another mention of methyl jasmonate

[Guest guest]

************************

A Cure For Leukemia?

************************

My friend, Rich Folts, sent me this article on leukemia last week. I

think you'll find it interesting if this subject is part of your life:

" Monday, December 31, 2007

Acute Myeloid Leukemia, Chronic Myeloid Leukemia, and Acute

Lymphocytic Leukemia Can be CURED by a Combination of Natural Medicines

This essay is reposted from our subscription Natural Medicine blog in

the public interest.

When I was a graduate student at Berkeley in the 1980's, I attended an

International Hematology Conference in San Francisco. I overheard a

conversation between one of America's prominent hematologists and some

of his colleagues.

'What would you do if you were diagnosed with acute myeloid leukemia?'

they asked.

'I would commit suicide,' he quickly responded.

Acute and chronic myeloid leukemia (AML and CML) are largely incurable

diseases. The drug Gleevec has showed some promise in the treatment of

CML, but it does not CURE the disease. Eventually, people taking

Gleevec become resistant to the drug. When this occurs, they become

susceptible to a 'blast crisis' which invariably ends their life

within months of diagnosis.

One of my friends died a horrible death from AML. He bled to death in

front of his entire family.

In 2005 a paper was published showing that the plant hormone

parthenolide induced apoptosis in AML stem and progenitor cells. This

cell death was mediated by a reduction in NF-kappaB, and an increase

in p53 activity. In some medical circles, parthenolide is now

considered a stand alone CURE for CML.

Unfortunately, parthenolide is not soluble in water thereby severely

limiting its bioavailability in the body.

In December, 2007, an orally available form of parthenolide was

developed by the authors of the first study. In tissue culture and dog

studies, this orally available form of parthenolide killed AML stem

and progenitor cells and blast cells from both CML and acute

lymphocytic leukemia. Normal stem cells were not harmed.

Parthenolide is active at very low concentrations (5 microM). Although

this compound is not soluble in water, it can be introduced topically

into the body via a DMSO gel. We will discuss this protocol in future

essays.

Methyl jasmonate can induce the differentiation of AML and other

leukemic cells into normal cells. This has nothing to do with killing

stem or progenitor cells. This form of re-differentiation is well

established in the lab, but the toxicity of the chemicals prevents

their use clinically. MJ is active in the re-differentiation process

at VERY LOW concentrations, 0.4 mM.

The p53 tumor suppressor plays a critical role in the death of

leukemic stem and progenitor cells. As cited in previous essays, p53

protein concentrations can be increased by flax lignans.

Three natural medicines, and possibly more, can kill leukemic stem and

progenitor cells and induce the re-differentiation of leukemic cells

into their normal counterpart. NO synthetic drug or drugs can

accomplish these clinical objectives. "

I wanted to pass this on so those of you interested in leukemia could

research it further. Onward and upward!

[Guest guest]

Here's a wikipedia article on methyl jasmonate. It includes (at the

bottom of the article) some links re cancer:

Methyl jasmonate - Wikipedia, the free encyclopedia

http://en.wikipedia.org/wiki/Methyl_jasmonate

And here's the original Grouppe Kurosawa post:

Grouppe Kurosawa Natural Medicines Public Blog: Acute Myeloid Leukemia,

Chronic Myeloid Leukemia, and Acute Lymphocytic Leukemia Can be CURED by

a Combination of Natural Medicines

http://grouppekurosawa.com/blog/2007/12/acute-myeloid-leukemia-chronic-myeloid

Posted by: " mcnjnj " olde_silas@...   mcnjnj

Mon Jan 7, 2008 12:19 pm (PST)

************************

A Cure For Leukemia?

************************

My friend, Rich Folts, sent me this article on leukemia last week. I

think you'll find it interesting if this subject is part of your life:

" Monday, December 31, 2007

Acute Myeloid Leukemia, Chronic Myeloid Leukemia, and Acute Lymphocytic

Leukemia Can be CURED by a Combination of Natural Medicines This essay

is reposted from our subscription Natural Medicine blog in the public

interest.

When I was a graduate student at Berkeley in the 1980's, I attended an

International Hematology Conference in San Francisco. I overheard a

conversation between one of America's prominent hematologists and some

of his colleagues.

'What would you do if you were diagnosed with acute myeloid leukemia?'

they asked.

'I would commit suicide,' he quickly responded. Acute and chronic

myeloid leukemia (AML and CML) are largely incurable diseases. The drug

Gleevec has showed some promise in the treatment of CML, but it does not

CURE the disease. Eventually, people taking Gleevec become resistant to

the drug. When this occurs, they become susceptible to a 'blast crisis'

which invariably ends their life within months of diagnosis.

One of my friends died a horrible death from AML. He bled to death in

front of his entire family.

In 2005 a paper was published showing that the plant hormone

parthenolide induced apoptosis in AML stem and progenitor cells. This

cell death was mediated by a reduction in NF-kappaB, and an increase in

p53 activity. In some medical circles, parthenolide is now considered a

stand alone CURE for CML.

Unfortunately, parthenolide is not soluble in water thereby severely

limiting its bioavailability in the body. In December, 2007, an orally

available form of parthenolide was developed by the authors of the first

study. In tissue culture and dog studies, this orally available form of

parthenolide killed AML stem and progenitor cells and blast cells from

both CML and acute lymphocytic leukemia. Normal stem cells were not

harmed. Parthenolide is active at very low concentrations (5 microM).

Although this compound is not soluble in water, it can be introduced

topically into the body via a DMSO gel. We will discuss this protocol in

future essays.

Methyl jasmonate can induce the differentiation of AML and other

leukemic cells into normal cells. This has nothing to do with killing

stem or progenitor cells. This form of re-differentiation is well

established in the lab, but the toxicity of the chemicals prevents their

use clinically. MJ is active in the re-differentiation process at VERY

LOW concentrations, 0.4 mM.

The p53 tumor suppressor plays a critical role in the death of leukemic

stem and progenitor cells. As cited in previous essays, p53 protein

concentrations can be increased by flax lignans. Three natural

medicines, and possibly more, can kill leukemic stem and progenitor

cells and induce the re-differentiation of leukemic cells into their

normal counterpart. NO synthetic drug or drugs can accomplish these

clinical objectives. "

I wanted to pass this on so those of you interested in leukemia could

research it further. Onward and upward!

[Guest guest]

Here's a wikipedia article on methyl jasmonate. It includes (at the

bottom of the article) some links re cancer:

Methyl jasmonate - Wikipedia, the free encyclopedia

http://en.wikipedia.org/wiki/Methyl_jasmonate

And here's the original Grouppe Kurosawa post:

Grouppe Kurosawa Natural Medicines Public Blog: Acute Myeloid Leukemia,

Chronic Myeloid Leukemia, and Acute Lymphocytic Leukemia Can be CURED by

a Combination of Natural Medicines

http://grouppekurosawa.com/blog/2007/12/acute-myeloid-leukemia-chronic-myeloid

Posted by: " mcnjnj " olde_silas@...   mcnjnj

Mon Jan 7, 2008 12:19 pm (PST)

************************

A Cure For Leukemia?

************************

My friend, Rich Folts, sent me this article on leukemia last week. I

think you'll find it interesting if this subject is part of your life:

" Monday, December 31, 2007

Acute Myeloid Leukemia, Chronic Myeloid Leukemia, and Acute Lymphocytic

Leukemia Can be CURED by a Combination of Natural Medicines This essay

is reposted from our subscription Natural Medicine blog in the public

interest.

When I was a graduate student at Berkeley in the 1980's, I attended an

International Hematology Conference in San Francisco. I overheard a

conversation between one of America's prominent hematologists and some

of his colleagues.

'What would you do if you were diagnosed with acute myeloid leukemia?'

they asked.

'I would commit suicide,' he quickly responded. Acute and chronic

myeloid leukemia (AML and CML) are largely incurable diseases. The drug

Gleevec has showed some promise in the treatment of CML, but it does not

CURE the disease. Eventually, people taking Gleevec become resistant to

the drug. When this occurs, they become susceptible to a 'blast crisis'

which invariably ends their life within months of diagnosis.

One of my friends died a horrible death from AML. He bled to death in

front of his entire family.

In 2005 a paper was published showing that the plant hormone

parthenolide induced apoptosis in AML stem and progenitor cells. This

cell death was mediated by a reduction in NF-kappaB, and an increase in

p53 activity. In some medical circles, parthenolide is now considered a

stand alone CURE for CML.

Unfortunately, parthenolide is not soluble in water thereby severely

limiting its bioavailability in the body. In December, 2007, an orally

available form of parthenolide was developed by the authors of the first

study. In tissue culture and dog studies, this orally available form of

parthenolide killed AML stem and progenitor cells and blast cells from

both CML and acute lymphocytic leukemia. Normal stem cells were not

harmed. Parthenolide is active at very low concentrations (5 microM).

Although this compound is not soluble in water, it can be introduced

topically into the body via a DMSO gel. We will discuss this protocol in

future essays.

Methyl jasmonate can induce the differentiation of AML and other

leukemic cells into normal cells. This has nothing to do with killing

stem or progenitor cells. This form of re-differentiation is well

established in the lab, but the toxicity of the chemicals prevents their

use clinically. MJ is active in the re-differentiation process at VERY

LOW concentrations, 0.4 mM.

The p53 tumor suppressor plays a critical role in the death of leukemic

stem and progenitor cells. As cited in previous essays, p53 protein

concentrations can be increased by flax lignans. Three natural

medicines, and possibly more, can kill leukemic stem and progenitor

cells and induce the re-differentiation of leukemic cells into their

normal counterpart. NO synthetic drug or drugs can accomplish these

clinical objectives. "

I wanted to pass this on so those of you interested in leukemia could

research it further. Onward and upward!