Guest guest Posted April 17, 2002 Report Share Posted April 17, 2002 A double-blind randomized placebo-controlled clinical trial has found that an extract of Hypericum perforatum was no more effective than placebo against moderately severe depression. The multi-site trial involved 340 participants. [Hypericum Depression Trial Group. Effect of Hypericum perforatum (St. 's Wort) in major depressive disorder. JAMA 287:2801-1814, 2002] http://jama.ama-assn.org/issues/v287n14/rfull/joc11936.html The trial was funded jointly by the National Center for Complementary and Alternative Medicine, the National Institute of Mental Health, and the NIH Office of Dietary Supplements. Although several smaller European studies have suggested that St. 's wort is useful in treating mild to moderately severe depression, experts have concluded that more rigorous trials were needed before firm conclusions could be drawn. This is the second well-designed trial to have negative results. --------------------------- IRA L. JACOBSON --------------------------- mailto:laser@... Quote Link to comment Share on other sites More sharing options...
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