Treating low SHBG please help

[Guest guest]

Hi guys,

I hope everyone is doing well. I want to know if anybody on the group has been

able to successfully treat low shbg, With low SHBG i am not habing any

improvement in my libido or ED even after taking HCG for two months. Now it

seems i am developing gynecomastia . I have a normal thyroid function and my

fasting insuln levels are also normal so the most common indicators for low SHBG

are also normal. In effect i have an untreatable case of secoundary hypogonadism

at a ripe old age of 26. According to the endo the low levels of shbg lead to

higher levels of free estrogens and limit the effect of free test which is

destroyed much quickly. The higher levels of fee estradiol are causing the

gynecomastia. After taking HCG for two months my total test was 748 and

estradiol at 35, SHBG was at 11 (range14- 70). Throid, Adrenals were also

normal. I would like to mention that i had Pre-Diaetes before starting TRT with

the Fasting Blood Sugar at 107. After TRT the FBS

came down to 93. Please help me in curing my ailment.

..

[Guest guest]

I thought SHBG had much higher affinity for testosterone than estradiol?

What level of hCG were you taking? ~2500 U/l per week?

should be no more than 250-500 every 3 days if taking it more than few months or

e2 will rise dramatically - of course some people struggle with e2 even still

>

> Hi guys,

> I hope everyone is doing well. I want to know if anybody on the group has been

able to successfully treat low shbg, With low SHBG i am not habing any

improvement in my libido or ED even after taking HCG for two months. Now it

seems i am developing gynecomastia . I have a normal thyroid function and my

fasting insuln levels are also normal so the most common indicators for low SHBG

are also normal. In effect i have an untreatable case of secoundary hypogonadism

at a ripe old age of 26. According to the endo the low levels of shbg lead to

higher levels of free estrogens and limit the effect of free test which is

destroyed much quickly. The higher levels of fee estradiol are causing the

gynecomastia. After taking HCG for two months my total test was 748 and

estradiol at 35, SHBG was at 11 (range14- 70). Throid, Adrenals were also

normal. I would like to mention that i had Pre-Diaetes before starting TRT with

the Fasting Blood Sugar at 107. After TRT the FBS

> came down to 93. Please help me in curing my ailment.

> .

>

>

>

>

>

>

[Guest guest]

I thought SHBG had much higher affinity for testosterone than estradiol?

What level of hCG were you taking? ~2500 U/l per week?

should be no more than 250-500 every 3 days if taking it more than few months or

e2 will rise dramatically - of course some people struggle with e2 even still

>

> Hi guys,

> I hope everyone is doing well. I want to know if anybody on the group has been

able to successfully treat low shbg, With low SHBG i am not habing any

improvement in my libido or ED even after taking HCG for two months. Now it

seems i am developing gynecomastia . I have a normal thyroid function and my

fasting insuln levels are also normal so the most common indicators for low SHBG

are also normal. In effect i have an untreatable case of secoundary hypogonadism

at a ripe old age of 26. According to the endo the low levels of shbg lead to

higher levels of free estrogens and limit the effect of free test which is

destroyed much quickly. The higher levels of fee estradiol are causing the

gynecomastia. After taking HCG for two months my total test was 748 and

estradiol at 35, SHBG was at 11 (range14- 70). Throid, Adrenals were also

normal. I would like to mention that i had Pre-Diaetes before starting TRT with

the Fasting Blood Sugar at 107. After TRT the FBS

> came down to 93. Please help me in curing my ailment.

> .

>

>

>

>

>

>

[Guest guest]

Can you post your labs with the range and units this helps people here to see a

better picture of what is going on. Also are you on just HCG alone for most men

secondary like myself we don't do so well.

I do both like Dr. Shippen (The Testosterone Syndrome) book he started doing

shots every 3 days to keep is estrogen's or Estradiol E2 this is the bad guy

down.

I started doing this with my Dr. I eat up the T shots as fast a I do them so I

do 70 mgs of 200mgs/ml of Depo T every 3 days and shoot HCG 400 IU's the 2 days

each in between my T shots this helps me stay leveled and holds down my high

Estradiol levels. I also use Arimidex to keep Estradiol down taking .25 mgs of

1/4 of a one mg pill every other day.

I do my shots into my thigh using a small 27g 1ml x 1/2 " lg. needle so I do a

shot every day. After 25 yrs of being told I am Primary adding HCG to my TRT my

levels doubled and I finely felt good. We also did an MRI on my Pituitary you

can read my story at this link.

http://forums.realthyroidhelp.com/viewtopic.php?f=5 & t=9239

What is wrong with my pituitary is due to a head injury from an auto accident

some 26 yrs ago. Once we started treating all the low normal labs on Cortisol,

Thyroid, Iron and more I started feeling better.

I can't help but feel the reason I need heart bypass surgery was do to all the

yrs. of not treating my low hormones. I just got out of the hosp. I was on my

back 15 weeks out cold the bypass went bad I died 5 times and had 5 surgery's.

My SHBG is 20 now with a lower number you need to keep your E2 down to about 15.

Doing HCG alone for me gave me big problems with E2 levels I was taking a 1mg

pill a day of arimidex and this was just keeping me at 30 pg/ml.

One thing you can do is to to this site and click on no's nick the click on

read all his posts. This Dr. went to this site some yrs. ago to get input for

the guys on there low T. Here is a Cut and Paste on one of his posts. From

this link a lot of guys print out all his posts and have make a book.

==========================================================================

This is primarily an observation, though there are exceptions.

And it applies only if a person is in a physiologic range.

Estradiol is made from Testosterone.

The brain preferentially measures Estradiol and other estrogens to testosterone

when determining LH and FSH production.

Estrogens are necessary to have testosterone receptors. Without estrogen, one's

cells may be deaf to testosterone.

Testosterone production is needed to overcome Estrogen's unwanted effects -

gynecomastia, etc. Though Thyroid hormone production is also a factor.

Both Estrogens (as measured by Estradiol), and Testosterone are important for

libido.

LH (and HCG), not only increases Testosterone but it increases Estradiol

production. One way of looking at this is that Estradiol production is the

actual reason for LH production, with Testosterone being an intermediate.

The observation is that in well functioning, physiologic level signaling male

adults, a common T to E2 ratio is somewhere around 20:1 to 30:1 - when using

ng/dL testosterone and pg/ml for estradiol and comparing the raw numbers. Thus

an estradiol level of 20 predicts a total testosterone of around 400-600.

This ratio then allows one to determine if estradiol production is too high or

low, in which case, problems in functioning may occur.

If Estradiol production is too high, then adding an aromatase inhibitor is an

option. Blocking the stronger estrogens with Tamoxifen is also an option. If

Estradiol is too low, then HCG is an option. And so forth.

Adding external testosterone throws a wrench in physiology because it also

lowers thyroid hormone production by shutting down testicular function. This

then allows Estradiol to further lower thyroid hormone by increasing thyroid

binding globulin production. This can destabilize mood, among other things, in

susceptible men. Testosterone in this case doesn't necessarily counteract the

negatives of estrogens.

How estrogen affects the nervous system is another complication. If estradiol

increases serotonin excessively (which lowers dopamine), then libido is reduced.

This is an effect not counteracted by testosterone.

The ratio is not hard coded. There is room for flexibility. For example, if

other components contributing to libido are in play, then the ratio can be

higher. But it does give one a starting point for determining what is happening

and what is usually expected.

Supraphysiologic levels of testosteron do not necessarily insure a person has

libido or other positive functions of testosterone unless the other systems are

also tuned for it. It would be great if it was this simple. But for some men,

the peak of testosterone may instead be inhibiting. Testosterone is a very

calming signal, helping reduce norepinephrine signaling. The high and excitement

from sex, however, is given by norepinephrine. Too high a testosterone with too

low an estradiol level would also blunt the libido component from estradiol.

Thus, excessive testosterone can be dulling instead to libido. As the levels go

down, then one may see libido improve as testosterone comes more into balance

with the other signals.

Quote:

Originally Posted by clloyd

I have seen where no stresses the importantance of the T:E ratio. If

someone's total or free test raises substantially through the use of TRT, and

their E2 stays in the 15-25 pg/ml range....I guess, how important is this ratio.

I have an E2 of 25 post TRT (14 pre-TRT). My Total test is currently too high at

1500 ng/ml compared to 400 pre-TRT. I hear a lot of folks here talk about the

15-25 range on E2 but this ignores the T:E ratio? In a lot of his posts he talks

about low SHBG.

http://forum.mesomorphosis.com/mens-health-forum/mariano-testosterone-e2-ratio-1\

34266293.html

__________________

Any statement I make on this site is for educational purposes only and will

change as medical knowledge progresses. It does not constitute medical advice,

does not substitute for proper medical evaluation from physician, does not

create a doctor/patient relationship or liability. If you would like medical

advice, please ask your doctor. Thank you.

Co-Moderator

Phil

> From: bilal naseem <twistedmetal83@...>

> Subject: Treating low SHBG please help

>

> Date: Saturday, May 16, 2009, 4:29 AM

> Hi guys,

> I hope everyone is doing well. I want to know if anybody on

> the group has been able to successfully treat low shbg, With

> low SHBG i am not habing any improvement in my libido or ED

> even after taking HCG for two months. Now it seems i am

> developing gynecomastia . I have a normal thyroid function

> and my fasting insuln levels are also normal so the most

> common indicators for low SHBG are also normal. In effect i

> have an untreatable case of secoundary hypogonadism at a

> ripe old age of 26. According to the endo the low levels of

> shbg lead to higher levels of free estrogens and limit the

> effect of free test which is destroyed much quickly. The

> higher levels of fee estradiol are causing the gynecomastia.

> After taking HCG for two months my total test was 748 and

> estradiol at 35, SHBG was at 11 (range14- 70). Throid,

> Adrenals were also normal. I would like to mention that i

> had Pre-Diaetes before starting TRT with the Fasting Blood

> Sugar at 107. After TRT the FBS

> came down to 93. Please help me in curing my ailment.

> .

>

>

>

>      

>

>

[Guest guest]

On Sat, 16 May 2009 01:29:19 -0700 (PDT), you wrote:

>

>Hi guys,

>I hope everyone is doing well. I want to know if anybody on the group has been

able to successfully treat low shbg, With low SHBG i am not habing any

improvement in my libido or ED even after taking HCG for two months. Now it

seems i am developing gynecomastia . I have a normal thyroid function and my

fasting insuln levels are also normal so the most common indicators for low SHBG

are also normal. In effect i have an untreatable case of secoundary hypogonadism

at a ripe old age of 26. According to the endo the low levels of shbg lead to

higher levels of free estrogens and limit the effect of free test which is

destroyed much quickly. The higher levels of fee estradiol are causing the

gynecomastia. After taking HCG for two months my total test was 748 and

estradiol at 35, SHBG was at 11 (range14- 70). Throid, Adrenals were also

normal. I would like to mention that i had Pre-Diaetes before starting TRT with

the Fasting Blood Sugar at 107. After TRT the FBS

> came down to 93. Please help me in curing my ailment.

Have they tried reducing estradiol through prescribing arimidex?