Re: High-dose FSO strategy

[Guest guest]

Thanks ,

I was waiting for you to weigh in on this. Are you also saying that you do not

like the FOCC diet altogether?

How are you feeling? Is everything ok at your end of the world?

Nili

[ ] High-dose FSO strategy

This diet is built on a house of cards. It is a

proposal to use exceedingly high doses of flax

seed oil with extremely high doses of caffeine,

over exertion in exercise, along with short

starvation fasts. Anyone can attempt it as there

is nothing that is controlled or

prescriptive. The cancer patients who tried this

for a single day apparently chose not to continue

and opted for chemo instead, and died.

I have often wondered why Budwig strongly

discouraged high doses of flax oil. Her

experience was not one of making proposals of

therapy, but of clinical practice of some, what,

60 years? She administered FSO all her life to

many thousands of patients and died in her

ninties. Not only was she credible but FSO (with

sulfur) in medicine was used continually for over

300 years before she popularized its use for cancer.

Flax seed oil consists of unsaturated oils

(mostly omega-3) in the form of

triglycerides. This means that digestion of each

mole of triglyceride yields a mole of glycerol

which is a cancer-feeding triose. Glycerol does

not seem to be unhealthy for those who are free

of chronic disease. The problems of glycerol and

cancer seems to be primarily one of the high

concentration of aquaglyceroporins in cancer cells. (See Below.)

Any distortive diet such as this will selectively

kill only those cancer cells that it can kill --

perhaps only those with low membrane

concentrations of glycerol-gobbling

aquaglyceroporins. It would thus share a common

feature with most chemotherapies: immediate

shrinkage followed by growth. The abstract below

suggests a more interesting strategy might be to

target the aquaporins, but even then one must

look at the prevalence and function of aquaporins

on any high-value real estate in the body, e.g.,

brain cortex, retina, pancreas, etc.

I am sorry that so often I can't get caught up in

everyone's flights of fancy, but it is only after

you throw out the garbage can you find the good

stuff. The devil is in the details.

Aquaporins­new players in cancer biology

Journal of Molecular Medicine

PublisherSpringer Berlin / Heidelberg

ISSN0946-2716 (Print) 1432-1440 (Online)

Volume 86, Number 5 / May, 2008

A. S. Verkman1 Mariko Hara-Chikuma1, 2 and s C. Papadopoulos1, 3

(1) Departments of Medicine and Physiology,

University of California, 1246 Health Sciences

East Tower, San Francisco, CA 94143-0521, USA

(2) Department of Dermatology, Graduate School

of Medicine, Kyoto University, Kyoto, Japan

(3) Academic Neurosurgery Unit, St. 's,

University of London, London, UK

Abstract The aquaporins (AQPs) are small,

integral-membrane proteins that selectively

transport water across cell plasma membranes. A

subset of AQPs, the aquaglyceroporins, also

transport glycerol. AQPs are strongly expressed

in tumor cells of different origins, particularly

aggressive tumors. Recent discoveries of AQP

involvement in cell migration and proliferation

suggest that AQPs play key roles in tumor

biology. AQP1 is ubiquitously expressed in tumor

vascular endothelium, and AQP1-null mice show

defective tumor angiogenesis resulting from

impaired endothelial cell migration.

AQP-expressing cancer cells show enhanced

migration in vitro and greater local tumor

invasion, tumor cell extravasation, and

metastases in vivo. AQP-dependent cell migration

may involve AQP-facilitated water influx into

lamellipodia at the front edge of migrating

cells. The aquaglyceroporin AQP3, which is found

in normal epidermis and becomes upregulated in

basal cell carcinoma, facilitates cell

proliferation in different cell types.

Remarkably, AQP3-null mice are resistant to skin

tumorigenesis by a mechanism that may involve

reduced tumor cell glycerol metabolism and ATP

generation. Together, the data suggest that AQP

expression in tumor cells and tumor vessels

facilitates tumor growth and spread, suggesting

AQP inhibition as a novel antitumor therapy.

For more on aquaporins by the same author, see:

http://jeb.biologists.org/cgi/content/full/212/11/1707

Journal of Experimental Biology 212, 1707-1715 (2009)

Review Article

Aquaporins: translating bench research to human disease

A. S. Verkman

[Guest guest]

,

I'm wondering, with respect to high PET SUV cancers:

Instead of flaxseed oil, do you think high percentage of MCT oil,

coconut oil, butter, some fish oil plus moderate amounts of protein and

very little carbohydrates would be a better way to rob cancer cells of

their main energy source? ie. a ketogenic diet. In severe cases, even

going the whole hog for a shorter period of time and mainly eating only

these fats?

I'd think you'd at least be able to put brakes on cachexia and reduce

lactic acid produced by cancer cells.

>

> Flax seed oil consists of unsaturated oils

> (mostly omega-3) in the form of

> triglycerides. This means that digestion of each

> mole of triglyceride yields a mole of glycerol

> which is a cancer-feeding triose. Glycerol does

> not seem to be unhealthy for those who are free

> of chronic disease. The problems of glycerol and

> cancer seems to be primarily one of the high

> concentration of aquaglyceroporins in cancer cells. (See Below.)

>

> Any distortive diet such as this will selectively

> kill only those cancer cells that it can kill --

> perhaps only those with low membrane

> concentrations of glycerol-gobbling

> aquaglyceroporins. It would thus share a common

> feature with most chemotherapies: immediate

> shrinkage followed by growth. The abstract below

> suggests a more interesting strategy might be to

> target the aquaporins, but even then one must

> look at the prevalence and function of aquaporins

> on any high-value real estate in the body, e.g.,

> brain cortex, retina, pancreas, etc.

>

>

[Guest guest]

The FSO strategy is a good one that has helped many people, but it is

not a panacea. I do think those who consider it should read up on

Budwig's whole program and then make decisions re personal

modifications. There are purists/fundamentalists who believe that

one should do things exactly as she did. I am not one of

those. Science has to march on.

As to my own health, I feel almost absolutely normal as if I have

never had cancer. There is still some rectal fibrosis. The

oncologist was concerned about a spot in my lung, but I put down my

foot -- no more CT scans. I'll deal with this in other ways if

necessary. I've regained 18 lbs and avoided all surgery.

I am getting as healthy as I can as quickly as I can as the smart

move is to assume that future holds another big battle for me. God's

on the side of the big battalions and it is the big battalions that I

am assembling. I feel a somewhat like the military commander who has

a lot of new tools and looks forward to the next battle to see how

well they work. Sick, huh?

The number one lesson that I personally learned from the cancer

experience is that there is no time or energy for research or lab

work while one's health is suffering such a devastating

beating. Right now though the only thing I am worried about is my

Lakers and the outcome of the NBA playoffs. The Eastern Conference

has too many great teams -- Celtics, Cavaliers, Magic -- life is so hard..!!

At 05:04 AM 5/8/2010, you wrote:

>

>Thanks ,

>I was waiting for you to weigh in on this. Are you also saying that

>you do not like the FOCC diet altogether?

>How are you feeling? Is everything ok at your end of the world?

>Nili

[Guest guest]

, I am so glad to hear that you are doing well and getting your energy

back. Also glad to hear of your weight gain. As we all know the loss or gain

of weight is quite an indicator as to how well you are doing in your fight

against cancer. I don't think there is any such thing as a panacea where cancer

is concerned and as we have all learned it affects different people in different

ways and the same holds true for the methods we try to employ in dealing with

it. I am glad to hear though that you are not against the FOCC in principle.

As you said, cancer is a battle and we need to accumulate tools and weapons to

deal with it and if each item we add is an additional weapon then the more we

can hope to achieve a manageable state of illness and health.

I noticed that in another post you touched on the issue of cachexia. The only

thing that I have found to deal with cachexia is Hydrazine Sulfite. Is there

anything else that you know of and recommend to deal with that awful part of

this disease?

Regards,

Nili

From: VGammill

Sent: Saturday, May 08, 2010 2:47 PM

Subject: Re: [ ] High-dose FSO strategy

The FSO strategy is a good one that has helped many people, but it is

not a panacea. I do think those who consider it should read up on

Budwig's whole program and then make decisions re personal

modifications. There are purists/fundamentalists who believe that

one should do things exactly as she did. I am not one of

those. Science has to march on.

As to my own health, I feel almost absolutely normal as if I have

never had cancer. There is still some rectal fibrosis. The

oncologist was concerned about a spot in my lung, but I put down my

foot -- no more CT scans. I'll deal with this in other ways if

necessary. I've regained 18 lbs and avoided all surgery.

I am getting as healthy as I can as quickly as I can as the smart

move is to assume that future holds another big battle for me. God's

on the side of the big battalions and it is the big battalions that I

am assembling. I feel a somewhat like the military commander who has

a lot of new tools and looks forward to the next battle to see how

well they work. Sick, huh?

The number one lesson that I personally learned from the cancer

experience is that there is no time or energy for research or lab

work while one's health is suffering such a devastating

beating. Right now though the only thing I am worried about is my

Lakers and the outcome of the NBA playoffs. The Eastern Conference

has too many great teams -- Celtics, Cavaliers, Magic -- life is so hard..!!

At 05:04 AM 5/8/2010, you wrote:

>

>Thanks ,

>I was waiting for you to weigh in on this. Are you also saying that

>you do not like the FOCC diet altogether?

>How are you feeling? Is everything ok at your end of the world?

>Nili

[Guest guest]

Hi - Just to be clear, this is not a diet, any more than a 3-day

regimen of the high dose antibiotic Cipro is a " diet " . This is an

investigational protocol based on new scientific findgs, e.g., see the

Das, Leaver, , and other papers cited in the web site, and some of

the other articles reviewed in the second and third cited papers.

These findings indicate that very high doses of UFAs are needed to kill

tumor cells, and when that concentration thresshold is reached, dramatic

tumor kill occurs. The fasting, exercise and caffeine used constitute a

biological trick to convert inert, albumin bound form of serum free

fatty acids to unbound, active form (see the cited papers on up to

8-fold boosts of unbound serum free fatty acids using this combination.)

The postulated mechanism of action for tumor kill at these high doses

appears to be very different than that considered in previous scientific

studies for UFA effects at lower doses and different than the theories

of Johanna Budwig. (By the way, I called her some 15 years ago and

asked her what percentage of patients using her approach were cured.

She told me " all of them, " which clearly is not true, from my experience

tracking complementary cancer treatments over the years. Omega three

fatty acids at lower doses have well established general anticancer

effects, but the percentage of cancer patients who have gained dramatic

benefits from lower dose ongoing ingestion seems more like 5-10%, from

my experience.) In summary, this is a protocol based on emerging

results in a niche field of science that, anomolously, can be carried

out through available dietary agents. It is really important to read

the underlying scientific results before assessing this. -

>

> This diet is built on a house of cards. It is a

> proposal to use exceedingly high doses of flax

> seed oil with extremely high doses of caffeine,

> over exertion in exercise, along with short

> starvation fasts. Anyone can attempt it as there

> is nothing that is controlled or

> prescriptive. The cancer patients who tried this

> for a single day apparently chose not to continue

> and opted for chemo instead, and died.

>

> I have often wondered why Budwig strongly

> discouraged high doses of flax oil. Her

> experience was not one of making proposals of

> therapy, but of clinical practice of some, what,

> 60 years? She administered FSO all her life to

> many thousands of patients and died in her

> ninties. Not only was she credible but FSO (with

> sulfur) in medicine was used continually for over

> 300 years before she popularized its use for cancer.

>

> Flax seed oil consists of unsaturated oils

> (mostly omega-3) in the form of

> triglycerides. This means that digestion of each

> mole of triglyceride yields a mole of glycerol

> which is a cancer-feeding triose. Glycerol does

> not seem to be unhealthy for those who are free

> of chronic disease. The problems of glycerol and

> cancer seems to be primarily one of the high

> concentration of aquaglyceroporins in cancer cells. (See Below.)

>

> Any distortive diet such as this will selectively

> kill only those cancer cells that it can kill --

> perhaps only those with low membrane

> concentrations of glycerol-gobbling

> aquaglyceroporins. It would thus share a common

> feature with most chemotherapies: immediate

> shrinkage followed by growth. The abstract below

> suggests a more interesting strategy might be to

> target the aquaporins, but even then one must

> look at the prevalence and function of aquaporins

> on any high-value real estate in the body, e.g.,

> brain cortex, retina, pancreas, etc.

>

> I am sorry that so often I can't get caught up in

> everyone's flights of fancy, but it is only after

> you throw out the garbage can you find the good

> stuff. The devil is in the details.

>

>

>

>

> Aquaporins­new players in cancer biology

>

> Journal of Molecular Medicine

> PublisherSpringer Berlin / Heidelberg

> ISSN0946-2716 (Print) 1432-1440 (Online)

> Volume 86, Number 5 / May, 2008

>

> A. S. Verkman1 Mariko Hara-Chikuma1, 2 and s C. Papadopoulos1, 3

> (1) Departments of Medicine and Physiology,

> University of California, 1246 Health Sciences

> East Tower, San Francisco, CA 94143-0521, USA

> (2) Department of Dermatology, Graduate School

> of Medicine, Kyoto University, Kyoto, Japan

> (3) Academic Neurosurgery Unit, St. 's,

> University of London, London, UK

>

> Abstract The aquaporins (AQPs) are small,

> integral-membrane proteins that selectively

> transport water across cell plasma membranes. A

> subset of AQPs, the aquaglyceroporins, also

> transport glycerol. AQPs are strongly expressed

> in tumor cells of different origins, particularly

> aggressive tumors. Recent discoveries of AQP

> involvement in cell migration and proliferation

> suggest that AQPs play key roles in tumor

> biology. AQP1 is ubiquitously expressed in tumor

> vascular endothelium, and AQP1-null mice show

> defective tumor angiogenesis resulting from

> impaired endothelial cell migration.

> AQP-expressing cancer cells show enhanced

> migration in vitro and greater local tumor

> invasion, tumor cell extravasation, and

> metastases in vivo. AQP-dependent cell migration

> may involve AQP-facilitated water influx into

> lamellipodia at the front edge of migrating

> cells. The aquaglyceroporin AQP3, which is found

> in normal epidermis and becomes upregulated in

> basal cell carcinoma, facilitates cell

> proliferation in different cell types.

> Remarkably, AQP3-null mice are resistant to skin

> tumorigenesis by a mechanism that may involve

> reduced tumor cell glycerol metabolism and ATP

> generation. Together, the data suggest that AQP

> expression in tumor cells and tumor vessels

> facilitates tumor growth and spread, suggesting

> AQP inhibition as a novel antitumor therapy.

>

> For more on aquaporins by the same author, see:

> http://jeb.biologists.org/cgi/content/full/212/11/1707

> Journal of Experimental Biology 212, 1707-1715 (2009)

>

> Review Article

>

> Aquaporins: translating bench research to human disease

> A. S. Verkman

>

>

>

>

[Guest guest]

Hi - Yes, I agree with your assessment of Budwig's approach and

attitude. If she were achieving close to 100% results, then this could

be established in a study with a small number of patients. With so

much more activity during this past decade in academic study of

complementary medicine, I believe that someone would have performed such

a study and published the results were this the case. (But Sanr, if you

are trying her protocol now and there is no need to make an immediate

evaluation and decision as to other options, by all means pursue it

earnestly, with the possibity that it could yield major or partial

benefits. Well-motivated patients who pursue multiple health-promoting

stategies can have excellent results.)

, I agree with you that under ordinary circumstances, caffeine in

doses of hundreds of miligrams would be undesirable for a cancer patient

or anyone. It's specific function in this regimen is to increase free

fatty acid levels and also, as a calcium ionophore, to promote influx of

calcium into cells, the hypothesized final step in cell death for cancer

cells with membranes compromised by high-dose unsaturated fatty acids.

And the exercise component would not be possible for many cancer

patients (although it's possible that a longer fast period in lieu of

exercise could yield successful results). If this protocol were to

prove successful for those patients able to try it, it is likely that

ultimately other components such as intravenous heparin, which also

boosts free fatty acid levels, could be substituted for it.

What is appealing about this protocol is the possibility of achieving

dramatic results in a short period, and the ability to make a clear

deterimination within a short period whether it succeeded or failed. -

[Guest guest]

wrote:

The postulated mechanism of action for tumor kill at these high doses

appears to be very different than that considered in previous scientific

studies for UFA effects at lower doses and different than the theories

of Johanna Budwig

But what were the theories of J. Budwig? I have read that she sees the human

body as an antenna capable of receiving vital electrons if polyunsaturated

fatty acids are correctly adjusted. It is exoteric and i cannot understand

this.Also, are you sure she used UFA at lower doses?

I read she used ELDI (it means " electron differentiation " )oil enemas (but I

do not know the dosage and even if an oil enema is possible), daily rubbing of

Eldi oils, flax seeds oil mayonnaise, and then

a lot of grounded flax seed , glasses of champagne( nice idea, but the

alcohol??) with grounded flax seeds ecc. Flax seeds have anticancer effect

because of lignans, too...

karla