Re: Pathogenesis of gallstones

[Guest guest]

I found this extremely interesting. It says to me that gallstones can

form very rapidly if changes are not made. I think flushing is a

change, but unless there are other long term or permanent changes,

ie, diet, then these stones will continue to form and you may flush

for 4 years and get out thousands of stone and keep getting them out.

Progress! Back to feeling hopeful, esp after two days of very guarded

testing during an ongoing family reunion. Yeah! Dawn

>

>

>

> 2. Nucleation: The next step in cholesterol gallstone formation is

> Nucleation promoters:

>

> Even when supersaturated with cholesterol, fresh bile from subjects

without

> gallstones rarely contains cholesterol crystals. The same bile, when

> incubated, forms crystals very slowly (up to 15 days). Bile of

patients

> with cholesterol gallstones, on the other hand, usually does contain

> cholesterol crystals, and its nucleation time, when incubated, is

much more

> rapid (mean of 2.9 days). Nucleation of cholesterol occurs far more

rapidly

> from gallbladder bile of patients with cholesterol gallstones than

from

> hepatic bile in the same patients, even when hepatic bile samples

are

> supersaturated with cholesterol. The addition of even small amounts

of

> gallbladder bile to the hepatic bile samples causes rapid

nucleation. These

> observations have led to the isolation of proteins in the

gallbladder that

> promote or retard the nucleation of cholesterol crystals.