fucoidan

March 30, 2007

Dennis:

Fucoidans are a group of polysaccharides that are quite similar

to the acemannans in aloe vera. I've had a page on fucoidans

references for years:

http://members.shaw.ca/duncancrow/fucoidans-references.html

What these do is primarily increase natural killer cells that are

supposed to eat cancer.

But biological support works only when the approach is fairly

broad, enough to hit the deficiencies, and a single supplement or

intervention is little more successful than a single medical

intervention.

If you're really interested in an immune system approach,

Transfer Factor is many times more potent than aloe, fucoidans or

the others, and although it's a purified product it is natural.

But you'll still need to support the immune response; this is

easily done with undenatured whey and selenium to increase

glutahtione. Glutathione level is the single biggest indicator of

general health and interestingly, of prognosis.

...And of course detox and nutrition. Part of detox, besides the

liver flushes, entails ensuring bowel ecology is not producing

excessive toxin load. Inulin, which is deficient by about 4/5 in

the modern diet, is key to bowel health. Eliminating the dietary

carbs helps a lot too.

These subjects are the forte of the candidiasis group:

candidiasis

Duncan

On 30 Mar 2007 at 10:51, oxyplus wrote:

>

> Posted by: " Dennis Lipter " black54@... dlipter

> Date: Thu Mar 29, 2007 8:02 am ((PDT))

>

> Anybody have any knowledge or experience with the use of Fucoidan for

> the treatment of tumors?

>

> Thanks,

>

> Dennis

February 4, 2008

Is anyone on the list taking this?

Do you know if it is ok for dogs to take?

**************

Biggest Grammy Award

surprises of all time on AOL Music.

(http://music.aol.com/grammys/pictures/never-won-a-grammy?NCID=aolcmp00300000002\

548)

February 4, 2008

In a message dated 2/4/08 9:54:55 PM Eastern Standard Time,

DudleyDelany@... writes:

>

> Hi All,

>

> If anyone would like to try Fucoidan, it is available at a discount from

> Amazon.com through this link:

>

> Dudley..what do you personally know about it? Do you use it? How does it

> mesh with other suppliments? Is it hard on the stomach? Can dogs use it?

> Please advise.

>

**************

Biggest Grammy Award surprises of all time on AOL Music.

(http://music.aol.com/grammys/pictures/never-won-a-grammy?NCID=aolcmp00300000002\

5

48)

February 4, 2008

In a message dated 2/4/08 10:22:07 PM Eastern Standard Time,

w.wilkins@... writes:

> isn't cancer a type of virus?

I think it sometimes is and sometimes isnt'...but I can't prove this.

**************

Biggest Grammy Award surprises of all time on AOL Music.

(http://music.aol.com/grammys/pictures/never-won-a-grammy?NCID=aolcmp00300000002\

548)

February 4, 2008

Is Fucoidan Limu?

In a message dated 2/4/08 11:47:32 PM Eastern Standard Time,

mkathryn59@... writes:

> IF any one wants to have the Fucoidan you can look at this web site of

> theirs.

> http://www.thelimucompany.com/ Pretty good stuff. I used to take it.

>

**************

Biggest Grammy Award surprises of all time on AOL Music.

(http://music.aol.com/grammys/pictures/never-won-a-grammy?NCID=aolcmp00300000002\

5

48)

February 4, 2008

Hi All,

If anyone would like to try Fucoidan, it is available at a discount from

Amazon.com through this link:

http://tinyurl.com/23ldy3

All the best,

Dudley Delany

dudley_delany

Fucoidan

Fucoidan:

Potent, New, Marine-Derived Immune Support

By A. Fleisher, MD, DHt, DABFM, DcABCT

The ocean is a vast source of a large number of health-giving substances.

Omega-3 fatty acids from deep sea fish are some of the best known of these

marine-derived nutrients. However, a lesser known, but equally important

sea-derived substance called fucoidan, a component of certain seaweeds, is

beginning to emerge as a powerful tool for enhancing immunity and other

important aspects of overall health and well-being.

Furthermore, a purified extract of certified organic fucoidan harvested from

the pristine waters off the coast of Nova Scotia provides health-supporting

properties that are evident after consumption of even extremely low doses.

Scientists have conducted an extensive array of in vitro and animal studies

that have found fucoidan exhibits powerful inhibitory action against herpes

and HIV viruses. Furthermore, newer, human research is confirming what these

in vitro and animal studies have found in the past. Other studies have

delved into a number of immune-enhancing characteristics of fucoidan,

indicating it may be of particular benefit for immune support during the

cold and flu season.

Moreover, studies indicate fucoidan may improve cardiovascular health,

reduce non-ulcer-related indigestion, control allergic reactions and even

inhibit the prions (denuded, ancient, pre-viral DNA/RNA particles)

responsible for the sheep version of " mad cow disease. "

What is Fucoidan?

Fucoidan is a sulfated polysaccharide found primarily in various species of

brown seaweed, such as hijiki, kombu, limu, moui, mozuku and wakame.

Variant forms of fucoidan have also been found in animal species, including

the sea cucumber. Extensive pharmaceutical research has been performed with

fucoidan, focusing on two distinct forms: F-fucoidan, which is composed of

over 95 percent sulfated esters of fucose and U-fucoidan, which is

approximately 20 percent glucuronic acid.

As a result of this scientific research, nutraceutical products containing

purified concentrates of U-fucoidan and F-fucoidan are currently being made

available as an immune enhancing food supplement.1

Research regarding fucoidan started around 1970, and since, fucoidan has

been cited in some 700 studies published in the National Library of

Medicine's database.

Overall, this substantial body of scientific research, together with

anecdotal evidence provided by a long history of culturally-based use of

fucoidan-rich seaweeds in regions such as Hawaii, Korea, Japan, Polynesia

and Tonga, clearly indicate that fucoidan demonstrates great potential as

safe, nutritional support for a wide variety of health conditions.

Sea-Derived Immune Support

The top benefits of fucoidan areain to its ability to strengthen the immune

system. In a number of in vitro and animal studies, it has inhibited coated

viruses such as herpes, HIV and human cytomegalovirus, a type of herpes

virus that can cause blindness and fatal pneumonia in individuals with

compromised immune systems.

Experiments have suggested that fucoidan may not only inhibit the initial

stages of viral infection, such as attachment to and penetration into host

cells, but also the later replication stages after virus penetration.[2]

In another interesting study in mice, researchers tested fucoidan, along

with other agents, to see whether any of them could prevent genital herpes

infections. The scientists administered fucoidan, or a number of other

agents, to the vaginas of the animals approximately 20 seconds prior to

inoculating the animals with a highly infectious herpes simplex virus type

2. The fucoidan was one of the agents that " provided significant protection "

against herpes virus infection.3

A pilot study by University of Chicago researchers found similar properties

when fucoidan was consumed orally by humans. Fifteen patients with active

herpes-type infections (including herpes simplex virus types 1 and 2, herpes

zoster or Epstein bar virus) and six subjects with latent infections,

consumed oral doses of fucoidan. Ingestion of fucoidan was associated with

increased healing rates in patients with active infections. In addition,

patients with latent infections remained asymptomatic while ingesting

fucoidan.4

The ability of fucoidan to inhibit the herpes virus may explain, in part,

why there is a much lower incidence of herpes simplex virus type 2

infections in Japan, compared with the west, in that the Japanese diet

contains a high consumption of fucoidan-containing seaweed.

Researchers have also tested fucoidan against other sexually transmitted

conditions, with promising results. Using a cell-line derived from the human

cervix, researchers have shown that Chlamydia trachomatis infection can be

blocked by fucoidan, which prevents the adherence of chlamydiae to target

cells.5

The same researchers previously observed that fucoidan and similar

substances could inhibit transmission of human immunodeficiency virus in

vitro.5 They suggested that fucoidan and similar compounds " could be used in

a vaginal formulation to inhibit infection by human immunodeficiency virus. "

After conducting the follow-up study with the chlamydia pathogenic organism,

the researchers noted, " The results of the present study suggest that the

same type of formulation may inhibit sexual transmission of chlamydia. " 5

In vitro studies testing fucoidan's inhibitory effects on the HIV and herpes

viruses have shown that fucoidan's mechanism of action involves blocking

virus entry into cells, rather than killing the virus directly. Fucoidan

appears to specifically block the host cell surface receptor that the virus

normally uses to enter the cell, rather than acting directly as a

virus-destroying agent.6

Research that digs deeper into the mechanism of action of fucoidan indicates

its reach extends far beyond simply inhibiting viruses. It has been shown to

influence the immune system in a number of ways. First, fucoidan has

stimulated an increase in levels of a cytokine known as interferon gamma.

Cytokines are proteins produced by white blood cells and are important in

regulating immunity. Interferon gamma is a cytokine that generates increased

immune activity during infections and cancer states.7-8

Another explanation for the immune-enhancing properties of fucoidan involve

its ability to stimulate natural killer cells, which play an important part

in the immune response by destroying cells infected with viruses. Natural

killer cells are also vital to seeking out and destroying tumor cells and

are a major defense against malignancies.

In a recent study, researchers investigated the effects of fucoidan on the

tumor growth of mouse leukemia cells and on T cell-mediated immune responses

in mice. The animals were fed a diet containing 1 percent fucoidan for 10

days and subcutaneously inoculated with leukemia cells. Thereafter, the mice

were fed with the diet containing fucoidan for 40 days. In mice receiving

the fucoidan, tumors were inhibited by 65.4 percent. Additionally, natural

killer cell activity significantly increased in the fucoidan-fed mice

compared to animals fed a normal diet.9

A French research study in 2002 showed that F-fucoidan can inhibit

hyperplasia (abnormal cell overgrowth) in rabbits.10 A Japanese research

report in 2005 indicated that F-fucoidan can induce apoptosis (spontaneous,

programmed, cancer cell death) in human lymphoma cell lines.11

Clearly, the immune-enhancing properties of fucoidan have far reaching

consequences for human health. Some studies are showing that it can down

regulate the aspect of the immune system that is responsible for allergic

reactions and help control allergic phenomena.

Fucoidan and the Heart

Fucoidan inhibits smooth muscle cell proliferation, which is of particular

interest in arterial occlusions following placement of stents in heart

patients.12 This effect was confirmed in a study of rabbits given fucoidan

by intramuscular and intravenous (IV) injection.13

A study using lamb hearts achieved similar results. The researchers induced

cardiac ischemia (heart damage caused by oxygen deprivation) in the hearts,

then exposed a number of the lamb hearts to fucoidan. In the animal hearts

exposed to fucoidan, there was better recovery of left ventricular function,

coronary blood flow and myocardial oxygen consumption after ischemia.14

Fucoidan is thought to achieve these heart protective effects by blocking

selectins, cell receptors important in the adhesion of white blood cells

known as leukocytes to capillary walls. When leukocytes adhere to the blood

vessel walls, it can lead to tissue damage, ultimately resulting in

atherosclerosis (hardening of the arteries). Acting as a selectin blocker,

fucoidan can inhibit the migration of leukocytes into blood vessel walls

that occurs when oxygen is reintroduced into ischemic tissue (known as

reperfusion ischemic necrosis) and thus prevent the organ damage that can

occur after oxygen reintroduction.14

Fucoidan's role as a natural anti-coagulant (blood thinner) also may explain

its protective effects on the heart, blood vessels and other vital organs.15

Thus, fucoidan has been demonstrated to possess significant cardioprotective

activity that may be of particular benefit to anyone with cardiovascular

health conditions and/or for prevention of heart and blood vessel problems.

Wide Variety of Applications

Fucoidan has been demonstrated to have a number of other interesting

properties. In one clinical trial, subjects with non-ulcer dyspepsia

(indigestion) were given 1.5 to 4.5 mg/kg/day of oral fucoidan for two

weeks. Symptoms of non-ulcer dyspepsia were relieved in the subjects given

fucoidan. Researchers believe these results are explained by studies that

have shown fucoidan can stop the ulcer-causing bacterium Helicobacter pylori

from adhering to gastric cells.16

Recently, fucoidan has been demonstrated to have inhibitory activity against

the prion infection " scrapie. " [17] This disease is closely related to bovine

spongiform encephalopathy (mad cow disease), but appears exclusively in

sheep and goats. There is also evidence that fucoidan inhibits infection by

the water borne parasite Cryptosporidium, which is responsible for serious,

chronic infectious diarrhea, especially in immunocompromised persons, e.g.,

cancer and AIDS patients, etc.18

A Unique Form of Fucoidan

A special form of fucoidan is harvested in the pristine waters off the coast

of Nova Scotia. It is extracted from organic-certified, hand-harvested

seaweeds using a proprietary, solvent-free, coldwater process. Furthermore,

the seaweed is collected just above the ocean's surface, not by dredging,

thereby being an environmentally friendly, sea-farming process. This ensures

that the seaweed is free from contamination and that the harvesting process

produces minimal environmental impact while allowing the plant to continue

to grow. This special method of extraction and the location of the ocean

harvest ensures that the fucoidan is free from the heavy metal contamination

that occurs in seaweeds produced in other areas of the world. This is

particularly important as studies have shown that kelp supplements may be

contaminated with arsenic.19

Conclusion

Fucoidan is emerging as one of the most intriguing immune system enhancers

of our time, possessing strong inhibitory activity against a number of

coated viruses, such as Herpes, Chicken pox (Varicella), EBV and HIV. Its

ability to significantly enhance natural killer cell activity also indicates

that it can strengthen immunity during the cold and flu season, as well as

help protect against formation and growth of abnormal cells. Furthermore,

the ability to help maintain cardiovascular and gastric health indicates

that fucoidan may be one of the most important substances ever derived from

the sea. Finally, it is essential that the most pristine and organic source

of fucoidan be used as a nutritional supplement, otherwise the active

constituents will not be present in the pure and sufficient quantities to be

biologically beneficial.

A. Fleisher, MD, DHt, DABFM, DcABCT

Dr. Mitch Fleisher is the Chief Medical Board Advisor for VRP.

References

1. " Discovered that the polysaccharide F-fucoidan contained in the seaweed

kombu can induce the production of HGF (Hepatocyte Growth Factor) in vivo

experiment " , Biotechnology Research Laboratories of Takara, 15 July 1999.

2. Hoshino T, Hayashi T, Hayashi K, Hamada J, Lee JB, Sankawa U. An

antivirally active sulfated polysaccharide from Sargassum horneri (TURNER)

C. AGARDH. Biol Pharm Bull. 1998 Jul;21(7):730-4.

3. Zeitlin L, Whaley KJ, Hegarty TA, Moench TR, Cone RA. Tests of vaginal

microbicides in the

http://www.vrp.com/ProductPage.aspx?ProdID=1475

<http://www.vrp.com/ProductPage.aspx?ProdID=1475 & zType=1> & zType=1

February 4, 2008

Hi Shirley,

I use a similar preparation called Modafilan. It is described here:

http://tinyurl.com/2gjmna

It is derived from brown seaweed and, in addition to fucoidan, contains organic

iodine and other nutrients said to boost immune function, combat cancer, and

remove heavy metals from the body. I take two capsules daily with meals. It is

just one of the many nutritional supplements I take. For a complete list, visit

http://tinyurl.com/grpm9

As far as I know, none of my supplements are hard on my stomach, but you might

check with your vet before giving either Fucoidan or Modafilan to your dog.

Sincerely,

Dudley

Re: Fucoidan

In a message dated 2/4/08 9:54:55 PM Eastern Standard Time,

DudleyDelany@... writes:

>

> Hi All,

>

> If anyone would like to try Fucoidan, it is available at a discount from

> Amazon.com through this link:

>

> Dudley..what do you personally know about it? Do you use it? How does it

> mesh with other suppliments? Is it hard on the stomach? Can dogs use it?

> Please advise.

>

**************

Biggest Grammy Award surprises of all time on AOL Music.

(http://music.aol.com/grammys/pictures/never-won-a-grammy?NCID=aolcmp00300000002\

5

48)

February 4, 2008

Bob,

isn't cancer a type of virus? If this may work for hiv virus? I think I'll

leave it there and retract the question. The FDA would immediately ban it if I

tried to carry the conversation further.

Billl