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Mayo Clinic Study

Mayo Clinic Rochester

Thursday, September 09, 1999

Mayo Clinic Study Implicates Fungus as Cause of Chronic Sinusitis

ROCHESTER, MINN. -- Mayo Clinic researchers say they have found the

cause of most chronic sinus infections -- an immune system response

to fungus. They say this discovery opens the door to the first

effective treatment for this problem, the most common chronic disease

in the United States. (See graph.)

An estimated 37 million people in the United States suffer from

chronic sinusitis, an inflammation of the membranes of the nose and

sinus cavity. Its incidence has been increasing steadily over the

last decade. Common symptoms are runny nose, nasal congestion, loss

of smell and headaches. Frequently the chronic inflammation leads to

polyps, small growths in the nasal passages which hinder breathing.

" Up to now, the cause of chronic sinusitis has not been known, " say

the Mayo researchers: Drs. Sherris, Eugene Kern and Jens

Ponikau , Mayo Clinic ear, nose and throat specialists. Their report

appears in the September issue of the journal Mayo Clinic

Proceedings.

" Fungus allergy was thought to be involved in less than ten percent

of cases, " says Dr. Sherris. " Our studies indicate that, in fact,

fungus is likely the cause of nearly all of these problems. And it is

not an allergic reaction, but an immune reaction. "

The researchers studied 210 patients with chronic sinusitis. Using

new methods of collecting and testing mucus from the nose, they

discovered fungus in 96 percent of the patients' mucus. They

identified a total of 40 different kinds of fungi in these patients,

with an average of 2.7 kinds per patient.

In a subset of 101 patients who had surgery to remove nasal polyps,

the researchers found eosinophils (a type of white blood cell

activated by the body's immune system) in the nasal tissue and mucus

of 96 percent of the patients.

The results, the researchers say, clearly portray a disease process

in which, in sensitive individuals, the body's immune system sends

eosinophils to attack fungi and the eosinophils irritate the

membranes in the nose. As long as fungi remain, so will the

irritation.

" This a potential breakthrough that offers great hope for the

millions of people who suffer from this problem, " says Dr. Kern. " We

can now begin to treat the cause of the problem instead of the

symptoms. "

More research is underway at Mayo Clinic to confirm that the immune

response to the fungus is the cause of the sinus inflammation. The

researchers are also working with pharmaceutical companies to set up

trials to test medications to control the fungus. They estimate that

it will be at least two years before a treatment will be widely

available.

The researchers distinguish chronic sinusitis -- sinusitis that lasts

three months or longer -- from acute sinusitis, which lasts a month

or less. They say that the cause of the acute condition is usually a

bacterial infection.

Antibiotics and over-the-counter decongestants are widely used to

treat chronic sinusitis. In most cases, antibiotics are not effective

for chronic sinusitis because they target bacteria, not fungi. The

over-the-counter drugs may offer some relief of symptoms, but they

have no effect on the inflammation.

" Medications haven't worked for chronic sinusitis because we didn't

know what the cause of the problem was, " says Dr. Ponikau. " Finally

we are on the trail of a treatment that may actually work. "

Thousands of kinds of single-cell fungi (molds and yeasts) are found

everywhere in the world. Fungal spores (the reproductive part of the

organism) become airborne like pollen. Some people develop allergies

to fungi. The new evidence from the Mayo study suggests that many

people also develop a different kind of immune system response.

Contact: e-mail: newsbureau@...

Also see Statement for Patients

Full-text report from Mayo Clinic Proceedings

LEGAL RESTRICTIONS AND TERMS OF USE APPLICABLE TO THIS SITE

USE OF THIS SITE SIGNIFIES YOUR AGREEMENT TO THE TERMS OF USE

File news_773.html last modified: Tuesday, 19-Mar-2002 14:57:08 CST

Copyright © 1996-2002 Mayo Foundation for Medical Education and

Research.

>

> Hello All,

>

> Can anyone direct me to some certain information without me having

to spend hours searching for it? I am in need of this for the media

binder that I'm preparing for next week. If you can be of

assistance, please write me directly at this addy. You might also

post to the group too as it might help others as well. Below is what

I need:

>

> 1. Where to find the Mayo Clinic study on Rhinosinusitis and Mold

exposure;

>

> 2. The Long Article that was posted on either this group or toxic

mold survivors group: It was on how long scientists, etc. have known

about mold exposures and health concerns. It believe it was posted

by a doctor. I can't remember which group... it could be been TMS.

(I hope someone remembers this article as it was a great one.)

>

> 3. Any information regarding the CA Toxic Mold Bill; and any other

states that have bills of this nature;

>

> 4. The Mark Tatum Story by the Associated Press with the picture

without his prosthetic face. Mark has mucormycosis.

>

> 5. The JAMA article pertaining to mycotoxins that came out a while

back. Can this be obtained without cost?

>

> 6. And if there is any way to quickly find a number of articles on

SCHOOLS WITH TOXIC MOLD;

>

> 7. and lastly (I think): Any information pertaining to Toxic Mold

and Multiple Chemical Sensitivity. The article by Sheila Bastein was

good, but don't know where to obtain a copy from the internet.

>

> YOUR HELP IS GREATLY APPRECIATED. Also, thanks to all that have

been so gracious to send personal stories for the binder that I'm

preparing. I will be forever grateful!

>

> Beverly Weikert

>

> National Toxic Mold Coalition

>

> Public Relations Supervisor/Board Member

>

> www.geocities.com/marbme12/NTMC.html

>

> Homeowners Against Deficient Dwellings

>

> Indiana Representative

>

> www.hadd.com

>

> Consultant to The Environmental Health Research Group

>

> www.myhealthrights.com

>

>

>

>

>

> ---------------------------------

>

Link to comment
Share on other sites

Guest guest

More on Mayo Clinic

Type in Dr. Sherris on the Mayo Search, he is one of the Dr's

that did the research

Allergic Diseases Division

Department of Internal Medicine

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Other Allergic Diseases

The Division of Allergic Diseases provides a wide range of

services for the evaluation, diagnosis and treatment of many other

allergic and respiratory diseases other than those listed in the

specialty clinics on our web site.

The following is a listed (although not all inclusive) are other

diseases that are evaluated.

Allergic bronchopulmonary aspergillosis

Anaphylaxis

Churg Strauss Vasculitis

Allergic Conjunctivitis

Cough

Drug allergy

Farmers Lung

Flushing Syndromes

Hypersensitivity pneumonitis

Mastocytosis

Nasal drainage, infections, polyps

Occupational asthma

Sarcoidosis

The physician at the Mayo Clinic, that is an Allergy/Asthma

specialist, performs a comprehensive history and physical

examination. This will include reviewing of outside information

provided by the patient. To make an appointment and get general

informations please call our appointment secretary at 507-284-9989.

Investigation is individualized and may include allergy skin testing,

pulmonary function tests, methacholine bronchial challenge tests,

rhinoscopy and upper airway endoscopy. All of this is available

within the area of the Allergy Division to maximize convenience,

utilization of resources and patient's time; and is under the direct

supervision of the allergist.

Other testing and consultation that may need to be done will be

individualized. Such testing may include allergy blood tests (RAST),

measurement of blood counts and total IgE. Chest x-ray and high

resolution CT scan of the lungs and sinuses may be required to detect

structural abnormalities or disease entities that could be causing or

aggravating the patient's breathing problems. If a consultation with

other specialists is needed, they are easily obtainable and available

in the same building where the Allergy Division is located.

Upon completion of testing and consultations the Mayo Clinic

Allergy/Asthma specialist will compile the information and offer the

diagnosis, treatment plan, answer any questions and arrange follow-up

plans.

Other Allergic Diseases Interest Group

Butterfield, J. H.

Frigas, E.

Hagan, J. B.

Li, J. T. C.

Maddox, D. E.

Van Dellen, R. G.

Volcheck, G. W.

Weiler, C. R.

How to Make an Appointment

Please call the Allergy Appointment Office at 507 284-9989 or fax at

507 284-5771. Our appointment office is open from 8:00 a.m. until

5:00 p.m. Monday-Friday. The Clinic is closed on Saturday and Sunday.

Appointments can be made by telephone or by mail. There are no

appointments available by e-mail.

Mayo Clinic Publications on Other Allergic Diseases

Blomgren JA, Markus PJ, Osmon DR, Estes LL, Hanssen AD, Li JTC.

Perioperative prophylactic antimicrobial selection in orthopedic

patients with a history of penicillin and/or cephalosporin allergy. J

Allergy Clin Immunol 107(2):S2, 2001

Li JTC, Markus PJ, Osmon DR, Estes LL, Gosselin VA, Hanssen AD.

Reduction of vancomycin use in orthopedic patients with a history of

antibiotic allergy. J Allergy Clin Immunol 105(1 Pt 2):S339, 2000.

Markus PJ, Kloos KE, Li JTC. Prevalence of self-reported allergy in

patients admitted for medical or surgical procedures. Ann Allergy

Asthma Immunol 86(1):106, 2001.

Li JTC, Estes LL, Markus PJ, Osmon DR, Gosselin VA, Hanssen AD.

Penicillin and cephalosporin allergy in hospitalized patients. Ann

Allergy Asthma Immunol 84:109, 2000.

Valyasevi MA; Van Dellen RG. Frequency of systemic reactions to

penicillin skin tests. Ann Allergy, Asthma & Immunol. 2000;85:363-

365.

Gross MD, Andriacci F, Gordon R, Maddox DE: Sarcoidosis presenting as

subcutaneous nodules. Arch Department of Dermatology, 113:1442, 1997.

Maddox DE: Occupational allergic disease. Clin Immunol Newsletter 10

(2):23-29, 1990.

Frigas E: Testing for bronchial sensitivity to formaldehyde gas. Mayo

Clin Proc 56:277, (April) 1981.

nsen RK, Butterfield, JH, Kao PC, Frigas E: Alternative

medicines for asthma. European J of Allergy and Clin Immunol (Supp.)

51:57, April 1996. (Abstract)

Butterfield JH, Schwenk NM, Colville DS, Kuipers BJ: Severe

Generalized Reactions to Ibuprofen: Report of a Case. J Rheumatol,

649-650, 1986.

Butterfield JH, Weiler D, Dewald G, Gleich GJ: Autonomously Growing

Human Mast Cell Leukemia Line. Fed Proc, 45:736, 1986.

Leiferman KM, Haugen HS, Gleich GJ, Butterfield JH: Subpopulations of

Human Skin Mast Cells Containing Major Basic Protein: Association

with Diseases Involving Mast Cells. J Invest Dermatol, 88:503, April,

1987.

Weiler D, Haugen HS, Leiferman KM, Gleich GJ, Butterfield JH: Mast

Cells in Carnoy's Fixed Tissue Stain Positively for Eosinophil Major

Basic Protein (MBP). Fed Proc, 46:936, 1987.

Leiferman KM, Weiler DA, Haugen HS, Gleich GJ, Butterfield JH:

Endocytosis of Eosinophil Granule Major Basic Protein by Mast Cells.

J Invest Dermatol, 90:581, April, 1988.

Butterfield JH, Weiler DA, Roche PC: Purification of Tryptase from a

Human Mast Cell Line. J Allergy Clin Immunol, 83:217 January, 1989.

Weiler DA, Butterfield JH: In Vitro Sensitivity of Human Mast Cells

to Chemotherapeutic Agents. J Allergy Clin Immunol, 83:234, January,

1989.

Hunt LW, Weiler DA, Colby TV, Gleich GJ, Butterfield JH: Quantitation

of Mast Cells in Usual Interstitial Pneumonitis (UIP) Using an

Indirect Immunofluorescent Stain for Mast Cell Tryptase. Chest,

92:171, August, 1989.

Bubak ME, Wentz-Murtha PE, Dunnette SL, Keating MU, Wallen ND, Weiler

DA, Butterfield JH, Blomgren JA, Pfenning MA, Gleich GJ, CE:

Eosinophil Derived Neurotoxin (EDN) in Nasal Lavages Correlates With

Weekly Hay Fever Symptoms During Seasonal Exposure While Mast Cell

Tryptase Does Not. Ann Allergy, 66:66, 1991.

Hunt LW, Geich GJ, Butterfield JH: Mast Cells in Fatal Asthma:

Visualization with an Immunofluorescent Stain to Mast Cell Tryptase.

Am Rev of Respir Dis, 142:A41, April, 1991.

Finoto S, Marshall J, Irani A, Schwartz L, Butterfield JH, Ohno I,

Dolovich J, Jordana M, Denburg J: Regulation of Protease and Cytokine

Expression in a Human Mast Cell Line (HMC-1): Effect of Nasal Polyp

Structural Cell-Derived Conditioned Media. J Allergy Clin Immunol,

89:246, January, 1992.

Van Oosterhout AJM, Butterfield JH, Delsman KC, Nijkamp FP: Human

Mast Cell Lines HMC-1 and D5 Subclone Produce Lipid Mediators But Do

Not Actively Release Histamine. Am Rev of Respir Dis, 145:A-852, May,

1992.

Buckely M, J, J, Ray K, Butterfield JH: Production

of Cytokines in a Human Mast Cell Line. " Cells and Cytokines in Lung

Inflammation " . Paris, France, 24-25, June, 1993

Butterfield JH, Khan DA: Measurement of a Prostaglandin D2 (PGD2)

Metabolite in Urine of Patients with Systemic Mast Cell Disease

(SMD). J Allergy Clin Immunol, 93:383, January, 1994.

Yocum MW, Butterfield JH, Gharib H: Elevated Serum Calcitonin Levels

in Systemic Mast Cell Disease. Poster presented at American

Associates of Clinical Endocrinologists. New Orleans, April, 1994.

Nilsson G, Blom T, Kusche-Gullberg M, Kjellen L, Butterfield JH,

Sundstrom C, Nilsson K, Hellman L: Phenotypic Characterization of the

Human Mast-Cell Line HMC-1. Scand J Immunol, 39:489-498, 1994.

Tam SY, Tsai M, Butterfield JH, Galli SJ: Expression of Functional

TRK a Receptor Tyrosine Kinase in Human Mast Cell Line HMC-1. Society

for Neuroscience Abstracts, Vol. 20, 1994.

Talley NJ, Butterfield JH, E: Mast Cell Infiltration and

Degranulation in Colonic Mucosa in Irritable Bowel Syndrome.

Gastroenterology, 105:A697, 1995.

Chan H, Tanaka R, JM, Butterfield JH: Tryptase cDNA Sequences

in a Human Mast Cell Line. Faseb J, 9:A1343.

Butterfield JH, Kao PC, Klee GG, Yocum MW: Aspirin Idiosyncrasy in

Systemic Mast Cell Disease: Positive Cytochemical Staining of HMC-1

cells for Calcitonin and Calcitonin Gene-Related Peptide. Poster

presented at American College of Allergy, Asthma, & Immunology.

Dallas, TX, November, 1995.

Baghestanian M, Agis H, Bevec D, Bankl HC, Butterfield JH, Füreder W,

Willheim M, Müller MR, Lechner K, Valent P: SCF-Mediated

Downregulation of c-kit in Human Mast Cells. J Invest Dermat, 105

(5):717, 1995.

Love KS, Lakshmanan RR, Butterfield JH, Fox CC: Expression of MHC

Class II Molecules on HMC-1 Cells is Upregulated by IFN-? but not IL-

4. J Allergy Clin Immunol, 97:313, January, 1996.

Jaffe JS, Wang Y, Post TJ, Glaum MC, Raible DG, Mohanty JG,

Butterfield JH, Lang DM, Schulman ES: Activated Human Lung Fragments

and Human Mast Cells Synthesize IL-13. J Allergy Clin Immunol,

97:707, January 1996.

Butterfield JH, Weiler D, Dewald G, Gleich GJ: Establishment of an

Immature Mast Cell Line from a Patient with Mast Cell Leukemia. Leuk

Res, 12:345-355, 1988.

Butterfield JH, Marcoux JP, Weiler D, Harner SG: Mast Cell

Pharyngitis As a Cause of Supraglottic Edema. Archives of

Otorhinolaryngol, 245:88-91, 1988.

Butterfield JH, Weiler DA: In Vitro Sensitivity of Immature Human

Mast Cells to Chemotherapeutic Agents. Int Arch Allergy Appl Immunol,

89:297-300, 1989.

Butterfield JH, Weiler DA, Hunt LW, Wynn SR, Roche PC: Purification

of Tryptase From a Human Mast Cell Line. J Leuk Biol, 47:409-419,

1990.

Valent P, Besemer J, Sillaber, Butterfield JH, Eher R, Majdic O,

Kishi K, Klepetko W, Eckersberger F, Lechner K, Bettelheim P: Failure

to Detect IL-3 Binding Sites on Human Mast Cells. J Immunol, 145:3432-

3437, 1990.

Valent P, Bevec D, Maurer D, Besemer J, De Padova F, Butterfield JH,

Speiser W, Majdic O, Lechner K, Bettelheim P: Interleukin 4 Promotes

Expression of Mast Cell ICAM-1 Antigen. Proc Natl Acad Sci USA,

88:3339-3342, 1991.

Sillaber C, Strobl H, Bevec LD, Ashman L, Butterfield JH, Lechner K,

Maurer D, Bettelheim P, Valent P: IL-4 Regulates C-kit Proto-Oncogene

Product Expression in Human Mast and Myeloid Progenitor Cells. J

Immunol, 147:4224-4228, 1991.

Hunt LW, Colby TV, Weiler DA, Sur S, and Butterfield JH:

Immunofluorescent Staining for Mast Cells in Idiopathic Pulmonary

Fibrosis: Quantification and Evidence for Extracellular Release of

Mast Cell Tryptase. Mayo Clin Proc, 67:941-948, 1992

Gauchat JF, Henchoz S, Mazzel G, Aubry JP, Brunner T, Blasey H, Life

P, Talabot D, -Romo L, J, Kishi K, Butterfield JH,

Dahinden C, Bonnefoy JY: Induction of Human IgE Synthesis in B Cells

by Mast Cells and Basophils. Nature, 365:340-343, September, 1993.

Furitsu T, Tsujimura T, Tono T, Ikeda H, Kitayama H, Koshimizu U,

Sugahara H, Butterfield JH, Ashman LK, Kanayama Y, Matsuzawa Y,

Kitamura Y, Kanakura Y: Identification of Mutations in the Coding

Sequence of the Proto-Oncogene C-Kit in a Human Mast Cell Leukemia

Cell Line Causing Ligand-Independent Activation of C-Kit Product. J

Clin Invest, 92:1736-1744, October, 1993.

Buckley MG, CMM, J, Pryor P, Ray K, Butterfield JH,

JW: IL-4 Enhances IL-3 and IL-8 Gene Expression in a Human

Leukemic Mast Cell Line. J Immunol, 84:410-415, 1995.

Butterfield JH, Kao PC, Klee GG, Yocum, MW: Aspirin Idiosyncrasy in

Systemic Mast Cell Disease: A New Look at Mediator Release During

Aspirin Desensitization. Mayo Clin Proc, 70:481-487, 1995.

Molinari JF, WR, J, Tanaka R, Butterfield JH, Abraham WM:

Role of Tryptase in Immediate Cutaneous Responses in Allergic Sheep.

J Appl Physiol, 79(6):1966-1970, 1995.

Love KS, Lakshmanan RR, Butterfield JH, Fox CC: IFN-? Stimulated

Enhancement of MHC Class II Antigen Expression by the Human Mast Cell

Line HMC-1. Cellular Immunol, 170:85-90, 1996.

Agis H, Fureder W, Bankl HC, Kundi M, Sperr WR, Willheim M, Boltz-

Nitulescu G, Butterfield JH, Kishi K, Lechner K, Valent P:

Comparative Immunophenotypic Analysis of Human Mast Cells, Blood

Basophils and Monocytes. Immunol, 87:535-543, 1996.

Werfel T, Oppermann M, Butterfield JH, Begemann G, Elsner J, Gotze O,

Zwirner J: The Human Mast Cell Line HMC-1 Expresses C5a Receptors and

Responds to C5a but not to C5a(desArg). Scand J Immunol, 44:30-36,

1996.

Wedi B, Elsner J, Czech W, Butterfield JH, Kapp A: Modulation of

Intercellular Adhesion Molecule 1 (ICAM-1) Expression on the Human

Mast Cell Line (HMC)-1 by Inflammatory Mediators. Allergy, 51:676-

684, 1996.

Baghestanian M, Agis H, Bevec D, Bankl HC, Hofbauer R, Kress HG,

Butterfield JH, Müller MR, Ashman LK, Füreder W, Willheim M, Lachner

K, Valent P: Stem Cell Factor-Induced Downregulation of c-kit in

Human Lung Mast Cells and HMC-1 Mast Cells. Exp Hemat, 24:1377-1386,

1996.

Jaffe JS, Raible DG, Post TJ, Wang Y, Glaum MC, Butterfield JH,

Schulman ES: Human Lung Mast Cell Activation Leads to IL-13 mRNA

Expression and Protein Release. Am J Respir Cell Mol Biol, 15:473-

481, 1996.

Finotto S, Marshall JS, Butterfield JH, Denburg JA: Specific

Inhibition of ?-Tryptase Expression in a Human Mast Cell Line by

Granulocyte-Macrophage Colony-Stimulating Factor Produced by Airways

Structural Cells. Am J Respir Cell Mol Biol, 15:355-360, 1996.

Wedi B, Lewrick H, Butterfield JH, Kapp A: Human HMC-1 Mast Cells

Exclusively Express the Fc?RII Subtype of IgG Receptor. Arch Dermatol

Res, 289:21-27, 1996.

Tam S-Y, Tsai M, Yamaguchi M, Yano K, Butterfield JH, Galli SJ:

Expression of Functional TrkA Receptor Tyrosine Kinase in the HMC-1

Human Mast Cell Line and in Human Mast Cells. Blood, 90(5):1807-1820,

September 1997.

Schumacher U, van Damme EJM, Peumans, WJ, Butterfield JH,

BS: Lectin Histochemistry of Human Leukaemic Mast Cells (HMC-1)

Transplanted into Severe Combined Immunodeficient (scid) Mice. Acta

histochem, 100:1-9, 1998.

Maeda K, Taniguchi H, Ohno I, Ohtsu H, Yamauchi K, Sakurai E, Tanno

Y, Butterfield JH, Watanabe T, Shirato K: Induction of L-Histidine

Decarboxylase in a Human Mast Cell Line, HMC-1. Exp Hemat, 26:325-

331, 1998.

Butterfield JH: Response of Severe Systemic Mastocytosis to

Interferon Alpha. British J Dermat, 138:489-495, 1998.

Schulman ES, Glaum MC, Post T, Wang Y, Raible DG, Mohanty J,

Butterfield

JH, Pelleg A: ATP Modulates Anti-IgE-Induced Release of Histamine

from Human Lung Mast Cells. Am J Respir Cell Mol Biol, 20:530-537,

1999.

Nicklas RA, Bernstein IL, Li JTC, et al. The diagnosis and management

of anaphylaxis. J Allergy and Clin Immunol 101:S465-S528, 1998.

Li JTC, CE. Asthma Induced by aspirin and metabisulfite. Current

Therapy of Respiratory Disease-3, Cherniack. 137-141, 1989.

Khan DA, Li JTC. Allergic bronchopulmonary aspergillosis. IN:

Medicine for the

Practicing Physician, pp 169-172, 4th Ed., 1996. Hurst JW (ed).

Appleton Lange, Norwalk, CT.

Li JTC. Mosquito Hypersensitivity. Ann Allergy 58:385, 1987. (Letter)

Quereshi S, Li JTC. Syncope in systemic mastocytosis. Ann Allergy

72:70, 1994.

Li JTC, Estes LL, Markus PJ, Osmon DR, Gosselin VA, Hanssen AD.

Penicillinand cephalosporin allergy in hospitalized patients. Ann

Allergy Asthma Immunol, 1999.

DL, Yunginger JW, Dunn WF, RT, Hunt LW: Anaphylaxis

Induced by the Carboxymethylcellulose Component of Injectable

Triamcinolone Acetonide Suspension (Kenalog). ls of Allergy, 74

(2), 163-166, February 1995.

Yocum MW. Anaphylaxis. In Hurst JW (editor in chief) Medicine for the

Practicing Physician 1995, Appleton and Lange

Yocum MW. Systemic mast cell disease. In Hurst JW. (editor in chief)

Medicine for the Practicing Physician , 1995, Appleton and Lange.

Klein JS, Yocum MW: Emergency room period incidence of community-

onset anaphylaxis. J Allergy Clin Immunol 95:637-638, 1995.

MW Yocum, JH Butterfield: Aspirin desensitization of a mastocytosis

patient. Ann Allergy 74:79, 1995.

Van Dellen RG, Gleich GJ: Penicillin skin tests as predictive and

diagnostic aids in penicillin allergy. Med Clin N Amer July 1970;

54:997-1007.

Van Dellen RG, s GA, Walsh WE, Gleich GJ: Differing patterns of

wheal and flare skin reactivity in patients allergic to the

penicillins. J Allergy April 1971; 47:230-236.

Van Dellen RG, s GA: Acute anaphylactic reactions and aspirin

allergy. Postgrad Med May 1979; 49:197-201.

Van Dellen RG: Prediction of penicillin hypersensitivity reaction

(abstract). p. 44 in: Clinical Reviews, Rochester, MN. Nov 1969; p.

56.

Van Dellen RG, Gleich GJ, Walsh WE: Differing patterns of wheal and

flare skin reactivity in patients allergic to the penicillins

(abstract). J Allergy Feb 1970; 45:121. Solley GO, Gleich GJ, Van

Dellen RG: Evaluation of skin tests in patients with penicillin

allergy (abstract 170). J Allergy Clin Immunol March 1979; 63:184.

Van Dellen RG, Batts KP, PE: Mastocytosis limited to the

gastrointestinal tract. Report of a patient with severe diarrhea

improved with treatment (abstract). Ann Allergy, Asthma & Immunol

1998; 80:85.

Valyasevi MA, Van Dellen RG: Systemic reaction to penicillin skin

testing

(abstract). Ann Allergy, Asthma, & Immunol 1999; 82:88.

Van Dellen RG: Exercise-induced anaphylaxis (clinical brief). Mayo

Clin Proc Feb 1981; 56:133.

Links for Related Topics

Allergy Education Materials

American Academy of Allergy, Asthma & Immunology

American College of Allergy, Asthma & Immunology

Asthma and Allergy Foundation of America

LEGAL RESTRICTIONS AND TERMS OF USE APPLICABLE TO THIS SITE

USE OF THIS SITE SIGNIFIES YOUR AGREEMENT TO THE TERMS OF USE

File other-allergic.htm last modified: Wednesday, 18-Jul-2001

12:33:55 CDT

Copyright © 1995-2002 Mayo Foundation for Medical Education and

Research. .

>

> Hello All,

>

> Can anyone direct me to some certain information without me having

to spend hours searching for it? I am in need of this for the media

binder that I'm preparing for next week. If you can be of

assistance, please write me directly at this addy. You might also

post to the group too as it might help others as well. Below is what

I need:

>

> 1. Where to find the Mayo Clinic study on Rhinosinusitis and Mold

exposure;

>

> 2. The Long Article that was posted on either this group or toxic

mold survivors group: It was on how long scientists, etc. have known

about mold exposures and health concerns. It believe it was posted

by a doctor. I can't remember which group... it could be been TMS.

(I hope someone remembers this article as it was a great one.)

>

> 3. Any information regarding the CA Toxic Mold Bill; and any other

states that have bills of this nature;

>

> 4. The Mark Tatum Story by the Associated Press with the picture

without his prosthetic face. Mark has mucormycosis.

>

> 5. The JAMA article pertaining to mycotoxins that came out a while

back. Can this be obtained without cost?

>

> 6. And if there is any way to quickly find a number of articles on

SCHOOLS WITH TOXIC MOLD;

>

> 7. and lastly (I think): Any information pertaining to Toxic Mold

and Multiple Chemical Sensitivity. The article by Sheila Bastein was

good, but don't know where to obtain a copy from the internet.

>

> YOUR HELP IS GREATLY APPRECIATED. Also, thanks to all that have

been so gracious to send personal stories for the binder that I'm

preparing. I will be forever grateful!

>

> Beverly Weikert

>

> National Toxic Mold Coalition

>

> Public Relations Supervisor/Board Member

>

> www.geocities.com/marbme12/NTMC.html

>

> Homeowners Against Deficient Dwellings

>

> Indiana Representative

>

> www.hadd.com

>

> Consultant to The Environmental Health Research Group

>

> www.myhealthrights.com

>

>

>

>

>

> ---------------------------------

>

Link to comment
Share on other sites

Guest guest

Beverly,

Attached, in PDF format, is the Mayo Clinic Article.

ph P. Klein, Sr.

Beverly Weikert <weikert004@...> wrote:

Hello All,

Can anyone direct me to some certain information without me having to spend hours searching for it? I am in need of this for the media binder that I'm preparing for next week. If you can be of assistance, please write me directly at this addy. You might also post to the group too as it might help others as well. Below is what I need:

1. Where to find the Mayo Clinic study on Rhinosinusitis and Mold exposure;

2. The Long Article that was posted on either this group or toxic mold survivors group: It was on how long scientists, etc. have known about mold exposures and health concerns. It believe it was posted by a doctor. I can't remember which group... it could be been TMS. (I hope someone remembers this article as it was a great one.)

3. Any information regarding the CA Toxic Mold Bill; and any other states that have bills of this nature;

4. The Mark Tatum Story by the Associated Press with the picture without his prosthetic face. Mark has mucormycosis.

5. The JAMA article pertaining to mycotoxins that came out a while back. Can this be obtained without cost?

6. And if there is any way to quickly find a number of articles on SCHOOLS WITH TOXIC MOLD;

7. and lastly (I think): Any information pertaining to Toxic Mold and Multiple Chemical Sensitivity. The article by Sheila Bastein was good, but don't know where to obtain a copy from the internet.

YOUR HELP IS GREATLY APPRECIATED. Also, thanks to all that have been so gracious to send personal stories for the binder that I'm preparing. I will be forever grateful!

Beverly Weikert

National Toxic Mold Coalition

Public Relations Supervisor/Board Member

www.geocities.com/marbme12/NTMC.html

Homeowners Against Deficient Dwellings

Indiana Representative

www.hadd.com

Consultant to The Environmental Health Research Group

www.myhealthrights.com

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