Re[2]: sifting through information

[Guest guest]

Hello Bret,

It's unlikely the effect has anything to do with pH. Other

antihistamine versions that would be predicted to have the same

effect (if it were based on HCl inhibition) do not work. There is

something more specific with regard to Tagamet and its H2 antagonism

that works on cancer cells.

You have a similar situation with omeprazole. It's a proton pump

inhibitor, so it decreases stomach acid. It has an effect against

cancer cells. The effect derives from its ability to inhibit the

proton pump dumping of lactate out of the cancer cells. When you

stop the lactate dumping the cells become more acidic and might not

function well enough to go into mitosis. The omeprazole won't do

this if it is allowed to be activated in the stomach. The trick is

to get it to activate in the acidic environment around the cancer so

it can enter the cell and shut down the proton pumps. Ironically it

is hyperacidity that damages the cells. If the omeprazole were

allowed to simply decrease stomach acid, nothing good would come of

it.

Mike

Saturday, August 1, 2009, 3:21:25 PM, you wrote:

BP> Reduced stomach acid,...H2 receptor antagonist,...could it be

BP> that reduced stomach acid has an affect on over ph of

BP> extracellular fluids? Of course it must, to some degree! How much? Hard to

say!

BP>  

BP> I have seen cimetidine used since 1980's,...patients seemed to do

BP> better,...but still did not affect the eventual outcomes in many

BP> cases,...still, improvement is improvement.

BP>