Guest guest Posted April 24, 2009 Report Share Posted April 24, 2009 Hello there. Mike wrote: << Since ceramide, a fatty acid, can induce ER stress in cancer cells leading to autophagy and apoptosis, I'm wondering about ways to increase ceramide production. It seems to me that an extraction of cannabinoids into coconut oil at 127 degrees (for decarboxylation) would provide both a carrier and a substrate for ceramide production. The cannabinoids are known to cause this stimulus and the lauric acid in the coconut oil would be the substrate/carrier. I think this might be enhanced by coadministration of vitamin D3. >> Please see below for articles regarding ceramide by Dr. (immunologist of Grouppe Kurosawa)... You might especially appreciate the first one, if you haven't seen it before. Best wishes, Glen from Illinois, USA ------------------------------------------------------- Ceramide, A Powerful Natural Anti-Cancer Compound (May 20, 2006) (http://grouppekurosawa.typepad.com/grouppe_kurosawa_natural_/2006/05/ceramide_a\ _powe.html) << ...curcumin, nicotinamide, palmitic acid and serine could be a VERY powerful combination for the treatment of cancer. >> -------------------------------------------------------- (http://grouppekurosawa.typepad.com/grouppe_kurosawa_natural_/2006/07/how_cerami\ de_th.html) Ceramide and Metformin are Synergistic Activators of Autophagy (June 03, 2008) _http://grouppekurosawa.typepad.com/grouppe_kurosawa_natural_/2008/06/cerami de-and-me.html_ (http://grouppekurosawa.typepad.com/grouppe_kurosawa_natural_/2008/06/ceramide-a\ nd-me.html) Ceramide and mTOR and the Control of Autophagy (June 03, 2008) (http://grouppekurosawa.typepad.com/grouppe_kurosawa_natural_/2008/06/ceramide-a\ nd-mt.html) << mTOR activation by NF-kappaB and AKT is the fundamental inhibitor of autophagy. In order for ceramide to be able to effectively activate autophagy, mTOR MUST be inhibited. >> How Ceramide Induces Autophagy Mediated Cell Death (June 05, 2008) (http://grouppekurosawa.typepad.com/grouppe_kurosawa_natural_/2008/06/how-cerami\ de-in.html) How Ceramide, the Cancer Death Lipid, Gets Neutralized (July 01, 2006) (http://grouppekurosawa.typepad.com/grouppe_kurosawa_natural_/2006/07/how_cerami\ de_th.html) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2009 Report Share Posted April 24, 2009 Mike, I tried this out and ingested some of the coconut oil and, uh... uhhh... Are you guys sure that sugar and dairy is bad for cancer? That chocolate ice cream in the freezer sure looks good. Yum. And those cookies too. In fact, just about everything in the refrigerator looks good. Wow. I sure am hungry all the sudden for some reason... Uh... what were we talking about? > > Since ceramide, a fatty acid, can induce ER stress in cancer cells leading to autophagy and apoptosis, I'm wondering about ways to increase ceramide production. > It seems to me that an extraction of cannabinoids into coconut oil at 127 degrees (for decarboxylation) would provide both a carrier and a substrate for ceramide production. The cannabinoids are known to cause this stimulus and the lauric acid in the coconut oil would be the substrate/carrier. I think this might be enhanced by coadministration of vitamin D3. > > I'd appreciate any comments on this, or perhaps ideas for enhancement, from any list members with a background that might provide insight. > (?) > > Thanks. > > Mike > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2009 Report Share Posted April 24, 2009 But seriously... In reading up on ceramide, it appears that serine and palmitic acid are needed for its production in the body. Now, it sure looks like our old friend undenatured whey isolate seems like an excellent source of serine. And coconut oil seems like a pretty good source of palmitic acid. As far as the cannabinoids increasing ceramide production -- I don't know anything about that. Is it true? > > Since ceramide, a fatty acid, can induce ER stress in cancer cells leading to autophagy and apoptosis, I'm wondering about ways to increase ceramide production. > It seems to me that an extraction of cannabinoids into coconut oil at 127 degrees (for decarboxylation) would provide both a carrier and a substrate for ceramide production. The cannabinoids are known to cause this stimulus and the lauric acid in the coconut oil would be the substrate/carrier. I think this might be enhanced by coadministration of vitamin D3. > > I'd appreciate any comments on this, or perhaps ideas for enhancement, from any list members with a background that might provide insight. > (?) > > Thanks. > > Mike > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2009 Report Share Posted April 24, 2009 Hello jrrjim, Typical Californian! Mike Friday, April 24, 2009, 5:43:59 PM, you wrote: j> Mike, I tried this out and ingested some of the coconut oil and, uh... uhhh... j> Are you guys sure that sugar and dairy is bad for cancer? That j> chocolate ice cream in the freezer sure looks good. Yum. And those j> cookies too. In fact, just about everything in the refrigerator j> looks good. Wow. I sure am hungry all the sudden for some reason... j> Uh... what were we talking about? j> >> >> Since ceramide, a fatty acid, can induce ER stress in cancer cells leading to autophagy and apoptosis, I'm wondering about ways to increase ceramide production. >> It seems to me that an extraction of cannabinoids into coconut oil at 127 degrees (for decarboxylation) would provide both a carrier and a substrate for ceramide production. The cannabinoids are known to cause this stimulus and the lauric acid in the coconut oil would be the substrate/carrier. I think this might be enhanced by coadministration of vitamin D3. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2009 Report Share Posted April 24, 2009 > As far as the cannabinoids increasing ceramide production -- I don't know anything about that. Is it true? > It is : Cannabinoid-induced acute ceramide generation (1) (2) (1) Ceramide: a new second messenger of cannabinoid action . (2) Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. (3) Cannabinoids: potential anticancer agents Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 25, 2009 Report Share Posted April 25, 2009 This is unlikely to work curatively, though it might inhibit the growth of many cancer cells or even kill them. You can find tens of thousands of such mixes and matches in " in vitro " testing and they just don't play out. Sometimes you do such things to buy yourself time to solve immune problems. For many it may seem counterintuitive, but the more you rely on inhibiting the growth of cancer the more likely you are to ultimately fail, and the more you rely on theory the more likely you are to fail. Always go with what you see clinically and repeatedly even if it is not nearly as exquisitely crafted as a treasured theory. A couple of weeks ago some at the retreat asked me what books have most influenced me. I had a problem answering that. I may have ten thousand books in just my home library. One book does stand out though I probably haven't thought about it for over 20 years. It is n Jaynes' book, " The Origin of Consciousness in the Breakdown of the Bicameral Mind. " In it Jaynes describes the attributes of consciousness, and one is the ability to form narratives. We are absolutely addicted to narratives and we form them about everything. So often this is what we do when we form theories. These theories so often take on a soritical form in which we are scaffolding speculation on top of speculation. The brighter a person is the easier it is to do this. It doesn't even matter if the theory immediately collapses as we can always think of a more exciting theory in ten minutes. The best ways to learn to beat cancer is to study the techniques of those who are consistently effective and study those cultures that historically had extremely low rates of cancer. This week at the Center we had a Haitian woman who described the horror in her nation decades ago when someone got breast cancer. No one had seen cancer and it was unbelievable. This week we also had an Amish family. I have seen enough Amish cancer that I now routinely examine for a founder effect. All of us are going to start experiencing germ line changes in our genome thanks to the ubiquitous chemicals that we sop up. The human race is in for quite a surprise. Mike, thank you for your contributions to the list. You routinely give good advice. At 09:22 AM 4/24/2009, you wrote: >Since ceramide, a fatty acid, can induce ER stress in cancer cells >leading to autophagy and apoptosis, I'm wondering about ways to >increase ceramide production. >It seems to me that an extraction of cannabinoids into coconut oil >at 127 degrees (for decarboxylation) would provide both a carrier >and a substrate for ceramide production. The cannabinoids are known >to cause this stimulus and the lauric acid in the coconut oil would >be the substrate/carrier. I think this might be enhanced by >coadministration of vitamin D3. > >I'd appreciate any comments on this, or perhaps ideas for >enhancement, from any list members with a background that might >provide insight. >(?) > >Thanks. > >Mike Quote Link to comment Share on other sites More sharing options...
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