Guest guest Posted July 14, 2002 Report Share Posted July 14, 2002 Have you read some of the product inserts on drugs lately. The drug companies do not know the exact mechanism of how the drugs effect certain things. Re: Drug sensitivity , Opiates usually dull the senses, reduce pain, relax smooth muscle, etc. A certain percentage of the population reacts to these drugs in the opposite way, and you sound like one of them. I would say you have an atypical reaction to opiates. Could hormone imbalances play a part? I think it's highly likely. You can also have people who become hyper-sensitive to a drug, where a tiny amount produces an exaggerated effect. Since MANY drugs have an unknow mechanism of action, it it basically a crap shoot!! Doctors are clueless on most of this stuff. Regards, K4 > I am interested to see if anyone here has experienced what I have and > if it may be related to hormone deficiencies like testosterone, > growth hormone, etc. > > When I was younger in my teens and twenties to be exact(I'm 38 now). > I noticed I had a much greater sensitivity to drugs like opiates > (oxycodone, hydrocodone, etc). I had taken these drugs in the past > for medical reasons and always experienced mood enhancing euphoria as > most people do. I was never a chronic user of any of these only when > prescribed for pain or anxiety. > The opiates in particular made me feel more " normal " or more like I > wanted to feel. They didn't make me dull or groggy, they made me > motivated, energetic, much more social, and sharper, which I know is > not the norm for most people. Anyway, within the last few years, I've > had to have some surgeries(testicular biopsy, wisdom tooth removal) > and also I had the gout(quite painful) and was prescribed oxycodone > (percocet) which was one of the drugs I had taken in the past that > really made me feel great. The effects now are much more subtle. They > do make me feel more motivated, but to much lessor of a degree. I > have suffered from fatigue, depression, and general aphathy for > several years and have been on many antidepressants without success > in the past. Last year I was diagnosed with low testosterone after my > phychiatrist had checked to find out if anything physical(hormonal, > illnesses, etc) could be making me so depressed, tired and withdrawn. > My total testosterone was 190, obviously low for any age. I tried > androgel without much improvement which also made me infertile(long > story), I'm going to a new endo next week with hope of maybe getting > on HCG and checking my growth hormone and anything else that might be > relative. I know this is long winded, but to get to the point of my > question....Has anyone noticed that certain hormonal deficiencies > could affect sensitivity or effectiveness of opiate drugs. I know > that the hypothalmus gland also has control over endorphins in the > brain and endorphins are very similar to opiates in their > mood/motivation enhancing properties. I strongly feel there might be > a link to hypothalmic function and the brains supply of endorphins, > which might explain depression and low motivation in some people. > Most antidepressants are targeting serotonin, but for me I feel > something else is missing. I hope getting my hormones in order will > help my mood and quality of life. Like everyone else, I just some > pleasure and joy back in my life and can't seem to find out where > it's gone or how to retrieve it. I sometimes feel very envious of > other people's ability to enjoy their lives and look foward to > getting up in the morning and having the motivational drive to excel > in their careers and enjoy the perks that that brings to their lives > as well as their family. I'm only 38, but sometimes I feel like I'm > 60 and am totaly afraid of what the " real " 60 might be like!. > > If any of this rings a bell with anyone here your input/experiences > would be greatly appreciated. > > thanks, > scott Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 14, 2002 Report Share Posted July 14, 2002 Yes, Basically the human body is always changing and with billions of people you just don't know how something will effect the other. My pharmacist is amazed that I get a better reaction with testosterone cypionate than Testosterone Enanthate. Re: Drug sensitivity Yes, that is often the case. I worked in Pharmacy for 12 years, so I'm pretty tuned into this stuff. Many drugs simply " work " . A very large percentage of drugs were discovered by accident, luck, or tradition (tribal medicine, etc). Many of these got on the market simply by going through refinement and testing periods to see what effects they have on the body. They don't even know exactly how aspirin does what it does - it just works!! Other drugs they do know the exact mechanism, and as they get more to the point where they are engineering drug molecules to do specific tasks, they understand more and more - and at the same time LESS and LESS! The more they learn, the more they realize they have only begun to scratch the surface... Regards, K4 > > I am interested to see if anyone here has experienced what I have > and > > if it may be related to hormone deficiencies like testosterone, > > growth hormone, etc. > > > > When I was younger in my teens and twenties to be exact(I'm 38 > now). > > I noticed I had a much greater sensitivity to drugs like opiates > > (oxycodone, hydrocodone, etc). I had taken these drugs in the past > > for medical reasons and always experienced mood enhancing euphoria > as > > most people do. I was never a chronic user of any of these only > when > > prescribed for pain or anxiety. > > The opiates in particular made me feel more " normal " or more like I > > wanted to feel. They didn't make me dull or groggy, they made me > > motivated, energetic, much more social, and sharper, which I know > is > > not the norm for most people. Anyway, within the last few years, > I've > > had to have some surgeries(testicular biopsy, wisdom tooth removal) > > and also I had the gout(quite painful) and was prescribed oxycodone > > (percocet) which was one of the drugs I had taken in the past that > > really made me feel great. The effects now are much more subtle. > They > > do make me feel more motivated, but to much lessor of a degree. I > > have suffered from fatigue, depression, and general aphathy for > > several years and have been on many antidepressants without success > > in the past. Last year I was diagnosed with low testosterone after > my > > phychiatrist had checked to find out if anything physical (hormonal, > > illnesses, etc) could be making me so depressed, tired and > withdrawn. > > My total testosterone was 190, obviously low for any age. I tried > > androgel without much improvement which also made me infertile (long > > story), I'm going to a new endo next week with hope of maybe > getting > > on HCG and checking my growth hormone and anything else that might > be > > relative. I know this is long winded, but to get to the point of my > > question....Has anyone noticed that certain hormonal deficiencies > > could affect sensitivity or effectiveness of opiate drugs. I know > > that the hypothalmus gland also has control over endorphins in the > > brain and endorphins are very similar to opiates in their > > mood/motivation enhancing properties. I strongly feel there might > be > > a link to hypothalmic function and the brains supply of endorphins, > > which might explain depression and low motivation in some people. > > Most antidepressants are targeting serotonin, but for me I feel > > something else is missing. I hope getting my hormones in order will > > help my mood and quality of life. Like everyone else, I just some > > pleasure and joy back in my life and can't seem to find out where > > it's gone or how to retrieve it. I sometimes feel very envious of > > other people's ability to enjoy their lives and look foward to > > getting up in the morning and having the motivational drive to > excel > > in their careers and enjoy the perks that that brings to their > lives > > as well as their family. I'm only 38, but sometimes I feel like I'm > > 60 and am totaly afraid of what the " real " 60 might be like!. > > > > If any of this rings a bell with anyone here your input/experiences > > would be greatly appreciated. > > > > thanks, > > scott > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 15, 2002 Report Share Posted July 15, 2002 --- Dwight Meeks <dee0726@...> wrote: Yes, Basically the human body is always changing and with billions of people you just don't know how something will effect the other.My pharmacist is amazed that I get a better reaction with testosterone cypionate than Testosterone Enanthate --- ken <ex_ex_y@...> wrote: Can I ask what benefits you noticed from switching to cypionate and was it your doctor or you who instigated it. The brand I use,Sustanon 100® (Organon) Injection (oily), testosterone propionate 20 mg, testosterone phenylpropionate 40 mg, and testosterone isocaproate 40 mg/mL. It seems to be the most popular brand here in Australia and to be honest I have no complaints with it, Ken. http://www.sold.com.au - SOLD.com.au - Find yourself a bargain! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 15, 2002 Report Share Posted July 15, 2002 Well with Enanthate it seems kind of dull. I mean if I wanted a testosterone that was low level enanthate was it for me. But I know that cypionate seems to last longer. With Enanthate it would drop me off after a feeling of doing real well. On that last day before my next injection it would give me false feeling as if I didn't need another shot but boy if I wake up next morning bam I knew I needed it. Thankfully with cypionate it is better and much much cheaper. I had the same problem with testoderm patches. They caused severed skin irritation for me. I have some Androgel but it does not quite raise my level as it should. At times I will use one pack of gel if my body seems to need it. Getting hormone levels to balance can be a tricky thing. I am just glad I can adjust my dosage carefully. As for the opionates, I totally hate them. In the past when I have had surgery and they give me medication to " RELAX " me I tend to get bent out of shape. My grandfather had the same problem. He would bounce off the wall if he was given a sleeping pill. Give him caffeine and he would go to sleep. I am the same way in some ways. Sometimes caffeine works for me sometimes it doesn't. It is nothing for me to brink 44oz of diet soda and go to bed without a problem. I have found as I am sure most people do it pays to switch around so often. With our changing lives with stress the body tries to adapt accordingly. But if some idiot doctor told me I needed to go off testosterone. I would simply tell him to take his opinion and get more understanding. Re: Drug sensitivity > Yes, > > > > Basically the human body is always changing and with billions of people > you just don't know how something will effect the other. My pharmacist > is amazed that I get a better reaction with testosterone cypionate than > Testosterone Enanthate. > Heard that one before. Manufacturer data says characteristics are nearly the same and can be used interchangeably, yet people use both can tell a difference. What I hear about cypionate is the peak doesn't seem as intense and the duration is longer. Purely subjective and from only two ppl. I use patch myself, and I can tell a HUGE difference between them, even though both supposedly contain absolutely pure testo with a gel and ethanol, and release the same amount of testo through the membrane. The androderm patch puts a tiger in my tank. Too bad it also burns ulcer in my skin that take 6+ weeks to heal. The testoderm patch does not burn me but I don't feel any different if I use it or I don't, yet T, free T, bound T, DHT, LH, FSH and friends are all well within the proper range. As to waning opiate sensitivity, there is often discussion about just that among users on alt.drugs.hard. A good place to get a well informed opinion is from a pharmacy newsgroup. So, really, what percentage of people who take hydrocodome will experience stimulation and euphoria? These are shown as the most common side effects. I thought the euphoria was behind the stats I saw recently that said hydrocodone is the number must abused opiate in north america? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 15, 2002 Report Share Posted July 15, 2002 Ken, I live here in the United States. I instigated the switch as I found out that I could buy 10 weeks worth of cypionate for $30.00 compared to one week of enanthate pre-filled syringe for $39.00. Even though I have insurance that covers both I am tired of giving the drug companies too much money. I would rather save my insurance company the money so that they will cover my growth hormone than deal with it. The funny thing is that I first experimented with the switch. Once I knew that cypionate worked better I switched. Now I just need to decide what I am going to do with all the enanthate that I have on hand... RE: Re: Drug sensitivity --- Dwight Meeks <dee0726@...> wrote: Yes, Basically the human body is always changing and with billions of people you just don't know how something will effect the other.My pharmacist is amazed that I get a better reaction with testosterone cypionate than Testosterone Enanthate --- ken <ex_ex_y@...> wrote: Can I ask what benefits you noticed from switching to cypionate and was it your doctor or you who instigated it. The brand I use,Sustanon 100R (Organon) Injection (oily), testosterone propionate 20 mg, testosterone phenylpropionate 40 mg, and testosterone isocaproate 40 mg/mL. It seems to be the most popular brand here in Australia and to be honest I have no complaints with it, Ken. http://www.sold.com.au - SOLD.com.au - Find yourself a bargain! Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.