Guest guest Posted July 25, 2009 Report Share Posted July 25, 2009 Most chemos trash the immune system. Usually monoclonal antibodies are ok. Vincristine and bleomycin have many side effects but they do spare immune function. Vinblastine though will damage immune function. If your goal is to spare immune function with chemo there are many strategies which will allow a much lower dose. These include IPT, chronotherapy, and the use of a variety of synergists such as pleuronic, mitoguazone, pentamidine (with benzimidazole), and SAHA. By using extremely low doses you can get away from using those protocols that use steroidal anti-inflammatories such as dexamethasone. Other drugs/supplements that can kick up chemo and/or reduce drug resistance include hydralazine with valproate acid, verapamil with disulfiram, ketakonazole, BSO, sanguinarine, progesterone, EGCG, caffeine, melatonin, Vit C with K3, pau d'arco, along with many others. There are many strategies to kick up the effectiveness of a cancer vaccine. One is to use very low doses of cyclophosphamide prior the injections, next pick an adjuvant that will steer the vaccine in a Th1 direction. It is better to inject multiple intradermal injections in the inguinal area because of much better exposure to the antigen presenting cells (APC, dendritic cells) in the skin and because of the proximity to the inguinal lymphatic chains. Both IL-2 and GM-CSF are useful, and as I mentioned earlier Viagra and Ribavirin seem to be quite useful in kicking up the right type of immune response. All of these things are available, but I have stopped making SAHA because of the expense. Pleuronic might kick up chemotherapy a thousand fold in lab research but I haven't used it. In general I like vaccines -- especially targeting subunit vaccines. I have many years of experience with these. In general I do not like chemotherapy. I have seen too many tumors shrink only to see them grow again. Sometimes it is necessary to do what you have to do stop a tumor in its tracks and give the immune system a chance to work. This always includes doing the things that In our one-week retreat program (Del Mar, California) we give seminars on the use of these meds and try to help provide sources for these things. We are trying to set up a service that can make hard-to-find meds/supplements readily available, including outside the US. 858-922-7410 Quote Link to comment Share on other sites More sharing options...
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