Re: Time of dosing - was Bihari Debate

[Guest guest]

>

> Hey Everyone,

>

> I'm using LDN for a Stage IV cancer dx. I was taking the 4.5mg at

night and just could not

> sleep (and this went on for 5 months). I had had previous sleep

problems, so wanted to

> rule out LDN, so switched to mornings. I slept well, thankfully.

>

> After reading the Bihari debate thread, I decided I needed to put it

back up to night

> dosing, so I did that last night. Oh boy ... let's just say I was

some kind of busy in my

> sleep last night! That is, wh

683

en I WAS sleeping and not waking! Heavy sigh ... now keep in

> mind that this is with 20mg of melatonin on board. I woke up a lot

and, when I wasn't

> waking up, my mind was racing! So, what do I do?

>

> What I'm considering doing is sneaking up on it, so to speak. I

thought I might start at,

> say 3pm to take it, then move it closer to bedtime every night and

find the exact point that

> it makes me wiggy during the night. For instance, perhaps if I took

it at 6pm, I would

> sleep OK, but any later would make me wakeful. At this point, I

just don't know what to

> do. I need LDN. I need sleep. And I don't want to take sleeping

pills ... none of the three

> heavy-hitters really work for me anyway.

>

> What to do?

>

> Sleepless in Lompoc,

>

>

==============

Take melatonin 1 1/2 hours before you take LDN. Order some Brownwood

Acres http://www.brownwoodacres.com Red Tart Cherry Juice Concentrate,

This has a natural melatonin and the montmorency tart cherries are

great for cancer. Drink 1 glass of this cherry juice 45 minutes

before you take LDN. Take 500mg to 1000mg of Magnesium before bed or

soak in bathtub with a half box of epsom salt 30 minutes before bed.

Take LDN at 10pm and do everything else before you take LDN. Read a

book before bed. The obvious feelngs you have during the nightime

dosing means LDN is doing its job and you are getting the most

endorphins possible to help your body fight the cancer, you weren't

feeling it during the day because endorphin production is lower during

the daytime possibly leaving your body vulnerable to not getting the

endorphin production you need to fight such a chronic disease.

You may even consider an over-the-counter sleep aid.

[Guest guest]

For instance, perhaps if I took it at 6pm, I would

sleep OK, but any later would make me wakeful. At this point, I just don't know what to

do. I need LDN. I need sleep. And I don't want to take sleeping pills ... none of the three

heavy-hitters really work for me anyway.

What to do?

Sleepless in Lompoc,

,Just my opinion here, but if you are at the point where you absolutely can not take it according to protocol, start experimenting. What do you have to loose? IF you can't take it all, you have no benefit from it, obviously. If you take it any other time but the recommended time, you risk it not working properly. But that risk has a better chance of success than not taking it at all, right? So go for it. What do you have to loose? Actually, you could be part of several others here who have found they have to do the same thing. And so far, it seems it has been quite successful. Maybe y'all could start documenting your symptoms and feelings of well being, along with the times you take your LDN. Like had said earlier, there just isn't any DOCUMENTED success stories. Well, let's get some documented!! IT could be that LDN would in fact work, at least for some, in spite of dosing

schedules. This would be a HUGE finding...offering hope of the benefits of LDN, to even more people. As things seem to begin to plateua, you could push the dose closer to 9pm, like you suggested. See what happens. Push the envelope as far as you can go, while still achieving success. If you go too far, push it back. Sooner or later, you will know exactly what works best for YOU! And if it doesn't work, well, it puts you right back to where you would have been had you not tried at all. Nothing lost, much gained.....DOCUMENTED EVIDENCE. In the meantime, I think just the feelings of empowerment for taking such an active role in your own well-being would be worth if, even if the experiment failed. In my world, as long as there is hope, there's a reason to keep trying.Just my opinion.Saundra

[Guest guest]

>

And if it doesn't work, well, it puts you right back to where you would have

been had you not

tried at all. Nothing lost, much gained.....DOCUMENTED EVIDENCE. 

> In the meantime, I think just the feelings of empowerment for taking such an

active role in

your own well-being  would be worth if, even if the experiment failed. In my

world, as long

as there is hope, there's a reason to keep trying.Just my opinion.Saundra

>

I had been taking it at 9am for the past couple of months. Is it working?

Nothing has really

worked to monitor me in the past ... when there was active cancer, it didn't

show up on

imaging or tumor markers. Over the past year, however, the markers have been

slowly

climbing and I just had them done again, so will get results next week.

So, at this point, I'm not real sure how I would document anything except that

it's been 16

months since my Stage IV dx and I'm feeling great!

xxoo

[Guest guest]

>

> So, at this point, I'm not real sure how I would document anything

except that it's been 16

> months since my Stage IV dx and I'm feeling great!

>

> xxoo

>

>

Well, I would say that is a fantastic start. I guess in your case,

just keep track of markers before LDN, and then after. This may be a

very slow collection of data for you. But also keep track of mood and

over all feelings of well-being, since LDN boosts endorphins, it

should in turn, help boost mood. I would say for anyone faced with

chronic disease, a good mood is definitely a positive result.

The very best of luck to you. Keep us updated.

Saundra

[Guest guest]

> So, at this point, I'm not real sure how I would document anything

except that it's been 16

> months since my Stage IV dx and I'm feeling great!

>

> xxoo

>

===============

For cancer, Document via bloodwork, scans & other tests run for stage

IV cancer.

[Guest guest]

Hi ,

Sorry to hear that you have stage IV cancer.

I too was like you with regards to sleeping, I have Graves Disease and

Thyroid Eye Disease.

I started taking LDN at a low dose of 1.5mg I had sleep issues to

begin with and taking LDN at night wasn't helping. I became too alert

and wide awake experienced palpitations which only lasted for about a

week. I stuck it out for 10 weeks got my labs done and then switched

to 3mg daytime dosing per Elaine and Dr.Zagon.

I too take mine at 9am I have slept so much better and even starting

dreaming.

If I were you I would stick to the time that is working best for you.

document how you feel along with blood test to see how LDN is working

for you.

I have see great improvements over all in the 4 months I have been

taking LDN my TED is now in the inactive stage and my inflammation

markers are reducing I will know more next week when I get new labs done.

I feel so much better than I have in years and i can honestly put it

down to LDN. daytime dosing is working for me and this is what I am

sticking too.

Here is a link to a picture of my eyes just before starting LDN and

then again in June when I was told that I am in the inactive stage of

TED. that was music to my ears.

http://www.ahsta.com/Portals/3/Images/Lolly%20Eyes.jpg

Some people do get a boost after the opiate blockade period, usually

about 4-6 hours on a dose of 4.5 mg. But that doesn't mean it's doing

its job any more or less whenever you take it. In other words, you get

benefits no matter when you take it and a single dose can cause

benefits for up to 72 hours. If night time dosing interferes with

sleep, then daytime dosing is just as good in terms of LDN " working

I wish you every success with your treatment.

Best wishes

Lolly

>

> Hey Everyone,

>

> I'm using LDN for a Stage IV cancer dx. I was taking the 4.5mg at

night and just could not

> sleep (and this went on for 5 months). I had had previous sleep

problems, so wanted to

> rule out LDN, so switched to mornings. I slept well, thankfully.

>

> After reading the Bihari debate thread, I decided I needed to put it

back up to night

> dosing, so I did that last night. Oh boy ... let's just say I was

some kind of busy in my

> sleep last night! That is, when I WAS sleeping and not waking!

Heavy sigh ... now keep in

> mind that this is with 20mg of melatonin on board. I woke up a lot

and, when I wasn't

> waking up, my mind was racing! So, what do I do?

>

> What I'm considering doing is sneaking up on it, so to speak. I

thought I might start at,

> say 3pm to take it, then move it closer to bedtime every night and

find the exact point that

> it makes me wiggy during the night. For instance, perhaps if I took

it at 6pm, I would

> sleep OK, but any later would make me wakeful. At this point, I

just don't know what to

> do. I need LDN. I need sleep. And I don't want to take sleeping

pills ... none of the three

> heavy-hitters really work for me anyway.

>

> What to do?

>

> Sleepless in Lompoc,

>

>

[Guest guest]

can someone direct me to where i can find info on this:

3mg daytime dosing per Elaine and Dr.Zagon

thanks

monique

[Guest guest]

LDN article by Elaine

http://tinyurl.com/69q6qp

Art

--

>

> can someone direct me to where i can find info on this:

> 3mg daytime dosing per Elaine and Dr.Zagon

>

> thanks

> monique

>

[Guest guest]

This is her article on dosing time where she references Dr. Zagon per

private conversation:

http://autoimmunedisease.suite101.com/article.cfm/benefits_of_low_dose_naltrexon\

e

This is her latest article that also discusses daytime dosing:

http://www.ahsta.com/ContributingWriters/ElaineArticle/tabid/180/Default.as\

px

Toni

[Guest guest]

For the curious, the following entry refers to an MS trial that used

morning dosing (you'll find it listed on the Lowdosenaltrexone.org

website),

kind regards,

Cris

.............

Dr. Evers Trial in Germany for Multiple Sclerosis (MS)

Conducted in the Multiple Sclerosis Clinic of Dr. Evers Hospital in

Sundern, Germany, the starting date was October 15, 2004. It is described

as a short-term scientific, randomized, placebo-controlled, double-blind

study involving patients with either secondary-progressive MS (SPMS) or

primary-progressive MS (PPMS).

(Editor's Note: Unfortunately, because of some early complaints of sleep

disturbance, the principal investigator of this trial switched all of the

study group to taking LDN at 9am in the morning, a questionable dosage

time. It is generally recognized that the most effective time to take LDN

is at bedtime, between 9pm and 3am, due to the fact that the endorphins for

each day are always produced at their peak rate in the pre-dawn hours. A

9am dosage time, as was used in this trial, might conceivably

suppress-rather than boost-a patient's immune system.)

The purpose of the study was to investigate what MS-associated symptoms are

positively influenced by LDN (low dose naltrexone, 3 mg per day). The

principal investigator, Dr. Mir, reported his findings at the First Annual

LDN Conference in 2005, as well as on his website

(http://www.klinik-dr-evers.de/).

Low Dose Naltrexone - Clinical Trials webpage:

http://www.low dose naltrexone.org/ldn_trials.htm

5a. Re: Time of dosing - was Bihari Debate

Posted by: " toni@... " toni@... cfidstoni

Date: Mon Jul 14, 2008 7:45 pm ((PDT))

This is her article on dosing time where she references Dr. Zagon per

private conversation:

http://autoimmunedisease.suite101.com/article.cfm/benefits_of_low_dose_naltrexon\

e

This is her latest article that also discusses daytime dosing:

http://www.ahsta.com/ContributingWriters/ElaineArticle/tabid/180/Default.as\

px

Toni