Fw: Systemic lupus erythematosus: a blissless disease of too much BLyS (B lymphocyte stimulator) protein

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----- Original Message -----

From: " Myrl Jeffcoat " <myrlj@...>

<myrlj@...>

Sent: Saturday, September 07, 2002 7:13 AM

Subject: Systemic lupus erythematosus: a blissless disease of too much BLyS

(B lymphocyte stimulator) protein

> Thank you for sending the following abstract.

>

> Systemic lupus erythematosus: a blissless disease of too much BLyS (B

> lymphocyte stimulator) protein [in Process Citation]

> Curr Opin Rheumatol 2002 Sep;14(5):522-8

> (ISSN: 1040-8711)

> Stohl W

>

> B lymphocyte stimulator (BLyS) protein is among the novel tumor necrosis

> factor (TNF) ligands and receptor superfamily members recently described.

> BLyS protein can promote B cell survival, expansion, and differentiation

> both and. Constitutive overexpression of BLyS protein can result in

systemic

> lupus erythematosus (SLE)-like disease in mice, and circulating levels of

> BLyS protein are elevated in a subset of human SLE patients. Treatment of

> SLE mice with a BLyS protein antagonist ameliorates disease progression

and

> enhances survival. By inference, BLyS protein may also play an important

> contributory role in pathogenesis and/or propagation of human SLE and

> becomes a legitimate candidate target for antagonist biologic agents.

>