Insulin and cancer.

[Guest guest]

I have advanced prostate cancer I found this little artical on the link betwein

Inculin and Cancer as because I often talk about the cancer diet Im on I know I

have to avoid simple sugara as well as fruit sugars But befor I read this I

dident know why cheers Ray

Integr Cancer Ther. 2003 Dec;2(4):315-29.

Insulin and cancer.

Boyd DB.

239 Glenville Road, Greenwich, CT 06831, USA. dbb@...

Obesity has recently been linked to mortality from the majority of cancers. The

insulin/insulin-like growth factor (IGF) system may partly explain this effect.

The metabolic syndrome, associated with hyperinsulinemia, may modulate this

effect. Recent evidence supports the role of insulin and IGF-1 as important

growth factors, acting through the tyrosine kinase growth factor cascade in

enhancing tumor cell proliferation. In addition, the metabolic syndrome

associated with a chronic inflammatory state and accompanying cytokine

abnormalities may also contribute to tumor progression. Growing links between

insulin and the etiology as well as prognosis in colon, prostate, pancreatic,

and, particularly, breast cancer are reviewed. Of particular concern is the

evidence that elevated IGF-1 may interfere with cancer therapy, adversely

affecting prognosis. The role of insulin is of concern because of the increasing

levels of obesity and the associated metabolic syndrome. Weight gain, through

typical Western diet; limited levels of activity; and, more recently,

stress-related changes in neuroendocrine function may lead to insulin resistance

and hyperinsulinemia. The opportunity for a multidisciplinary approach involving

nutrition, exercise, and stress reduction in an integrative setting may be

crucial to limiting the insulin-resistant state and improving cancer outcomes.

PMID: 14713323 [PubMed - indexed for MEDLINE]