Re: Re: Curcumin- The European Journal of Cancer Article

[Guest guest]

Hello ,

Whether they are good or not depends on your frame of reference.

They are found in the cytosol (the " goop " inside the cell) and within

the mitochondria. They " stick " other chemicals to glutathione

(conjugation) in phase II detoxification to allow them to be removed

from the cell. Blocking them would end up in saving glutathione, but

the cell would be less able to " clean house " .

Mike

Saturday, March 7, 2009, 3:52:48 PM, you wrote:

MB> Is curcumin's ability to block glutathione S-transferases good or

MB> not?  Isn't glutathione a great anti-oxidant?

MB>  

MB> Thanks.

MB>  

MB>

MB>

[Guest guest]

Mike Any references?

Mike Golden wrote:

>

> Hello Me,

>

> Oh, I should add that curcumin promotes the production of the

> glutathione S-transferases which, in turn, cojugate curcumin with

> glutathione. Keep in mind that everything gets detoxified, that's why

> we have to keep taking things (supplements). The " mission statement "

> of the cells

> is to, eventually, get rid of everything that they take in.

> Isn't biology wonderful?

>

> Mike, again

>

> Saturday, March 7, 2009, 4:39:31 PM, you wrote:

>

> MG> Hello ,

>

> MG> Whether they are good or not depends on your frame of reference.

> MG> They are found in the cytosol (the " goop " inside the cell) and within

> MG> the mitochondria. They " stick " other chemicals to glutathione

> MG> (conjugation) in phase II detoxification to allow them to be removed

> MG> from the cell. Blocking them would end up in saving glutathione, but

> MG> the cell would be less able to " clean house " .

>

> MG> Mike

>

> MG> Saturday, March 7, 2009, 3:52:48 PM, you wrote:

>

> MB>> Is curcumin's ability to block glutathione S-transferases good or

> MB>> not? Isn't glutathione a great anti-oxidant?

> MB>>

> MB>> Thanks.

> MB>>

> MB>>

>

> MB>>

[Guest guest]

What I wrote came from between my ears. A quick look at Google just now

brings up things like:

http://pubs.acs.org/doi/abs/10.1021/tx7002245

Human Glutathione S-Transferase-Mediated Glutathione Conjugation of

Curcumin and Efflux of These Conjugates in Caco-2 Cells

I'm strapped for time right now but will dig up something for you later

if a Google search is not productive.

Mike

Cuns-Rial@... wrote:

>

> Mike Any references?

>

>

> Mike Golden wrote:

> >

> > Hello Me,

> >

> > Oh, I should add that curcumin promotes the production of the

> > glutathione S-transferases which, in turn, cojugate curcumin with

> > glutathione. Keep in mind that everything gets detoxified, that's why

> > we have to keep taking things (supplements). The " mission statement "

> > of the cells

> > is to, eventually, get rid of everything that they take in.

> > Isn't biology wonderful?

> >

> > Mike, again

> >

> > Saturday, March 7, 2009, 4:39:31 PM, you wrote:

> >

> > MG> Hello ,

> >

> > MG> Whether they are good or not depends on your frame of reference.

> > MG> They are found in the cytosol (the " goop " inside the cell) and

> within

> > MG> the mitochondria. They " stick " other chemicals to glutathione

> > MG> (conjugation) in phase II detoxification to allow them to be removed

> > MG> from the cell. Blocking them would end up in saving glutathione, but

> > MG> the cell would be less able to " clean house " .

> >

> > MG> Mike

> >

> > MG> Saturday, March 7, 2009, 3:52:48 PM, you wrote:

> >

> > MB>> Is curcumin's ability to block glutathione S-transferases good or

> > MB>> not? Isn't glutathione a great anti-oxidant?

> > MB>>

> > MB>> Thanks.

> > MB>>

> > MB>>

> >

> > MB>>