Re: Curcumin bioavailability and cancer

[Guest guest]

I've read about the poor bioavailability of curcumin so I'm taking

LifeExtensions 'Super Bio-Curcumin.' It says it has up to 7 times greater

absorption and that taking one 400 mg capsule is equivalent to taking 2,772 mg

of a typical 95% curcumin extract. I am curious as to how much I should take

though?? I've been taking 2 a day although the bottle says to take 1. I've

thought about going for 3 a day, but I don't know if I should?? I can honestly

say that, since I've been taking these pills, I have noticed a drastic

improvement in my health. I've recommended curcumin to anyone and everyone

who'll listen(most don't, but I still try). Thank you for your help.

Exerpt

Heat-Solubilized Curcumin Should Be Considered in Clinical Trials for Increasing

Bioavailability Biji T. Kurien and R. Hal Scofield

The recent article by Dhillon et al. is of great interest to those working with

curcumin. As the investigators suggest, the usefulness of curcumin could be

minimized because of its poor oral bioavailability . Data from this study show

that only 22 to 41 ng/mL were detectable in plasma even when 8 g curcumin/day

was given orally Curcumin levels in the microgram range have been shown to be

necessary to show antiproliferative effects in in vitro studies . The solution

to this problem would be to increase the solubility of curcumin before oral

administration to patients. We have shown that we could increase the solubility

of curcumin 12-fold by heating a solution of curcumin in water to boiling for 10

minutes..

------------ - --------- --------- --------- --------- --------- ----

Curcumin may Prevent Breast Cancer in Women Who Took Hormones

It's not only estrogen that can spark breast cancer. Some malignant tumors are

sensitive to the hormone progestin. And studies have shown that postmenopausal

women who took a combination of estrogen and progestin in hormone replacement

therapy (HRT) have an increased likelihood of developing progestin-fueled breast

cancer. But new research concludes a natural therapy could help. University of

Missouri researchers have found that curcumin, a popular Indian spice derived

from the turmeric root, could reduce the risk of breast cancer risk in women

exposed to HRT.

Read more at :

http://www.jmbblog.com/2009/07/cancer-alternative-treatments-digest-part-37-curc\

umin/

[Guest guest]

Our doctor says that you can take up to 9,000 mg. of Curcumin per day, without

any problem.

From: le Hall

Sent: Thursday, April 01, 2010

I've read about the poor bioavailability of curcumin so I'm taking

LifeExtensions 'Super Bio-Curcumin.'� It says it has up to 7 times greater

absorption and that taking one 400 mg capsule is equivalent to taking 2,772 mg

of a typical 95% curcumin extract. I am curious as to how much I should take

though?? I've been taking 2 a day although the bottle says to take 1. I've

thought about going for 3 a day, but I don't know if I should?? I can honestly

say that, since I've been taking these pills, I have noticed a drastic

improvement in my health. I've recommended curcumin to anyone and everyone

who'll listen(most don't, but I still try). Thank you for your help

[Guest guest]

I have also read that Curcumin / Turmeric is not easily absorbable into our

bodies when taken orally. I think that is why some products combine it with

Bromelain.

However, I wonder if a LIPOSOMAL form, which I understand is a more absorbable

form, would work? I know that there is a method on the internet on how to make

Liposomal Vitamin C using an ultrasonic tool/jewelry cleaner. Perhaps this same

method could be used to make LIPOSOMAL curcumin?

http://curezone.com/forums/fmp.asp?i=1554526

I just received my ultrasonic jewelry cleaner from Harbor Freight for $39.99

plus $9.00 for 4th class shipping to Hawaii. Got it w/in 4 weeks.

My plan was to make some liposomal Vitamin C for a friend who has cancer.

Ordered my Vitamin C powder from Vitamin Menu for $3.94 per half lb and ordered

my Non-GMO lecithin granules from Vitacost for around $8.00/lb.

Just sharing. phine

>

> I've read about the poor bioavailability of curcumin so I'm taking

LifeExtensions 'Super Bio-Curcumin.' It says it has up to 7 times greater

absorption and that taking one 400 mg capsule is equivalent to taking 2,772 mg

of a typical 95% curcumin extract. I am curious as to how much I should take

though?? I've been taking 2 a day although the bottle says to take 1. I've

thought about going for 3 a day, but I don't know if I should?? I can honestly

say that, since I've been taking these pills, I have noticed a drastic

improvement in my health. I've recommended curcumin to anyone and everyone

who'll listen(most don't, but I still try). Thank you for your help.

>

>

>

[Guest guest]

Curcumin gives me a headache worse than my daily headache yet I can eat turmeric

in food without a problem. What's up with that?

V

> From: ngitig@...

> Date: Fri, 2 Apr 2010

>

> Our doctor says that you can take up to 9,000 mg. of Curcumin per day, without

any problem.

>

>

> From: le Hall

> Sent: Thursday, April 01, 2010

>

> I've read about the poor bioavailability of curcumin so I'm taking

LifeExtensions 'Super Bio-Curcumin.'� It says it has up to 7 times greater

absorption and that taking one 400 mg capsule is equivalent to taking 2,772 mg

of a typical 95% curcumin extract. I am curious as to how much I should take

though?? I've been taking 2 a day although the bottle says to take 1. I've

thought about going for 3 a day, but I don't know if I should?? I can honestly

say that, since I've been taking these pills, I have noticed a drastic

improvement in my health. I've recommended curcumin to anyone and everyone

who'll listen(most don't, but I still try). Thank you for your help

[Guest guest]

Curcumin aka Turmeric is a great anti-cancer supplement. A little expensive, but

not too bad.

The Life Extension 'Super Bio-Curcumin' looks very interesting. Says its equal

to 2772 mg's of a 95% curcumin extract. That's what I took, Dr's Best brand

w/Bioperene.

Dr's Best -

http://www.iherb.com/Doctor-s-Best-Best-Curcumin-C3-Complex-500-mg-120-Capsules/\

13?at=0

or http://bit.ly/ciGQJf

For a few dollars more, the Super Bio-Curcumin seems worth it.

>

> I've read about the poor bioavailability of curcumin so I'm taking

LifeExtensions 'Super Bio-Curcumin.' It says it has up to 7 times greater

absorption and that taking one 400 mg capsule is equivalent to taking 2,772 mg

of a typical 95% curcumin extract. I am curious as to how much I should take

though?? I've been taking 2 a day although the bottle says to take 1. I've

thought about going for 3 a day, but I don't know if I should?? I can honestly

say that, since I've been taking these pills, I have noticed a drastic

improvement in my health. I've recommended curcumin to anyone and everyone

who'll listen(most don't, but I still try). Thank you for your help.

>

[Guest guest]

My full notes:

CURCUMIN (main active ingredient in turmeric) is 1 of the top cancer-healing

herbs.

Properties:

Curcumin's a COX-2, 5-LO, and and NFK-β inhibitor; antimetastatic,

antiinflammatory, antioxidant, antifungal, antibacterial, antiviral,

antiallergenic, anti-spasmodic, carminative, diuretic, and anti-angiogenic;

induces apoptosis, enhances immunity; depletes iron (a benefit for cancer

patients).

Efficacy w/particular types of cancer:

“Curcumin eliminates human tumor cells such as melanoma, glioma, and

others†(Chen et al., 2005; Deeb et al., 2004; Dhandapani et al., 2007;

Karmakar et al., 2006; Marin et al., 2007; Shishodia et al., 2007).â€

Curcumin's especially effective w/ER+ breast cancer, myeloma

(http://beating-myeloma.org/search/node/curcumin), melanoma, pancreatic, colon

and perhaps also prostate (particularly in high dosage)

(www.herbalfields.com/c7.html) cancer, and (in dose dependent manner) chronic

myeloid leukemia (CML). Also effective w/brain (www.brain-treatments.net) and

esophageal (www.medicalnewstoday.com/articles/168987.php;

www.news24.com/Content/SciTech/News/1132/23a16a18d89646c9b7379ea0b3d43eb6/28-10-\

2009-08-13/Scientists_Curry_kills_cancer) cancer. Effective w/glioma; " Curcumin

can cross the BBB. " " Bharat Aggarwal [from] M.D. ...reporting that

curcumin blocks most of the mechanisms by which prostate cancer cells survive

and grow...`The potential is unlimited,' says Aggarwal….clinical studies [on]

curcumin in treating colorectal cancer…myeloma "

www.alternet.org/healthwellness/79774/?page=entire

" medulloblastoma...curcumin enhances the killing efficiency of nontoxic doses of

cisplatin and gamma-rays " (Elamin MH et al., " Curcumin inhibits the Sonic

Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells " _Mol

Carcinog_ 2009).

Dosage: May need to take at least 3.6g of curcumin to achieve anticancer effect;

I've seen 10g of curcumin recommended for melanoma; " [Dr.] Aggarwal notes that

clinical studies have found that a daily dose of up to 12 grams (about a

tablespoon) a day for three months is safe "

(www.alternet.org/healthwellness/79774/?page=entire; for more info,

www.breastcancerchoices.org/curcumin.html).

“Dr. Bharat Aggarwal of MD …www.curcuminresearch.org…

1 g/day for week one; if no side effects then,

2 g/day for week…4 g/day for week…8 g/day for week four; for eight weeks

(can be split into three separate doses)…After 8 weeks, if no improvement is

noted, curcumin is less likely to do anything for youâ€

www.inspire.com/groups/advanced-breast-cancer/discussion/curcumin-dosage-recomme\

ndations

Brands and administration:

Eat it w/fat (e.g., coconut milk or yogurt). Take a brand that contains

(bio)piperine (which makes it 2000% more bioavailable). (I also heard " If you

take the powdered curcumin, get the straight curcumin (not mixed with turmeric)

and take it with coconut oil...or some sort of fat. " ). Curcumin vaseline was

effective (and reduced pain) w/squamous cell and ulcerating oral cancers

Use a good brand of curcumin, such as

Turmeric Extract (www.sourcenaturals.com/products/GP1301/Source Naturals)

www.thorne.com/media/Meriva_Curcumin_Phytosome.pdf

www.afisupplements.com (apparently recommended by Dr. Aggarwal)

Master herbalist Yance makes Botanical Treasure

(www.NaturaHealthProducts.com); I imagine it’s spectacular. For info,

http://mercola.fileburst.com/PDF/ExpertInterviewTranscripts/InterviewDonnieYance\

..pdf

Liposomal curcumin is available from www.letstalkhealth.com

Nanocurcumin's available from www.theravalues.com (in Japan; apparently

recommended by Dr. Aggarwal)

I would use curcumin, not turmeric, but FYI, the best brand of TURMERIC I know

of is www.newchapter.com/products/TurmericForce

Indications:

According to Block, M.D. (2009), curcumin’s indicated for almost all

cancer patients in almost all situations (except for Contraindications below). I

would particularly take it at the time of surgery (and for at least a month

afterward), since it’s antimetastatic.

Side effects on contraindications (see also under chemo section below):

Generally “no side effects [from] high doses of Curcumin; rare cases of

stomach upset or diarrhoea may be resolved by temporarily reducing the dosage

and taking with food….Do not use Curcumin if you suffer from gallstones or a

blocked bile ductâ€

Interaction w/other natural supplements:

curcumin's synergistic w/genistein (in fermented soy), green tea, & bromelain.

Interactions w/chemo:

" curcumin inhibited camptothecin-, mechlorethamine-, and doxorubicin-induced

apoptosis of...breast cancer "

www.cancerres.aacrjournals.org/contents-by-date.0.shtml (abstract 62/13/3868)

" Curcumin....can diminish the usefulness of certain...drugs " (Gammill,

10/12/03), such as cytoxan.

" While curcumin is a SAPK inhibitor it does...things...beneficial during

chemo...lowers NF-kappaB...an important factor in drug resistance [MDR]

[www.denvernaturopathic.com/news/multidrugresistance.html]...At least...with

doxorubicin, 5-FU, cisplatin and Paclitaxel....curcumin [made] myeloma...more

sensitive to...Vincristine and melphalan....reduced drug resistance to

Vincristine [in other types of cancer]....increased the effect doxorubicin, 5-FU

and Paclitaxel in a dose dependent manner [in] prostate

cancer....reduced...resistance to cisplatin [for] fibrosarcoma...elevated liver

enzymes normalized....drug resistance in ovarian cancer...reduced....reduce

IL-6....cancer cells resistant to doxorubicin were sensitized...after treatment

with curcumin. I...encourage its use with prostate, ovarian and maybe other

cancers. [May enhance effects of] Cisplatin, 5-FU, Vincristine and

Paclitaxel....may be best used to sensitize cancer cells before chemo is begun "

www.denvernaturopathic.com (Curcumin Update #2 12/14/03)

For more info,

www.lef.org/magazine/mag2002/jul2002_report_curcumin_01.html

www.turmeric-curcumin.com

www.curcuminresearch.org (Dr. Bharat Aggarwal of MD )

http://margaret.healthblogs.org/life-with-myeloma/discovery-of-curcumin

www.breastcancerchoices.org/curcumin.html

www.p2preactor.com/article4986.html

www.1to1vitamins.com/news/2005/artl5877.html (prevents lung mets in BC)

www.yourmedicaldetective.com/public/770.cfm (prevents lung mets in BC)

www.anticancerways.com ( " Turmeric and black pepper fight cancer stem cells " by

Servan-Schreiber, M.D., PhD; BC)

http://linkinghub.elsevier.com/retrieve/pii/S0944711309001184 (BC)

www.brain-treatments.net (links to studies)

[Guest guest]

It needs to be cooked to digest well. My yoga master taught us that 40 years

ago.

GB

>

> Curcumin gives me a headache worse than my daily headache yet I can eat

turmeric in food without a problem. What's up with that?

>

> V

>

> > From: ngitig@...

> > Date: Fri, 2 Apr 2010

> >

> > Our doctor says that you can take up to 9,000 mg. of Curcumin per day,

without any problem.

> >

> >

> > From: le Hall

> > Sent: Thursday, April 01, 2010

> >

> > I've read about the poor bioavailability of curcumin so I'm taking

LifeExtensions 'Super Bio-Curcumin.'� It says it has up to 7 times greater

absorption and that taking one 400 mg capsule is equivalent to taking 2,772 mg

of a typical 95% curcumin extract. I am curious as to how much I should take

though?? I've been taking 2 a day although the bottle says to take 1. I've

thought about going for 3 a day, but I don't know if I should?? I can honestly

say that, since I've been taking these pills, I have noticed a drastic

improvement in my health. I've recommended curcumin to anyone and everyone

who'll listen(most don't, but I still try). Thank you for your help

>

[Guest guest]

>that Curcumin / Turmeric is not easily absorbable into our bodies when taken

orally

UNLESS taken w/biopiperine (black pepper extract).

>Think I read that the key to absorbing the turmeric is to use black pepper

along with it.

Not black pepper, but the black pepper extract biopiperine.

Just check the label of your curcumin supplement to make sure it contains it.

Liposomal curcumin (which I imagine is the most powerful form) is available from

www.letstalkhealth.com

Also, my guess is that 1 of the best combination products for healing cancer is

Symplex C (liposomal resveratrol, curcumin, CoQ10, vit. C, glutathione) from

Letstalkhealth.com

Leonard

[Guest guest]

Ok that leads me to a question. I assume this is similar to maijuana. Therefore

heating it in milk to make a tea would do it then?

Cheri

> It needs to be cooked to digest well. My yoga master taught us that 40

> years ago.

>

[Guest guest]

I would thing it depends on the tincture. Alcohol or vinegar would be better

than powder and would make the powder more bioavailable. I often use turmeric

in an Indian pickle.

GB

>

> I tinctured it; does this work as well as the powder or fresh root?

> Sanr

>

>

>

>

> It needs to be cooked to digest well. My yoga master taught us that 40

> years ago.

>

> GB

>

[Guest guest]

It does work better when cooked in oil but you can also cook it in water. It

needs to be cooked to increase the bioavailability. There is a recipe for the

joints called Golden Milk. To make it, the turmeric powder needs to be cooked

with water in a paste for at leasst 8 min. a fourth of a tsp. of paste is

added to milk and heated. A tsp. of almond oil is added with a pinch or

cinammon or nutmeg on top. Honey can be added for flavor.

GB

> It needs to be cooked to digest well. My yoga master taught us that 40

> years ago.

>

[Guest guest]

UCLA has a study on this.

GB

> > It needs to be cooked to digest well. My yoga master taught us that 40

> > years ago.

> >

>

>

>

>

>

>

[Guest guest]

I have a 500 mg. curcumin/bioperine capsule from Best. Do you all think those

are okay to take? I'm sure the natural form is always best, but if the capsules

are effective then I prefer those.

> It needs to be cooked to digest well. My yoga master taught us that 40

> years ago.

>

[Guest guest]

Here is a cheaper way and better for you . 1lb.of turmic add 1oz of ground

black pepper. take a 1/2 tsp. 3X aday. the piperine in black pepper makes the

curcumin more bio-available.

Taking it this way; the cost is fractional of that of capsule .A 10 month

supply will cost about the same as one month supply of capsules . Also you have

better quality control.