Guggul

[Guest guest]

Reneé,

That's only one of hundreds of sites with data on Commiphora Mukul. If

you do a search on it at www.google.com you'll have plenty of reading

for the rest of the day. ;-)

Celeste

Reneé wrote:

> www.holisticonline.com

> Name: GuggulBiological Name: Commiphora mukulOther Names: Gugulipid,

[Guest guest]

In a message dated 04/11/2002 5:49:54 PM Pacific Daylight Time, thighmaster@... writes:

Just go to the web site for this group --

/group/hypothyroidism -- and read message #3301. Then

you can use your favorite search engine to find the best price on the

products I've mentioned.

Hope,

I would add that I tried the health food store guggul before I tried the Syntrax guggul I bought over the internet. I notice a definite, though not unpleasant, heating action w/ the Syntrax stuff. The HFS brand had no effect I could detect. I take it w/ tyrosine as Celeste recommends in the post she mentioned. I don't know if that adds to the effect significantly or not but I know tyrosine in general is supposed to support optimal thyroid function.

Good luck!

in LA

"The fact that an opinion has been widely held is no evidence whatever that it is not utterly absurd."

Bertrand (1872 - 1970)

[Guest guest]

Hope,

Just go to the web site for this group --

/group/hypothyroidism -- and read message #3301. Then

you can use your favorite search engine to find the best price on the

products I've mentioned.

Best wishes,

Celeste

Hope Owen wrote:

> ive been recently reading the posts on guggle a lot lately and i was

curious

> where can i find this? and how much does it cost? i feel so cold all

the

> time that i would love to give it a whirl.

[Guest guest]

Thanks Celeste and - ill look around on the web now that i know what

to look for!

>From: " a1thighmaster " <thighmaster@...>

>Reply-hypothyroidism

>hypothyroidism

>Subject: Re: guggul

>Date: Fri, 12 Apr 2002 00:47:40 -0000

>

>Hope,

>

>Just go to the web site for this group --

>/group/hypothyroidism -- and read message #3301. Then

>you can use your favorite search engine to find the best price on the

>products I've mentioned.

>

>Best wishes,

>Celeste

>

>Hope Owen wrote:

> > ive been recently reading the posts on guggle a lot lately and i was

>curious

> > where can i find this? and how much does it cost? i feel so cold all

>the

> > time that i would love to give it a whirl.

>

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[Guest guest]

Guggulsterone seems interesting for those who are fighting colon cancer...

karla

Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in

colon cancer cells.

Kim ES, Hong SY, Lee HK, Kim SW, An MJ, Kim TI, Lee KR, Kim WH, Cheon JH.

Department of Internal Medicine and Institute of Gastroenterology, Yonsei

University College of Medicine, Seoul 120-752, Korea.

The plant sterol guggulsterone has been shown to exert anti-tumor effects,

making it a candidate chemotherapeutic agent. We investigated the anti-tumor

effects of guggulsterone on colon cancer cells and elucidated the underlying

molecular mechanisms related to angiogenesis. The apoptotic effects of

guggulsterone were examined by cell survival assay. Western blot analysis was

used to determine the levels of various down-stream intracellular proteins

involved in angiogenesis, including signal transducer and activator of

transcription 3 (STAT3), vascular endothelial growth factor (VEGF),

hypoxia-inducible factor-1alpha (HIF-1alpha) and aryl hydrocarbon receptor

nuclear translocator (ARNT). Using chromatin immunoprecipitation assay, we

tested whether guggulsterone affects the recruitment of STAT3, ARNT and

HIF-1alpha to the human VEGF promoter. To investigate the effect of

guggulsterone on vascular endothelial cell migration and invasion, tube

formation and migration assays were conducted using human umbilical vein

endothelial cells (HUVECs). Matrix metalloproteinase (MMP)-2 and -9 activities

were measured by gelatin zymography. Guggulsterone significantly reduced cell

viability in colon cancer cells in a dose-dependent manner and blocked VEGF,

ARNT and STAT3 expression prominently in hypoxic conditions. The recruitment of

STAT3 and ARNT, but not HIF-1alpha, to the VEGF promoter was inhibited by

guggulsterone treatment. HUVECs produced much foreshortened and severely broken

tubes and showed decreased migration activity under guggulsterone effects. In

addition, zymography revealed that MMP-2 and -9 enzyme activities were markedly

lower in the presence of guggulsterone. The results of this study suggest that

guggulsterone not only induces apoptosis, but also inhibits angiogenesis and

metastasis in colon cancer cells by blocking STAT3 and VEGF expression,

suggesting its therapeutic potential in the treatment of colorectal cancer.

PMID: 19020709 [PubMed - indexed for MEDLINE]

Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth

in murine colorectal cancer xenografts.

An MJ, Cheon JH, Kim SW, Kim ES, Kim TI, Kim WH.

Department of Internal Medicine and Institute of Gastroenterology, Brain Korea

21 Project for Medical Science, Yonsei University College of Medicine, 134

Shinchon-dong, Seodaemun-gu, Seoul 120-752, Republic of Korea.

The plant sterol guggulsterone has recently been shown to have anti-tumorigenic

potential. This study was designed to investigate the anti-tumor efficacy of

guggulsterone and to elucidate its molecular mechanisms in colon cancer.

Guggulsterone significantly increased apoptosis in HT-29 cells by activating

caspases-3 and -8. Furthermore, guggulsterone decreased cIAP-1, cIAP-2, and

Bcl-2 levels and increased the levels of truncated Bid, Fas, p-JNK, and p-c-Jun.

The size of HT-29 xenograft tumors in guggulsterone-treated mice was

significantly smaller than of the size of tumors in control mice. The present

study suggests a potential therapeutic use for this compound in the treatment of

colorectal cancer