Drug sensitivity

[Guest guest]

, I cannot take the low sedation, for it does not work for me! I just stay wide awake! Frustration to say the least! But I just have to have total "knock me out" intubation general anesthesia. I don't like it, but I have to have it or I go wild on the table with the pain. Would rather do the general thing than feel anything!

And by the way, I really do have a high tolerance of pain. One Thursday, I ruptured my left achilles tendon. The doctor thought I had just sprained it badly, Xrayed it, and told me to stay off it for a few days. I did, and went back to work the following Monday. The swelling went down somewhat, and although it was tender, I could put weight on it. I taught school for a couple of days but kept "running" into walls. It seems my foot would not stop when it was supposed to. I would have to lift my whole foot off the ground and set it down by using a big knee action.

Well, I went to the doctor again and they got rather nervous and told me I needed to see the ortho guy. I went right over. He is a personal friend of ours. Well, his partner saw me instead because my doctor was not there at that moment. They had called him and soon he arrived. So, here I was on my belly on the exam table. They were both talking at once saying how the tendon was halfway up my calf.

They kept asking me if I was able to walk. I told them, "It walks just fine. But it doesn't work right!" THey were amazed because they told me that when you rupture an achilles tendon, you cannot walk for the pain is so intense. They both watched me as I walked out the office. I had surgery a couple of days later!

SO, you can see that I CAN handle a lot of pain! Go figure why I can't handle a tube down my throat or up.......well, you know what I mean.

debby

[ ] Drug Sensitivity

Dear Debby,I don't know if my drug sensitivity is due to the AIH or just a heriditary thing. My father is also very drug sensitive. A little bit goes a long way with us. I'm sure that my inability to clear drugs out of my system doesn't help. When they give me sedation for endoscopies I just get wild instead of relaxing. So they give me more and I get wilder. We are working on a different system. How do you react to sedation? Low dosage and as few meds as possible and talking me through things works best for me. Take care....

[Guest guest]

I am interested to see if anyone here has experienced what I have and

if it may be related to hormone deficiencies like testosterone,

growth hormone, etc.

When I was younger in my teens and twenties to be exact(I'm 38 now).

I noticed I had a much greater sensitivity to drugs like opiates

(oxycodone, hydrocodone, etc). I had taken these drugs in the past

for medical reasons and always experienced mood enhancing euphoria as

most people do. I was never a chronic user of any of these only when

prescribed for pain or anxiety.

The opiates in particular made me feel more " normal " or more like I

wanted to feel. They didn't make me dull or groggy, they made me

motivated, energetic, much more social, and sharper, which I know is

not the norm for most people. Anyway, within the last few years, I've

had to have some surgeries(testicular biopsy, wisdom tooth removal)

and also I had the gout(quite painful) and was prescribed oxycodone

(percocet) which was one of the drugs I had taken in the past that

really made me feel great. The effects now are much more subtle. They

do make me feel more motivated, but to much lessor of a degree. I

have suffered from fatigue, depression, and general aphathy for

several years and have been on many antidepressants without success

in the past. Last year I was diagnosed with low testosterone after my

phychiatrist had checked to find out if anything physical(hormonal,

illnesses, etc) could be making me so depressed, tired and withdrawn.

My total testosterone was 190, obviously low for any age. I tried

androgel without much improvement which also made me infertile(long

story), I'm going to a new endo next week with hope of maybe getting

on HCG and checking my growth hormone and anything else that might be

relative. I know this is long winded, but to get to the point of my

question....Has anyone noticed that certain hormonal deficiencies

could affect sensitivity or effectiveness of opiate drugs. I know

that the hypothalmus gland also has control over endorphins in the

brain and endorphins are very similar to opiates in their

mood/motivation enhancing properties. I strongly feel there might be

a link to hypothalmic function and the brains supply of endorphins,

which might explain depression and low motivation in some people.

Most antidepressants are targeting serotonin, but for me I feel

something else is missing. I hope getting my hormones in order will

help my mood and quality of life. Like everyone else, I just some

pleasure and joy back in my life and can't seem to find out where

it's gone or how to retrieve it. I sometimes feel very envious of

other people's ability to enjoy their lives and look foward to

getting up in the morning and having the motivational drive to excel

in their careers and enjoy the perks that that brings to their lives

as well as their family. I'm only 38, but sometimes I feel like I'm

60 and am totaly afraid of what the " real " 60 might be like!.

If any of this rings a bell with anyone here your input/experiences

would be greatly appreciated.

thanks,

scott

[Guest guest]

> I am interested to see if anyone here has experienced what I have

and

> if it may be related to hormone deficiencies like testosterone,

> growth hormone, etc.

You're trying to solve an equation with too many variables. :-)

It may or may not have something to do with testo?

There's nothing inherently " bad " about experiencing euphoria when

exposed to a euphoriant. The badness is the result of a chain of

events that starts with feeling as if a person can't live without the

substance, and will do anything to get more.

Maybe the difference between us and an addict is we can say no?

There's a physiological reason for waning sensitivity, has to do with

neurotransmitters and receptors in the brain, and how the brain

compensates itself for what happens when it experiences euphoria.

Been a lot of study done on that topic in the last decade, where

researchers radioactively tag molecules of the substance in question,

inject it into a willing volunteer, then continuously scan the

person's brain and observe absorption patterns. I know a research

scientist studying how 'set and setting' affects levels of

neurotransmitters in crack users while they are using. It's really

quite fascinating.

But speaking of addiction, couldn't it be said we're all addicted to

testo? We believe we can't live without, in fact we do feel pretty

awful if we don't have it... LOL Just kidding.

Testo therapy is supposed to replace the testo that should have been

present in the body and isn't. Low testo is proven to cause to

depression and irritability. Replacing the missing hormone should

alleviate the problems caused by the lack.

The short answer to your question is really that no one knows but

there are a few theories... Have fun exploring your brain, and don't

get yourself in trouble.

:-)

[Guest guest]

,

Opiates usually dull the senses, reduce pain, relax smooth muscle,

etc. A certain percentage of the population reacts to these drugs in

the opposite way, and you sound like one of them. I would say you

have an atypical reaction to opiates. Could hormone imbalances play a

part? I think it's highly likely. You can also have people who become

hyper-sensitive to a drug, where a tiny amount produces an

exaggerated effect. Since MANY drugs have an unknow mechanism of

action, it it basically a crap shoot!! Doctors are clueless on most

of this stuff.

Regards,

K4

> I am interested to see if anyone here has experienced what I have

and

> if it may be related to hormone deficiencies like testosterone,

> growth hormone, etc.

>

> When I was younger in my teens and twenties to be exact(I'm 38

now).

> I noticed I had a much greater sensitivity to drugs like opiates

> (oxycodone, hydrocodone, etc). I had taken these drugs in the past

> for medical reasons and always experienced mood enhancing euphoria

as

> most people do. I was never a chronic user of any of these only

when

> prescribed for pain or anxiety.

> The opiates in particular made me feel more " normal " or more like I

> wanted to feel. They didn't make me dull or groggy, they made me

> motivated, energetic, much more social, and sharper, which I know

is

> not the norm for most people. Anyway, within the last few years,

I've

> had to have some surgeries(testicular biopsy, wisdom tooth removal)

> and also I had the gout(quite painful) and was prescribed oxycodone

> (percocet) which was one of the drugs I had taken in the past that

> really made me feel great. The effects now are much more subtle.

They

> do make me feel more motivated, but to much lessor of a degree. I

> have suffered from fatigue, depression, and general aphathy for

> several years and have been on many antidepressants without success

> in the past. Last year I was diagnosed with low testosterone after

my

> phychiatrist had checked to find out if anything physical(hormonal,

> illnesses, etc) could be making me so depressed, tired and

withdrawn.

> My total testosterone was 190, obviously low for any age. I tried

> androgel without much improvement which also made me infertile(long

> story), I'm going to a new endo next week with hope of maybe

getting

> on HCG and checking my growth hormone and anything else that might

be

> relative. I know this is long winded, but to get to the point of my

> question....Has anyone noticed that certain hormonal deficiencies

> could affect sensitivity or effectiveness of opiate drugs. I know

> that the hypothalmus gland also has control over endorphins in the

> brain and endorphins are very similar to opiates in their

> mood/motivation enhancing properties. I strongly feel there might

be

> a link to hypothalmic function and the brains supply of endorphins,

> which might explain depression and low motivation in some people.

> Most antidepressants are targeting serotonin, but for me I feel

> something else is missing. I hope getting my hormones in order will

> help my mood and quality of life. Like everyone else, I just some

> pleasure and joy back in my life and can't seem to find out where

> it's gone or how to retrieve it. I sometimes feel very envious of

> other people's ability to enjoy their lives and look foward to

> getting up in the morning and having the motivational drive to

excel

> in their careers and enjoy the perks that that brings to their

lives

> as well as their family. I'm only 38, but sometimes I feel like I'm

> 60 and am totaly afraid of what the " real " 60 might be like!.

>

> If any of this rings a bell with anyone here your input/experiences

> would be greatly appreciated.

>

> thanks,

> scott

[Guest guest]

Yes, that is often the case. I worked in Pharmacy for 12 years, so

I'm pretty tuned into this stuff. Many drugs simply " work " . A very

large percentage of drugs were discovered by accident, luck, or

tradition (tribal medicine, etc). Many of these got on the market

simply by going through refinement and testing periods to see what

effects they have on the body. They don't even know exactly how

aspirin does what it does - it just works!! Other drugs they do know

the exact mechanism, and as they get more to the point where they are

engineering drug molecules to do specific tasks, they understand more

and more - and at the same time LESS and LESS! The more they learn,

the more they realize they have only begun to scratch the surface...

Regards,

K4

> > I am interested to see if anyone here has experienced what I have

> and

> > if it may be related to hormone deficiencies like testosterone,

> > growth hormone, etc.

> >

> > When I was younger in my teens and twenties to be exact(I'm 38

> now).

> > I noticed I had a much greater sensitivity to drugs like opiates

> > (oxycodone, hydrocodone, etc). I had taken these drugs in the

past

> > for medical reasons and always experienced mood enhancing

euphoria

> as

> > most people do. I was never a chronic user of any of these only

> when

> > prescribed for pain or anxiety.

> > The opiates in particular made me feel more " normal " or more like

I

> > wanted to feel. They didn't make me dull or groggy, they made me

> > motivated, energetic, much more social, and sharper, which I know

> is

> > not the norm for most people. Anyway, within the last few years,

> I've

> > had to have some surgeries(testicular biopsy, wisdom tooth

removal)

> > and also I had the gout(quite painful) and was prescribed

oxycodone

> > (percocet) which was one of the drugs I had taken in the past

that

> > really made me feel great. The effects now are much more subtle.

> They

> > do make me feel more motivated, but to much lessor of a degree. I

> > have suffered from fatigue, depression, and general aphathy for

> > several years and have been on many antidepressants without

success

> > in the past. Last year I was diagnosed with low testosterone

after

> my

> > phychiatrist had checked to find out if anything physical

(hormonal,

> > illnesses, etc) could be making me so depressed, tired and

> withdrawn.

> > My total testosterone was 190, obviously low for any age. I tried

> > androgel without much improvement which also made me infertile

(long

> > story), I'm going to a new endo next week with hope of maybe

> getting

> > on HCG and checking my growth hormone and anything else that

might

> be

> > relative. I know this is long winded, but to get to the point of

my

> > question....Has anyone noticed that certain hormonal deficiencies

> > could affect sensitivity or effectiveness of opiate drugs. I know

> > that the hypothalmus gland also has control over endorphins in

the

> > brain and endorphins are very similar to opiates in their

> > mood/motivation enhancing properties. I strongly feel there might

> be

> > a link to hypothalmic function and the brains supply of

endorphins,

> > which might explain depression and low motivation in some people.

> > Most antidepressants are targeting serotonin, but for me I feel

> > something else is missing. I hope getting my hormones in order

will

> > help my mood and quality of life. Like everyone else, I just some

> > pleasure and joy back in my life and can't seem to find out where

> > it's gone or how to retrieve it. I sometimes feel very envious of

> > other people's ability to enjoy their lives and look foward to

> > getting up in the morning and having the motivational drive to

> excel

> > in their careers and enjoy the perks that that brings to their

> lives

> > as well as their family. I'm only 38, but sometimes I feel like

I'm

> > 60 and am totaly afraid of what the " real " 60 might be like!.

> >

> > If any of this rings a bell with anyone here your

input/experiences

> > would be greatly appreciated.

> >

> > thanks,

> > scott

>

>

>

>

>

>

>

[Guest guest]

> Yes,

>

>

>

> Basically the human body is always changing and with billions of

people

> you just don't know how something will effect the other. My

pharmacist

> is amazed that I get a better reaction with testosterone cypionate

than

> Testosterone Enanthate.

>

Heard that one before. Manufacturer data says characteristics are

nearly the same and can be used interchangeably, yet people use both

can tell a difference. What I hear about cypionate is the peak doesn't

seem as intense and the duration is longer. Purely subjective and

from only two ppl.

I use patch myself, and I can tell a HUGE difference between them,

even though both supposedly contain absolutely pure testo with a gel

and ethanol, and release the same amount of testo through the

membrane. The androderm patch puts a tiger in my tank. Too bad it

also burns ulcer in my skin that take 6+ weeks to heal. The testoderm

patch does not burn me but I don't feel any different if I use it or I

don't, yet T, free T, bound T, DHT, LH, FSH and friends are all well

within the proper range.

As to waning opiate sensitivity, there is often discussion about just

that among users on alt.drugs.hard. A good place to get a well

informed opinion is from a pharmacy newsgroup.

So, really, what percentage of people who take hydrocodome will

experience stimulation and euphoria? These are shown as the most

common side effects. I thought the euphoria was behind the stats I saw

recently that said hydrocodone is the number must abused opiate in

north america?