Re: High-dose FSO strategy - diet

[Guest guest]

Cachexia is a greater problem than diet. A person can have very

little tumor load and still have cachexia. You have to take a

multi-prong approach.

Lactic acid isn't always such a bad thing. Sometimes it can be

trapped in the cancer cell much to the regret of the cancer

cell..!! Quercetin can help accomplish this.

Distortive diets can be great for buying time, but don't depend on

them for a cure. Dietary extremes can be a great first stab at a

high SUV cancer.

At 05:07 AM 5/8/2010, you wrote:

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>,

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>I'm wondering, with respect to high PET SUV cancers:

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>Instead of flaxseed oil, do you think high percentage of MCT oil,

>coconut oil, butter, some fish oil plus moderate amounts of protein and

>very little carbohydrates would be a better way to rob cancer cells of

>their main energy source? ie. a ketogenic diet. In severe cases, even

>going the whole hog for a shorter period of time and mainly eating only

>these fats?

>

>I'd think you'd at least be able to put brakes on cachexia and reduce

>lactic acid produced by cancer cells.

[Guest guest]

,  How many ct scans have you had?

Thanks,  Robyn

________________________________

[Guest guest]

I wanted to reply to the various postings on treatment approaches using

flaxseed oil (FSO).

It has been known for decades that omega-3 fats such as alpha-linolenic

acid (ALA), the main component of flaxseed oil (FSO), have anticancer

effects. I knew an advanced prostate cancer patient who kept his

cancer at bay for 10 years incorporating, among other agents, two ounces

of flaxseed oil into his daily smoothie, and it seems that some roughly

5-10% of patients who use this approach do gain significant anticancer

benefits.

There is a recently published report that at very high blood levels of

agents such as ALA, something very different and dramatic occurs, which

is total kill of every cancer cell. This was found using an advanced,

90% clinically predictive assay technique using fresh human tumors of

five cancer types. The only two clinical trials that ever achieved

such very high doses of this class of agents using local administration

in the vicinity of tumor achieved tumor shrinkage, and the results were

dramatic in one of these two clinical studies (for glioblastoma).

There is a new approach being clinically tested to achieve these very

high levels of ALA, the level that appears could actually totally kill

tumor anywhere in the body, using FSO at a high but tolerable dose, with

a biological trick using fasting, exercise, and caffeine to mobilize the

ALA from inert to active form for the hours necessary to penetrate

cancer cell membranes. There would be a greater chance of success for

a patient who could undergo the 90-minute period of moderate exercise

that would significantly boost free fatty acid levels, but without

exercise, extending the fast period from 8 to 12 or more hours may be

able to be successful. See www.ufachallenge.org

<http://www.ufachallenge.org> , username " membrane " , password " effect " ,

for details about this approach, which can be pursued independently by

any patient.

So once again, this finding about total tumor kill by ALA and other

omega-3 fatty acid agents at a very high dosage is new, and is a very

different effect than the anticancer effects at lower doses, which can

be beneficial, but without a " home run " effect, as has

accurately noted. The various biological hypotheses about how lower

dose ALA may kill cancer cells do not appear to apply to this high dose

(it seems to be a membrane fluidization and destabilization effect that

is involved). It remains to be seen whether this new very high dose

approach will truly work with human patients, but the scientific method

holds forth the possibility of either success or failure based upon

objective testing. We will know more in time which outcome actually

occurs. -

[Guest guest]

Isn t fish oil a better source of ALA than flax oil?

Louise

[Guest guest]

Hi Louise - This is a good question. There have been mixed results for

in vitro studies of anticancer activity of various omega-3 fatty acids,

with some indicating stronger effect by DHA and EPA, components of fish

oil, versus ALA (alpha-linolenic acid), the main component of flaxseed

oil (55%), and others showing equally strong effect by both. In my own

recently published study (http://www.lipidworld.com/content/8/1/54

<http://www.lipidworld.com/content/8/1/54> ) with an advanced assay

system that has been found 90% clinically predictive, using fresh human

tumor specimens, all of these had roughly the same anticancer activity.

Fish oil, however, contains a significantly higher percentage of

saturated fatty acids than flaxseed oil, the latter containing only 10%.

Saturated fatty acids are molecules with compact shapes (figuratively,

like a clothes-pin), versus unsaturated fatty acids, such as DHA, EPA,

and ALA, which are larger molecules (like a shuttlecock). Unsaturated

fatty acids seem to kill cancer cells by disrupting the cell membrane,

making it permeable - saturated fatty acids act counter to that by

stabilizing the cell membrane. Thus keeping a low percentage of

saturated fatty acids is important.

Finally, there is a key issue of balancing efficacy and safety. I have

known many patients who for various reasons have ingested eight ounces

of flaxseed oil over the course of a few minutes with no adverse

effects, and I've tried this myself. DHA could possibly have a more

potent anticancer effect, but could be harmful to normal cells at very

high doses as well. ALA is a more common molecule in the human diet,

and it seems likely that normal cells would be more likely to handle

extremely high serum levels with no adverse effects. -

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> Isn t fish oil a better source of ALA than flax oil?

>

> Louise

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