The Liver, cleaving, and ester groups and other add ons

[Guest guest]

Testosterone pellets are generally " bioidentical " yam/soy derived testosterone

in crystal

form and often there is a blood soluble binding agent involved. Testopel has a

binding

agent. but If I remember correctly, Sotopelle does not have a binding agent.

The T in Testosterone pellets does not have an ester group attached, and so they

do not

need to loose the ester group through the blood filtering process inorder to be

able to

lock in and activate the T receptors in the body. In more simple terms, once

the T

molecules drift away from the implanted pellets and get into the blood stream,

they are

ready to be put to work and they are not destroyed by the liver. This is how

the T

produced through the testicles and from the adrenal glands behaves once it hits

the blood

stream.

I have my suspicions about why the HRT for women went to a predominately pill

based

course of therapy. We are conditioned to take pills for what ails us, and you

can not

patent putting E into a cream for absorbtion nor can you patent putting E into a

crystal

pellet form.

By going to a primarliy pill based HRT for women, what they were putting into

their bodies

had to be similar enough to E to activate the receptors, but as long as the

preparation was

oral based, they had to deal with getting the molecule past the liver without

being

destroyed and being highly liver toxic.

E shots have been around for a quite a while(I find it intersting that E is not

a controlled

substance like T) and they too are nothing more than E molecules(soy/yam

derived) with

an ester group attached. Once in the body, an enzyme breaks off or cleaves the

ester

group off the E molecule and it can now circulate around the body without being

destroyed

by the liver and the estergroup is gone which will allow the molecule to finally

lock into the

recptor and activate it. As long as the estergroup is attached the E or T for

that matter can

not lock into the receptor and activate it. Once again the estergroups are used

to increase

the half life of the T or E once in the body.

So if a person was somehow lacking in the enzyme responsible for cleaving off

the ester

group, injectable T and E would not work very well for them.

Another thing that is done to oral T and oral E is to attach a C17 hydroxyl(sp?)

group, and

these kinds of T and E are genreally hard on the body as they are tough on the

liver. It is

very common for body builders who use oral T variotions to take herbal liver

detox

suppliments to help cleanse and protect their livers.

Of course an E based pill similar to Andriol would have the estergroup, and

Andriol

(testosterone undecanoate) is able to by-pass the liver via the lymphatic system

introduced into the blood stream.

I'm very impressed with your information.

Did I miss the testosterone pellet that is used to treat andropause?

I was told it was testosterone in a crystalline form and dissolves

gradually into the blood stream, not requiring it to be metabolized in

the liver.

The wife could not benefit from the oral estrogen forms of HRT and

suffered terribly with the doctor accusing of being psychosomatic.

He never tested her blood to see if she is in the group of women

that can not metabolize the oral form of estrogen. After 1 1/2 years a

newspaper article saved her when she started pellets. Since 1991 she

has always received both T and E in the same balance as before menopause.

ernestnolan