had two easily > disturbed, very weepy days with purple eyes and much > more difficult > behaviour than normal. Is this possibly linked to > the TMG or is it a > co-incidence? Does anyone know or have similar > experiences? > xx Sally > ____________ _________ _________ _________ _________ _________ _ 8:00? 8:25? 8:40? Find a flick in no time with the Search movie showtime shortcut. http://tools. search.. com/shortcuts/ #news No virus found in this incoming message. Checked by AVG Free Edition. Version: 7.5.446 / Virus Database: 268.18.5/707 - Release Date: 01/03/2007 14:43 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2007 Report Share Posted March 2, 2007 Looking it up on Enzymestuff and references to the Pfeiffer Centre they say that over-methylation types show anxiety/panic -- this is almost my daiughter's main symptom (apart from ignoring everyone else) -- when she had taken the TMG she was panicking in situations she has faced many many times and previously enjoyed. This would make sense if the TMG was adding to already high methylation. She did badly on B6 -- hyper speech and unable to stop talking rubbish. What I'm looking to see is what I should give her instead. I will look up niacinamide. I think you have recommended it before xx Sally Cochran wrote: Yes, if you give TMG, a methylator to a child who is overmethylated this is often the response you get, weepy, overemotional. You could try a different methylator, DMG, mb12, but my best guess is she is already methylated and any other methylators will make her worse.i Fwiw, I recently read that they give large amounts of niacinamide to overmethylators to balance out the methylation. I had a hard time with that as ours was clearly undermethylated (TMG was wonderful for her) but so was niacinamide, however a recent trial again with niacinamide with no methylators found the same thing after about a week, weepy behavior. Hope I didn't confuse you with the second part of the last paragraph, confusing. I'd be interested to see what she did with about 400 mgs of niacinamide a day. TMG I picked up 2 sample tablets of TMG at the conference and without thinking about it I gave them to my daughter. She has had two easily disturbed, very weepy days with purple eyes and much more difficult behaviour than normal. Is this possibly linked to the TMG or is it a co-incidence? Does anyone know or have similar experiences? xx Sally No virus found in this incoming message. Checked by AVG Free Edition. Version: 7.5.446 / Virus Database: 268.18.5/707 - Release Date: 01/03/2007 14:43 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2007 Report Share Posted March 2, 2007 I can only find niacinamide recommended as a variant of DMG, TMG and MB12 ie for the under-methylated. Most advice seems to be to try all the methylators to see if any of them works ie if one doesn't work for you then try a different one. The only different one I can find is DeFelice on Enzymestuff who says if over-methylated try selenium in the form of selenomethionine xx Sally Cochran wrote: Yes, if you give TMG, a methylator to a child who is overmethylated this is often the response you get, weepy, overemotional. You could try a different methylator, DMG, mb12, but my best guess is she is already methylated and any other methylators will make her worse. Fwiw, I recently read that they give large amounts of niacinamide to overmethylators to balance out the methylation. I had a hard time with that as ours was clearly undermethylated (TMG was wonderful for her) but so was niacinamide, however a recent trial again with niacinamide with no methylators found the same thing after about a week, weepy behavior. Hope I didn't confuse you with the second part of the last paragraph, confusing. I'd be interested to see what she did with about 400 mgs of niacinamide a day. TMG I picked up 2 sample tablets of TMG at the conference and without thinking about it I gave them to my daughter. She has had two easily disturbed, very weepy days with purple eyes and much more difficult behaviour than normal. Is this possibly linked to the TMG or is it a co-incidence? Does anyone know or have similar experiences? xx Sally No virus found in this incoming message. Checked by AVG Free Edition. Version: 7.5.446 / Virus Database: 268.18.5/707 - Release Date: 01/03/2007 14:43 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 2, 2007 Report Share Posted March 2, 2007 Sally, Not exactly a methylation expert at all, but some kids are known to be under methylated (like ours) and do well on supplements that are methylating like TMG and others. Other children (like yours, I think) are over methylated and react with weepy behaviors when given methylators (everything but the hyperactivity which does not, I think signify over methylation). If you just google "overmethylators and Bill Walsh" you will come up with some articles to read that will explain much better than I....the difference between over and under methylators. There are even specific supplements recommended for each type and could be helpful to you, or give you a guideline as to what to try next. Since getting methylation right or balanced is key to helping our kids it is well worth the effort. When you find the articles if you have questions you can bring them here and I am sure others as well as I...will try to help. TMG I picked up 2 sample tablets of TMG at the conference and without thinking about it I gave them to my daughter. She has had two easily disturbed, very weepy days with purple eyes and much more difficult behaviour than normal. Is this possibly linked to the TMG or is it a co-incidence? Does anyone know or have similar experiences?xx Sally No virus found in this incoming message. Checked by AVG Free Edition. Version: 7.5.446 / Virus Database: 268.18.5/707 - Release Date: 01/03/2007 14:43 Quote Link to comment Share on other sites More sharing options...
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