Fw: reading on APLS

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----- Original Message ----- From: Kathi

Sent: Sunday, October 27, 2002 6:52 PM

Subject: reading on APLS

Associated Conditions So what is an Associated condition? Lets look at Arthritis, Rheumatism or any combinations of the two. Millions of people in the world suffer from those conditions but very few of them have Lupus. However sure as hell every Lupus sufferer has some kind of arthritic/rheumatic condition. Ergo they are associated conditions! Maybe that is a little simplistic but if we take for instance the Raynauds Phenomenon we will see that it occurs along with a number of other diseases one of them being Lupus and as we examine each of these conditions we will see the thread between all of them and Lupus. In addition to those conditions I have included two others with direct connections with Arthritis/Rheumatism and are accepted as being associated with or caused by Lupus. They are Fybromyalgia and Vasculitis. All of the above conditions/syndromes, call them what you like have a strong connective tissue disorder/autoimmune disease connection and all of them require all or some of the Lupus treatments The story doesn't end there, as there are also the conditions caused by the side effects of the cocktail of drugs Lupus sufferers are required to take. In 's case she has developed Osteoporosis solely due to taking high dosages of steroids over a prolonged period of time. Others sufferers will I'm sure have there own tales to tell! Now someone may say, Hey wait a minute you haven't mentioned my kidney problems, my heart problems my breathing problems, my.......................... Sorry, my friends that is Lupus!! Rheumatic and Arthritic Conditions Fybromialgia Vasculitus Reynauds Phenonenon Sjogrens Syndrome Myosities Group Scleroderma Antiphospholipid Syndrome On these pages we have recommended what we consider the best links for your further information and suggestions for further reading on the subject. Unfortunately we haven't been able to find practical books for all the conditions (in some instances the only books have been weighty tomes costing well over £100.00!) and it hasn't always been possible to provide the links for both US and UK buyers. http://www.monicaslupus.co.uk/associated.htm Antiphospholipid Syndrome (APLS) is a rare autoimmune disorder characterized by recurring blood clots that usually appear before 45 years of age. It may also be associated with repeated spontaneous abortions for no apparent reason in young women. There may be a family history of blood clotting disorders in some cases. APS may occur in individuals with lupus or related autoimmune diseases or as a primary syndrome in otherwise healthy individuals. Antiphospholipid antibody syndrome associated with large aortic valve vegetation and stroke F Grondin, JP Giannoccaro An unusual case of an aortic valve mass in a patient with a stroke and primary antiphospholipid antibody syndrome is discussed. The association of cardiac abnormalities and antiphospholipid syndrome is reviewed. http://www.pulsus.com/CARDIOL/11_02/Gron_ed.htm Antiphospholipid Syndrome by Letko, M.D. Ocular Immunology & Uveitis Service at the Massachusetts Eye & Ear Infirmary Harvard Medical School Boston, MA CC (6/97): Blurry vision, headaches. HPI: A 55 year old woman complained of blurry vision in both eyes and headaches. The patient consulted her ophthalmologist who treated her Pred Forte and Atropine eye drops into both eyes without improvement. ROS: Hypertension, migraine, thyroid gland dysfunction, spastic colitis, colon polyps, anemia, recurrent UTIs, chlamydia, chills, fever, night sweat, fatigue, malaise, dizziness, paresthesia, alopecia, myalgia, arthralgia. Examination Visual acuity: 20/40 OD and 20/25 OS IOP: normal http://www.uveitis.org/Enhanced/MD_info/antiphospholipid_syndrome.htm The Antiphospholipid Syndrome and "Multiple Sclerosis" http://www.infotech.demon.co.uk/MS.htm The main symptoms of the syndrome are- Vein Thrombosis (leg, arm or internal organ) Artery Thrombosis - Brain - headaches, neurological features Limb - pain and circulation problems Heart - chest pain Other organs - lungs, kidneys Recurrent abortion or miscarriage (usually in the 2nd or 3rd trimester. Low platelet count (thrombocytopenia) Livedo reticularis (lacy, mottled pattern on skin) Migraine Epilepsy Memory loss Chorea (abnormal motor skills) Stoke http://www.uklupus.co.uk/antip.html LUNGS IN ANTIPHOSPHOLIPID SYNDROME - THREE CASE REPORTS http://vestnik.szd.si/st5ang/st5ang-285-289.htm Mycoplasma penetrans Bacteremia and Primary Antiphospholipid Syndrome1 Mycoplasma penetrans, a rare bacterium so far only found in HIV-infected persons, was isolated in the blood and throat of a non-HIV-infected patient with primary antiphospholipid syndrome (whose etiology and pathogenesis are unknown). http://www.cdc.gov/ncidod/eid/vol5no1/yanez.htm Antiphospholipid Antibodies And Systemic Lupus Erythematosus http://www.hamline.edu/lupus/articles/Antiphospholipid_Antibodies_and_Systemic_Lupus_Erythematosus.html Antiphospolipid Syndromein HIV Infection ­­Report on Four Cases http://216.239.51.100/search?q=cache:7ccrB4-IC0gC:www.acii.net/issues/20016cr1.pdf+antiphospholipid%2Bhiv & hl=en & ie=UTF-8 Criteria for the Diagnosis of Antiphospholipid Antibody Syndrome Clinical Laboratory Recurrent venous thrombosis Recurrent arterial thrombosis Recurrent fetal loss+ Persistent thrombocytopenia Livedo reticularis IgG or IgM anticardiolipin (anti-B2-glycoprotein-I dependent) antibody (> 20 IU) ++ Lupus anticoagulant* Patients must have at least one clinical and 1 laboratory finding and laboratory test result must be positive on at least 2 occasions more than 3 months apart. + As defined by Branch and Silver. (At least 3 spontaneous abortions, fetal death,or early neonatal death due to preterm delivery required because of fetal distress. )1 This may soon be supplanted by a direct test for antibody to B2-glycoprotein-I. *Phospholipid-dependent screening test, such as activated partial thromboplastin time, must be abnormal. FROM:JAMA 277;1549-1551 http://prl.humc.edu/obgyn/web/fellow/conferences/antiph.htm What is antiphospholipid syndrome? A phospholipid (fos"fo-LIP'id) is a fat (lipid) that contains phosphorous. It undergoes hydrolysis (hi-DROL'ih-sis), which means it splits into fatty acids, glycerin and a nitrogen compound when water is added. The antiphospholipid (an"tih-fos"fo-LIP'id) syndrome (APLS) is defined by antiphospholipid antibodies and blood clots forming in blood vessels recurrent pregnancy loss, or a decrease in the number of blood platelets http://www.americanheart.org/presenter.jhtml?identifier=4459 New Registry Will Benefit Patients with Antiphospholipid Syndrome (APS) Patients with antiphospholipid syndrome (APS) will benefit from a new national registry and tissue repository sponsored by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the National Center on Minority Health and Health Disparities (NCMHD). The coordinating center will reside at the University of North Carolina, Chapel Hill (UNC). http://www.niams.nih.gov/ne/press/2001/04_19.htm Vascular spasm, antiphospholipid antibody syndrome, bilateral hand tremors http://www.medhelp.org/forums/neuro/messages/30512a.html Bacterial proteins cause autoimmunity in the antiphospholipid syndrome With the availability of complete genome sequences from many microbes, it is now possible to learn, purely through database analysis, which species carry a peptide sequence of interest http://www.eurekalert.org/pub_releases/2002-03/joci-bpc030102.php Total IgG from Patients with AntiphospholipidAntibodies Causes a Specific Abnormality in theOptical Waveform Profile in the "PrecoagulationPhase" of the Prothrombin Time http://216.239.53.100/search?q=cache:TDNmkgylIHMC:www.organonteknika.com/products/docs_hemostasis/braun2001isth.pdf+antiphospholipid & hl=en & ie=UTF-8 Massive proteinuria in apatient with primaryantiphospholipid syndrome and its response toimmunosupressive therapy http://216.239.53.100/search?q=cache:K9C-LBq2-_UC:www.clinnephrol.com/clinnephrol/login/march01/PDF/cn03e12.pdf+antiphospholipid & hl=en & ie=UTF-8 Skin Disorders Associated with Antiphospholipid Syndrome This diseases can be seen in patients with lupus and other autoimmune diseases (secondary) and also in patients without any underlying autoimmune disease (primary). These patients commonly present to dermatologists with skin ulcers, digital infarcts, and livedo reticularis ( purplish mottling of the skin. However, more serious internal complications can be seen including recurrent abortions, deep venous thrombosis, and thrombosis of internal arterial and venous blood vessels. The diagnosis is made by detecting the presence of anti cardiolipin antibodies and also the presence of lupus anticoagulant tests (coagulation studies). These patients require anticoagulation therapy and wound care. http://www.hopkinsmedicine.org/dermatology/AISDC/ctdisease/ Research published recently in the Journal of Clinical Investigation establishes for the first time that pathogens containing sequences also found in human ß2-glycoprotein-I induce autoantibodies in mice that can result in antiphospholipid syndrome. http://www.mediscover.net/related.cfm?Hnid=580 T lymphocyte subsets in primary antiphospholipid syndrome J Rheumatol. 1994 Dec;21(12):2242-5. Unique Identifier : AIDSLINE MED/95213986 Papo T; Piette JC; Legac E; Frances C; Grenot P; Debre P; Godeau P; Autran B; Department of Internal Medicine, Groupe Hospitalier; Pitie-Salpetriere, Paris, France. -------------------------------------------------------------------------------- Abstract: OBJECTIVE. To study T, natural killer (NK) and B blood cell subsets in primary antiphospholipid syndrome (APS). METHODS. We studied 10 patients with primary APS and 12 healthy subjects. Blood lymphocytes counts, proportions of B cells (CD19+), total CD5 and CD5 B cells, NK cells (CD16+CD56+), T cells (CD3+), CD4+ helper (naive CD4+CD45RA+, memory CD4+CD45RO+ and CD4+CD29+, activated CD4+CD25+), CD8 (immunoregulatory CD8+CD57+, activated CD8+HLA-DR+) T cell subsets were measured by flow cytometry analysis. RESULTS. In the primary APS group, we observed a lower total lymphocyte count (p = 0.009), an expansion of naive CD4 cells (p = 0.025), a lower proportion of memory CD4 cells (p = 0.04) and an increased ratio of naive/memory CD4 cells (p = 0.015). CONCLUSION. Blood T cells phenotypes in primary APS differ markedly from healthy controls, indicating that immunologic abnormalities in primary APS might extend beyond autoantibody production. -------------------------------------------------------------------------------- Keywords: Adult Antiphospholipid Syndrome/*IMMUNOLOGY B-Lymphocytes Comparative Study CD4 Lymphocyte Count Enzyme-Linked Immunosorbent Assay Female Flow Cytometry Human Killer Cells, Natural Lymphocyte Count Male *T-Lymphocyte Subsets JOURNAL ARTICLE 950730 M9570829 http://www.aegis.com/pubs/aidsline/1995/jul/M9570829.html Transient visual symptoms in systemic lupus erythematosus and antiphospholipid syndrome http://www.szp.swets.nl/szp/journals/oi091049.htm Chronic fatigue syndrome and/or fibromyalgia as a variation of antiphospholipid antibody syndrome: an explanatory model and approach to laboratory diagnosis. http://www.cfsresearch.org/cfs/research/treatment/15nf.htm Bilateral Adrenal Hemorrhage as the Initial Presentation of an Antiphospholipid Syndrome http://216.239.51.100/search?q=cache:Gf6X89IEU6IC:www.naiponline.org/presentation/NAIP-Vignettes/PreethaBasaviah.doc+antiphospholipid & hl=en & ie=UTF-8 A case of 's disease caused by the antiphospholipid syndrome http://www.endocrine-abstracts.org/ea/0003/ea0003p60.htm The infectious origin of the antiphospholipid syndrome: induction by passive transfer of anti- ?2GPI Abs induced by common bacteria http://www.biomedcentral.com/1465-9905/id/ar247 Venous Sinus Thrombosis and Pulmonary Emboli due to Antiphospholipid Antibody Syndrome http://titan.med.virginia.edu/uma/kayserppt_files/frame.htm Antiphospholipid antibodies in patients with retinal vascular occlusion http://www.dog.org/2000/e-abstract_2000/292.html Prevalence of hepatitis C virus infection in patients with antiphospholipid syndrome http://216.239.53.100/search?q=cache:Y14HC8c2arkC:www.munksgaard.dk/pdf/081pdf.nsf/all/305770/%24FILE/HE300505.PDF+antiphospholipid & hl=en & ie=UTF-8