Re: Re: immune update/synergists -

[Guest guest]

,

The use of conventional chemotherapies for melanoma would not be my

first choice, but that said, lets look at this from a conventional

perspective with an eye to toward getting the maximum benefit with

the fewest side effects.

If they are prescribing Sutent for your melanoma, it is probably

because you are KIT mutated or perhaps for VEGF inhibition. The KIT

mutation can be more safely dealt with by using Gleevec. If you use

Sutent then you probably want to use a lower dose (ask for the 12-1/2

mg oral capsules) and add other VEGF inhibitors and angiogenesis

inhibitors to your protocol. Definitely check your KIT status. You

can use less Sutent if you use it with temsirolimus (mTOR inhibitor),

though most of this research has been done on renal cancer. You can

certainly consider the other strategies as mentioned in my earlier

posts. I would strongly suggest that you consider disulfiram and

zinc (perhaps as the iodide, acetate, or gluconate).

VEGF inhibitors have been shown to lead to more aggressive

cancers. This is probably due to selective die-off. A very good

tool for use against melanoma is cimetidine. Incidentally, I saw a

case of rapid shrinkage of melanoma with a woman who used

ciprofloxacin for a systemic infection. Cipro is cytotoxic to

mitochondrial DNA in some cancer cells.

At 12:10 PM 7/25/2009, you wrote:

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>How can one get the effect of Sutent at a low dose, meaning with all

>the benefits but without the toxicity, as you have just described?

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> > Most chemos trash the immune system. Usually monoclonal antibodies

> > are ok. Vincristine and bleomycin have many side effects but they do

> > spare immune function. Vinblastine though will damage immune

> > function. If your goal is to spare immune function with chemo there

> > are many strategies which will allow a much lower dose. These

> > include IPT, chronotherapy, and the use of a variety of synergists

> > such as pleuronic, mitoguazone, pentamidine (with benzimidazole), and

> > SAHA. By using extremely low doses you can get away from using those

> > protocols that use steroidal anti-inflammatories such as dexamethasone.

> >

> > Other drugs/supplements that can kick up chemo and/or reduce drug

> > resistance include hydralazine with valproate acid, verapamil with

> > disulfiram, ketakonazole, BSO, sanguinarine, progesterone, EGCG,

> > caffeine, melatonin, Vit C with K3, pau d'arco, along with many others.

> >

> > There are many strategies to kick up the effectiveness of a cancer

> > vaccine. One is to use very low doses of cyclophosphamide prior the

> > injections, next pick an adjuvant that will steer the vaccine in a

> > Th1 direction. It is better to inject multiple intradermal

> > injections in the inguinal area because of much better exposure to

> > the antigen presenting cells (APC, dendritic cells) in the skin and

> > because of the proximity to the inguinal lymphatic chains. Both IL-2

> > and GM-CSF are useful, and as I mentioned earlier Viagra and

> > Ribavirin seem to be quite useful in kicking up the right type of

> > immune response.

> >

> > All of these things are available, but I have stopped making SAHA

> > because of the expense. Pleuronic might kick up chemotherapy a

> > thousand fold in lab research but I haven't used it.

> >

> > In general I like vaccines -- especially targeting subunit

> > vaccines. I have many years of experience with these. In general I

> > do not like chemotherapy. I have seen too many tumors shrink only to

> > see them grow again. Sometimes it is necessary to do what you have

> > to do stop a tumor in its tracks and give the immune system a chance

> > to work. This always includes doing the things that

> >

> > In our one-week retreat program (Del Mar, California) we give

> > seminars on the use of these meds and try to help provide sources for

> > these things. We are trying to set up a service that can make

> > hard-to-find meds/supplements readily available, including outside the US.

> >

> >

> > 858-922-7410

> >