Guest guest Posted March 15, 2009 Report Share Posted March 15, 2009 -There are rumors about the antiangiogenic Avastin being approved for adjuvant chemo of colon cancer...probably we'll know next month karla -------- Avastin is designed to cut off the blood supply to tumors by starving them of oxygen and is already approved, along with chemotherapy, for patients with advanced cancer of the colon, lung and breast. A month of Avastin treatment costs about $4,400. The clinical trial is seeking to show its ability to prevent colon cancer recurrence by wiping out microscopic cancer cells that may remain in the body after tumors have been removed by surgery, known as use in the " adjuvant setting. " " In the adjuvant setting, any regimen needs to accomplish a higher cure rate, " said Dr. Roman -Soler, chairman of oncology at the Montefiore-Einstein Cancer Center in New York. He and others said even a small increase would be significant. The 2,700-patient trial, funded by the National Institutes of Health, is designed to show whether use of Avastin plus chemotherapy, followed by six months of Avastin alone, results in more patients being cancer free after three years compared with just treating them with chemotherapy. The next interim review of the study, which is designed to show that Avastin reduces the likelihood of cancer recurrence or death by 20 percent to 25 percent, is slated for November, although such reviews rarely trigger a public release of data. Approval in the adjuvant setting for colon, breast and lung cancer could add more than $4 billion to annual U.S. sales by 2015, according to Sanford Bernstein analyst Geoffrey Porges. For that to happen, Avastin would need to show a clear benefit. Reuters Insight, which tracks industry trends for institutional investors, found earlier this year that 60 percent of polled oncologists would prescribe adjuvant Avastin if the drug were shown to reduce the rate of tumor recurrence by 25 percent. But another 30 percent said they would hold out for a reduction of at least 50 percent in the recurrence rate. ------- and now there are doubts about avastin incresing recurrences.... -- In , robert-blau@... wrote: > > Ralph W. Moss, Ph.D. Weekly CancerDecisions.com > Newsletter #383 03/15/09 > > CANCER DECISIONS FREE WEEKLY NEWSLETTER > > SHADOW FALLS ON ANTI-ANGIOGENIC DRUGS > > A new study has raised the disturbing prospect that anti-angiogenesis > drugs might have the contradictory effect of helping tumors invade > normal tissues and organs, i.e., to metastasize.... > > To read this week's newsletter, please click or go to: > http://www.cancerdecisions.com/031509.html > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 15, 2009 Report Share Posted March 15, 2009 robert-blau@... wrote: > SHADOW FALLS ON ANTI-ANGIOGENIC DRUGS > A new study has raised the disturbing prospect that anti-angiogenesis > drugs might have the contradictory effect of helping tumors invade > normal tissues and organs, i.e., to metastasize.... > Wow, and I've been using Dr Chi's Angiostop for the past few months ... with a rapidly rising CA 125 ... this alarms me a little bit ... xxo Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 15, 2009 Report Share Posted March 15, 2009 this stuff has horrendous side effects, does it not? > > > > Ralph W. Moss, Ph.D. Weekly CancerDecisions.com > > Newsletter #383 03/15/09 > > > > CANCER DECISIONS FREE WEEKLY NEWSLETTER > > > > SHADOW FALLS ON ANTI-ANGIOGENIC DRUGS > > > > A new study has raised the disturbing prospect that anti-angiogenesis > > drugs might have the contradictory effect of helping tumors invade > > normal tissues and organs, i.e., to metastasize.... > > > > To read this week's newsletter, please click or go to: > > http://www.cancerdecisions.com/031509.html > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 15, 2009 Report Share Posted March 15, 2009 " He and others said even a small increase would be significant. " What does that really mean? What does the 20 - 25% figure in the rave about Avastin used for Colon Cancer mean? What many of us have learned is that a month or two more survival, and that is often questionable, is considered " significant' to Conventional practitioners. Additionally, we also have learned that sometimes the percentages used are meaningless because of the method used to calculate the benefit. There are two methods when using percentages one being the Relative and the other, the Absolute. Without going through the entire formula, the white-coat propagandists can take a seemingly low 2% benefit and claim it to be 40%. When speaking with patients or writing articles, instead of using the actual 2% benefit they use the 40%. Wouldn't you take the risk if there was a 40% improvement vs. 2%? Suppose though, the true benefit was only 2% and that offering only a couple of months, maybe, survival and that with a worrisome Quality of Life factor. The real thrust of the article was for investors and the following paragraph shows why: " Approval in the adjuvant setting for colon, breast and lung cancer could add more than $4 billion to annual U.S. sales by 2015, according to Sanford Bernstein analyst Geoffrey Porges. " That's FOUR BILLION! Then we need to re-read the following Moss Report which indicates that Avastin and other drugs may actually bring about increased Metastasis: http://www.cancerdecisions.com/031509.html Joe C. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 15, 2009 Report Share Posted March 15, 2009 -Yes, high blood pressure, stroke, intestinal perforation.... wounds cannot be healed if you are on this drug. If my husband was on these drugs (he is 60 y.o.) I could not sleep at night, watching if he is still breathing.... sigh. karla " minolfa " wrote: -There are rumors about the antiangiogenic Avastin being approved for adjuvant chemo of colon cancer...probably we'll know next month karla Quote Link to comment Share on other sites More sharing options...
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