Re: LDN with Lomotil or Imodium?

[Guest guest]

It would appear to me that as they are mu receptoragonists they would interfere with the transient blockadeof the antagonist LDN, but only of the mu receptors.So whichever immune cells are produced in responseto the mu receptor blockade would not get produced.The other receptors wouldn't be affected as long as thedrugs aren't agonists for them.Jaco [low dose naltrexone] LDN with Lomotil or Imodium?

Many people with Crohn's disease have chronic diarrhea. Many of those

people control their diarrhea with regular doses of Lomotil (lonox) or

Imodium (loperamide) . Both of these drugs are opioids, but their

mechanism of action is local, in the large intestine, rather than

systemic--at least on my understanding. Does anyone know FOR SURE--on

the basis of an unimpeachable medical or pharmacological authority (as

opposed to hearsay or the opinion of, say, a local family doctor,

etc.)--whether these two drugs can be taken at the same time as LDN?

Thanks in advance to anyone who can address this point.

[Guest guest]

Jaco--Are you a pharmacologist or physician?

[Guest guest]

RED PILL and Others: Would you please respond to this? I completely understand that Lomotil is narcotic. Imodium, by binding with the opiate receptors in the gut wall would seem to me to be compatible with LDN? Is my logic sound or not? *** Lomotil does have Diphenoxylate iwhich is chemically related to the narcotic drug meperidine = Demerol. Lomotil Jump to: navigation, search Lomotil Combination of Diphenoxylate mu opiate receptor agonist Atropine muscarinic acetylcholine receptors antagonist Identifiers CAS number ? ATC code ? PubChem ? Therapeutic considerations Pregnancy cat. ? Legal status POM(UK) Schedule V(US) Routes Oral Lomotil is the trade name of a popular oral anti-diarrheal drug in the United States, manufactured by Pfizer. Its UK BAN generic name is Co-phenotrope. Its active ingredients are diphenoxylate and atropine. Diphenoxylate is anti-diarrheal and atropine is anticholinergic. Diphenoxylate is chemically

related to the narcotic drug meperidine. A subtherapeutic amount of atropine sulfate is present to discourage deliberate overdosage. Atropine has no anti-diarrheal properties, but will cause tachycardia when overused. The medication diphenoxylate works by slowing down the movement of the intestines. The inactive ingredients of Lomotil (as a liquid - it comes in pill form as well) are cherry flavor, citric acid, ethyl alcohol 15%, FD & C Yellow No. 6, glycerin, sodium phosphate, sorbitol, and water. Other trade names for the same therapeutic combination are Lofene, Logen, Lomanate and Lonox, among others. In other countries, Lomotil may have other names. In the United States, Lomotil (Diphenoxylate HCl and atropine sulfate) is classified as a Schedule V

controlled substance by federal law, and is available only for a medical purpose.[1] Loperamide - Clinical Pharmacology In vitro and animal studies show that Loperamide hydrochloride acts by slowing intestinal motility and by affecting water and electrolyte movement through the bowel. ***Loperamide binds to the opiate receptor in the gut wall. Consequently, it inhibits the release of acetylcholine and prostaglandins, thereby reducing peristalsis, and increasing intestinal transit time. Loperamide increases the tone of the anal sphincter, thereby reducing incontinence and urgency. In man, Loperamide hydrochloride prolongs the transit time of the intestinal contents. It reduces the daily fecal volume, increases the viscosity and bulk density, and diminishes the loss of fluid and electrolytes. Tolerance to the antidiarrheal effect has not been observed. Clinical studies have indicated that the apparent elimination half-life of Loperamide in man is 10.8 hours with a range of 9.1 to 14.4 hours. Plasma levels of unchanged drug remain below 2 nanograms per mL after the intake of a 2 mg capsule of Loperamide hydrochloride. Plasma levels are highest approximately 5 hours after administration of the capsule and 2.5 hours after the liquid. The peak plasma levels of Loperamide were similar for both formulations. Elimination of Loperamide mainly occurs by oxidative N-demethylation. Cytochrome P450 (CYP450) isozymes, CYP2C8 and CYP3A4, are thought to play an important role in Loperamide N-demethylation process

since quercetin (CYP2C8 inhibitor) and ketoconazole (CYP3A4 inhibitor) significantly inhibited the N-demethylation process in vitro by 40% and 90%, respectively. In addition, CYP2B6 and CYP2D6 appear to play a minor role in Loperamide N-demethylation. Excretion of the unchanged Loperamide and its metabolites mainly occurs through the feces. In those patients in whom biochemical and hematological parameters were monitored during clinical trials, no trends toward abnormality during Loperamide hydrochloride therapy were noted. Similarly, urinalyses, EKG and clinical ophthalmological examinations did not show trends toward abnormality. I am diagnosed with IBS and use Imodium. It seems to me it is compatible with LDN.Janet "I absolutely believe to my soul that this corporate greed andcorporate power has an ironclad hold on our democracy." -- Sen. , Iowa, 2008