RE: Rx of Pancreatic Cancer with LDN and ALA

[Guest guest]

Thank you so much . You brought answer to my prayers.

Mirian

low dose naltrexone From: JMcCandless@...Date: Wed, 18 Jun 2008 02:01:44 -0700Subject: [low dose naltrexone] Rx of Pancreatic Cancer with LDN and ALA

For those who may not have access to IV ALA or adoctor to administer it, this article talks about useof oral form that is as effective as the IV form.ALPHA-LIPOIC ACID ®Topic: Plasma Pharmacokinetics of R-Lipoic Acid Keywords: PHARMACOKINETICS - Alpha-Lipoic Acid,R-Lipoic Acid, Racemic, Rac-LA, RLA, Sodium Salt,Potassium Salt, Na, K Reference: "The plasma pharmacokinetics ofR-(+)-lipoic acid administered as sodium R-(+)-lipoateto healthy human subjects," Carlson DA, AR, etal, Altern Med Rev, 2007; 12(4): 343-51. (Address:GeroNova Research, Inc., 4677 Meade St, Richmond,California 94804, USA. E-mail: davidgeronova ). Summary: In this study, the pharmacokinetics ofR-lipoic acid in humans were investigated. In oneexperiment, 12 subjects were orally administered 600mg RLA (as NaRLA based on the RLA content) dissolvedin 200 mL purified water 3-4 hours after a light meal.This was not found to have any adverse effects onplasma RLA levels. In a second experiment, 1 subjectwas given 3 doses of RLA (600 mg each), at 0, 15, and30 minutes. This resulted in a Cmax of 21.9 mcg/mL,AUC of 1,049 mcg/min/mL, and extended the Tmax to 45minutes. Interestingly, the authors state, "Anunexpected finding of this study was that, at plasmaconcentrations as high as 30 mcg/mL…negligible freeRLA was detected." The authors conclude, "Asanticipated from the preliminary study, NaRLA is lessprone to polymerization, completely soluble in water,and displays significantly higher Cmax and AUC valuesand decreased time to maximum concentration (Tmax) andT1 & #47;2 values than RLA or rac-LA. In order tosignificantly extend Cmax and AUC, it is possible toadminister three 600-mg RLA doses (as NaRLA) at15-minute intervals to achieve plasma concentrationssimilar to those from a slow (20-minute) infusion ofLA. This is the first study to report negligibleunbound RLA even at the highest achievable plasmaconcentrations." Also, see Life Extension's new Super ® ALA; I amrecommending this along with LDN for a patient withmetastatic cancer in Turkey whose doctor will notconsider Dr. Berkson's protocol and who is unwillingto go the chemotherapy route. Dr. JM

[Guest guest]

What dosage do you recommend of the Super ® ALA? Should we stick with Life Expension's brand? Etta [low dose naltrexone] Rx of Pancreatic Cancer with LDN and ALAFor those who may not have access to IV ALA or a

doctor to administer it, this article talks about use

of oral form that is as effective as the IV form.

ALPHA-LIPOIC ACID ®

Topic: Plasma Pharmacokinetics of R-Lipoic Acid

Keywords: PHARMACOKINETICS - Alpha-Lipoic Acid,

R-Lipoic Acid, Racemic, Rac-LA, RLA, Sodium Salt,

Potassium Salt, Na, K

Reference: "The plasma pharmacokinetics of

R-(+)-lipoic acid administered as sodium R-(+)-lipoate

to healthy human subjects," Carlson DA, AR, et

al, Altern Med Rev, 2007; 12(4): 343-51. (Address:

GeroNova Research, Inc., 4677 Meade St, Richmond,

California 94804, USA. E-mail: davidgeronova (DOT) com ).

Summary: In this study, the pharmacokinetics of

R-lipoic acid in humans were investigated. In one

experiment, 12 subjects were orally administered 600

mg RLA (as NaRLA based on the RLA content) dissolved

in 200 mL purified water 3-4 hours after a light meal.

This was not found to have any adverse effects on

plasma RLA levels. In a second experiment, 1 subject

was given 3 doses of RLA (600 mg each), at 0, 15, and

30 minutes. This resulted in a Cmax of 21.9 mcg/mL,

AUC of 1,049 mcg/min/mL, and extended the Tmax to 45

minutes. Interestingly, the authors state, "An

unexpected finding of this study was that, at plasma

concentrations as high as 30 mcg/mL…negligible free

RLA was detected." The authors conclude, "As

anticipated from the preliminary study, NaRLA is less

prone to polymerization, completely soluble in water,

and displays significantly higher Cmax and AUC values

and decreased time to maximum concentration (Tmax) and

T1 & #47;2 values than RLA or rac-LA. In order to

significantly extend Cmax and AUC, it is possible to

administer three 600-mg RLA doses (as NaRLA) at

15-minute intervals to achieve plasma concentrations

similar to those from a slow (20-minute) infusion of

LA. This is the first study to report negligible

unbound RLA even at the highest achievable plasma

concentrations.. "

Also, see Life Extension's new Super ® ALA; I am

recommending this along with LDN for a patient with

metastatic cancer in Turkey whose doctor will not

consider Dr. Berkson's protocol and who is unwilling

to go the chemotherapy route. Dr. JM