Vaccine Induced Demyelination and Autism

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Vaccine Induced Demyelination

http://www.healing-arts.org/children/vaccines/vaccines-demyelination.htm

 

Myelination is an essential part of human brain development. Nerves can only

conduct pulses of energy efficiently if covered by myelin. Like insulation on an

electric wire, the fatty coating of myelin keeps the pulses confined and

maintains the integrity of the electrical signal so that it has a high

signal-to-noise ratio. When the insulation on a wire is damaged or destroyed,

the flow of electrical current may be interrupted and a short-circuit occurs.

Oligodendrocyte cells give white matter its color by manufacturing myelin. If

myelin falls into disrepair, nerve axons cease to function, even though they

themselves aren't damaged. Protecting oligodendrocytes after brain or spinal

cord injury might keep nerve cells intact.

At birth, relatively few pathways have myelin insulation. Myelination in the

human brain continues from before birth until at least 20 years of age. Up until

the age of 10 or so, vast areas of the cortex are not yet myelinated. Up to the

age of 20, large areas of the frontal lobes are not yet myelinated. 1

Myelination begins in the developmentally oldest parts of the brain, like the

brain stem, moving to the areas of the nervous system that have developed more

recently, like the prefrontal lobe and cortex. Myelin spreads throughout the

nervous system in stages, which vary slightly in each individual. Impairment of

myelination can alter neural communication without necessarily causing severe

CNS (central nervous system) damage.

The prefrontal portions of the cerebrum have a profound influence on human

behavior. 2 If an individual is injected with vaccines,most of which have

adjuvants like mercury and aluminum compounds, as well as foreign proteins (some

from other species in which the vaccines were grown) and biological organisms,

unprotected nerves may be impacted. The argument for a role of vaccines in the

development of autistic disorders hinges on these biological effects upon

nerves, damaging them in a way that influences behavior and learning patterns.

The argument for adjuvants evoking an auto-immune response does not hinge on any

inherent neuro-toxicity of these compounds, but on the initiation of an allergic

response.

The model by which adjuvants initiate an immune response is that of Experimental

Allergic Encephalomyelitis (EAE). To date, EAE is recognized as the best

available animal model of several degenerative human diseases, like multiple

sclerosis and post-vaccinal encephalopathies. EAE 3 is generally thought to be

an autoimmune response to myelin basic protein ( MBP ). Oddly, MBP can also

suppress EAE, and many observations suggest that an independent immune response

to so-called " adjuvant " material is also necessary to EAE induction. Of course,

this is why adjuvants are used in vaccines, to dramatically increase the

likelihood of an immune response to the administered biological material.

Thus, EAE may be a result of a pair of interactive immune responses, one against

MBP , and one against the adjuvant. If so, the adjuvant should, like MBP ,

suppress EAE. Root-Bernstein, et al. (1986) presented data from experiments on

strain 13 guinea pigs demonstrating EAE suppression by muramyl dipeptide, an

active component of complete Freund's adjuvant. In the past, adjuvants have only

been classified as immunopotentiators, not immunosuppressants. Apparently,

adjuvants are both. This study strengthens the argument that adjuvants may be

crucial to initiating an auto-immune response leading to post-vaccine

neurological symptoms.

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References

1. KM, Meade BD, Decker MD, et al. Comparison of 13 acellular

pertussis vaccines: overview and serologic responses. Pediatrics 1995;96:548-57.

2. Orenstein WA , Brugliera PD. Preface: Immunization in medical education.

Am J Prev Med 1994; 10(suppl):v-viii.

3. Root-Bernstein RS; Yurochko F; Westall FC. Clinical suppression of

experimental allergic encephalomyelitis by muramyl dipeptide " adjuvant " . Brain

Res Bull, 17: 4, 1986 Oct, 473-6.

 Also: 

Auto-Immunity, Vaccines and Autism

http://www.healing-arts.org/children/vaccines/vaccines-auto-immunity.htm#auto

Auto-Immunity, Vaccines and Autism

http://www.healing-arts.org/children/vaccines/vaccines-auto-immunity.htm#auto