Re: Noscapine/Ralph Moss

[Guest guest]

hi marion

thank you so,so much for the information.

i live in south africa and aspen pharmacare is a fantastic company here with a

great reputation.

i have never heard of Noscapine,but ill check it out

regards

bobby

From: n Morse

Sent: Monday, July 20, 2009 7:50 PM

Subject: Re: [ ] Noscapine/Ralph Moss

Hi ,

Ralph Moss who has studied cancer alternatives for over 30 years has this to

say about Noscapine:

Noscapine

NOTE: The following information is mainly for people outside the US, since the

drug in question is not available in North America, but is commonly used in

South Africa and other countries.

Georgia scientists have found that a common cough suppressant called noscapine

has anticancer effects. Noscapine is derived from a non-addictive component of

the opium poppy (Papaver somniferum). It is a major component of the plant,

present in amounts up to 11 percent. Some of its trade names are Nitepax,

Coscotabs, Capval, Longatin, Narcotussin, Nectadon, Tusscapine, etc. It was

first isolated by in 1817.

Noscapine induces cancer cells to undergo programmed cell death

(apoptosis)..........

[Guest guest]

Hi ,

Ralph Moss who has studied cancer alternatives for over 30 years has this to say

about

Noscapine:

Noscapine

NOTE: The following information is mainly for people outside the US, since the

drug in

question is not available in North America, but is commonly used in South Africa

and

other countries.

Georgia scientists have found that a common cough suppressant called noscapine

has

anticancer effects. Noscapine is derived from a non-addictive component of the

opium

poppy (Papaver somniferum). It is a major component of the plant, present in

amounts up

to 11 percent. Some of its trade names are Nitepax, Coscotabs, Capval, Longatin,

Narcotussin, Nectadon, Tusscapine, etc. It was first isolated by in 1817.

Noscapine induces cancer cells to undergo programmed cell death (apoptosis). It

does

this by binding to tubulin, a protein within cells that forms cellular filaments

called

microtubules. Interestingly, this is the same way that the better known but

toxic agent,

paclitaxel (Taxol), works. When investigators gave noscapine to animals that had

been

implanted with human breast or bladder tumors, it dramatically shrank these

growths.

Certain derivatives of noscapine are proving even more effective, at least in

the

laboratory. (Zhou J, Gupta K, Aggarwal S, et al. Brominated derivatives of

noscapine are potent

microtubule-interfering agents that perturb mitosis and inhibit cell

proliferation. Mol Pharmacol.

2003;63:799-807)

In animals, a three-week regimen of noscapine reduced the size of breast tumors

by 80

percent, and some tumors were eliminated entirely. Unlike taxol, noscapine is

virtually

nontoxic, has a good safety record, and can be taken orally.

Noscapine inhibits the growth of brain cancer cells (i.e., glioblastoma). In

laboratory

experiments, an oral dose of 300 milligrams per kilogram in mice significantly

reduced

the size of these deadly tumors. Prof. Harish C. Joshi of the Emory University

School of

Medicine in Atlanta, a recognized expert on microtubules, has stated that the

“unique

properties of noscapine, including its ability to cross the blood-brain barrier,

interfere

with microtubule dynamics, arrest tumor cell division, reduce tumor growth, and

minimally affect other dividing tissues and peripheral nerves, warrant

additional

investigation of its therapeutic potential.†(Landen JW, Hau V, Wang M, et al.

Noscapine crosses

the blood-brain barrier and inhibits glioblastoma growth. Clin Cancer Res. 2004

;10:5187-201)

The anticancer potential of noscapine was discovered as part of a classroom

assignment

by a 29-year-old graduate student named Keqiang Ye. He was given a routine class

exercise of researching tubulin-binding drugs. “It was a bit serendipitous,â€

Ye said. “I

came to Dr. Joshi’s lab knowing nothing about the biology of cells or cancer,

and 20 days

later I found noscapine†i.e., as a treatment for cancer. The results were

published in the

prestigious Proceedings of the National Academy of Sciences (Feb. 17, 1998).

These

dramatic findings may explain the long folk association of opium poppies with

anticancer

effects.

Noscapine (Nitepax) comes in 100 ml and 200 ml bottles. It is orange colored and

orange

flavored.

Bottom Line: Although noscapine has been used safely and legally for over 30

years in

South Africa, Sweden, Japan, Portugal, Norway, etc. it has never been approved

by the

FDA and is not on the US market. It is also hard to find over the Internet. The

drug is

highly promising, but there is no commercial incentive for any pharmaceutical

company

to undertake costly clinical trials, since this item is in the public domain.

One manufacturer is said to be Aspen Pharmacare, Ltd, which makes a noscapine

product

called Nitepax. I know nothing further about this company and unfortunately

cannot

suggest any North American sources of this interesting

________________________________

From: Shoham <jonathan.shoham@...>

Sent: Saturday, July 18, 2009 3:57:45 AM

Subject: [ ] Noscapine

My integrative doctor has suggested Noscapine as a non-toxic substitute to Taxol

at 1gr/day

I wanted to find out if anyone has had experience using Noscapine?

Also, I can get it locally but it seems very expensive as my compounder charges

around $15 per gr. Anyone have cheaper sources?