Re: More on glutathione and Cancer

[Guest guest]

Here is what DR. Steve says on oxidative stress, it looks like to me is that

this is his approach.

http://grouppekurosawa.com/blog/2008/07/peitc-natural-compound-found-highly

Looks like watercress plays a big role.

> I do not have the biochemical expertise of some of our

> members here, so

[Guest guest]

I had the same thing happen to me. I was first treated at the Seattle Cancer

center and for the first four treatments, I had to switch to Rockwood Cancer

Treatment Center because I could no longer take the long drive from Spokane to

Seattle every two weeks. The chief oncologists would not give me glutathione

even though I showed him the countless studies that showed decreased nerve

damage. I too have the nerve damage to my hands and feet. It sucks but at leat

I am still above ground.

Al

Spokane WA

________________________________

From: jrrjim <jim.mcelroy10@...>

....Now here is the sad part. I had actually read these studies before

receiving chemotherapy, and I PLEADED with my oncologist to give me

glutathione injections. He refused. Refused. Refused. And here I

sit with oxaliplatin induced permanent neuropathy.

[Guest guest]

-I cannot understand why your oncologist refused glutathione.

My husband, stage III b colon cancer, had adjuvant chemo

with oxaliplatin and Xeloda and had glutathione infusion before

every treatment...also, he had calcium-magnesium infusions.He did

not develop neuropathy.

However, I do not know if this chemo really helped him....

he is 33 months after surgery and we worry about recurrence risk.

Some stage III patients are cured by surgery only, others

have disease progression despite golden standard chemo.

A recent research says that adjuvant chemo has " curative " role.

My husband (and I) are not convinced, and he is following an

alternative protocol..

Karla

Evidence for Cure by Adjuvant Therapy in Colon Cancer: Observations

Based on Individual Patient Data From 20,898 Patients on 18

Randomized Trials.............

PURPOSE: Limited data are available on the time course of treatment

failures (recurrence and/or death), the nature and duration of

adjuvant treatment benefit, and long-term recurrence rates in

patients with resected stage II and III colon cancer. METHODS: The

data set assembled by the Adjuvant Colon Cancer Endpoints Group, a

collection of individual patient data from 18 trials and more than

20,800 patients testing fluorouracil-based adjuvant therapy in

patients with stage II or III colon cancer, was analyzed. RESULTS: A

significant overall survival (OS) benefit of adjuvant therapy was

consistent over the 8-year follow-up period. The risk of recurrence

in patients treated with adjuvant chemotherapy never exceeds that of

control patients, signifying that adjuvant therapy cures some

patients, as opposed to delaying recurrence. After 5 years,

recurrence rates were less than 1.5% per year, and after 8 years,

they were less than 0.5% per year. Significant disease-free survival

(DFS) benefit from adjuvant chemotherapy was observed in the first 2

years. After 2 years, DFS rates in treated and control patients were

not significantly different, and after 4 years, no trend toward

benefit was demonstrated. This benefit was primarily driven by

patients with stage III disease. CONCLUSION: Adjuvant chemotherapy

provides significant DFS benefit, primarily by reducing the

recurrence rate, within the first 2 years of adjuvant therapy with

some benefit in years 3 to 4, translating into long-term OS benefit.

This reflects the curative role of chemotherapy in the adjuvant

setting. After 5 years, recurrence rates in patients treated on

clinical trials are low, and after 8 years, they are minimal; thus,

long-term follow-up for recurrence is of little value.

PMID: 19124803 [PubMed - as supplied by publisher]

[Guest guest]

I totally agree that neuropathy is miserable side effect to suffer from

as I see my mom suffering daily from cisplatin-induced peripheral

neuropathy. She says she feels like she is walking on cotton wool! Does

gluthatione help to reverse neuropathy then? Thanks

HP

[Guest guest]

Try wool wool, as from sheep. Try greasy dirty wool covered with grit

and grime on your hands and feet. It's like wearing filthy greasy

gritty wool socks and gloves, 24 hours a day.

>

> I totally agree that neuropathy is miserable side effect to suffer

from

> as I see my mom suffering daily from cisplatin-induced peripheral

> neuropathy. She says she feels like she is walking on cotton wool!

Does

> gluthatione help to reverse neuropathy then? Thanks

>

> HP

>

[Guest guest]

Hello jrrjim,

I mentioned this to you a long time ago, but....Near infrared LED

therapy has become somewhat mainstream for peripheral neuropathy.

This is sometimes referred to as stochastic light therapy. Anodyne is

the " Kleenex " or " Coke " (brand recognition) of that world. The

Anodyne units are way too expensive. You can put the same thing

together for 100 bucks.

There is some dispute with recent studies crying " placebo effect " ,

but many patients claim very significant improvement.

Another approach that I know (from experience) often works is

microcurrent electrotherapy.

Mike

Tuesday, January 27, 2009, 6:51:25 PM, you wrote:

j> Try wool wool, as from sheep. Try greasy dirty wool covered with grit

j> and grime on your hands and feet. It's like wearing filthy greasy

j> gritty wool socks and gloves, 24 hours a day.

j>

>>

>> I totally agree that neuropathy is miserable side effect to suffer

j> from

>> as I see my mom suffering daily from cisplatin-induced peripheral

>> neuropathy. She says she feels like she is walking on cotton wool!

j> Does

>> gluthatione help to reverse neuropathy then? Thanks

>>

>> HP

>>

--

Best regards,

Mike mailto:goldenmike@...

[Guest guest]

Many of them do. Others (spindle poisons, pole aggragation disrupters,

substances that cause cytochrome c leakage)....most likely do, but

exactly " how " they work is not known. Redox reactions are very common in

biochemistry.

Mike

rrjim wrote:

>

> I do not have the biochemical expertise of some of our members here, so

> if I make an error in logical deduction, please correct it.

> the best cancer diet is heavy in meat and dairy!!!!

>

> Mike, you said that glutathione levels are only important for those

> considering oxidative stress on cancer cells (in terms of possibly

> intefering with such therapies). Outside of chemo and arte, are there

> any other approaches that introduce oxidative stress on cancer cells?

>

>