Re: Curcumin plus Celebrex vs cancer

[Guest guest]

,

I am familiar with this one. In fact I had two of my pancreatic ductal CA

patients enrolled in it.

I found out that Professor Arber who was running the study, was using curcumin

without piperin. I called him on the phone to talk with him about that, but

could not reach him. Told one of my patients taking part in the study to speak

with him on that.

Arber said that he knows that piperin is needed to enhance absorbtion, but that

he is confined to using curcumin that the study dictates using. shame...ha?

BTY, they used 8 gr of curcumin/day (without piperin) and 800 mg/day of

celecoxib

Gubi

[ ] Curcumin plus Celebrex vs cancer

It is amazing how much useful medical research comes out of such a small

country. Maybe it's because the Israelis tax the wealthy. I'd sure like to

import this idea to Del Mar, California. Anyhow, this simple combination

has been demonstrated in pancreatic cancer. Maybe Gubi on the list can make

a local phone call and report on the dosages.

By Viva Press

March 27, 2011

Next time you order a curry dish at your local Indian restaurant, you'll be

happy to know that Tel Aviv University research shows you may be winning the

fight against cancer, too.

According to the research, turmeric -- the bright yellow spice in curry --

combined with an arthritis drug may help treat cancer.

Dr. Shahar Lev-Ari of Tel Aviv University's School of Public Health at the

Sackler Faculty of Medicine found that curcumin - turmeric's active

ingredient - can fight cancer when used in combination with Celecoxib, a

popular anti-inflammatory drug used to treat arthritis.

Lev-Ari and colleagues said the unusual combination helps alleviate the

inflammatory response caused when cancer takes root in the body. The

researchers said the treatment has had promising results in human clinical

trials.

" Although more testing will be needed before a possible new drug treatment

is developed, one could combine curcumin with a lower dose of a cancer

anti-inflammatory drug, to better fight colon cancer, " Lev-Ari said in a

statement.

The researchers said they hope their findings will help in the fight against

all cancers.

" It has the promise of being an important life-extending therapy,

particularly for non-curable pancreatic cancer, suggested by the very

promising results we achieved for 20 pancreatic cancer patients, " said Nadir

Arber of the Sackler Faculty of Medicine.

The findings were recently published in the journal, Therapeutic Advances in

Gastroenterology.

[Guest guest]

Gubi, many people are dealing with colorectal cancer (my husband

included) Do you know patients with colon cancer in human trials

of curcumin and celocoxib, how are they doing?

thanks

carla

[Guest guest]

Carla, giving you a link to such study that is starting soon

http://www.bioportfolio.com/resources/trial/109231/Phase-Iii-Trial-Of-Gemcitabin\

e-Curcumin-And-Celebrex-In-Patients-With-Metastatic.html

same hospital in Tel Aviv that did the study with pancreatic cancer.

Gubi

[ ] Re: Curcumin plus Celebrex vs cancer

Gubi, many people are dealing with colorectal cancer (my husband

included) Do you know patients with colon cancer in human trials

of curcumin and celocoxib, how are they doing?

thanks

carla

[Guest guest]

hi,

vincent/gubi ,

being in india im using curcuminoid 500 mg + piperine 5 mg + lycopene 10% 25

mg ( 2 tablets a day ) and approx 2 gms of organic curcumin for my mother

for her collorectal cancer with mets. would u say that should be increased ?

regards

sumeet

[Guest guest]

What is piperin and where can I get it. use how much with 8 grams of curcumin?

Thanks, Robyn

[Guest guest]

Curcumin contains the curcuminoids, so she is taking about 2-1/2 grams per

day. She probably needs three times this. If you have access to

cyclodextrin I would wet it and mash them together. You want to use a

significant excess of cyclodetrin because of it high molecular weight.

Bromelain might well kick up the curcumin - I'm watching this combination.

If you can't get the celebrex you might use sulindac. I too have stage four

colorectal cancer and use curcumin and sulindac as part of my own protocol

(a few pills after breakfast and a few pills after dinner) and I have no

evidence of cancer. I do add ashwagandha and MSM to prevent further mets.

I add a couple of other things I make in the lab, plus I do take detox

seriously.

I have spent decades studying cancer, developing meds, and working around

the clock with cancer patients. I doubt that I spend more than 30 seconds a

day thinking about my own situation. I do think that diets are

overemphasized. I have seen diets that are horrifyingly strict. It is

usually adequate to fall back to an ancestral diet and do your best to steer

clear of modern chemicals.

Forget all the nonsense about stress causing cancer. Everyone has stress.

It is the lack of adequate partying that sinks people. There is no better

stress reliever. I can't get my colleagues to go there because they don't

know how to teach their lab rats to whoop it up. I am going to start a

medical school and teach the new docs to write prescriptions for the type of

party indicated for different patients and different cancers. I need a

Latin motto for the school, perhaps something like " Sextus, Drugae, et

Rockus et Rollibus..!!! " I'll have my Opus Dei friends (Pax, in aeternum)

clean up the Latin.

_____

From: [mailto: ] On

Behalf Of sumeet dhawan

Sent: Thursday, March 31, 2011 8:36 AM

Subject: Re: [ ] Curcumin plus Celebrex vs cancer

vincent/gubi ,

being in india im using curcuminoid 500 mg + piperine 5 mg + lycopene 10% 25

mg ( 2 tablets a day ) and approx 2 gms of organic curcumin for my mother

for her collorectal cancer with mets. would u say that should be increased ?

regards

sumeet

[Guest guest]

Piperin is the active ingredient in black pepper.

What is piperin and where can I get it. use how much with 8 grams of curcumin?

[Guest guest]

,

Could you please get into some more details on the curcumin/cyclodextrin. What

ratio? (1:3?).

Wet with water, or mix the two with some warmed up fat like coconut oil or ghee?

Do they need to be mixed together at all, or just adding them both to a warm cup

of water or juice and stirring is enough?

Gubi

RE: [ ] Curcumin plus Celebrex vs cancer

Curcumin contains the curcuminoids, so she is taking about 2-1/2 grams per

day. She probably needs three times this. If you have access to

cyclodextrin I would wet it and mash them together. You want to use a

significant excess of cyclodetrin because of it high molecular weight.

Bromelain might well kick up the curcumin - I'm watching this combination.

If you can't get the celebrex you might use sulindac. I too have stage four

colorectal cancer and use curcumin and sulindac as part of my own protocol

(a few pills after breakfast and a few pills after dinner) and I have no

evidence of cancer. I do add ashwagandha and MSM to prevent further mets.

I add a couple of other things I make in the lab, plus I do take detox

seriously.

I have spent decades studying cancer, developing meds, and working around

the clock with cancer patients. I doubt that I spend more than 30 seconds a

day thinking about my own situation. I do think that diets are

overemphasized. I have seen diets that are horrifyingly strict. It is

usually adequate to fall back to an ancestral diet and do your best to steer

clear of modern chemicals.

Forget all the nonsense about stress causing cancer. Everyone has stress.

It is the lack of adequate partying that sinks people. There is no better

stress reliever. I can't get my colleagues to go there because they don't

know how to teach their lab rats to whoop it up. I am going to start a

medical school and teach the new docs to write prescriptions for the type of

party indicated for different patients and different cancers. I need a

Latin motto for the school, perhaps something like " Sextus, Drugae, et

Rockus et Rollibus..!!! " I'll have my Opus Dei friends (Pax, in aeternum)

clean up the Latin.

_____

[Guest guest]

Gubi,

There are different ways of doing this. If you use the prescribed ratio

then you'll be using a large excess of cyclodextrin. A simple ratio of

curcumin to cyclodextrin is 1:2 or 1:3 by weight. You would make a slurry

or dough with water and stir or knead. The curcumin is the guest molecule

inside this inclusion compound.

I do think it would be far more effective vs cancer to synthesize the

cyclodextrin from 2-deoxy-D-glucose. If desired a hydroxypropyl branch

could be added to make it more water soluble and suitable for injection if

necessary. Then you would want a 1:3 ratio. This would be one of a hundred

things that I could patent but patenting would only serve to keep it out of

the hands of cancer patients.

_____

From: [mailto: ] On

Behalf Of Gubi

Sent: Saturday, April 02, 2011 12:41 AM

Subject: Re: [ ] Curcumin plus Celebrex vs cancer

,

Could you please get into some more details on the curcumin/cyclodextrin.

What ratio? (1:3?).

Wet with water, or mix the two with some warmed up fat like coconut oil or

ghee?

Do they need to be mixed together at all, or just adding them both to a warm

cup of water or juice and stirring is enough?

Gubi

RE: [ ] Curcumin plus Celebrex vs cancer

Curcumin contains the curcuminoids, so she is taking about 2-1/2 grams per

day. She probably needs three times this. If you have access to

cyclodextrin I would wet it and mash them together. You want to use a

significant excess of cyclodetrin because of it high molecular weight.

Bromelain might well kick up the curcumin - I'm watching this combination.

If you can't get the celebrex you might use sulindac. I too have stage four

colorectal cancer and use curcumin and sulindac as part of my own protocol

(a few pills after breakfast and a few pills after dinner) and I have no

evidence of cancer. I do add ashwagandha and MSM to prevent further mets.

I add a couple of other things I make in the lab, plus I do take detox

seriously.

I have spent decades studying cancer, developing meds, and working around

the clock with cancer patients. I doubt that I spend more than 30 seconds a

day thinking about my own situation. I do think that diets are

overemphasized. I have seen diets that are horrifyingly strict. It is

usually adequate to fall back to an ancestral diet and do your best to steer

clear of modern chemicals.

Forget all the nonsense about stress causing cancer. Everyone has stress.

It is the lack of adequate partying that sinks people. There is no better

stress reliever. I can't get my colleagues to go there because they don't

know how to teach their lab rats to whoop it up. I am going to start a

medical school and teach the new docs to write prescriptions for the type of

party indicated for different patients and different cancers. I need a

Latin motto for the school, perhaps something like " Sextus, Drugae, et

Rockus et Rollibus..!!! " I'll have my Opus Dei friends (Pax, in aeternum)

clean up the Latin.

_____

[Guest guest]

Thank you .

Is the 2DG for glycolytic inhibition?

Gubi

RE: [ ] Curcumin plus Celebrex vs cancer

Curcumin contains the curcuminoids, so she is taking about 2-1/2 grams per

day. She probably needs three times this. If you have access to

cyclodextrin I would wet it and mash them together. You want to use a

significant excess of cyclodetrin because of it high molecular weight.

Bromelain might well kick up the curcumin - I'm watching this combination.

If you can't get the celebrex you might use sulindac. I too have stage four

colorectal cancer and use curcumin and sulindac as part of my own protocol

(a few pills after breakfast and a few pills after dinner) and I have no

evidence of cancer. I do add ashwagandha and MSM to prevent further mets.

I add a couple of other things I make in the lab, plus I do take detox

seriously.

I have spent decades studying cancer, developing meds, and working around

the clock with cancer patients. I doubt that I spend more than 30 seconds a

day thinking about my own situation. I do think that diets are

overemphasized. I have seen diets that are horrifyingly strict. It is

usually adequate to fall back to an ancestral diet and do your best to steer

clear of modern chemicals.

Forget all the nonsense about stress causing cancer. Everyone has stress.

It is the lack of adequate partying that sinks people. There is no better

stress reliever. I can't get my colleagues to go there because they don't

know how to teach their lab rats to whoop it up. I am going to start a

medical school and teach the new docs to write prescriptions for the type of

party indicated for different patients and different cancers. I need a

Latin motto for the school, perhaps something like " Sextus, Drugae, et

Rockus et Rollibus..!!! " I'll have my Opus Dei friends (Pax, in aeternum)

clean up the Latin.

_____

[Guest guest]

Yes, but glycolytic inhibition is not enough. Everyone seems to ignore the

fact that cancer is opportunistic and there is no easy solution to shutting

down all cancer-feeding pathways, some of which are not obvious. An example

would the feasting off the lysate from the fibrin and stromal tissues that

bind the tumor. As always, the devil is in the details.

_____

From: [mailto: ] On

Behalf Of Gubi

Sent: Saturday, April 02, 2011 10:57 PM

Subject: Re: [ ] Curcumin plus Celebrex vs cancer

Thank you .

Is the 2DG for glycolytic inhibition?

Gubi

RE: [ ] Curcumin plus Celebrex vs cancer

Gubi,

There are different ways of doing this. If you use the prescribed ratio

then you'll be using a large excess of cyclodextrin. A simple ratio of

curcumin to cyclodextrin is 1:2 or 1:3 by weight. You would make a slurry

or dough with water and stir or knead. The curcumin is the guest molecule

inside this inclusion compound.

I do think it would be far more effective vs cancer to synthesize the

cyclodextrin from 2-deoxy-D-glucose. If desired a hydroxypropyl branch

could be added to make it more water soluble and suitable for injection if

necessary. Then you would want a 1:3 ratio. This would be one of a hundred

things that I could patent but patenting would only serve to keep it out of

the hands of cancer patients.

[Guest guest]

,

Is there a particular advantage of the cyclodextrin being synthesized from 2Dg

versus taking the 2DG seperatly?

Gubi

RE: [ ] Curcumin plus Celebrex vs cancer

Gubi,

There are different ways of doing this. If you use the prescribed ratio

then you'll be using a large excess of cyclodextrin. A simple ratio of

curcumin to cyclodextrin is 1:2 or 1:3 by weight. You would make a slurry

or dough with water and stir or knead. The curcumin is the guest molecule

inside this inclusion compound.

I do think it would be far more effective vs cancer to synthesize the

cyclodextrin from 2-deoxy-D-glucose. If desired a hydroxypropyl branch

could be added to make it more water soluble and suitable for injection if

necessary. Then you would want a 1:3 ratio. This would be one of a hundred

things that I could patent but patenting would only serve to keep it out of

the hands of cancer patients.

[Guest guest]

If you are going to consume a bit of sugar or starch you might let the

starch (dextrin) do a bit of the heavy lifting. 2DG has a long safe track

record and I currently use it as part of a combination protocol.

Cyclodextrin is also a useful carrier for parthenolide.

Everything I say is for public domain. I say this as I have seen my

recommendations patented by others for the financial exploitation of cancer

patients.

_____

From: [mailto: ] On

Behalf Of Gubi

Sent: Sunday, April 03, 2011 12:51 AM

Subject: Re: [ ] Curcumin plus Celebrex vs cancer

,

Is there a particular advantage of the cyclodextrin being synthesized from

2Dg versus taking the 2DG seperatly?

Gubi

RE: [ ] Curcumin plus Celebrex vs cancer

Gubi,

There are different ways of doing this. If you use the prescribed ratio

then you'll be using a large excess of cyclodextrin. A simple ratio of

curcumin to cyclodextrin is 1:2 or 1:3 by weight. You would make a slurry

or dough with water and stir or knead. The curcumin is the guest molecule

inside this inclusion compound.

I do think it would be far more effective vs cancer to synthesize the

cyclodextrin from 2-deoxy-D-glucose. If desired a hydroxypropyl branch

could be added to make it more water soluble and suitable for injection if

necessary. Then you would want a 1:3 ratio. This would be one of a hundred

things that I could patent but patenting would only serve to keep it out of

the hands of cancer patients.