Re: Curcumin plus Celebrex (or aspirin or other NSAIDs) vs cancer

April 1, 2011

, Thanks for posting this. To follow up on some replies, a good source

of curcumin is the Meriva tumeric phytosomal source, offered inexpensively under

different brands. This is about 10x more absorbable than the plain powder form.

Actually, just boiling in water for about 10 minutes, alternatively, also boosts

biovailability about 10-fold, as shown in one study. (I am personally against

using bioprene to increase absorbability by essentially irritating the

intestine--at least this is not well tolerated by certain people).

Anticancer effects of Aspirin and other NSAIDs, as well as curcumin and other

polyphenols, have been studied extensively, and many of these studies find a

mechanism of action totally different than anti-inflammatory properties are at

play. Curcumin and other polyphenols that are antioxidants in most contexts act

as pro-oxidants in tumor cell mitochondria, and their anti-cancer activity is

actually blocked by antioxidants such as NAC in many studies. Aspirin also

hits the cancer cell mitochondria, acts to decouple oxidative phospholyation

(compromising metabolism), and blocks the ability of cells to sequester calcium,

an escape valve tumor cells can use to avoid the damaging effects of inflowing

calcium ions. Both of these appear to be synergistic with certain anticancer

lipids, and I use both at a certain point in the sequence in a 6-day intensive

lipid regimen. -

>

> It is amazing how much useful medical research comes out of such a small

> country. Maybe it's because the Israelis tax the wealthy. I'd sure like to

> import this idea to Del Mar, California. Anyhow, this simple combination

> has been demonstrated in pancreatic cancer. Maybe Gubi on the list can make

> a local phone call and report on the dosages.

>

> By Viva Press

> March 27, 2011

>

> Next time you order a curry dish at your local Indian restaurant, you'll be

> happy to know that Tel Aviv University research shows you may be winning the

> fight against cancer, too.

>

> According to the research, turmeric -- the bright yellow spice in curry --

> combined with an arthritis drug may help treat cancer.

>

> Dr. Shahar Lev-Ari of Tel Aviv University's School of Public Health at the

> Sackler Faculty of Medicine found that curcumin - turmeric's active

> ingredient - can fight cancer when used in combination with Celecoxib, a

> popular anti-inflammatory drug used to treat arthritis.

>

> Lev-Ari and colleagues said the unusual combination helps alleviate the

> inflammatory response caused when cancer takes root in the body. The

> researchers said the treatment has had promising results in human clinical

> trials.

>

> " Although more testing will be needed before a possible new drug treatment

> is developed, one could combine curcumin with a lower dose of a cancer

> anti-inflammatory drug, to better fight colon cancer, " Lev-Ari said in a

> statement.

>

> The researchers said they hope their findings will help in the fight against

> all cancers.

>

> " It has the promise of being an important life-extending therapy,

> particularly for non-curable pancreatic cancer, suggested by the very

> promising results we achieved for 20 pancreatic cancer patients, " said Nadir

> Arber of the Sackler Faculty of Medicine.

>

> The findings were recently published in the journal, Therapeutic Advances in

> Gastroenterology.

April 7, 2011

Hi ,

Did I get it right that you use both aspirin and curcumin with your PUFA

overdose? What brand of Meriva turmeric do you recommend? This is the only 1 I

found but it contains soybeans and am avoiding soy:

http://www.swansonvitamins.com/SWU493/ItemDetail

Did u mean to boil ordinary turmeric powder to increase bioavailability?

Thanks,

steffi

, Thanks for posting this. To follow up on some replies, a good

source of curcumin is the Meriva tumeric phytosomal source, offered

inexpensively under different brands. This is about 10x more absorbable than the

plain powder form. Actually, just boiling in water for about 10 minutes,

alternatively, also boosts biovailability about 10-fold, as shown in one study.

(I am personally against using bioprene to increase absorbability by essentially

irritating the intestine--at least this is not well tolerated by certain

people).