Guest guest Posted October 19, 2008 Report Share Posted October 19, 2008 Hi Chuck - you wrote… " I doubt that evening administration will make a difference for T4 only medication, but Armour or T3 could change the blood levels during sleep " Research reported in the journal 'Clinical Endocrinology' found that taking the same dose of levothyroxine (i.e., Synthroid) at bedtime, as compared to first thing in the morning, might be better. " Effects of evening vs morning thyroxine ingestion on serum thyroid hormone profiles in hypothyroid patients " http://www3.interscience.wiley.com/journal/117998170/abstract?CRETRY=1 & SRETRY=0 Although a small study, it was conclusive in its findings and the researchers actually described the results as " striking " and which have " important consequences for the millions of patients who take levothyroxine daily " . Researchers reported that taking medication at bedtime, rather than the morning, results in “higher thyroid hormone concentrations and lower TSH concentrations.” TSH decreased and Free T4 levels rose in all patients by changing thyroxine ingestion from early morning to bedtime and T3 levels rose in all but one subject. And TSH decreased irrespective of the starting TSH levels, suggesting better absorption of the thyroid medication when taken in the evening. Interestingly, the researchers found that the circadian TSH rhythm -- the typical daily fluctuations of TSH that occur during a 24-hour period -- does not vary. The researchers suggest this may be because the conversion process of T4 to T3 may be more effective in the evening. This study didn't take into account the effects of T3 containing drugs The researchers suggested several explanations for the results and three of these are that (1) even when waiting at least 30 minutes to eat, breakfast may be interfering with the intestinal absorption of levothyroxine thyroxine. (2)“Bowel motility is slower at night,” which means that it takes longer for the levothyroxine tablet to transit through the intestinal system, resulting in longer exposure to the intestinal wall, and therefore, better uptake of the medication. (3)The conversion process of T4 to T3 may be more effective in the evening. They also reported reported that taking levothyroxine at bedtime, rather than the morning, results in “higher thyroid hormone concentrations and lower TSH concentrations.” TSH decreased and Free T4 levels rose in all patients by changing thyroxine ingestion from early morning to bedtime and T3 levels rose in all but one subject. Also, TSH decreased irrespective of the starting TSH levels, suggesting better absorption of the thyroid medication when taken in the evening. Interestingly, the researchers found that the circadian TSH rhythm - the typical daily fluctuations of TSH that occur during a 24-hour period - does not vary. You have also seen the many messages from members here, and surely other forums where they are reporting how much better they feel since starting night-time dosing and how their sleep pattern has changed and how much better they feel throughout the day. Since taking my Armour at night, I have cut back by one grain as I was finding during the morning, I was getting the 'too much' effect of feeling spaced out and some palpitations. I no longer get those since decreasing the dose. Sheila Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 19, 2008 Report Share Posted October 19, 2008 Sheila, Again, that is likely an effect of absorption, not efficacy. They would need to prove that an increased dosage given in the morning is somehow less beneficial. Chuck > ... Research reported in the journal 'Clinical Endocrinology' found that > taking the same dose of levothyroxine (i.e., Synthroid) at bedtime, as > compared to first thing in the morning, might be better.... Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 19, 2008 Report Share Posted October 19, 2008 I took 3 grains of armour daily before night-time dosing. I took 1 1/2 grains before breakfast and 1 1/2 grains in the afternoon. Since night-time dosing, there must be better absorption because many have experimenters have need to decrease their dose, including my DH and myself. In the case of us two, we appear to have proved that a decrease taking it at night is more beneficial than taking an increased dose in the morning. I think if this subject is to continue, it should perhaps be taken on to the LABGAB science forum. We need a bigger study to show the effect of all thyroid hormone replacement taken at night. Sheila Sheila, Again, that is likely an effect of absorption, not efficacy. They would need to prove that an increased dosage given in the morning is somehow less beneficial. Chuck > ... Research reported in the journal 'Clinical Endocrinology' found that > taking the same dose of levothyroxine (i.e., Synthroid) at bedtime, as > compared to first thing in the morning, might be better.... .._,___ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 19, 2008 Report Share Posted October 19, 2008 Hi Chuck and Sheila ~ I have no studies to cite, but I've read T3 peaks in the body around midnight and does most of its detoxification efforts in the liver during the night. This may explain why a night-time dose is more effective. take care, ~ -----Original Message-----From: thyroid treatment [mailto:thyroid treatment ]On Behalf Of Sheila Sent: Sunday, October 19, 2008 12:40 PMthyroid treatment Subject: RE: Re: anxiety I took 3 grains of armour daily before night-time dosing. I took 1 1/2 grains before breakfast and 1 1/2 grains in the afternoon. Since night-time dosing, there must be better absorption because many have experimenters have need to decrease their dose, including my DH and myself. In the case of us two, we appear to have proved that a decrease taking it at night is more beneficial than taking an increased dose in the morning. I think if this subject is to continue, it should perhaps be taken on to the LABGAB science forum. We need a bigger study to show the effect of all thyroid hormone replacement taken at night. Sheila Sheila,Again, that is likely an effect of absorption, not efficacy. They would need to prove that an increased dosage given in the morning is somehow less beneficial.Chuck> ... Research reported in the journal 'Clinical Endocrinology' found that > taking the same dose of levothyroxine (i.e., Synthroid) at bedtime, as > compared to first thing in the morning, might be better.... .._,___ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 19, 2008 Report Share Posted October 19, 2008 Chuck probably has an explanation for that - I have done tons of research but my old brain can't retain what it used to, but there is a vague memory of this somewhere. Luv Sheila Hi Chuck and Sheila ~ I have no studies to cite, but I've read T3 peaks in the body around midnight and does most of its detoxification efforts in the liver during the night. This may explain why a night-time dose is more effective. take care, ~ I took 3 grains of armour daily before night-time dosing. I took 1 1/2 grains before breakfast and 1 1/2 grains in the afternoon. Since night-time dosing, there must be better absorption because many have experimenters have need to decrease their dose, including my DH and myself. In the case of us two, we appear to have proved that a decrease taking it at night is more beneficial than taking an increased dose in the morning. I think if this subject is to continue, it should perhaps be taken on to the LABGAB science forum. We need a bigger study to show the effect of all thyroid hormone replacement taken at night. Sheila Sheila, Again, that is likely an effect of absorption, not efficacy. They would need to prove that an increased dosage given in the morning is somehow less beneficial. Chuck > ... Research reported in the journal 'Clinical Endocrinology' found that > taking the same dose of levothyroxine (i.e., Synthroid) at bedtime, as > compared to first thing in the morning, might be better.... .._,___ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 19, 2008 Report Share Posted October 19, 2008 Would that not involve a costly research project Chuck? Is it not similar to the split dosing (for dogs anyway) in that the PIL says once a day in the morning when it is common knowledge that twice a day is better? Mo > > Again, that is likely an effect of absorption, not efficacy. They would > need to prove that an increased dosage given in the morning is somehow > less beneficial. > > Chuck > > > ... Research reported in the journal 'Clinical Endocrinology' found that > > taking the same dose of levothyroxine (i.e., Synthroid) at bedtime, as > > compared to first thing in the morning, might be better.... > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 19, 2008 Report Share Posted October 19, 2008 T3 is involved in detoxification ? Tell me more? Mo > > Hi Chuck and Sheila ~ > > I have no studies to cite, but I've read T3 peaks in the body around > midnight and does most of its detoxification efforts in the liver during the > night. This may explain why a night-time dose is more effective. > > take care, > > ~ > > RE: Re: anxiety > > > I took 3 grains of armour daily before night-time dosing. I took 1 1/2 > grains before breakfast and 1 1/2 grains in the afternoon. Since night-time > dosing, there must be better absorption because many have experimenters have > need to decrease their dose, including my DH and myself. In the case of us > two, we appear to have proved that a decrease taking it at night is more > beneficial than taking an increased dose in the morning. I think if this > subject is to continue, it should perhaps be taken on to the LABGAB science > forum. > > > > We need a bigger study to show the effect of all thyroid hormone > replacement taken at night. > > > > Sheila > > Sheila, > > Again, that is likely an effect of absorption, not efficacy. They would > need to prove that an increased dosage given in the morning is somehow > less beneficial. > > Chuck > > > ... Research reported in the journal 'Clinical Endocrinology' found that > > taking the same dose of levothyroxine (i.e., Synthroid) at bedtime, as > > compared to first thing in the morning, might be better.... > > ._,___ > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 19, 2008 Report Share Posted October 19, 2008 Hi , You wrote: > > > I have no studies to cite, but I've read T3 peaks in the body around > midnight and does most of its detoxification efforts in the liver during > the night. This may explain why a night-time dose is more effective.... It also peaks in the afternoon, so I am not sure this fits entirely. However, it is consistent with what I said about the difference between T4 and T3, since T3 will peak a couple of hours after taking it, but T4 barely ripples, regardless of when you take it. Chuck Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 19, 2008 Report Share Posted October 19, 2008 Mo, You wrote: > > Would that not involve a costly research project Chuck? There are two issues. If taking it at night just allows for a lower dose, then you could just as well take a slightly larger dose in the morning. However, at least some claimed better sleep and all around better effects. For that, my guess is that it would much less likely to happen for T4 only meds than for Armour. But yes, to tease such an effect out of the noise would take a costly research project. Chuck Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 20, 2009 Report Share Posted April 20, 2009 Sharon, Sorry you're having anxiety. I have dealt with that all my life, sometimes very severe. Lately as long as I am stabilizing my blood sugar I'm ok. Which means I have to eat something with protein and fat every 2 or 3 hours. I'm starting the Bee's Egg Drink to help with this as well. (Though I only do 2 eggs, butter, and about 1/2 tsp of coconut oil at a time right now. I'm able to handle lots of cinnamon.) Eggs tend to bring me out of an anxiety attack. Seriously. Anyway, massage helps, aromatherapy has helped me in the past. Peppermint, lavender. There are some Young Living essential oils for calming anxiety and other emotions. (I sell them so if you have any questions you can email me off list or look up the website.) Rescue Remedy by Bach's Flower essences is sometimes helpful. Passionflower in an alcohol-free liquid form dropper worked pretty well for me too but it's a little pricey. But it has helped me within 10 minutes and it tastes just like tea. Herbal teas are a little less expensive, such as chamomile, valerian. Lots of things I've tried as you can see. Not to promote medication because I've had some horrible experiences and don't recommend going on them, but unfortunately I've had to be on Klonopin in desperate moments. Now I'm going through the tapering off which is hard especially on top of the candida stuff. Hope you find something that works. I really believe the candida is what causes the anxiety so as long as you're not feeding it, but feeding yourself the good stuff I'm sure you will get some relief. ita Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 20, 2009 Report Share Posted April 20, 2009 Deep breathing is the best thing you can do, Sharon. Keep your mouth closed so you're only breathing through your nose. Make sure you take the deep breaths all the way down into your belly because the body's natural relaxation trigger spot is located right above the navel. So, as you inhale you should expand your belly and then gently contract your belly as you exhale. Do this at least 3 times and in this case, more IS better! It also helps to try and smooth out the " texture " of your breath and to make the inhale breaths last the same length of time as the exhale breaths. I'm a yoga teacher and I teach this breath technique to all my students to encourage relaxation. It switches your body from the flight/fright response (the sympathetic nervous system) to the parasympathetic nervous system (relaxation response). jackie > > To any of you experiencing anxiety... > > What do you do to relieve anxiety? Especially when you are out and about or > at work. > > -Sharon > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 21, 2009 Report Share Posted April 21, 2009 > > Sharon, > > Sorry you're having anxiety. I have dealt with that all my life, sometimes very severe. Lately as long as I am stabilizing my blood sugar I'm ok. Which means I have to eat something with protein and fat every 2 or 3 hours. I'm starting the Bee's Egg Drink to help with this as well. (Though I only do 2 eggs, butter, and about 1/2 tsp of coconut oil at a time right now. I'm able to handle lots of cinnamon.) Eggs tend to bring me out of an anxiety attack. Seriously. Anyway, massage helps, aromatherapy has helped me in the past. Peppermint, lavender. There are some Young Living essential oils for calming anxiety and other emotions. (I sell them so if you have any questions you can email me off list or look up the website.) Rescue Remedy by Bach's Flower essences is sometimes helpful. Passionflower in an alcohol-free liquid form dropper worked pretty well for me too but it's a little pricey. But it has helped me within 10 minutes and it tastes just like tea. +++Hi ita. Please do not recommend treatments for candida sufferers other than those I recommend - see this article on Anxiety & Depression: http://www.healingnaturallybybee.com/articles/treat6.php +++More treatments is not better, since " proper nutrients " are what heals such symptoms. People who use alternative treatments, herbs, teas, etc. often overwhelm their bodies, which can slow or even stop the healing process. Bee Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 21, 2009 Report Share Posted April 21, 2009 Jackie, Its my husband having the anxiety.. He says when he does the deep breathing he gets lightheaded. What would cause that? Is there a way to avoid getting lightheaded? Another question: Are there trigger points to help when you get carsick when riding in a car? That's another one of his issues. Thanks for any advice! -Sharon Deep breathing is the best thing you can do, Sharon. Keep your mouth closed so you're only breathing through your nose. Make sure you take the deep breaths all the way down into your belly because the body's natural relaxation trigger spot is located right above the navel. So, as you inhale you should expand your belly and then gently contract your belly as you exhale. Do this at least 3 times and in this case, more IS better! It also helps to try and smooth out the " texture " of your breath and to make the inhale breaths last the same length of time as the exhale breaths. I'm a yoga teacher and I teach this breath technique to all my students to encourage relaxation. It switches your body from the flight/fright response (the sympathetic nervous system) to the parasympathetic nervous system (relaxation response). jackie No virus found in this incoming message. Checked by AVG - www.avg.com Version: 8.5.287 / Virus Database: 270.12.0/2066 - Release Date: 04/20/09 17:56:00 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 21, 2009 Report Share Posted April 21, 2009 > Its my husband having the anxiety.. He says when he does > the deep breathing he gets lightheaded. What would cause that? Is there a > way to avoid getting lightheaded? Hi Sharon, some people get lightheaded when they do deep breathing because their body is not used to the amount of oxygen that they are taking in and being distributed throughout the body. If your husband gets light headed he should stop the deep breathing and resume whatever is his " normal " method of breathing and then try the deep, nose breathing again. If he continues to " practice " this method of breathing his body will become used to it and the lightheadedness will diminish. I mentioned in my earlier post that the body's natural relaxation trigger point is in the belly. Interestingly, the body's stress trigger point is in the upper chest. When a person is stressed they often breathe very shallowly, usually only into their chest area. Therefore, they are constantly triggering their stress response just by the way they breathe! Stress hormones are constantly being secreted, we don't get adequate oxygen, we blow out our adrenals, etc...just because we're not breathing well. Did you ever notice how when you are in a stressful situation sometimes your body automatically takes a deep, expansive breath through your belly? Like a big sigh? After that you almost always feel calmer, clearer and better able to handle whatever is stressing you out. It's because you took that deep breath into the belly and triggered your own relaxation hormones. The body is wise enough to know what to do but we so often bypass it anbd go right back into bad, shallow breathing rhythms. Conscious deep breathing is sooooooo healing on a number of levels. Many, many people never take deep breaths, plus, we're so used to keeping our belly sucked in for vanity reasons that we've become a society of stressed out people because we're not getting adequate and relaxing, deep breaths. > > Another question: Are there trigger points to help when > you get carsick when riding in a car? That's another one of his issues. > There probably is but I don't know it. I would imagine you could Google and find out. jackie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2009 Report Share Posted April 22, 2009 > > > > > > Jackie, > > Its my husband having the anxiety.. He says when he does > the deep breathing he gets lightheaded. What would cause that? Is there a > way to avoid getting lightheaded? > > Another question: Are there trigger points to help when > you get carsick when riding in a car? That's another one of his issues. > > > > Thanks for any advice! > > -Sharon > > > Hi Sharon, his anxiety is most likely due to too much die off. When it is too overwhelming deep breathing makes it worse for me. Have him cut back on antifungals. kelly > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2009 Report Share Posted April 22, 2009 >Another question: Are there trigger points to help when you get carsick when riding in a car? That's another one of his issues. +++Hi Sharon. Yes, there are trigger points on the wrists. You can buy wrist bands that put pressure on the points, which can be wore when needed, in a car or on a boat: http://www.travelband.com/about-travelband.htm Bee Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2009 Report Share Posted April 22, 2009 > Its my husband having the anxiety.. He says when he does > the deep breathing he gets lightheaded. What would cause that? > Is there a way to avoid getting lightheaded? Hyperventilating. (Getting too much oxygen). Breath just as deeply but more slowly. (Fewer breaths per minute). - Roy Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 14, 2009 Report Share Posted June 14, 2009 5-htp helped my anxiety and depression. Also helps me sleep longer and deeper. I take 100mg three times a day on an empty stomache. > > Does anyone know of a supplement or anything over-the-counter that helps with anxiety? I would appreciate any suggestions. Thank you for your help! > > Sue > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 16, 2009 Report Share Posted June 16, 2009 This may seem like I'm being a jokester, but I'm actually serious: What about medical marijhuana? I saw a documentary on it recently and some of the things it shows promise for are brain trauma, (which, if hypoperfusion of the brain is the cause of " brain fog " , might apply to us), pain, anxiety and sleep disorders. Sounds like just the thing for CFS'rs. I'm in Canada and marijhuana is not viewed as a serious drug and we do make it available, via prescription, to those to whom it is deemed necessary and/or helpful, (predominately those undergoing chemo and/or people in great pain). I think the U.S. views it as a more serious drug, but is it available by prescription there? I sure haven't had the nerve to even suggest it to my doc and I question whether I'd want to be " high " when I'm already fuzzy brained all the time anyway. But I am curious, especially about its benefit for sleep. Any comments or experiences? > > Does anyone know of a supplement or anything over-the-counter that helps with anxiety? I would appreciate any suggestions. Thank you for your help! > > Sue > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 16, 2009 Report Share Posted June 16, 2009 " sb2boys " <sb2boys@...> wrote: > > Does anyone know of a supplement or anything over-the-counter that > helps with anxiety? I would appreciate any suggestions. > Thank you for your help! > > Sue Best to look into causes for the anxiety, take a wider view of personal case on all levels of being, then address the causes of the anxiety more closely. Carol W. willis_protocols Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 16, 2009 Report Share Posted June 16, 2009 >>> it shows promise for brain trauma, <<<< What did they mean? What promise does it show? I'm trying to picture how pot would help a brain injury. Some people do use it to " take the edge off/relax/go to sleep " , etc., so guess you might say it could help anxiety or sleep. But, it also can cause MAJOR anxiety and paranoia in others. Plus, it is a drug and can be very addictive. So, then one could develop anxiety if they " came off " of it, wanted to skip it, or do not have it available. And , as Carol said, the core source of anxiety would have to be examined, to not end up just " anesthestising " , and causing problems to escalate. I'm not saying it should not be used as medicine, for specific things, but these points need consideration. I was told by Medical Marijuana people years ago, plus my doctor that I qualify for it, due to my Neuro movement disorders. But at that time, did not find clear evidence from others that it would help. And I'm highly sensitive to all drugs, and clean and sober, and want to stay that way. But, it's on the back burner...waaaaay back...for future...something severe and untreatable...other than just " taking the edge off " . It also causes memory loss and other brain changes (damage? don't know. My Pot Head friends are pretty cognitively fried and apathetic...but this may vary). In case I ever begin Medical Marijuana, please try to forget that I wrote this lol. my 2c, Katrina > > > > Does anyone know of a supplement or anything over-the-counter that helps with anxiety? I would appreciate any suggestions. Thank you for your help! > > > > Sue > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 17, 2009 Report Share Posted June 17, 2009 > > Does anyone know of a supplement or anything over-the-counter that helps with anxiety? I would appreciate any suggestions. Thank you for your help! > > Sue > GABA! Magnesium. I also find that low B12 causes physiological anxiety. Nina Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 17, 2009 Report Share Posted June 17, 2009 40 years ago, it was the perfect hangover cure. I don't think that I could now cope with the dissociation it induces. However, if my pain levels get worse, I'll give it another whirl R Re: Anxiety > This may seem like I'm being a jokester, but I'm actually serious: What > about medical marijhuana? I saw a documentary on it recently and some of > the things it shows promise for are brain trauma, (which, if hypoperfusion > of the brain is the cause of " brain fog " , might apply to us), pain, > anxiety and sleep disorders. Sounds like just the thing for CFS'rs. I'm > in Canada and marijhuana is not viewed as a serious drug and we do make it > available, via prescription, to those to whom it is deemed necessary > and/or helpful, (predominately those undergoing chemo and/or people in > great pain). I think the U.S. views it as a more serious drug, but is it > available by prescription there? > > I sure haven't had the nerve to even suggest it to my doc and I question > whether I'd want to be " high " when I'm already fuzzy brained all the time > anyway. But I am curious, especially about its benefit for sleep. > > Any comments or experiences? > > > >> >> Does anyone know of a supplement or anything over-the-counter that helps >> with anxiety? I would appreciate any suggestions. Thank you for your >> help! >> >> Sue >> > > > > > ------------------------------------ > > This list is intended for patients to share personal experiences with each > other, not to give medical advice. If you are interested in any treatment > discussed here, please consult your doctor. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 17, 2009 Report Share Posted June 17, 2009 > > > > Does anyone know of a supplement or anything over-the-counter that helps with anxiety? I would appreciate any suggestions. Thank you for your help! > > > > Sue > > > > GABA! > Magnesium. > > I also find that low B12 causes physiological anxiety. > > Nina Also, Valerian. For nighttime: benadryl, although it can dehydrate you. Otherwise, it makes you feel calm and cozy and gives you good dreams. People also swear by Resue Remedy. Something I have not tried is Rescue Remedy, but people swear by it. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 18, 2009 Report Share Posted June 18, 2009 Treatments I recommend for anxiety: 1. Relaxation/brain training/mind-body therapies. 1. RelaxMate II photostimulation glasses. www.selfhealthsystems.com 2. Guided imagery CD’s/mp3’s. i. ‘Letting Go of Stress’ by Dr. Emmett - www.drmiller.com ii. ‘Stress Relief Through Guided Imagery’ by Dr. Rossman - www.thehealingmind.org 3. emWave biofeedback technology by HeartMath. www.heartmath.com.au 4. Holosync audio technology. www.meditate.com.au/ & www.centerpointe.com/ 5. Meditation. 6. Coherent breathing. www.coherence.com/ 7. Kundalini yoga meditation. www.theinternetyogi.com/ 1. Neurotransmitter modulation. 1. 5-HTP or St ’s Wort à Serotonin. 2. GABA. Quote Link to comment Share on other sites More sharing options...
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