Rare Study of Diet and Prostate Cancer Progression

January 25, 2010

From Medscape

News Author: Nick Mulcahy

January 13, 2010 –– In a finding that was

unexpected, consumption of eggs and chicken with

skin might increase the risk for disease

progression in men with localized prostate cancer.

The research, published online December 30 in the

American Journal of Clinical Nutrition, is only

the second-ever study of post diagnosis diet in men with prostate cancer.

The researchers hypothesized that red meat, with

its high saturated-fat content, would increase

the risk for prostate cancer progression and that poultry and eggs would not.

However, in a prospective study of 1294 men with

prostate cancer, post diagnostic consumption of

eggs and poultry with skin were each associated

with 2-fold increases in risk for prostate cancer

progression. Red meat had no effect on progression.

Our results are entirely novel.

" Our results are entirely novel and it will be

important to examine these dietary factors in

future studies " said lead author Richman,

MS, from the Harvard School of Public Health in Boston, Massachusetts.

So should clinicians tell men with prostate

cancer to forgo scrambled egg breakfasts and chicken wings at dinner?

More research is needed before translating these

results into clinical practice.

Ms. Richman stopped short of advising as much.

" More research is needed before translating these

results into clinical practice, " she told Medscape Oncology.

But Ms. Richman, who is a doctoral candidate in

both epidemiology and nutrition, expressed

another concern: " It is important to note that

cancer survivors are at increased risk of heart

disease and diabetes and limiting consumption of

poultry with skin is consistent with current

guidelines for reducing heart disease risk. "

There are plausible scientific explanations for

the effect of both eggs and poultry with skin on

prostate cancer progression, write the study authors.

Heterocyclic amines, which are mutagens that can

be present at much higher concentrations in

well-done poultry than in other meats, induce

prostate adenocarcinomas in rats and have been

shown to covalently bind and damage DNA in

cultured human prostate tissue, they write. Also,

eggs help determine the level of an individual's

plasma choline, which is a marker associated with

a greater risk of prostate cancer developing in men.

Research into diet and cancer postdiagnosis needs

more support, suggested Ms. Richman.

" I was surprised so little research has been done

on postdiagnostic diet and risk of prostate

cancer progression, considering the growing

number of men living with prostate cancer in the

United States and around the world, " she said.

Study Details

The study comprised men participating in the

Cancer of the Prostate Strategic Urologic

Research Endeavor (CaPSURE) and the data come

from a substudy on diet and lifestyle.

The 1294 men who had localized prostate cancer

but no recurrence or progression at the start of

the study in 2004/05 were followed for an average

of 2 years. During follow-up, there were 127

events (ranging from death to biochemical recurrence).

Intakes of processed and unprocessed red meat,

fish, total poultry, and skinless poultry were

not associated with prostate cancer recurrence or

progression, write the authors.

However, greater consumption of eggs and poultry

with skin was associated with 2-fold increases in risk.

Specifically, in a comparison of the groups of

men who ate, on average, less than 1 serving or

none of these foods weekly and those who averaged

about 5 servings a week, the greater consumption

of eggs produced a hazard ratio (HR) of 2.02 (95%

confidence interval [CI], 1.10 - 3.72; P for

trend = .05), and greater consumption of poultry

with skin had an HR of 2.26 (95% CI, 1.36 - 3.76; P for trend = .003).

Because men who eat poultry with skin tend to

have diets that are high in saturated fat, the

investigators performed a further analysis to

ensure that this factor, which was hypothesized

to be troublesome, was not at play.

Among men with the same total saturated-fat

consumption, the researchers compared those who

consumed approximately 3 servings a week of

poultry with skin with those who consumed 0 servings a week.

" Since all the men consumed the same amount of

saturated fat, a higher intake of saturated fat

could not explain the increased risk we observed

among the men who consumed more poultry with skin, " explained Ms. Richman.

This insight led to the theory that the above

mentioned heterocyclic amines might affect the risk for progression.

The Other Postdiagnosis Study

Other studies have looked at diet and the

development of prostate cancer and found that

processed or cured meats are more strongly

associated with an increased risk for advanced

prostate cancer than for total prostate cancer.

With regard to eating eggs and poultry and the

risk of developing prostate cancer, the " results

have been largely inconclusive, " write the authors.

The only other research into diet and disease

progression among men who already have prostate

cancer was conducted by this same group of researchers.

Using data from the Health Professionals

Follow-Up Study, they found a decreased risk for

prostate cancer progression associated with high

postdiagnostic fish and tomato sauce intake. Both

fish and tomato sauce are low in saturated fat,

leading the researchers to their hypotheses about

saturated fat affecting the progression of prostate cancer.

This study was supported by the Department of

Defense and the Prostate Cancer Foundation. The

CaPSURE study was originally funded by TAP

Pharmaceutical Products. The authors have

disclosed no relevant financial relationships.

Am J Clin Nutr. Published online December 30, 2009.

January 25, 2010

reading this news article by Nick Mulcahy I am remined of the articles in Dr

Ross book The Cell Factor and the research Dr Budwig Did in the 1950 into

oils and it efect on cancer In Nick Mulcahy articles The researchers

hypothesized that red meat, with its high saturated-fat content, would increase

the risk for prostate cancer progression and that poultry and eggs would not but

articles dos not go into much depth as to why Chicken and saturated fats are Bad

for us. I can only suppose the sex hormones in the Chicken has some thing to do

with it, and prostate cancer is sex hormone dependent

Dr Ross book he talks about the damage that saturated fats do to the

cells in our body Dr Budwig talks about how Omega 3 fatty acids can help repair

Cells Damage by fatty acids I have read There is another way beside fish to

get omega 3 Omega 3 fatty acids, can repair the damage cause by commercially

processed fats and oils. Dr Budwig research has shown the tremendous effects

that commercially processed fats and oils have in destroying cell membranes and

lowering the voltage in the cells of our bodies, which then result in chronic

and terminal disease. but it a bit more then that.

Dr Ross wrote in his book, that commercially processed fats, and oil

molecules, are smaller then normal fat molecule and omega 3 fatty acids. Now

our normal cells. don't know one lot of fat molecule. from any other lot of

fats, so when a fat molecule comes along, the cell use it to repair it damage

outer membrane now because commercially processed fats and oil molecules, are

smaller, nutrients have a hard time getting though them, When this happens the

cell start to starve. But one way the cell can fix this, is to make it self

bigger so it has more area so it can get mote nutrients in . The problem is, to

do this, the cell has to change the cell codes in it nucleus the one that tell

it when to die when to divide when it dos this, as it dos divides the two cells

can easily become cancer cells, having omega 3 once a day, the cell can use

the omega 3 fatty acids to replace the trans fatty acids in it outer membrane

Dr Budwig mix of one table spoon of flack seed oil and two table spoons of

cottage cheese to every pound of body weight has help so Meany people she said

to just on it for three months how it works is the cottage cheese , which is

rich in sulfur protein, has a chemical reaction with the flack seed oil the

reaction that is produced makes the oil water soluble and easily absorbed into

the cell membrane. cheers Ray

From: VGammill

Sent: Tuesday, January 26, 2010 1:11 PM

Subject: [ ] Rare Study of Diet and Prostate Cancer Progression

From Medscape

News Author: Nick Mulcahy

January 13, 2010 -- In a finding that was

unexpected, consumption of eggs and chicken with

skin might increase the risk for disease

progression in men with localized prostate cancer.

The research, published online December 30 in the

American Journal of Clinical Nutrition, is only

the second-ever study of post diagnosis diet in men with prostate cancer.

The researchers hypothesized that red meat, with

its high saturated-fat content, would increase

the risk for prostate cancer progression and that poultry and eggs would not.

However, in a prospective study of 1294 men with

prostate cancer, post diagnostic consumption of

eggs and poultry with skin were each associated

with 2-fold increases in risk for prostate cancer

progression. Red meat had no effect on progression.

Our results are entirely novel.

" Our results are entirely novel and it will be

important to examine these dietary factors in

future studies " said lead author Richman,

MS, from the Harvard School of Public Health in Boston, Massachusetts.

So should clinicians tell men with prostate

cancer to forgo scrambled egg breakfasts and chicken wings at dinner?

More research is needed before translating these

results into clinical practice.

Ms. Richman stopped short of advising as much.

" More research is needed before translating these

results into clinical practice, " she told Medscape Oncology.

But Ms. Richman, who is a doctoral candidate in

both epidemiology and nutrition, expressed

another concern: " It is important to note that

cancer survivors are at increased risk of heart

disease and diabetes and limiting consumption of

poultry with skin is consistent with current

guidelines for reducing heart disease risk. "

There are plausible scientific explanations for

the effect of both eggs and poultry with skin on

prostate cancer progression, write the study authors.

Heterocyclic amines, which are mutagens that can

be present at much higher concentrations in

well-done poultry than in other meats, induce

prostate adenocarcinomas in rats and have been

shown to covalently bind and damage DNA in

cultured human prostate tissue, they write. Also,

eggs help determine the level of an individual's

plasma choline, which is a marker associated with

a greater risk of prostate cancer developing in men.

Research into diet and cancer postdiagnosis needs

more support, suggested Ms. Richman.

" I was surprised so little research has been done

on postdiagnostic diet and risk of prostate

cancer progression, considering the growing

number of men living with prostate cancer in the

United States and around the world, " she said.

Study Details

The study comprised men participating in the

Cancer of the Prostate Strategic Urologic

Research Endeavor (CaPSURE) and the data come

from a substudy on diet and lifestyle.

The 1294 men who had localized prostate cancer

but no recurrence or progression at the start of

the study in 2004/05 were followed for an average

of 2 years. During follow-up, there were 127

events (ranging from death to biochemical recurrence).

Intakes of processed and unprocessed red meat,

fish, total poultry, and skinless poultry were

not associated with prostate cancer recurrence or

progression, write the authors.

However, greater consumption of eggs and poultry

with skin was associated with 2-fold increases in risk.

Specifically, in a comparison of the groups of

men who ate, on average, less than 1 serving or

none of these foods weekly and those who averaged

about 5 servings a week, the greater consumption

of eggs produced a hazard ratio (HR) of 2.02 (95%

confidence interval [CI], 1.10 - 3.72; P for

trend = .05), and greater consumption of poultry

with skin had an HR of 2.26 (95% CI, 1.36 - 3.76; P for trend = .003).

Because men who eat poultry with skin tend to

have diets that are high in saturated fat, the

investigators performed a further analysis to

ensure that this factor, which was hypothesized

to be troublesome, was not at play.

Among men with the same total saturated-fat

consumption, the researchers compared those who

consumed approximately 3 servings a week of

poultry with skin with those who consumed 0 servings a week.

" Since all the men consumed the same amount of

saturated fat, a higher intake of saturated fat

could not explain the increased risk we observed

among the men who consumed more poultry with skin, " explained Ms. Richman.

This insight led to the theory that the above

mentioned heterocyclic amines might affect the risk for progression.

The Other Postdiagnosis Study

Other studies have looked at diet and the

development of prostate cancer and found that

processed or cured meats are more strongly

associated with an increased risk for advanced

prostate cancer than for total prostate cancer.

With regard to eating eggs and poultry and the

risk of developing prostate cancer, the " results

have been largely inconclusive, " write the authors.

The only other research into diet and disease

progression among men who already have prostate

cancer was conducted by this same group of researchers.

Using data from the Health Professionals

Follow-Up Study, they found a decreased risk for

prostate cancer progression associated with high

postdiagnostic fish and tomato sauce intake. Both

fish and tomato sauce are low in saturated fat,

leading the researchers to their hypotheses about

saturated fat affecting the progression of prostate cancer.

This study was supported by the Department of

Defense and the Prostate Cancer Foundation. The

CaPSURE study was originally funded by TAP

Pharmaceutical Products. The authors have

disclosed no relevant financial relationships.

Am J Clin Nutr. Published online December 30, 2009.

January 26, 2010

Ray, please clarify what you mean by one tablespoon of flax seed oil with

2 tablespoon of cottage cheese

to every pound of body weight. If I am 110 pounds, how many tablespoons

do I need every day?

Thanks.

Jim

In a message dated 1/25/2010 11:14:13 P.M. Eastern Standard Time,

rjcrossley@... writes:

reading this news article by Nick Mulcahy I am remined of the articles in

Dr Ross book The Cell Factor and the research Dr Budwig Did in the

1950 into oils and it efect on cancer In Nick Mulcahy articles The

researchers hypothesized that red meat, with its high saturated-fat content,

would

increase the risk for prostate cancer progression and that poultry and eggs

would not but articles dos not go into much depth as to why Chicken and

saturated fats are Bad for us. I can only suppose the sex hormones in the

Chicken has some thing to do with it, and prostate cancer is sex hormone

dependent

Dr Ross book he talks about the damage that saturated fats do to

the cells in our body Dr Budwig talks about how Omega 3 fatty acids can help

repair Cells Damage by fatty acids I have read There is another way beside

fish to get omega 3 Omega 3 fatty acids, can repair the damage cause by

commercially processed fats and oils. Dr Budwig research has shown the

tremendous effects that commercially processed fats and oils have in destroying

cell membranes and lowering the voltage in the cells of our bodies, which

then result in chronic and terminal disease. but it a bit more then that.

Dr Ross wrote in his book, that commercially processed fats, and

oil molecules, are smaller then normal fat molecule and omega 3 fatty acids.

Now our normal cells. don't know one lot of fat molecule. from any other

lot of fats, so when a fat molecule comes along, the cell use it to repair it

damage outer membrane now because commercially processed fats and oil

molecules, are smaller, nutrients have a hard time getting though them, When

this happens the cell start to starve. But one way the cell can fix this, is

to make it self bigger so it has more area so it can get mote nutrients in

.. The problem is, to do this, the cell has to change the cell codes in it

nucleus the one that tell it when to die when to divide when it dos this, as

it dos divides the two cells can easily become cancer cells, having omega 3

once a day, the cell can use the omega 3 fatty acids to replace the trans

fatty acids in it outer membrane

Dr Budwig mix of one table spoon of flack seed oil and two table spoons of

cottage cheese to every pound of body weight has help so Meany people she

said to just on it for three months how it works is the cottage cheese ,

which is rich in sulfur protein, has a chemical reaction with the flack seed

oil the reaction that is produced makes the oil water soluble and easily

absorbed into the cell membrane. cheers Ray

From: VGammill

Sent: Tuesday, January 26, 2010 1:11 PM

_ @ @can_ (mailto: )

Subject: [ ] Rare Study of Diet and Prostate Cancer Progression

From Medscape

News Author: Nick Mulcahy

January 13, 2010 -- In a finding that was

unexpected, consumption of eggs and chicken with

skin might increase the risk for disease

progression in men with localized prostate cancer.

The research, published online December 30 in the

American Journal of Clinical Nutrition, is only

the second-ever study of post diagnosis diet in men with prostate cancer.

The researchers hypothesized that red meat, with

its high saturated-fat content, would increase

the risk for prostate cancer progression and that poultry and eggs would

not.

However, in a prospective study of 1294 men with

prostate cancer, post diagnostic consumption of

eggs and poultry with skin were each associated

with 2-fold increases in risk for prostate cancer

progression. Red meat had no effect on progression.

Our results are entirely novel.

" Our results are entirely novel and it will be

important to examine these dietary factors in

future studies " said lead author Richman,

MS, from the Harvard School of Public Health in Boston, Massachusetts.

So should clinicians tell men with prostate

cancer to forgo scrambled egg breakfasts and chicken wings at dinner?

More research is needed before translating these

results into clinical practice.

Ms. Richman stopped short of advising as much.

" More research is needed before translating these

results into clinical practice, " she told Medscape Oncology.

But Ms. Richman, who is a doctoral candidate in

both epidemiology and nutrition, expressed

another concern: " It is important to note that

cancer survivors are at increased risk of heart

disease and diabetes and limiting consumption of

poultry with skin is consistent with current

guidelines for reducing heart disease risk. "

There are plausible scientific explanations for

the effect of both eggs and poultry with skin on

prostate cancer progression, write the study authors.

Heterocyclic amines, which are mutagens that can

be present at much higher concentrations in

well-done poultry than in other meats, induce

prostate adenocarcinomas in rats and have been

shown to covalently bind and damage DNA in

cultured human prostate tissue, they write. Also,

eggs help determine the level of an individual's

plasma choline, which is a marker associated with

a greater risk of prostate cancer developing in men.

Research into diet and cancer postdiagnosis needs

more support, suggested Ms. Richman.

" I was surprised so little research has been done

on postdiagnostic diet and risk of prostate

cancer progression, considering the growing

number of men living with prostate cancer in the

United States and around the world, " she said.

Study Details

The study comprised men participating in the

Cancer of the Prostate Strategic Urologic

Research Endeavor (CaPSURE) and the data come

from a substudy on diet and lifestyle.

The 1294 men who had localized prostate cancer

but no recurrence or progression at the start of

the study in 2004/05 were followed for an average

of 2 years. During follow-up, there were 127

events (ranging from death to biochemical recurrence).

Intakes of processed and unprocessed red meat,

fish, total poultry, and skinless poultry were

not associated with prostate cancer recurrence or

progression, write the authors.

However, greater consumption of eggs and poultry

with skin was associated with 2-fold increases in risk.

Specifically, in a comparison of the groups of

men who ate, on average, less than 1 serving or

none of these foods weekly and those who averaged

about 5 servings a week, the greater consumption

of eggs produced a hazard ratio (HR) of 2.02 (95%

confidence interval [CI], 1.10 - 3.72; P for

trend = .05), and greater consumption of poultry

with skin had an HR of 2.26 (95% CI, 1.36 - 3.76; P for trend = .003).

Because men who eat poultry with skin tend to

have diets that are high in saturated fat, the

investigators performed a further analysis to

ensure that this factor, which was hypothesized

to be troublesome, was not at play.

Among men with the same total saturated-fat

consumption, the researchers compared those who

consumed approximately 3 servings a week of

poultry with skin with those who consumed 0 servings a week.

" Since all the men consumed the same amount of

saturated fat, a higher intake of saturated fat

could not explain the increased risk we observed

among the men who consumed more poultry with skin, " explained Ms. Richman.

This insight led to the theory that the above

mentioned heterocyclic amines might affect the risk for progression.

The Other Postdiagnosis Study

Other studies have looked at diet and the

development of prostate cancer and found that

processed or cured meats are more strongly

associated with an increased risk for advanced

prostate cancer than for total prostate cancer.

With regard to eating eggs and poultry and the

risk of developing prostate cancer, the " results

have been largely inconclusive,have been largely

The only other research into diet and disease

progression among men who already have prostate

cancer was conducted by this same group of researchers.

Using data from the Health Professionals

Follow-Up Study, they found a decreased risk for

prostate cancer progression associated with high

postdiagnostic fish and tomato sauce intake. Both

fish and tomato sauce are low in saturated fat,

leading the researchers to their hypotheses about

saturated fat affecting the progression of prostate cancer.

This study was supported by the Department of

Defense and the Prostate Cancer Foundation. The

CaPSURE study was originally funded by TAP

Pharmaceutical Products. The authors have

disclosed no relevant financial relationships.

Am J Clin Nutr. Published online December 30, 2009.

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January 27, 2010

Just curious, why is the dept. of defense spending money on this research? It

makes me wary of this research...

>

> reading this news article by Nick Mulcahy I am remined of the articles in Dr

Ross book The Cell Factor and the research Dr Budwig Did in the 1950 into

oils and it efect on cancer In Nick Mulcahy articles The researchers

hypothesized that red meat, with its high saturated-fat content, would increase

the risk for prostate cancer progression and that poultry and eggs would not but

articles dos not go into much depth as to why Chicken and saturated fats are Bad

for us. I can only suppose the sex hormones in the Chicken has some thing to do

with it, and prostate cancer is sex hormone dependent

>

> Dr Ross book he talks about the damage that saturated fats do to the

cells in our body Dr Budwig talks about how Omega 3 fatty acids can help repair

Cells Damage by fatty acids I have read There is another way beside fish to

get omega 3 Omega 3 fatty acids, can repair the damage cause by commercially

processed fats and oils. Dr Budwig research has shown the tremendous effects

that commercially processed fats and oils have in destroying cell membranes and

lowering the voltage in the cells of our bodies, which then result in chronic

and terminal disease. but it a bit more then that.

>

> Dr Ross wrote in his book, that commercially processed fats, and oil