Guest guest Posted September 9, 2010 Report Share Posted September 9, 2010 Could theobromine be a possible natural non-toxic parp inhibitor? http://www.mitochondrial.net/abstract/pm/16870158 If you are going to do radiation to the breast then you might consider various sensitizers. Those I like include vit E succinate, quercetin, dipyridamole, carbogen with hyperthermia (although I have not tried this with TNBC/IBC), ethacrynic acid, and PARP inhibitors. There are various non-toxic substances that can be used to help induce PARP cleavage. These include caffeine (and the other xanthines), niacinamide, and curcumin. I occasionally make a very effective one (dithiodinicotinic acid) but I wait till several people need it at the same time because it is expensive to make and it takes me at least a week. Five years ago I was making plenty and just giving it away as we had private funding. Unfortunately the monies dried up, I think mostly because the donor could not understand the chemistry nor the importance of the compound. I wish I had saved about ten kilos; I would wallow in it. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 9, 2010 Report Share Posted September 9, 2010 Yes. Good catch..!! At 11:49 AM 9/9/2010, you wrote: > > >Could theobromine be a possible natural non-toxic parp inhibitor? > ><http://www.mitochondrial.net/abstract/pm/16870158>http://www.mitochondrial.net\ /abstract/pm/16870158 > > > >If you are going to do radiation to the breast then you might > >consider various sensitizers. Those I like include vit E succinate, > >quercetin, dipyridamole, carbogen with hyperthermia (although I have > >not tried this with TNBC/IBC), ethacrynic acid, and PARP > >inhibitors. There are various non-toxic substances that can be used > >to help induce PARP cleavage. These include caffeine (and the other > >xanthines), niacinamide, and curcumin. I occasionally make a very > >effective one (dithiodinicotinic acid) but I wait till several people > >need it at the same time because it is expensive to make and it takes > >me at least a week. Five years ago I was making plenty and just > >giving it away as we had private funding. Unfortunately the monies > >dried up, I think mostly because the donor could not understand the > >chemistry nor the importance of the compound. I wish I had saved > >about ten kilos; I would wallow in it. Quote Link to comment Share on other sites More sharing options...
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