Re: melantonin [and antioxidant sources]

[Guest guest]

In a message dated 3/28/08, aug20 writes:

> myself have taken up to 20 mg of melatonin, with never a single

> side-effect---hangover or whatever.

I have had just the opposite effect.

[Guest guest]

Hi.

Please understand that I myself am not a researcher or a medical

practitioner of any kind, and that this is conjecture, but very

serious conjecture, I believe, because of the source:

I am in touch regularly with a distinguished scientist in his 70's,

whose name is Dr. Herbert Weissbach, and Dr. Weissbach has been

studying antioxidants for decades. His opinion is, after all the studying he has

done, that external antioxidants, those taken in pill and capsule form by mouth,

that is, are almost immediately destroyed by the body before they can do any

good, and that they stand little to no chance of entering the cell mitochondria.

Personally, I think Dr. Weissbach's opinion merits serious

consideration.

I myself have taken up to 20 mg of melatonin, with never a single

side-effect---hangover or whatever. That would, in my case, appear to

bear out what Dr. Weissbach says.

I think the best thing I can do to get as much antioxidant activity

going in my body as possible is to eat lots of raw vegetables and

fruits, as well as algae such as chlorella, spirulina and blue-green.

I do take selenium, grape seed extract and some other supplements,

but I am not as sure as I once was as to how much good they actually

do.

Best wishes,

Elliot

[Guest guest]

> I have found that the quality of melatonin is very

> important. I have taken inferior products that have

> produced no effect. You could be experiencing the

> same thing.

>

, what brand are you taking?

Thanks,

>

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[Guest guest]

I think melatonin's 1 of the most important supplements to take.

" good sources Nature's Way, Source Natural, Nutricology and

NatureMade " www.annieappleseedproject.org/repfromcanco.html.

My notes on melatonin:

take 15-50mg; less than 15mg may be ineffective; take only at night

(never early in the day), ideally at bedtime. Side effects usually go

away within a few days. Effective w/advanced melanoma,

estrogen-positive metastatic breast cancer, metastatic colorectal, &

lung (including metastasized SCLC & cisplatin-resistant metastatic

NSCLC) cancer, met. renal cell carcinoma, GBM, and single brain

metastasis. Reduces multidrug resistance (MDR)

(www.denvernaturopathic.com/news/multidrugresistance.html). Enhances

effects of tamoxifen (especially for metastasized breast cancer);

helpful to take during radiation; synergistic w/radiation for GBM.

Synergistic w/interferon for renal cancer. I heard that it enhances

effectiveness and reduces toxicity of IL-2 but also can be dangerously

synergistic w/IL-2. " Could be used with Adriamycin and cisplatin "

www.annieappleseedproject.org/repfromcanco.html. Use good brand.

promotes differentiation; prevents metastasis; " antiproliferative[,

enhances] immunity, modulation of oncogene expression, and

anti-inflammatory, anti-oxidant and anti-angiogenic....anticachectic,

anti-asthenic and thrombopoietic....[20 mg/day enhanced] efficacy...of

chemotherapy in...metastatic...chemotherapy-resistant

tumor....[reduced] chemotherapy-induced asthenia, thrombocytopenia,

stomatitis, [lymphocytopeni,] cardiotoxicity and neurotoxicity "

www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=11862501\

& dopt=Abstract

" melatonin…inhibited [MCF-7 breast cancer] cells by 78 percent…blocked

cell division in cancer cells. It interfered with `spindle

formation'…the mechanism of action of…Taxol " Ralph Moss, 1997

" melatonin acts synergistically with these chemotherapeutic

agents…amelioration of hypotension, myelotoxicity, and lymphocytopenia

[from chemo] " from " Melatonin: From basic research to cancer treatment

clinics. " Vijayalaxmi, CR Jr, Reiter RJ, et al. J Clin Oncol 20:

2575-2601, 2002.

For more info, see www.webcom.com/cfsc/cancer.html

www.allnutritionals.com/natural-products/melatonin.shtml

www.mdanderson.org/departments/cimer/display.cfm?id=4BAD47B2-1DB0-4C9C-83F5851BE\

7646ADF & method=displayFull & pn=6EB86A59-EBD9-11D4-810100508B603A14

www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstract & list\

_uids=11862501

Life Extension Magazine (LEF.org), March 2002 issue (research review)

[Guest guest]

Are there side effects to melatonin? Where is the research?

I take 3mg now and am groggy when I get up at night. I have been taking

3mg for about a month (dx lobular breast cancer). --CC

>

> I think melatonin's 1 of the most important supplements to take.

>

>snip> My notes on melatonin:

> take 15-50mg;

[Guest guest]

I have found no side effects in my research of melatonin . As you know

as we grow older or in the case of cancer we produce insufficient melatonin .the

idea is to make up the difference with supplements .If 3mg is causing you to be

drowsy when you get up then maybe you will need to cut back.

CC wrote:

Are there side effects to melatonin? Where is the research?

I take 3mg now and am groggy when I get up at night. I have been

taking 3mg for about a month (dx lobular breast cancer). --CC

[Guest guest]

I've read that some cancer patients benefit from as much as 40 mgs of melatonin.

As mentioned, if groggy the next day, cut back dosage.

Bill