SINCE 1988- Autoimmunity induced by chemicals

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J Toxicol Clin Toxicol 1988;26(3-4):125-56

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Autoimmunity induced by chemicals.

Bigazzi PE.

University of Connecticut Health Center, Farmington 06032.

Immunotoxicologic studies have demonstrated that autoimmune responses and/or

autoimmune diseases are induced in humans and experimental animals by chronic

exposure to various chemicals. The present review is focused on seven groups

of chemically induced human disorders, i.e. systemic lupus erythematosus,

autoimmune hemolytic anemia, myasthenia gravis, pemphigus,

glomerulonephritis, thyroiditis and hepatitis. Results obtained from studies

of the available experimental counterparts of these diseases, i.e. those

models obtained from the exposure of laboratory animals to various chemicals,

are then analyzed. Finally, we present the lessons that can be derived from

immunotoxicologic investigations regarding mechanisms of induction,

heterogeneity of chemicals involved, humoral vs. cellular immune responses

and genetic predisposition to chemically induced autoimmunity.

Publication Types:

* Review

* Review, Tutorial

PMID: 3047416 [PubMed - indexed for MEDLINE]

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ids=9129190 & dopt=Abstract</A>

Toxicology 1997 Apr 11;119(1):1-21

Autoimmunity caused by xenobiotics.

Bigazzi PE.

Department of Pathology, University of Connecticut Health Center, Farmington

06032, USA.

A number of clinical reports and experimental studies have shown that

autoimmune responses and/or autoimmune diseases are induced in humans and

laboratory animals by chronic exposure to various chemicals. The present

review is focused on the most frequent groups of chemically induced human

disorders. Results obtained from studies of the available counterparts of

these diseases, i.e. those models obtained from the exposure of laboratory

animals to various chemicals are analyzed. Although significant progress has

been achieved to the realization that environmental agents may cause profound

changes in our immune system and result in autoimmune disease,

epidemiological, clinical and experimental work is still needed to acquire a

better understanding of the mechanisms involved.

Publication Types:

* Review

* Review, Tutorial

PMID: 9129190 [PubMed - indexed for MEDLINE]

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