Guest guest Posted August 1, 2009 Report Share Posted August 1, 2009 Hello Bret, Probably not in the case of cancer cells. The largely glycolytic energy production in cancer cells produces a tremendous amount of lactic acid. This would be a deal breaker for cancer cells which tend to be overly mitotic. Mitosis requires a fairly alkaline interior environment. The cancer cells adapt very well by overexpressing membrane proton pumps. This way they can continually dump lactate into the microenvironment around the cells. This does several things for the cancer cells. It allows them to maintain an internal pH that runs from neutral to moderately alkaline, favoring mitosis. It allows them to get lactate back into the bloodstream so it is converted into pyruvate and then glucose which resupplies them with fuel. It also maintains an acidic pH in the interstitial fluid around the cells which inhibits immune response, not to mention the inhibition of the action of a variety of chemotherapies (nice bonus for them). The upregulated proton pumps also allow the cancer cells to pump various chemotherapies, as well as natural modalities, out of the cytoplasm before they can have much efficacy. Efforts to try and alkalize the interior of cancer cells can be precarious. The cells will keep themselves in the pH range they require via the pumps. If you are able to make them slightly more alkaline, you are helping them. On the other hand, if you can alkalize the microenvironment right around the cells you might unmask them to the immune system to some degree (they have other ways to block this). Efforts to alkalize this microenvironment in lab animals in order to get chemo drugs to penetrate better have met with some success. The problem here is that you can't duplicate this in a very large mammal, such as a human, without causing dangerous hyperalkalosis in the entire system. A little baking soda in the drinking water of a very small lab mouse is one tyhing. If you extrapolate the amount of soda it would take to do the same in a human, it's goodbye, Charlie. Mike Saturday, August 1, 2009, 2:59:42 PM, you wrote: BP> Question of the day? BP> If you change the overall ph of extracellular fluids,....does BP> this mean that the ph inside a cancer cell is also changed? -- Best regards, Mike mailto:goldenmike@... Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 2, 2009 Report Share Posted August 2, 2009 Dr. Otto Warburg proved that internal ph of cancer cells ranged 6.5 to 7. Also here is a quote for Dr. Brewer who tested Warburg's findings: Brewer Writes: In the absence of oxygen, the glucose undergoes fermentation to lactic acid. The cell pH then drops to 7 and finally down to 6.5. Step 3 In the acid medium the DNA loses its positive and negative radical sequence. In addition, the amino acids entering the cell are changed. As a consequence, the RNA is changed and the cell completely loses its control mechanism. Step 4 In the acid medium the various cell enzymes are completely changed. Von Ardenne has shown that lysosomal enzymes are changed into very toxic compounds. These toxins kill the cells in the main body of the tumor mass. A tumor therefore consists of a thin layer of rapidly growing cells surrounding the dead mass [3]. The acid toxins leak out from the tumor mass and poison the host. They thus give rise to the pains generally associated with cancer. They can also act as carcinogens. So, some very profound researches don't share your belief that higher alkalinity is good for cancer bad for the patient. In fact they feel the opposite! Here are some highly technical links for you to comment on! http://www.mwt.net/~drbrewer/highpH.htm http://www.kangen1info.com/files/New_Dr_Otto_Warburg.pdf Could you comment please! - On Sat, 8/1/09, Mike Golden <goldenmike@...> wrote: Hello Bret, Probably not in the case of cancer cells. The largely glycolytic energy production in cancer cells produces a tremendous amount of lactic acid. This would be a deal breaker for cancer cells which tend to be overly mitotic. Mitosis requires a fairly alkaline interior environment. The cancer cells adapt very well by overexpressing membrane proton pumps. This way they can continually dump lactate into the microenvironment around the cells. This does several things for the cancer cells. It allows them to maintain an internal pH that runs from neutral to moderately alkaline, favoring mitosis. It allows them to get lactate back into the bloodstream so it is converted into pyruvate and then glucose which resupplies them with fuel. It also maintains an acidic pH in the interstitial fluid around the cells which inhibits immune response, not to mention the inhibition of the action of a variety of chemotherapies (nice bonus for them). The upregulated proton pumps also allow the cancer cells to pump various chemotherapies, as well as natural modalities, out of the cytoplasm before they can have much efficacy. Efforts to try and alkalize the interior of cancer cells can be precarious. The cells will keep themselves in the pH range they require via the pumps. If you are able to make them slightly more alkaline, you are helping them. On the other hand, if you can alkalize the microenvironment right around the cells you might unmask them to the immune system to some degree (they have other ways to block this). Efforts to alkalize this microenvironment in lab animals in order to get chemo drugs to penetrate better have met with some success. The problem here is that you can't duplicate this in a very large mammal, such as a human, without causing dangerous hyperalkalosis in the entire system. A little baking soda in the drinking water of a very small lab mouse is one tyhing. If you extrapolate the amount of soda it would take to do the same in a human, it's goodbye, Charlie. Mike Saturday, August 1, 2009, 2:59:42 PM, you wrote: BP> Question of the day? BP> If you change the overall ph of extracellular fluids,....does BP> this mean that the ph inside a cancer cell is also changed? Quote Link to comment Share on other sites More sharing options...
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