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In einer eMail vom 25.03.2006 08:08:06 Westeuropäische Normalzeit schreibt jackalope_lepus@...:

Avian flu is just one bug of many plagues

this speaking makes it look pretty harmless. Not worse than any other plague .

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He ignores the need to invest in the world public health

infrastructure. Avian flu is just one bug of many plagues on the way

if we do nothing. There will be more global pandemics.

As for American skepticism, he forgets Orson Welles " War of the Worlds "

broadcast and the reaction of so many.

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  • 1 month later...
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, I agree completely! ------------------- Date: Mon, 24 Apr 2006 23:05:52 -0000 From: "djberle" <dberle@...> Subject: another perspective (was...voicemail....) With all due respect to your frustration...I feel for the s. I can only imagine the position these people are placed in...with vices that grip them on all sides. I commend them for trying hard to raise the level of awareness and keep it all in check. We are trying to unfold decades of damage and deceit and evidence of harm. Decades. I thikn they are doing the best that they possibly can with the constraints around them. I expect if we keep pushing for more research and science..the truth will keep unfolding and it will become much easier for those in the limelight to speak up. A producer at Good morning America told me that 'thimerosal' is a more taboo/volatile word than abortion, lethal injection and even war. (ture story). I expect some may disagree with me but I thank the s for all they have done by taking an extremely private experience and trying to help more by exposing themselves. Could they do more? Sure. Probably. Could they have done a whole heck of alot less? Most definitely. With respect,

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  • 2 years later...

More Targeted Cancer Therapies Set to Become " Blockbusters "

Zosia Chustecka

Medscape Medical News 2008. © 2008 Medscape

October 10, 2008 ­ Targeted cancer therapies, in

addition to advancing the treatment of cancer,

have become a growing commercial success story,

and sales of these products are driving the

overall growth of the oncology pharmaceutical

market. At the moment, 5 such products are

bringing in annual sales of more than $1 billion,

and 8 more are forecast to reach this

" blockbuster " status over the next few years,

according to a new Datamonitor report.

The 3 top-selling targeted cancer therapeutics

are rituximab (Rituxan), trastuzumab (Herceptin),

and bevacizumab (Avastin), and all 3 are from

Roche/Genentech. The other 2 products that have

sales of more than $1 billion are cetuximab

(Erbitux; Bristol-Myers Squibb/ImClone) and imatinib (Gleevec; Novartis).

The 8 products that have fast-growing sales and

are predicted by Datamonitor to become

blockbusters within the next few years are:

* erlotinib (Tarceva; OSI/Genentech/Roche)

* bortezomib (Velcade; Takeda/ & )

* sunitinib (Sutent; Pfizer)

* lenalidomide (Revlimid; Celgene)

* panitumumab (Vectibix; Amgen/Takeda)

* sorafenib (Nexavar; Onyx/Bayer Schering)

* lapatinib (Tykerb; GlaxoKline)

* nilotinib (Tasigna; Novartis)

Combined sales of targeted cancer therapies

totaled $17.3 billion in 2007, and had increased

by a " staggering 33% in just a year, " commented

Datamonitor's oncology analyst Tom Gray, PhD. For

comparison, sales for conventional chemotherapy

(branded cytotoxics only) totaled $10.2 million

in 2007. These figures comprise sales in 7 major

markets worldwide ­ the United States, the United

Kingdom, France, Germany, Italy, Spain, and Japan.

There are currently 24 targeted cancer

therapeutics available in these 7 markets, and

Datamonitor predicts that sales of these products

will continue to increase, by around 11% each

year, until they reach $42 billion or more by the year 2017.

" Sales of targeted therapies have helped to drive

overall growth in the cancer market because not

only are they very successful and popular, they

are higher priced than cytotoxics, " Dick

from Datamonitor told Medscape Oncology.

However, the higher price of these targeted

products has created problems for their

acceptance into national healthcare systems, the

report notes. It cites as a prime example the

United Kingdom, where the National Institute for

Health and Clinical Excellence (NICE) has

recommended against the use of several of the new

targeted therapies on the grounds of low

cost-effectiveness. The most recent example of

this was in August 2008, when NICE recommended

against the use of bevacizumab, sorafenib,

sunitinib, and temsirolimus (Torisel; Wyeth) for

the treatment of kidney cancer, eliciting

protests from prominent cancer specialists, as

reported at the time by Medscape Oncology .

" If other healthcare systems follow the UK's

example, which looks like an increasing

possibility, this could significantly dampen the

growth of the market, and will ultimately impact

the effectiveness of treatment available to patients, " Dr. Gray commented.

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