Re: Hormone therapy breast cancer risk study

[Guest guest]

Well the study is talking about HRT and not BHRT [bio-Identical Hormone

Replacement Therapy], that's a huge difference. Yes HRT certainly does increase

the risk of breast cancer, and they have been proving that for years.

Pat Haas (happy to be doing well on BHRT)

" everonward11 " wrote:

>

> I just realized that some people don't like to open URLS so here is the

article about the new study.

> Marie

>

> - - - -

> The Canadian Press

> Updated: Fri. Sep. 24 2010 8:31 AM ET

>

> TORONTO — The first Canadian study of its kind is adding to a growing body of

international evidence suggesting that the use of hormone replacement therapy

may raise the risk of breast cancer.

>

> However, some doctors counter that such studies do not prove a

cause-and-effect association between taking hormones and the onset of breast

cancer, and stress there could be many other factors playing a role in the

development of the disease.

>

> The study by the Canadian Cancer Society found there was a significant

decrease in the rate of new breast cancers among post-menopausal women between

2002 and 2004 -- coinciding with a huge drop in the use of hormone replacement

therapy, or HRT......<snip>

[Guest guest]

Is there research about RANKL and bio identical hormones?

Interestingly, propolis is a natural inhibitor of RANKL

karla

How HRT and the Pill Can Lead to Breast Cancer: New Research Suggests Possible

Treatment

ScienceDaily (Oct. 1, 2010) — Breast cancer is one of the most common cancers,

affecting up to one in eight women during their lives in Europe, the UK and USA.

Large population studies such as the Women's Health Initiative and the Million

Women Study have shown that synthetic sex hormones called progestins used in

hormone replacement therapy, HRT, and in contraceptives can increase the risk of

breast cancers

Now medical researchers at the Institute of Molecular Biotechnology of the

Austrian Academy of Sciences in Vienna have identified a key mechanism which

allows these synthetic sex hormones to directly affect mammary cells.

The research builds on previous work by Prof f Penninger, the IMBA director,

who found the first genetic evidence that a protein called RANKL is the master

regulator of healthy bones. In a complex system that regulates bone mass, RANKL

activates the cells that break down bone material when it needs to be replaced.

When the system goes wrong and we make too much of the protein it triggers bone

loss, leading to osteoporosis in millions of patients around the world every

year. Finding exactly the same molecule in breast tissues led the scientists to

the new link between sex hormones and breast cancer.

In a scientific article published in the journal Nature, the research team show

that a synthetic female sex hormone used in HRT and contraceptive pills can

trigger RANKL in breast cells of mice. As a consequence, these mammary cells

start to divide and multiply and fail to die when they should. Moreover, stem

cells in the breast become able to renew themselves, ultimately resulting in

breast cancer.

In a different set of mouse treatment tests, reported in a second Nature

article, researchers at Amgen have found that pharmacologic blocking of the

RANKL system significantly delays mammary tumor formation leading to

significantly fewer breast cancers in mice. In another mouse model, RANKL

inhibition not only decreased breast tumor formation but also reduced lung

metastasis.

" Ten years ago we formulated the hypothesis that RANKL might be involved in

breast cancer and it took us a long time to develop systems to prove this idea, "

says Prof f Penninger. " I have to admit it completely surprised me just how

massive the effects of the system were. Millions of women take progesterone

derivatives in contraceptives and for hormonal replacement therapy. Since our

results show that the RANKL system is an important molecular link between a

synthetic sex hormone and breast tumors, one day women may be able to reduce

their risk by taking blocking medicines in advance to prevent breast cancer. "

A monoclonal antibody, denosumab, that blocks RANKL has been recently approved

in the US and the EU for the treatment of osteoporosis, and is currently under

review for the treatment of bone metastases in patients with advanced cancer.

" Further studies will be needed to prove the principle of our findings, " says Dr

Schramek, who carried out the studies with Prof f Penninger at the

Institute of Molecular Biotechnology in Vienna. " But we hope that medical trials

using denosumab can be started in the near future to test whether the mouse

studies can be directly translated to human breast cancer. "

This work was an international collaboration between lead researchers at IMBA

and scientists at the Medical University of Vienna; the Garvan Institute of

Medical Research, Sydney, Australia; the Ontario Cancer Institute, University of

Toronto, Toronto, Canada; Harvard School of Public Health, Harvard Medical

School and the Ragon Institute of MGH/MIT and Harvard, Boston, USA; the

Institute for Genetics, Centre for Molecular Medicine (CMMC), and Cologne

Excellence Cluster (CECAD), University of Cologne, Germany; University College

London, UK; and the University of Erlangen-Nuremberg, Germany.

Email or share this story:| More

> >

> > I just realized that some people don't like to open URLS so here is the

article about the new study.

> > Marie

> >

> > - - - -

> > The Canadian Press

> > Updated: Fri. Sep. 24 2010 8:31 AM ET

> >

> > TORONTO — The first Canadian study of its kind is adding to a growing body

of international evidence suggesting that the use of hormone replacement therapy

may raise the risk of breast cancer.

> >

> > However, some doctors counter that such studies do not prove a

cause-and-effect association between taking hormones and the onset of breast

cancer, and stress there could be many other factors playing a role in the

development of the disease.

> >

> > The study by the Canadian Cancer Society found there was a significant

decrease in the rate of new breast cancers among post-menopausal women between

2002 and 2004 -- coinciding with a huge drop in the use of hormone replacement

therapy, or HRT......<snip>

>

[Guest guest]

Dr. Lanphier, you explained it so beautifully. Thank you!

Pat Haas - near Seattle

, " Dr. Loretta Lanphier " wrote:

>

> There are many studies that have been done with bioidentical HRT.

Double-blind studies have almost become comical because they are so easily made

to say whatever the " funder " of the study wants.

[Guest guest]

the O' Meara research has too much " omissis " in my opinion...

see " characteristics of 174 users of HRT:

estrogen receptor positive at diagnosis :29 percent MISSING DATA

progesterone receptor positive at dx: 33 percent MISSING DATA

karla

>

> There are many studies that have been done with bioidentical HRT.

Double-blind studies have almost become comical because they are so easily made

to say whatever the " funder " of the study wants. This is one of many reasons

why so many pharmaceutical drugs kill and maim even after all those important

clinical trials and studies indicated that the drug is safe. We are not clones

and conventional medicine acts on the premise that we are all the same. This is

why conventional medicine does not have good success when it comes to most

disease. If one is truly deficient then balancing the hormones as well as the

entire body is VERY important for cancer survival. I don't think anyone has

said or implied they are a cure for cancer or will keep one from getting cancer

-- although maybe I missed that part. However, I do know that a balanced body

has a better chance of avoiding cancer than one that is not balanced.

Indicating that all hormone therapy is the same or has the same effect on the

body is incorrect.

>

> Several pages to research from Lynn on our list:

>

> http://www.breastcancerchoices.org/progesterone

>

> According to more than 20 studies, breast cancer patients taking hormones

after diagnosis survive as long as or longer than those who take no hormones.

> http://www.breastcancerchoices.org/hrt

>

> I would refer you to Dr. Wren's actual study where 50% of the breast cancer

patients died who did NOT take HRT. None of those taking HRT died. Write him

again and he will reinforce those findings in his own work.

>

> The O'Meara research he actually quotes which is NOT anecdotal attributes a

considerable advantage to taking HRT after diagnosis of breast cancer.

> http://breastcancerchoices.org/files/omeara_HRT_post_bc.pdf

>

> Here is an excellent article reviewing taking hormones after breast cancer

diagnosis.

> http://www.obgmanagement.com/pdf/1406/1406OBGM_Article1.pdf

>

> Be Well

> Dr.L

>