Worm Pills, an Effective Treatment for Malignant Melanoma and Other Cancers

[Guest guest]

THURSDAY, AUGUST 14, 2008

Mebendazole is a generic, inexpensive prescription medicine used to

treat worm infections. This drug is called a spindle poison because

it interrupts the formation of microtubules, cellular filaments that

separate newly made DNA. Chemo drugs such as Taxol and alkylating

agents are also spindle poisons, but they have toxicities that

mebendazole does not have.

http://en.wikipedia.org/wiki/Mebendazole

http://www.mayoclinic.com/health/drug-information/DR600879

In the last few years, a number of studies have found that

mebendazole is a powerful inducer of apoptosis in a wide variety of

cancer cells, both in culture dishes and mouse models.

In the following study, half maximal cytotoxic doses of mebendazole

in the range 0.1 to 0.8 microM (VERY low) killed a wide diversity of

cancer cells, including lung, breast, ovary, colon and

osteosarcomas. These studies were also conducted in mice.

Mebendazole also inhibited angiogenesis.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed & cmd=Retrieve & dopt=Abstr\

act & list_uids=12231542 & itool=pubmed_docsum

Unlike microtubule disruptive drugs such as Taxol and alkylating

agents, mebendazole does not harm normal cells.

The following study was published this month. It shows that

mebendazole kills two different strains of chemotherapy resistant

melanoma cells. One strain contained a mutant p53 protein while the

other harbored a normal p53 tumor suppresor protein. Mebandazole

kills the cells equally. The half maximal cytotoxic dose was 0.32

microM.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?

db=pubmed & cmd=Retrieve & dopt=Abstract & list_uids=18667591 & itool=pubmed_docsum

Cimetidine, the generic version of the anti-ulcer drug Tagamet,

promotes the toxicity of mebendazole by inhibiting its degradation

in the liver.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed & cmd=Retrieve & dopt=Abstr\

act & list_uids=3663452 & itool=pubmed_d

ocsum

The average blood concentration of mebendazole after a single

clinical dose is 1.67 microM. This value vastly exceeds the

concentration of mebendazole needed to kill a host of different

cancer cells.

Mebendazole is usually sold as a chewable tablet. When chewed and

allowed to remain in the mouth for a short period, the mebendazole

can enter the blood through the mucosal

membranes of the mouth. Of course, it can also enter the blood via

the GI tract. This drug is extremely non-toxic even in doses of 4.5

grams a day.

Microtubule inhibitors are THE target of interest for chemo drugs.

In this case, a simple anti-worm drug inhibits microtubule

functioning at low non-toxic concentrations. In a culture dish and

in mice, mebendazole induces apoptosis in a diversity of cancer

cells at extremely low concentrations.

Unfortunately, this drug will NEVER enter clinical trials as a

treatment for cancer. There is no money to be made.

Fortunately, physicians can prescribe this drug for the treatment of

cancer without a clinical trial. This blog and the referenced

articles contain all the scientific justification that they will

need.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

This essay is reposted from our subscription blog in the public

interest.