Guest guest Posted July 8, 2008 Report Share Posted July 8, 2008 Hi, I have some questions about when redistribution might occur after a round, and what it might look like given an event tonight. We have seen good results for 8-9 rounds (depending on how you count aborts) over mostly 2.6 day weekends using a 3-on/4-off schedule. Our last round, a longer 3.6 day one, went quite well this past weekend. Dosage has been 1/6th mg per lb of DMSA and ALA for the last 4-5 rounds with no bad effects. The last dose was yesterday morning at 6AM. He was fine and in good form (bouncy, engaged, etc) all day today afterwards. However, at about 9PM tonight (15 hours after the last dose) out of the blue he had screaming fits and couldn't fall asleep for about 45 minutes. While he claimed he ran into a towel rack (~15 min) earlier and _may_ have had a very slight bruise by his eye, I couldn't see screaming from a bump like that lasting 45 minutes and it seemed quite odd that he didn't complain at all immediately around the time when he said it happened. [He's still a 6 year old that's a bit impressionable and not fully articulate.] Crudely, to see whether it might be redistribution, I've tried to estimate how much DMSA (4 hour half-life) and ALA (3 hour half life) would be left after 15 hours using AC chelation. Including the residuals of the previous 3 hour doses as well as the last one, I think that roughly 1/96 mg/lb (.5 mg) of ALA and 1/24 mg/lb of DMSA (2mg) would still be in his bloodstream. [He weighs about 45 lbs.] -Could a bad headache/screaming be signs of a redistribution issue? [There are few such descriptions in the archives, but it sounds as if that's possible.] -Do most redistribution problems happen soon after stopping a round, or do they also occur at random much later (e.g. 15 hours later in this case)? -Do they happen consistently at about the same time after rounds are done? -I take it that 1/96 mg/lb (.5 mg) of ALA and 1/24 mg/lb of DMSA (2mg) could still cause this kind of effect?? As mentioned, results for 8 recent rounds have been just super with almost no side effects (save for one fever). Is this likely to be more than a fluke, or (I hope) a paranoid delusion on my part (for supposing possible redistribution)? Many thanks in advance for your input. Quote Link to comment Share on other sites More sharing options...
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