Re:Interaction with Dental Numbing Agents

[Guest guest]

Hi...

You referred to my message (and you are welcome) - to be really shure about this topic, i looked up those 3 drugs listed.

They are described this way:

Lidocaine HCl = Lidocaine hydrocloride. Lidocaine alters depolarization in neurons, by blocking the fast voltage gated sodium (Na+) channels in the cell membrane. With sufficient blockade, the membrane of the presynaptic neuron will not depolarize and so fail to transmit an action potential, leading to its anesthetic effects. Careful titration allows for a high degree of selectivity in the blockage of sensory neurons, whereas higher concentrations will also affect other modalities of neuron signaling.

Citanest Forte = prilocaine hydrochloride. The hydrochloride salt form of prilocaine, an intermediate-acting local anesthetic of the amide type chemically related to lidocaine. Prilocaine hydrochloride binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions. This leads to a stabilization of the neuronal membrane and inhibits depolarization and results in a reversible blockage of nerve impulse generation and propagation along nerve fibres and subsequent reversible loss of sensation.

Carbocaine = mepivacaine is a local anaesthetic, with a medium duration of action, which provides a good alternative to Xylocaine (lidocaine) in medical anaesthesia. Carbocaine is an amide-type local anaesthetic, which has a rapid onset. It can be used for a number of anaesthetic techniques, including local infiltration, minor and major nerve blocks, epidural block, arthroscopy and intravenous regional anaesthesia.

NONE of those interact with systemic opiod mµ-receptors. They block your nerves by other means, and as so they are safe to use concurrent with LDN.

[Guest guest]

hey peter i have lidocaine ointment for neck pain, so what you

described below, is lidocaine safe with ldn?

>

> Hi...

>

> You referred to my message (and you are welcome) - to be really

shure about this topic, i looked up those 3 drugs listed.

>

> They are described this way:

>

> Lidocaine HCl = Lidocaine hydrocloride. Lidocaine alters

depolarization in neurons, by blocking the fast voltage gated sodium

(Na+) channels in the cell membrane. With sufficient blockade, the

membrane of the presynaptic neuron will not depolarize and so fail to

transmit an action potential, leading to its anesthetic effects.

Careful titration allows for a high degree of selectivity in the

blockage of sensory neurons, whereas higher concentrations will also

affect other modalities of neuron signaling.

>

> Citanest Forte = prilocaine hydrochloride. The hydrochloride salt

form of prilocaine, an intermediate-acting local anesthetic of the

amide type chemically related to lidocaine. Prilocaine hydrochloride

binds to voltage-gated sodium ion channels in the neuronal membrane,

thereby preventing the permeability of sodium ions. This leads to a

stabilization of the neuronal membrane and inhibits depolarization and

results in a reversible blockage of nerve impulse generation and

propagation along nerve fibres and subsequent reversible loss of

sensation.

>

> Carbocaine = mepivacaine is a local anaesthetic, with a medium

duration of action, which provides a good alternative to Xylocaine

(lidocaine) in medical anaesthesia. Carbocaine is an amide-type local

anaesthetic, which has a rapid onset. It can be used for a number of

anaesthetic techniques, including local infiltration, minor and major

nerve blocks, epidural block, arthroscopy and intravenous regional

anaesthesia.

> NONE of those interact with systemic opiod mµ-receptors. They block

your nerves by other means, and as so they are safe to use concurrent

with LDN.

>

>

>

>

>

[Guest guest]

Interaction with Dental Numbing Agents

Posted by: "kim.doll70" kim.doll70@... kim.doll70

Sun Aug 10, 2008 12:32 pm (PDT)

hey peter i have lidocaine ointment for neck pain, so what youdescribed below, is lidocaine safe with ldn?>> Hi...

As I wrote, the 3 drugs listed are NOT interacting with mµ-receptors (which is the main target of naltrexone) in our cell-membranes - OTHER channels in the cell-membrane, so-called ION EXCHANGE CHANNELS are short-term blocked by the whole "Lidocaine-family" to which those 3 mentioned all belong - they have more or less the same numbing action, though different "time to live", and - just to stupulate - seemingly NO adverse reactions to LDN. This goes, I believe, as well for dermal ointments.

[Guest guest]

That's good to know. I would hate to be in the chair and feel

everything that is happening.

>

> Hi...

>

> You referred to my message (and you are welcome) - to be really

shure about this topic, i looked up those 3 drugs listed.

>

> They are described this way:

>

> Lidocaine HCl = Lidocaine hydrocloride. Lidocaine alters

depolarization in neurons, by blocking the fast voltage gated sodium

(Na+) channels in the cell membrane. With sufficient blockade, the

membrane of the presynaptic neuron will not depolarize and so fail

to transmit an action potential, leading to its anesthetic effects.

Careful titration allows for a high degree of selectivity in the

blockage of sensory neurons, whereas higher concentrations will also

affect other modalities of neuron signaling.

>

> Citanest Forte = prilocaine hydrochloride. The hydrochloride salt

form of prilocaine, an intermediate-acting local anesthetic of the

amide type chemically related to lidocaine. Prilocaine hydrochloride

binds to voltage-gated sodium ion channels in the neuronal membrane,

thereby preventing the permeability of sodium ions. This leads to a

stabilization of the neuronal membrane and inhibits depolarization

and results in a reversible blockage of nerve impulse generation and

propagation along nerve fibres and subsequent reversible loss of

sensation.

>

> Carbocaine = mepivacaine is a local anaesthetic, with a medium

duration of action, which provides a good alternative to Xylocaine

(lidocaine) in medical anaesthesia. Carbocaine is an amide-type

local anaesthetic, which has a rapid onset. It can be used for a

number of anaesthetic techniques, including local infiltration,

minor and major nerve blocks, epidural block, arthroscopy and

intravenous regional anaesthesia.

> NONE of those interact with systemic opiod mµ-receptors. They

block your nerves by other means, and as so they are safe to use

concurrent with LDN.

>

>

>

>

>